31 research outputs found
ŠŠøŠ½ŠµŃŠøŠŗŠ° Š²Š¾ŃŃŃŠ°Š½Š¾Š²Š»ŠµŠ½ŠøŃ Š¶ŠµŠ»ŠµŠ·Š° ŠæŃŠø Š²Š¾ŃŃŃŠ°Š½Š¾Š²ŠøŃŠµŠ»ŃŠ½Š¾Š¹ ŠæŠ»Š°Š²ŠŗŠµ ŃŃŠ“Š¾ŃŠ³Š¾Š»ŃŠ½ŃŃ Š¾ŠŗŠ°ŃŃŃŠµŠ¹
ŠŃŃŠ»ŠµŠ“Š¾Š²Š°Š½Š¾ Š²Š»ŠøŃŠ½ŠøŠµ ŠøŠ½ŃŠµŠ½ŃŠøŠ²Š½Š¾ŃŃŠø ŃŠµŠæŠ»Š¾Š¾Š±Š¼ŠµŠ½Š° Š½Š° ŠŗŠøŠ½ŠµŃŠøŠŗŃ Š²Š¾ŃŃŃŠ°Š½Š¾Š²Š»ŠµŠ½ŠøŃ Š¶ŠµŠ»ŠµŠ·Š° Š² ŠæŃŠ¾ŃŠµŃŃŠµ ŠæŠ»Š°Š²ŠŗŠø ŃŃŠ“Š¾ŃŠ³Š¾Š»ŃŠ½ŃŃ
Š¾ŠŗŠ°ŃŃŃŠµŠ¹. ŠŠ¾ŠŗŠ°Š·Š°Š½Š¾, ŃŃŠ¾ Ń ŃŠ¾ŃŃŠ¾Š¼ ŠøŠ½ŃŠµŠ½ŃŠøŠ²Š½Š¾ŃŃŠø ŃŠµŠæŠ»Š¾Š¾Š±Š¼ŠµŠ½Š° ŠæŠ¾Š²ŃŃŠ°ŠµŃŃŃ ŃŠŗŠ¾ŃŠ¾ŃŃŃ Š²Š¾ŃŃŃŠ°Š½Š¾Š²ŠøŃŠµŠ»ŃŠ½ŃŃ
ŠæŃŠ¾ŃŠµŃŃŠ¾Š². ŠŃŠ»ŠµŠ“ŃŃŠ²ŠøŠµ ŃŠ¾ŃŃŠ° ŠŗŠ¾ŃŃŃŠøŃŠøŠµŠ½ŃŠ° ŃŠµŠæŠ»Š¾Š¾Š±Š¼ŠµŠ½Š° ŃŠ²ŠµŠ»ŠøŃŠøŠ²Š°ŠµŃŃŃ Š³Š»ŃŠ±ŠøŠ½Š° Š²Š¾ŃŃŃŠ°Š½Š¾Š²Š»ŠµŠ½Š½Š¾Š³Š¾ ŃŠ»Š¾Ń Š¾ŠŗŠ°ŃŃŃŠ°, ŃŃŃŠµŃŃŠ²ŠµŠ½Š½Š¾ ŠøŠ·Š¼ŠµŠ½ŃŃŃŃŃ ŠµŠ³Š¾ ŃŃŃŃŠŗŃŃŃŠ° Šø Ń
ŠøŠ¼ŠøŃŠµŃŠŗŠøŠ¹ ŃŠ¾ŃŃŠ°Š² Š¾Š±ŃŠ°Š·ŃŃŃŠµŠ¹ŃŃ Š¼ŠµŃŠ°Š»Š»ŠøŃŠµŃŠŗŠ¾Š¹ ŃŠ°Š·Ń.ŠŠ¾ŃŠ»ŃŠ“Š¶ŠµŠ½Š¾ Š²ŠæŠ»ŠøŠ² ŃŠ½ŃŠµŠ½ŃŠøŠ²Š½Š¾ŃŃŃ ŃŠµŠæŠ»Š¾Š¾Š±Š¼ŃŠ½Ń Š½Š° ŠŗŃŠ½ŠµŃŠøŠŗŃ Š²ŃŠ“Š½Š¾Š²Š»ŠµŠ½Š½Ń Š·Š°Š»ŃŠ·Š° Š² ŠæŃŠ¾ŃŠµŃŃ ŠæŠ»Š°Š²ŠŗŠø ŃŃŠ“Š¾Š²ŃŠ³ŃŠ»ŃŠ½ŠøŃ
Š¾ŠŗŠ°ŃŠøŃŃŠ². ŠŠ¾ŠŗŠ°Š·Š°Š½Š¾, ŃŠ¾ ŠæŃŠø Š·ŃŠ¾ŃŃŠ°Š½Š½Ń ŃŠ½ŃŠµŠ½ŃŠøŠ²Š½Š¾ŃŃŃ ŃŠµŠæŠ»Š¾Š¾Š±Š¼ŃŠ½Ń ŠæŃŠ“Š²ŠøŃŃŃŃŃŃŃ ŃŠ²ŠøŠ“ŠŗŃŃŃŃ Š²ŃŠ“Š½Š¾Š²Š»ŃŠ²Š°Š»ŃŠ½ŠøŃ
ŠæŃŠ¾ŃŠµŃŃŠ². ŠŠ½Š°ŃŠ»ŃŠ“Š¾Šŗ Š·ŃŠ¾ŃŃŠ°Š½Š½Ń ŠŗŠ¾ŠµŃŃŃŃŃŠ½ŃŃ ŃŠµŠæŠ»Š¾Š¾Š±Š¼ŃŠ½Ń Š·Š±ŃŠ»ŃŃŃŃŃŃŃŃ Š³Š»ŠøŠ±ŠøŠ½Š° Š²ŃŠ“Š½Š¾Š²Š»ŠµŠ½Š¾Š³Š¾ ŃŠ°ŃŃ Š¾ŠŗŠ°ŃŠøŃŠ°, ŃŃŃŃŃŠ²Š¾ Š·Š¼ŃŠ½ŃŃŃŃŃŃ Š¹Š¾Š³Š¾ ŃŃŃŃŠŗŃŃŃŠ° ŃŠ° Ń
ŃŠ¼ŃŃŠ½ŠøŠ¹ ŃŠŗŠ»Š°Š“ Š¼ŠµŃŠ°Š»ŠµŠ²Š¾Ń ŃŠ°Š·Šø, ŃŠ¾ ŃŃŠ²Š¾ŃŃŃŃŃŃŃ.Influence of intensity of heat exchange is investigational on kinetics reduction of iron in the process of melting ore-coal pellets. It is rotined that speed of reduction processes rises with growth of intensity of heat exchange. Because of growth of coefficient of heat exchange the depth of the recovered layer of pellet is increased, his structure and chemical composition of appearing metallic phase changes substantially
Hippocampal CA3 Transcriptome Signature Correlates with Initial Precipitating Injury in Refractory Mesial Temporal Lobe Epilepsy
Background: Prolonged febrile seizures constitute an initial precipitating injury (IPI) commonly associated with refractory mesial temporal lobe epilepsy (RMTLE). in order to investigate IPI influence on the transcriptional phenotype underlying RMTLE we comparatively analyzed the transcriptomic signatures of CA3 explants surgically obtained from RMTLE patients with (FS) or without (NFS) febrile seizure history. Texture analyses on MRI images of dentate gyrus were conducted in a subset of surgically removed sclerotic hippocampi for identifying IPI-associated histo-radiological alterations.Methodology/Principal Findings: DNA microarray analysis revealed that CA3 global gene expression differed significantly between FS and NFS subgroups. An integrative functional genomics methodology was used for characterizing the relations between GO biological processes themes and constructing transcriptional interaction networks defining the FS and NFS transcriptomic signatures and its major gene-gene links (hubs). Co-expression network analysis showed that: i) CA3 transcriptomic profiles differ according to the IPI; ii) FS distinctive hubs are mostly linked to glutamatergic signalization while NFS hubs predominantly involve GABAergic pathways and neurotransmission