Timing and dynamics of Late Wolstonian Substage 'Moreton Stadial' (MIS 6) glaciation in the English West Midlands, UK

Glaciation during the late Middle Pleistocene is widely recognized across continental northwest Europe, but its extent and palaeoenvironmental significance in the British Isles are disputed. Although glaciogenic sediments at Wolston, Warwickshire, in the English West Midlands, have been used to define the stratotype of the Wolstonian Stage, their age has been variably assigned between marine isotope stages (MIS) 12 and 6. Here we present sedimentological and stratigraphical observations from five sites across the English West Midlands whose chronology is constrained by new luminescence ages from glaciofluvial sediments, supplemented by cosmogenic 36 Cl exposure dating of erratic boulders. The ages suggest that between 199 ± 5 and 147 ± 2.5 ka the British Ice Sheet advanced into the English West Midlands as far south as Moreton-in-Marsh, Gloucestershire. This advance is assigned to the Moreton Stadial of the Late Wolstonian Substage. Dating of the glaciation to this substage allows correlation of the Moreton Stadial glacial deposits in the English West Midlands with those of the Drenthe Stadial during the Late Saalian Substage across continental northwest Europe

Taken by strum: ukuleles and participatory music-making in Hamilton, Aotearoa/New Zealand

Ethnographic study of ukulele playing in Hamilton, N

Frozen Mode Regime in an Optical Waveguide With Distributed Bragg Reflector

We introduce a glide symmetric optical waveguide exhibiting a stationary inflection point (SIP) in the Bloch wavenumber dispersion relation. An SIP is a third order exceptional point of degeneracy (EPD) where three Bloch eigenmodes coalesce to form a so-called frozen mode with vanishing group velocity and diverging amplitude. We show that the incorporation of chirped distributed Bragg reflectors and distributed coupling between waveguides in the periodic structure facilitates the SIP formation and greatly enhances the characteristics of the frozen mode regime. We confirm the existence of an SIP in two ways: by observing the flatness of the dispersion diagram and also by using a coalescence parameter describing the separation of the three eigenvectors collapsing on each other. We find that in the absence of losses, both the quality factor and the group delay at the SIP grow with the cubic power of the cavity length. The frozen mode regime can be very attractive for light amplification and lasing, in optical delay lines, sensors, and modulators.Comment: 11 pages, 14 figure

Design of a Modified Coupled Resonators Optical Waveguide Supporting a Frozen Mode

We design a three-way silicon optical waveguide with the Bloch dispersion relation supporting a stationary inflection point (SIP). The SIP is a third order exceptional point of degeneracy (EPD) where three Bloch modes coalesce forming the frozen mode with greatly enhanced amplitude. The proposed design consists of a coupled resonators optical waveguide (CROW) coupled to a parallel straight waveguide. At any given frequency, this structure supports three pairs of reciprocal Bloch eigenmodes, propagating and/or evanescent. In addition to full-wave simulations, we also employ a so-called ''hybrid model'' that uses transfer matrices obtained from full-wave simulations of sub-blocks of the unit cell. This allows us to account for radiation losses and enables a design procedure based on minimizing the eigenmodes' coalescence parameter. The proposed finite-length CROW displays almost unitary transfer function at the SIP frequency, implying a nearly perfect conversion of the input light into the frozen mode. The group delay and the effective quality factor at the SIP frequency show an $N^{3}$ scaling, where $N$ is the number of unit cells in the cavity. The frozen mode in the CROW can be utilized in various applications like sensors, lasers and optical delay lines.Comment: 14 pages, 17 figure

Videogame player experiences with micro-transactions: an interpretative phenomenological analysis

Background: Videogame monetisation methods have become a billion-dollar industry. Concerns surrounding micro-transaction use and potential negative psychological impact have become prevalent in recent years. For example, there is a suggested association between loot box buying and problem gambling, although this does not capture the nuanced experiences of players with a broad range of micro-transactions. Aim: The present study aimed to identify convergences and divergences in videogame player experiences with micro-transactions, using interpretative phenomenological analysis. Method: Eleven participants took part in online semi-structured interviews. Interviews focused on participants’ feelings, beliefs and motivations surrounding micro-transaction use. Results: Six super-ordinate themes were identified: (i) self-control vs. impulsivity, (ii) motivations for use, (iii) obligation to play after purchases, (iv) guilt and regret, (v) feeling tricked or cheated and (vi) comparing micro-transaction use and gambling. Sub-themes relating to motivations for micro-transaction use and comparisons between micro-transaction and gambling also emerged. Conclusions: Key motivations for micro-transaction use were giving back to or ‘rewarding’ game developers for their work and social connectedness. Participants who engaged with battle pass micro-transactions often felt a sense of obligation to continue playing the game after purchasing. Micro-transaction use was explained by participants' need for autonomy, relatedness, and competence. It is recommended that cognitive behavioural therapy could be used to treat maladaptive cognitive beliefs related to micro-transaction use

