Energy adaptive glass matter

Natures eco-systems are living multi-functional mechanical, information systems of chemical composition forming hierarchical structures. They have the ability to learn and adapt to changing climatic circumstance and self regulation of thermal adsorption, from nano scale components. Current technological developments strategies for buildings is a static one, by this understanding materials do not react to differing climatic zones or recognition of global positioning. This is in contrast to natures adaptive function , a responsive system to regulate material composition. Could our buildings use these principles to move from being mere material entities to becoming adaptive, self- regulated conduction performance system, based upon bio-logically adaptive approaches. To exploit the functionalities and behaviour of material science to act as a thermal energy adsorption layer by the application of bio-logically inspired engineering aims, by the principles of capture in enabling thermal transfer and control to regulate thermal management of matter by the objectives of: 1. Thermal conductivity matter behaviour exchange.( Material Adaptivity ) 2. Adaptive real-time performance to enable thermal heat exchange and thermal material management.(Matter Autonomy

Natures buildings as trees : biologically inspired glass as an energy system

The adaptive capacity in creating intelligent glass surfaces will be investigated using the principles of solar absorbance and active fluidic conductivity management as an energy system. To act as a thermal adsorption layer by applying bio-logically inspired engineering aims, of capture in enabling thermal transfer and control to regulate material composition. The creation of an adaptive cooling layer,by responsive measures to mirror our eco-systems through the employment of programmable self-awareness measures to regulate solar adsorption. These strategies for adaptation could enable the transformation of tall buildings, from mere material entities to mimic the intelligent surfaces of trees. Nature’s eco-systems are living multi-functional mechanical, information systems of chemical composition forming hierarchical structures. They have the ability to learn and adapt to changing climatic circumstance by self-regulation of solar adsorption, to achieve material thermal management. These programmable controls of adaptive material performance change in relationship to solar capture. Could this be harnessed to exploit the functionalities and behavior of materials on the surfaces of buildings to act as an energy system, by the application of bio-logically inspired engineering aims: 1. Material absorbency: thermal conductivity adsorption of solar irradiance. 2. Adaptive real-time performance: material autonomy

Biologically inspired transparent material as an energy system

Glazed envelopes on buildings play a major role in operational energy consumptionas they define the boundary conditions between the climate outside and the thermalcomfort inside a building. Glass façades are viewed as an uncontrolled load that setsthe operational performance requirements for air-cooling mechanical systems. Thesefaçades are determined by code compliant performance levels set by a singleprescriptive static, the U value. This is energetically weak, a dynamic IR absorberstrategy is needed, since performance requires change by the hour, season, andweather conditions to sync with a warming earth atmosphere. A transparent dynamicIR absorber , will be modulated by temperature-dependance of the absorber by activetailored flows in a microfluidic based platform, than conventional IR static absorbers.Nature’s characterization of materials is a thermally dynamic response in real time toa microenvironment. This functionality of heat seeking materials would advance a transparent material by energy capture and storage. The hypothesis demonstratesnature’s use of fluidics to direct the structural assembly of a polymer into a thermallyfunctional device, to actively regulate solar radiation as an IR absorber, to lower thepolymer device phase transition temperature. This research determines thisfunctionality by hierarchical multi micro-channel network scaling, as a leaf resistor. Resistor conduit analysis defines flow target resistance through simulation to generatea multi micro-channel network, for enhanced solar radiation absorption. This isdemonstrated by precise hydrodynamic control in a network using switching of waterflow as a thermal switching medium to regulate heat transport flow. Nature evaluatesheat flow transport in real time that is not emulated in current glass façade staticperformance. The knowledge gap is therefore to advance a transparent material from astatic function, to a dynamic IR absorber for solar modulation, and this isdemonstrated in this research

From concept to crystals via prediction: multi‐component organic cage pots by social self‐sorting

We describe the a priori computational prediction and realization of multi‐component cage pots, starting with molecular predictions based on candidate precursors through to crystal structure prediction and synthesis using robotic screening. The molecules were formed by the social self‐sorting of a tri‐topic aldehyde with both a tri‐topic amine and di‐topic amine, without using orthogonal reactivity or precursors of the same topicity. Crystal structure prediction suggested a rich polymorphic landscape, where there was an overall preference for chiral recognition to form heterochiral rather than homochiral packings, with heterochiral pairs being more likely to pack window‐to‐window to form two‐component capsules. These crystal packing preferences were then observed in experimental crystal structures

