The institutionalization of Participatory Guarantee Systems (PGS) in Brazil: organic and fair trade initiatives

Since the nineties the Brazilian organic movements have been looking for alternatives to certification. They have argued that in and of itself or alone certification of family farms and small enterprise is not enough to promote either the learning processes associated with organic production or stimulate development of the local market. The discussion on a Brazilian System for Fair Trade began in 2004, and PGS were considered helpful for organizing farmers, providing guarantees and improving the market. In 2007, a draft of PGS regulation for use in organic was elaborated. The same actors who helped build the Organic System are also discussing Fair Trade System. With the help of public resources, NGOs and family farmers have established systems that provide credibility to consumers with regard to organic qualities and fair trade criteria. The use of PGS is a trend for family farmers trying to access quality markets and also helps participatory research. To some, one perceived challenge is to integrate the two policies (organic and fair trade) since the target publics are similar and the international cooperation agencies give support to both. However, current international initiatives for regulating PGS do not take into account the position of local movements. In the nineties a strategy blind to such a weakness split the organic movements in Latin America and it is unlikely that a similar strategy will promote harmonization or equivalence in the future

Primes and Consequences: A Systematic Review of Meritocracy in Intergroup Relations

Psychological interest in Meritocracy as an important social norm regulating most of the western democratic societies has significantly increased over the years. However, the way Meritocracy has been conceptualized and operationalized in experimental studies has advanced in significant ways. As a result, a variety of paradigms arose to understand the social consequences of Meritocracy for intergroup relations; in particular, to understand the adverse consequences of Meritocracy for disadvantaged group members. The present research seeks to understand whether there is strong support for the idea that (manipulated) Meritocracy disproportionally affects members of low status groups, and also to understand which specific components of this norm have been successfully manipulated and to what consequences. And this is particularly important given the recent call for greater transparency in how the success of experimental manipulations is reported. Thus, we carried out a systematic review examining the content of different prime tasks, summarizing prime manipulation checks' effectiveness, and analyzing whether priming Meritocracy leads to less favorable orientations toward low status groups. Results across 33 studies revealed that despite the existing differences in the components highlighted, the salience of any of the Meritocracy dimensions facilitates the use of internal causal attributions, negative evaluations and stereotyping toward low status groups, affecting negatively decisions involving low-status group members, particularly in specific domains, as organizational contexts. These results carry both practical and theoretical implications for future research on the role of Meritocracy in intergroup settings.info:eu-repo/semantics/publishedVersio

Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial.

INTRODUCTION AND AIMS: Naloxone is an opioid antagonist used for emergency resuscitation following opioid overdose. Prisoners with a history of heroin use by injection have a high risk of drug-related death in the first weeks after prison-release. The N-ALIVE trial was planned as a large prison-based randomised controlled trial (RCT) to test the effectiveness of naloxone-on-release in the prevention of fatal opiate overdoses soon after release. The N-ALIVE pilot trial was conducted to test the main trial's assumptions on recruitment of prisons and prisoners, and the logistics for ensuring that participants received their N-ALIVE pack on release. DESIGN AND METHODS: Adult prisoners who had ever injected heroin, were incarcerated for ≥7 days and were expected to be released within 3 months were eligible. Participants were randomised to receive, on liberation, a pack containing a single 'rescue' injection of naloxone or a control pack with no naloxone syringe. The trial was double-blind prior to prison-release. RESULTS: We randomised 1685 prisoners (842 naloxone; 843 control) across 16 prisons in England. We stopped randomisation on 8 December 2014 because only one-third of administrations of naloxone-on-release were to the randomised ex-prisoner; two-thirds were to others whom we were not tracing. DISCUSSION AND CONCLUSIONS: Prevention RCTs are seldom conducted within prisons; we demonstrated the feasibility of conducting a multi-prison RCT to prevent fatality from opioid overdose in the outside community. We terminated the N-ALIVE trial due to the infeasibility of individualised randomisation to naloxone-on-release. Large RCTs are feasible within prisons.The pilot N-ALIVE Trial was grant-funded by the Medical Research Council (MC_G0800012) and co- ordinated by the MRC Clinical Trials Unit at Univer- sity College London, which core-funds MKBP, LC and AMM. SMB was funded by Medical Research Council program number MC_U10526079

Physiological and Movement Demands of Rugby League Referees: Influence on Penalty Accuracy.

