Effect of modeling of inherent damping on the response and collapse performance of seismically isolated buildings

Data availability statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.Supporting Information is available online at: https://onlinelibrary.wiley.com/doi/10.1002/eqe.3773#support-information-section .Copyright © 2022 The Authors. This paper investigates the effect of inherent damping modeling on the computed seismic response and collapse performance of selected seismically isolated buildings. The analyzed seismically isolated buildings were designed by the procedures of the ASCE/SEI 7–16 standard. The structure is a six-story perimeter frame building designed with special moment resisting frames or with special concentrically braced frames (SCBF) for a location in California. Three different seismic isolation systems are considered: (i) triple friction pendulum (TFP) bearings without moat walls, (ii) TFP bearings with moat walls (double concave [DC] friction pendulum bearings with moat walls have effectively the same ultimate behavior), and (iii) DC friction pendulum bearings without moat wall. The superstructure inherent damping schemes considered are (i) zero damping, (ii) modal damping, (iii) Zareian-Medina damping, (iv) added virtual viscous dampers with and without force-caps, and (v) added virtual viscous dampers with the same damping constant value. The response parameters computed are peak floor accelerations, peak story drift ratios, peak residual story drift ratios, peak isolator horizontal displacement, and floor acceleration spectra. Also, the probability of collapse in the maximum considered earthquake (MCER) is computed. It is shown that the modeling approach for the inherent damping has minor effects on the computed responses and the collapse probability of the studied seismically isolated buildings, except for the peak floor acceleration and the floor response spectra for periods below one second. It is suggested that a convenient way to model inherent damping is to use virtual viscous dampers with all having the same damping constant

Performance evaluation of seismically isolated buildings near active faults

Data availability statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.Copyright © 2022 The Authors. This paper investigates the collapse risk of seismically isolated buildings that are designed by the procedures of the ASCE/SEI 7-16 standard for sites within 5 km of the active fault that controls the hazard. The study is based on six-story perimeter frame buildings designed with special concentrically braced frames for a location in California. The seismic isolation systems considered in this study are comprised of either: (i) triple friction pendulum bearings with high friction coefficients at the sliding interfaces, (ii) triple friction pendulum bearings with low friction coefficient at the sliding surfaces and enhanced with fluid viscous dampers, or (iii) triple friction pendulum bearings with low friction coefficients at the sliding surfaces. The paper demonstrates that the seismically isolated buildings designed per Section 17.3.3 in ASCE/SEI 7-16 standard, but with either increased isolator displacement capacity or increased superstructure strength by comparison to the minimum required, can achieve an acceptable collapse risk. It is also demonstrated that the seismic isolation systems that have the best collapse performance for far-field motions are not necessarily the best for the near-field pulse-like ground motions.University at Buffal

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition

Introduction IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury. Methods To elucidate the contribution of the lectin pathway to IgAN, we measured the 11 plasma lectin pathway components in a well-characterized cohort of patients with IgAN. Results M-ficolin, L-ficolin, mannan-binding lectin (MBL)–associated serine protease (MASP)-1 and MBL-associated protein (MAp) 19 were increased, whereas plasma MASP-3 levels were decreased in patients with IgAN compared with healthy controls. Progressive disease was associated with low plasma MASP-3 levels and increased glomerular staining for C3b/iC3b/C3c, C3d, C4d, C5b-9, and factor H–related protein 5 (FHR5). Glomerular FHR5 deposition positively correlated with glomerular C3b/iC3b/C3c, C3d, and C5b-9 deposition, but not with glomerular C4d. These observations, together with the finding that glomerular factor H (fH) deposition was reduced in progressive disease, are consistent with a role for fH deregulation by FHR5 in renal injury in IgAN. Conclusion Our data indicate that circulating MASP-3 levels could be used as a biomarker of disease severity in IgAN and that glomerular staining for FHR5 could both indicate alternative complement pathway activation and be a tissue marker of disease severity

Fail-safe optimization of viscous dampers for seismic retrofitting

This paper presents a new optimization approach for designing minimum-cost fail-safe distributions of fluid viscous dampers for seismic retrofitting. Failure is modeled as either complete damage of the dampers or partial degradation of the dampers' properties. In general, this leads to optimization problems with large number of constraints. Thus, the use of a working-set optimization algorithm is proposed. The main idea is to solve a sequence of relaxed optimization sub-problems with a small sub-set of all constraints. The algorithm terminates once a solution of a sub-problem is found that satisfies all the constraints of the problem. The retrofitting cost is minimized with constraints on the inter-story drifts at the peripheries of frame structures. The structures considered are subjected to a realistic ensemble of ground motions, and their response is evaluated with time-history analyses. The transient optimization problem is efficiently solved with a gradient-based sequential linear programming algorithm. The gradients of the response functions are calculated with a consistent adjoint sensitivity analysis procedure. Promising results attained for 3-D irregular frames are presented and discussed. The numerical results highlight the fact that the optimized layout and size of the dampers can change significantly even for moderate levels of damage

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks

RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which occurs at inactivated replication forks by the annealing of blocked leading and lagging strand ends. RuvAB was recently proposed to bind replication forks and directly catalyze their conversion into HJs. We report here the isolation and characterization of two separation-of-function ruvA mutants that resolve HJs, based on their capacity to promote conjugational recombination and recombinational repair of UV and mitomycin C lesions, but have lost the capacity to reverse forks. In vivo and in vitro evidence indicate that the ruvA mutations affect DNA binding and the stimulation of RuvB helicase activity. This work shows that RuvA's actions at forks and at HJs can be genetically separated, and that RuvA mutants compromised for fork reversal remain fully capable of homologous recombination

Corneal Sensitivity and Dry Eye Symptoms in Patients with Keratoconus.