Modelling flooding due to runoff from spoil heaps during heavy rainfall

This is the final version. Available from Taylor & Francis via the DOI in this record. Flash floods generated by runoff from abandoned spoil heaps have posed great risks to neighbouring areas but there has been little study on the process, so it is difficult to evaluate the effectiveness of runoff retention or detention measures. These events are likely to become more frequent in a future climate change scenario. To provide a means by which interested parties can study such events, including methods of mitigation, a computer modelling approach is proposed using free open-source software. Unlike conventional tools that solve the shallow water equations, the software tool uses a cellular automata approach to reduce the computational overhead. It is also easy to use so it is suitable for use by practitioners who are not hydrology experts. The method is illustrated by modelling a historical flood in the UK involving spoil heap runoff. Good correlation was observed between the characteristics of the actual and simulated flood event.Research Fund for Coal and SteelEngineering and Physical Sciences Research Counci

Measurement Duration but Not Distance, Angle, and Neighbour-Proximity Affects Precision in Enteric Methane Emissions when Using the Laser Methane Detector Technique in Lactating Dairy Cows

SIMPLE SUMMARY: Methane that is breathed out and eructed from ruminants is a potent greenhouse gas that contributes to climate change. Although metabolic chambers are the “gold standard” for measuring methane from livestock, their application in production farms is very limited. There is a need to develop proxy methods that can be applied in such production environments. The proprietary Laser Methane Detector (LMD) has been trialed for the previous decade and has demonstrated its usefulness as a non-invasive and portable instrument to determine methane output from ruminants. In validating the reliability and stability of the data generated by the LMD, the current study gives answers to some very practical assumptions used in the use of the LMD and enhances the confidence in its use in ruminants. ABSTRACT: The laser methane detector (LMD), is a proprietary hand-held open path laser measuring device. Its measurements are based on infrared absorption spectroscopy using a semiconductor laser as a collimated excitation source. In the current study, LMD measurements were carried out in two experiments using 20 and 71 lactating dairy cows in Spain and Scotland, respectively. The study aimed at testing four assumptions that may impact on the reliability and repeatability of the LMD measurements of ruminants. The study has verified that there is no difference in enteric methane measurements taken from a distance of 3 m than from those taken at a distance of 2 m; there was no effect to the measurements when the measurement angle was adjusted from 90° to 45°; that the presence of an adjacent animal had no effect on the methane measurements; and that measurements lasting up to 240 s are more precise than those taken for a shorter duration. The results indicate that angle, proximity to other animals, and distance had no effects and that measurements need to last a minimum of 240 s to maintain precision

Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils

<p>Abstract</p> <p>Background</p> <p>Polymorphonuclear neutrophils (PMN) constitute an essential cellular component of innate host defense against microbial invasion and exhibit a wide array of responses both to particulate and soluble stimuli. As the cells recruited earliest during acute inflammation, PMN respond rapidly and release a variety of potent cytotoxic agents within minutes of exposure to microbes or their products. PMN rely on the redistribution of functionally important proteins, from intracellular compartments to the plasma membrane and phagosome, as the means by which to respond quickly. To determine the range of membrane proteins available for rapid recruitment during PMN activation, we analyzed the proteins in subcellular fractions enriched for plasma membrane and secretory vesicles recovered from the light membrane fraction of resting PMN after Percoll gradient centrifugation and free-flow electrophoresis purification using mass spectrometry-based proteomics methods.</p> <p>Results</p> <p>To identify the proteins light membrane fractions enriched for plasma membrane vesicles and secretory vesicles, we employed a proteomic approach, first using MALDI-TOF (peptide mass fingerprinting) and then by HPLC-MS/MS using a 3D ion trap mass spectrometer to analyze the two vesicle populations from resting PMN. We identified several proteins that are functionally important but had not previously been recovered in PMN secretory vesicles. Two such proteins, 5-lipoxygenase-activating protein (FLAP) and dysferlin were further validated by immunoblot analysis.</p> <p>Conclusion</p> <p>Our data demonstrate the broad array of proteins present in secretory vesicles that provides the PMN with the capacity for remarkable and rapid reorganization of its plasma membrane after exposure to proinflammatory agents or stimuli.</p

Assessment of an in situ temporal calibration method for time-resolved optical tomography

A 32-channel time-resolved optical imaging device is de- veloped at University College London to produce functional images of the neonatal brain and the female breast. Reconstruction of images using time-resolved measurements of transmitted light requires careful calibration of the temporal characteristics of the measurement system. Since they can often vary over a period of time, it is desirable to evaluate these characteristics immediately after, or prior to, the acqui- sition of image data. A calibration technique is investigated that is based on the measurement of light back-reflected from the surface of the object being imaged. This is facilitated by coupling each detector channel with an individual source fiber. A Monte Carlo model is em- ployed to investigate the influence of the optical properties of the object on the back-reflected signal. The results of simulations indicate that their influence may be small enough to be ignored in some cases, or could be largely accounted for by a small adjustment to the cali- brated data. The effectiveness of the method is briefly demonstrated by imaging a solid object with tissue-equivalent optical properties