Personalized early detection and prevention of breast cancer: ENVISION consensus statement

Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness–implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas

Application of the luminescence single-aliquot technique for dose estimation in the Marmara Sea

Turkoz, Mustafa Burak/0000-0002-4127-7650; Bolukdemir, Mustafa/0000-0002-7911-7863; Bolukdemir, Mustafa Hicabi/0000-0002-7911-7863WOS: 000233786300008PubMed: 15961197The aim of this study is to obtain the equivalent dose, which is the important quantity for all the studies related to the use of luminescence in dating sediments. Recent advances in luminescence dating have led to increasing application of the technique to sediment from the depositional environmental samples. The sample used in this study is the active main fault sample that was collected from the Sea of Marmara in NW Turkey. Equivalent dose was measured using both the multiple-aliquots and the single-aliquot techniques. In this study single aliquot regeneration on additive dose (SARA) procedure was also used. The result obtained was not in agreement with the results evaluated from the multiple-aliquots procedure. So a simple modification was suggested for SARA. procedure. In our modified procedure the calculated dose (D) values were obtained by using the additive dose protocol instead of regeneration protocol. (c) 2005 Elsevier Ltd. All rights reserved

Comparison of the decay-rate parameter of the luminescence signal generated by various laboratory radiation doses

Turkoz, Mustafa Burak/0000-0002-4127-7650; Bolukdemir, Mustafa Hicabi/0000-0002-7911-7863; Bolukdemir, Mustafa/0000-0002-7911-7863WOS: 000231307200010In this work the parameter a representing the decay-rate of luminescence signal was investigated for two different samples, for luminescence dating purpose. The procedures of preheating/measurement and dose/preheating/measurement were repeatedly used for the natural and beta-irradiated forms of the samples at different infrared-stimulation time. Experimental data has shown that the IRSL signal decays in a way, which depends on the beta-dose given to the samples. This behavior is different from that observed by DULLER1 who did not find such dose-dependence

Clinical Significance of HER2 Overexpression in Gastric and Gastroesophageal Junction Cancers

PMID = 2617966

The effects of fixed and removable orthodontic retainers: a systematic review.

OBJECTIVE: In the view of the widespread acceptance of indefinite retention, it is important to determine the effects of fixed and removable orthodontic retainers on periodontal health, survival and failure rates of retainers, cost-effectiveness, and impact of orthodontic retainers on patient-reported outcomes. METHODS: A comprehensive literature search was undertaken based on a defined electronic and gray literature search strategy ( PROSPERO: CRD42015029169). The following databases were searched (up to October 2015); MEDLINE via OVID, PubMed, the Cochrane Central Register of Controlled Trials, LILACS, BBO, ClinicalTrials.gov, the National Research Register, and ProQuest Dissertation and Thesis database. Randomized and non-randomized controlled clinical trials, prospective cohort studies, and case series (minimum sample size of 20) with minimum follow-up periods of 6 months reporting periodontal health, survival and failure rates of retainers, cost-effectiveness, and impact of orthodontic retainers on patient-reported outcomes were identified. The Cochrane Collaboration's Risk of Bias tool and Newcastle-Ottawa Scale were used to assess the quality of included trials. RESULTS: Twenty-four studies were identified, 18 randomized controlled trials and 6 prospective cohort studies. Of these, only 16 were deemed to be of high quality. Meta-analysis was unfeasible due to considerable clinical heterogeneity and variations in outcome measures. The mean failure risk for mandibular stainless steel fixed retainers bonded from canine to canine was 0.29 (95 % confidence interval [CI] 0.26, 0.33) and for those bonded to canines only was 0.25 (95 % CI: 0.16, 0.33). A meta-regression suggested that failure of fixed stainless steel mandibular retainers was not directly related to the period elapsed since placement (P = 0.938). CONCLUSION: Further well-designed prospective studies are needed to elucidate the benefits and potential harms associated with orthodontic retainers