PURPOSE: To investigate corneal sensitivity to selective mechanical, chemical, and thermal stimulation and to evaluate their relation to dry eye symptoms in patients with keratoconus. METHODS: Corneal sensitivity to mechanical, chemical, and thermal thresholds were determined using a gas esthesiometer in 19 patients with keratoconus (KC group) and in 20 age-matched healthy subjects (control group). Tear film dynamics was assessed by Schirmer I test and by the non-invasive tear film breakup time (NI-BUT). All eyes were examined with a rotating Scheimpflug camera to assess keratoconus severity. RESULTS: KC patients had significatly decreased tear secretion and significantly higher ocular surface disease index (OSDI) scores compared to controls (5.3+/-2.2 vs. 13.2+/-2.0 mm and 26.8+/-15.8 vs. 8.1+/-2.3; p0.05). The mean threshold for selective mechanical (KC: 139.2+/-25.8 vs. control: 109.1+/-24.0 ml/min), chemical (KC: 39.4+/-3.9 vs. control: 35.2+/-1.9%CO2), heat (KC: 0.91+/-0.32 vs. control: 0.54+/-0.26 Delta degrees C) and cold (KC: 1.28+/-0.27 vs. control: 0.98+/-0.25 Delta degrees C) stimulation in the KC patients were significantly higher than in the control subjects (p0.05), whereas in the control subjects both mechanical (r = 0.52, p = 0.02), chemical (r = 0.47, p = 0.04), heat (r = 0.26, p = 0.04) and cold threshold (r = 0.40, p = 0.03) increased with age. In the KC group, neither corneal thickness nor tear flow, NI-BUT or OSDI correlated significantly with mechanical, chemical, heat or cold thresholds (p>0.05 for all variables). CONCLUSIONS: Corneal sensitivity to different types of stimuli is decreased in patients with keratoconus independently of age and disease severity. The reduction of the sensory input from corneal nerves may contribute to the onset of unpleasant sensations in these patients and might lead to the impaired tear film dynamics

An efficient likelihood-free Bayesian computation for model selection and parameter estimation applied to structural dynamics

Model selection is a challenging problem that is of importance in many branches of the sciences and engineering, particularly in structural dynamics. By definition, it is intended to select the most plausible model among a set of competing models, that best matches the dynamic behaviour of a real structure and better predicts the measured data. The Bayesian approach is based essentially on the evaluation of a likelihood function and is arguably the most popular approach. However, in some circumstances, the likelihood function is intractable or not available even in a closed form. To overcome this issue, likelihood-free or approximate Bayesian computation (ABC) algorithms have been introduced in the literature, which relax the need of an explicit likelihood function to measure the degree of similarity between model prediction and measurements. One major issue with the ABC algorithms in general is the low acceptance rate which is actually a common problem with the traditional Bayesian methods. To overcome this shortcoming and alleviate the computational burden, a new variant of the ABC algorithm based on an ellipsoidal nested sampling technique is introduced in this paper. It has been called ABC-NS. This paper will demonstrate how the new algorithm promises drastic speedups and provides good estimates of the unknown parameters. To demonstrate its practical applicability, two illustrative examples are considered. Firstly, the efficiency of the novel algorithm to deal with parameter estimation is demonstrated using a moving average process based on synthetic measurements. Secondly, a real structure called the VTT benchmark, which consists of a wire rope isolators mounted between a load mass and a base mass, is used to further assess the performance of the algorithm in solving the model selection issue

Phage Display against Corneal Epithelial Cells Produced Bioactive Peptides That Inhibit Aspergillus Adhesion to the Corneas

Dissection of host-pathogen interactions is important for both understanding the pathogenesis of infectious diseases and developing therapeutics for the infectious diseases like various infectious keratitis. To enhance the knowledge about pathogenesis infectious keratitis, a random 12-mer peptide phage display library was screened against cultured human corneal epithelial cells (HCEC). Fourteen sequences were obtained and BLASTp analysis showed that most of their homologue counterparts in GenBank were for defined or putative proteins in various pathogens. Based on known or predicted functions of the homologue proteins, ten synthetic peptides (Pc-A to Pc-J) were measured for their affinity to bind cells and their potential efficacy to interfere with pathogen adhesion to the cells. Besides binding to HCEC, most of them also bound to human corneal stromal cells and umbilical endothelial cells to different extents. When added to HCEC culture, the peptides induced expression of MyD88 and IL-17 in HCEC, and the stimulated cell culture medium showed fungicidal potency to various extents. While peptides Pc-C and Pc-E inhibited Aspergillus fumigatus (A.f) adhesion to HCEC in a dose-dependent manner, the similar inhibition ability of peptides Pc-A and Pc-B required presence of their homologue ligand Alb1p on A.f. When utilized in an eyeball organ culture model and an in vivo A.f keratitis model established in mouse, Pc-C and Pc-E inhibited fungal adhesion to corneas, hence decreased corneal disruption caused by inflammatory infiltration. Affinity pull-down of HCEC membrane proteins with peptide Pc-C revealed several molecules as potential receptors for this peptide. In conclusion, besides proving that phage display-selected peptides could be utilized to interfere with adhesion of pathogens to host cells, hence could be exploited for managing infectious diseases including infectious keratitis, we also proposed that the phage display technique and the resultant peptides could be used to explore host-pathogen interactions at molecular levels