Hyperattenuated Crescent Sign Observed During Endovascular Aneurysm Repair

Background. Ruptured abdominal aortic aneurysms have a high mortality rate with only 50% of patients surviving to presentation at the emergency department.1 Of those who present, approximately one-third will demonstrate the classically described triad of sudden onset abdominal pain, shock, and pulsatile abdominal mass.1 With advancements in technology, radiographic studies have become an integral component of patient evaluation for rupture. Methods. Review of one case and corresponding radiographic findings. Results. Hyperattenuated crescent sign observed intraoperatively without direct correlation with rupture. Conclusions. The hyperattenuated crescent is an important radiographic finding that one should be alerted to in the evaluation of AAA patients. The presence of the sign does not mandate emergent surgery, but care should be taken to optimize the patient’s resuscitation and monitoring in preparation for rupture. Observation of the crescent is not limited to CT imaging and may serve as an important intraoperative finding that may guide operative decision-making

Developing and Integrating the Management of Elder Abuse in Primary Practice: A Case Study Using A Web-Based CME Course Format

Introduction: As the population in the United States continues to age, more attention in primary practice settings is now devoted toward managing the care of the elderly. The occurrence of elder abuse is a growing problem. It is a condition many professionals in primary care may be ill prepared with the knowledge or resources to identify and manage. [See PDF for complete abstract

Estimating expansion of the range of oak processionary moth (Thaumetopoea processionea) in the UK from 2006 to 2019

1. The expansion of oak processionary moth (OPM) in South-East England continues despite ongoing efforts to control the pest since its introduction in 2006. 2. Using locations of OPM larval nests, supplied by the Forestry Commission and recorded as part of ongoing surveillance and control measures from 2006 onwards, we show that the expansion of the range of OPM in South-East England up to 2019 was biphasic with a higher rate of expansion from 2015 onwards. 3. The maximum rate of OPM range expansion in the United Kingdom from 2006 to 2014 was estimated as 1.66 km/year (95% CI = [1.22, 2.09]), whereas the 2015–2019 expansion rate was estimated as 6.17 km/year (95% CI = [5.49, 6.84]). This corresponds to an estimated species range distribution area of 7077 km2 in 2019. 4. To explain the faster expansion of OPM range from 2015 onwards, we discuss potential reasons that include: natural capability of species of both short- and long-distance dispersal; external factors such as environmental heterogeneity; a reduction of active control

Atlas-based segmentation of neck muscles from MRI for the characterisation of Whiplash Associated Disorder

Whiplash-associated disorder (WAD) is a commonly occurring injury that often results from neck trauma suffered in car accidents. However the cause of the condition is still unknown and there is no definitive clinical test for the presence of the condition. Researchers have begun to analyze the size of neck muscles and the presence of fatty infiltrates to help understand WAD. However this analysis requires a high precision delineation of neck muscles which is very challenging due to a lack of distinctive features in neck magnetic resonance imaging (MRI). This paper presents a novel atlas-based neck muscle segmentation method which employs discrete cosine-based elastic registration with affine initialization. Our algorithm shows promising results based on clinical data with an average Dice similarity coefficient (DSC) of 0.84±0.0004

A classroom deployment of a haptic system for learning cell biology

The use of haptic systems in the classroom for enhancing science education is an underexplored area. In the education literature, it has been reported that certain concepts in science education are difficult for students to grasp and, as a result, misconceptions can be formed in the students' knowledge. We conducted a study with 62 Year 8 (typically 12-13 years old) students who used a haptic application to study cell biology, specifically the concept of diffusion across a cell membrane. The preliminary analysis of the feedback from the students suggests opportunities for haptic applications to enhance their learning, and also highlights a number of points to consider in the design of the application, including the choice of haptic interface and the design of the virtual environment

Paging through history: parchment as a reservoir of ancient DNA for next generation sequencing.

Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of researchers. However, prior PCR-based work has indicated that this may be challenged by cross-individual and cross-species contamination, perhaps from the bulk parchment preparation process. Here we apply next generation sequencing to two parchments of seventeenth and eighteenth century northern English provenance. Following alignment to the published sheep, goat, cow and human genomes, it is clear that the only genome displaying substantial unique homology is sheep and this species identification is confirmed by collagen peptide mass spectrometry. Only 4% of sequence reads align preferentially to a different species indicating low contamination across species. Moreover, mitochondrial DNA sequences suggest an upper bound of contamination at 5%. Over 45% of reads aligned to the sheep genome, and even this limited sequencing exercise yield 9 and 7% of each sampled sheep genome post filtering, allowing the mapping of genetic affinity to modern British sheep breeds. We conclude that parchment represents an excellent substrate for genomic analyses of historical livestock

Additive friction stir processing and hybrid metal additive manufacturing of high melting point materials: A review

Ever since the beginning of 4th industrial revolution, metal additive manufacturing has revolutionized the paradigm of printing high melting point materials. In this context, this paper reviews experimental and computational aspects of friction stir processing and hybrid techniques applied for metal additive manufacturing of high melting point materials like steel, and titanium alloys. Initially, friction stir processing working principle has been discussed. Secondly, friction stir processing is compared with other severe plastic deformation techniques and summarized their advantages, disadvantages and applications in a tabular form. Then based on the state-of-the-art of literature, additive friction stir processing and hybrid metal additive manufacturing processes are discussed for high melting point materials and results have been presented with respect to their microstructural developments, mechanical behavior, etc. Finally, gaps are highlighted for high melting point materials that shows importance of selecting process parameters, tooling capacity, computational analysis, mathematical modelling, etc., and presented these as future scope of work

Deep Learning and Random Forest-Based Augmentation of sRNA Expression Profiles

The lack of well-structured annotations in a growing amount of RNA expression data complicates data interoperability and reusability. Commonly - used text mining methods extract annotations from existing unstructured data descriptions and often provide inaccurate output that requires manual curation. Automatic data-based augmentation (generation of annotations on the base of expression data) can considerably improve the annotation quality and has not been well-studied. We formulate an automatic augmentation of small RNA-seq expression data as a classification problem and investigate deep learning (DL) and random forest (RF) approaches to solve it. We generate tissue and sex annotations from small RNA-seq expression data for tissues and cell lines of homo sapiens. We validate our approach on 4243 annotated small RNA-seq samples from the Small RNA Expression Atlas (SEA) database. The average prediction accuracy for tissue groups is 98% (DL), for tissues - 96.5% (DL), and for sex - 77% (DL). The "one dataset out" average accuracy for tissue group prediction is 83% (DL) and 59% (RF). On average, DL provides better results as compared to RF, and considerably improves classification performance for 'unseen' datasets

Post-prophylaxis Toxoplasma chorioretinitis following donor-recipient mismatched liver transplantation

Toxoplasmosis may be transferred by organ transplantation. The most common clinical presentation is with multisystem disease, although isolated ocular toxoplasmosis has been described. Many centers have suggested that universal use of co‐trimoxazole prophylaxis obviates the need for specific Toxoplasma testing. We report a case of donor‐acquired ocular toxoplasmosis after liver transplantation despite co‐trimoxazole prophylaxis. The diagnosis was confirmed by Toxoplasma polymerase chain reaction assay in conjunction with seroconversion. The fact that the infection was donor acquired was confirmed by serological mismatch and the absence of sporozoite‐specific antigen antibody in the recipient