modulation. Both networks have relevant hubs related to nervous system development, what is consistent with cell genesis activity in the hippocampus of RMTLE patients. Moreover, two candidate genes for therapeutic targeting came out from this analysis: SSTR1, a relevant common hub in febrile and afebrile transcriptomes, and CHRM3, due to its putative role in epilepsy susceptibility development. MRI texture analysis allowed an overall accuracy of 90% for pixels correctly classified as belonging to FS or NFS groups. Histological examination revealed that granule cell loss was significantly higher in FS hippocampi.Conclusions/Significance: CA3 transcriptional signatures and dentate gyrus morphology fairly correlate with IPI in RMTLE, indicating that FS-RMTLE represents a distinct phenotype. These findings may shed light on the molecular mechanisms underlying refractory epilepsy phenotypes and contribute to the discovery of novel specific drug targets for therapeutic interventions
Non-conventional sources of peptides presented by MHC class I
Effectiveness of immune surveillance of intracellular viruses and bacteria depends upon a functioning antigen presentation pathway that allows infected cells to reveal the presence of an intracellular pathogen. The antigen presentation pathway uses virtually all endogenous polypeptides as a source to produce antigenic peptides that are eventually chaperoned to the cell surface by MHC class I molecules. Intriguingly, MHC I molecules present peptides encoded not only in the primary open reading frames but also those encoded in alternate reading frames. Here, we review recent studies on the generation of cryptic pMHC I. We focus on the immunological significance of cryptic pMHC I, and the novel translational mechanisms that allow production of these antigenic peptides from unconventional sources
Diagnosis of late-onset Pompe disease and other muscle disorders by next-generation sequencing
More than just childās play?: An experimental investigation of the impact of an appearance-focused internet game on body image and career aspirations of young girls
Ā© 2017, The Author(s). In recent years, elements of the modern environment (such as television, Internet, toys and clothes) have been criticized for having an increasingly sexualized or appearance focus, which has been suggested to be detrimental to girlsā development. The current study examined the impact of an appearance-focused Internet game on young girlsā body image and career cognitions and aspirations. Eighty British girls aged 8ā9 years were randomly assigned to play an appearance-focused or a non-appearance focused game for 10 minutes. Girls in the appearance-focused game condition displayed greater body dissatisfaction compared to the control condition. Type of game did not impact girlsā perceived capacity to do various jobs. However, girls who played the appearance-focused game reported a greater preference for feminine careers compared to the control group. This provides preliminary evidence that appearance-focused Internet games may be detrimental to young girlsā body image and aspirations. Internet games should be included in our consideration of influential messages for young girls