Leaf venation, as a resistor, to optimize a switchable IR absorber

Leaf vascular patterns are the mechanisms and mechanical support for the transportation of fluidics for photosynthesis and leaf development properties. Vascular hierarchical networks in leaves have far-reaching functions in optimal transport efficiency of functional fluidics. Embedding leaf morphogenesis as a resistor network is significant in the optimization of a translucent thermally functional material. This will enable regulation through pressure equalization by diminishing flow pressure variation. This paper investigates nature’s vasculature networks that exhibit hierarchical branching scaling applied to microfluidics. To enable optimum potential for pressure drop regulation by algorithm design. This code analysis of circuit conduit optimization for transport fluidic flow resistance is validated against CFD simulation, within a closed loop network. The paper will propose this self-optimization, characterization by resistance seeking targeting to determine a microfluidic network as a resistor. To advance a thermally function material as a switchable IR absorber

Four-Stage Audit Demonstrating Increased Uptake of HIV Testing in Acute Neurology Admissions Using Staged Practical Interventions.

BACKGROUND: UK National Guidelines (UKNG) advise HIV testing in clinically indicated neurological presentations. We audited the impact of our practical strategies to increase uptake of HIV testing at a regional acute neurology admissions unit. METHODS: We audited HIV testing in 4 periods over 2 years: before we designed a UKNG-based "HIV testing in Neurology" protocol ("pre-protocol"); after dissemination of the protocol alone ("post-protocol"); post-protocol dissemination combined with both a tailored departmental admissions clerking proforma to prompt for HIV testing & consenting, and regular focussed tutorials to doctors on HIV testing in neurological patients ("post-proforma"); and finally one year after the post-proforma period ("+1 year"). We also looked at the total number of HIV tests sent from the unit during the two-year period. We assessed significance using Fisher's exact test. RESULTS: 47.8% of all acute neurology non-stroke admissions were eligible for HIV testing during all the audit periods. Testing rates were as follows: pre-protocol 21.9%; post-protocol 36.6%; post-proforma 83.3%; and at +1 year 65.4% (p<0.05 for both post-protocol and +1 year when compared to pre-protocol). Documentation of consent for HIV testing improved from 25% to 67.6% with the HIV-tailored clerking proforma. The total number of HIV tests requested from the unit doubled in the post-proforma period compared to pre-protocol (p<0.05). CONCLUSION: In conclusion: the combination of an HIV testing protocol, a tailored departmental clerking proforma and regular focussed teaching to doctors on indications for HIV testing led to a sustained increase in HIV testing uptake in our regional acute neurology admissions unit

PPA2-associated sudden cardiac death: extending the clinical and allelic spectrum in 20 new families

Purpose Biallelic hypomorphic variants in PPA2, encoding the mitochondrial inorganic pyrophosphatase 2 protein, have been recently identified in individuals presenting with sudden cardiac death, occasionally triggered by alcohol intake or a viral infection. Here we report 20 new families harboring PPA2 variants. Methods Synthesis of clinical and molecular data concerning 34 individuals harboring five previously reported PPA2 variants and 12 novel variants, 11 of which were functionally characterized. Results Among the 34 individuals, only 6 remain alive. Twenty-three died before the age of 2 years while five died between 14 and 16 years. Within these 28 cases, 15 died of sudden cardiac arrest and 13 of acute heart failure. One case was diagnosed prenatally with cardiomyopathy. Four teenagers drank alcohol before sudden cardiac arrest. Progressive neurological signs were observed in 2/6 surviving individuals. For 11 variants, recombinant PPA2 enzyme activities were significantly decreased and sensitive to temperature, compared to wild-type PPA2 enzyme activity. Conclusion We expand the clinical and mutational spectrum associated with PPA2 dysfunction. Heart failure and sudden cardiac arrest occur at various ages with inter- and intrafamilial phenotypic variability, and presentation can include progressive neurological disease. Alcohol intake can trigger cardiac arrest and should be strictly avoided