Research into the physiological and movement demands of Rugby League (RL) referees is limited, with only one study in the European Super League (SL). To date, no studies have considered decision-making in RL referees. The purpose of this study was to quantify penalty accuracy scores of RL referees and determine the relationship between penalty accuracy and total distance covered (TD), high-intensity running (HIR) and heart rate per 10-min period of match-play. Time motion analysis was undertaken on 8 referees over 148 European SL games during the 2012 season using 10Hz GPS analysis and heart rate monitors. The number and timing of penalties awarded was quantified using Opta Stats. Referees awarded the correct decision on 74 ± 5% of occasions. Lowest accuracy was observed in the last 10-minute period of the game (67 ± 13%), with a moderate drop (ES= 0.86) in accuracy observed between 60-70 minutes and 70-80 minutes. Despite this, there were only small correlations observed between HRmean, total distance, HIR efforts and penalty accuracy. Although a moderate correlation was observed between maximum velocity and accuracy. Despite only small correlations observed, it would be rash to assume that physiological and movement demands of refereeing have no influence on decision-making. More likely, other confounding variables influence referee decision-making accuracy, requiring further investigation. Findings can be used by referees and coaches to inform training protocols, ensuring training is specific to both cognitive and physical match demands

An alternative dosing strategy for ropeginterferon alfa-2b may help improve outcomes in myeloproliferative neoplasms: An overview of previous and ongoing studies with perspectives on the future

Ropeginterferon alfa-2b is a novel, long-acting mono-pegylated proline-IFN-alpha-2b approved for treatment of polycythemia vera in adults, regardless of thrombotic risk level or treatment history. Clinical trial data indicate the dose and titration of ropeginterferon alfa-2b is safe and effective. However, additional studies may provide rationale for an amended, higher initial dosage and rapid titration. This article is an overview of current and upcoming studies of ropeginterferon alfa-2b in myeloproliferative neoplasms that support the exploration of an amended dosing scheme in order to optimize patient tolerability and efficacy outcomes

Games based learning for Exploring Cultural Conflict

In this paper we discuss the early stage design of MIXER, a technology enhance educational application focused at supporting children in learning about cultural conflict, achieved through the use of a game with an effective embodied AI agent. MIXER is being developed re-using existing technology applied to a different context and purpose with the aim of creating an educational and enjoyable experience for 9-11 year olds. This paper outlines MIXER’s underpinning technology and theory. It presents early stage design and development, highlighting current research directions

Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

<p>Abstract</p> <p>Background</p> <p>Adherent and invasive <it>Escherichia coli </it>(AIEC) are commonly found in ileal lesions of Crohn's Disease (CD) patients, where they adhere to intestinal epithelial cells and invade into and survive in epithelial cells and macrophages, thereby gaining access to a typically restricted host niche. Colonization leads to strong inflammatory responses in the gut suggesting that AIEC could play a role in CD immunopathology. Despite extensive investigation, the genetic determinants accounting for the AIEC phenotype remain poorly defined. To address this, we present the complete genome sequence of an AIEC, revealing the genetic blueprint for this disease-associated <it>E. coli </it>pathotype.</p> <p>Results</p> <p>We sequenced the complete genome of <it>E. coli </it>NRG857c (O83:H1), a clinical isolate of AIEC from the ileum of a Crohn's Disease patient. Our sequence data confirmed a phylogenetic linkage between AIEC and extraintestinal pathogenic <it>E. coli </it>causing urinary tract infections and neonatal meningitis. The comparison of the NRG857c AIEC genome with other pathogenic and commensal <it>E. coli </it>allowed for the identification of unique genetic features of the AIEC pathotype, including 41 genomic islands, and unique genes that are found only in strains exhibiting the adherent and invasive phenotype.</p> <p>Conclusions</p> <p>Up to now, the virulence-like features associated with AIEC are detectable only phenotypically. AIEC genome sequence data will facilitate the identification of genetic determinants implicated in invasion and intracellular growth, as well as enable functional genomic studies of AIEC gene expression during health and disease.</p