Numerical relativity simulation of GW150914 beyond general relativity

We produce the first astrophysically-relevant numerical binary black hole gravitational waveform in a higher-curvature theory of gravity beyond general relativity. We simulate a system with parameters consistent with GW150914, the first LIGO detection, in order-reduced dynamical Chern-Simons gravity, a theory with motivations in string theory and loop quantum gravity. We present results for the leading-order corrections to the merger and ringdown waveforms, as well as the ringdown quasi-normal mode spectrum. We estimate that such corrections may be discriminated in detections with signal to noise ratio $\gtrsim 180-240$, with the precise value depending on the dimension of the GR waveform family used in data analysis.Comment: 7 pages + appendices, 8 figures, Updated to match Phys. D. Rev articl

Numerical binary black hole collisions in dynamical Chern-Simons gravity

We produce the first numerical relativity binary black hole gravitational waveforms in a higher-curvature theory beyond general relativity. In particular, we study head-on collisions of binary black holes in order-reduced dynamical Chern-Simons gravity. This is a precursor to producing beyond-general-relativity waveforms for inspiraling binary black hole systems that are useful for gravitational wave detection. Head-on collisions are interesting in their own right, however, as they cleanly probe the quasinormal mode spectrum of the final black hole. We thus compute the leading-order dynamical Chern-Simons modifications to the complex frequencies of the postmerger gravitational radiation. We consider equal-mass systems, with equal spins oriented along the axis of collision, resulting in remnant black holes with spin. We find modifications to the complex frequencies of the quasinormal mode spectrum that behave as a power law with the spin of the remnant, and that are not degenerate with the frequencies associated with a Kerr black hole of any mass and spin. We discuss these results in the context of testing general relativity with gravitational wave observations

Numerical relativity simulation of GW150914 beyond general relativity

We produce the first astrophysically relevant numerical binary black hole gravitational waveform in a higher-curvature theory of gravity beyond general relativity. We simulate a system with parameters consistent with GW150914, the first LIGO detection, in order-reduced dynamical Chern-Simons gravity, a theory with motivations in string theory and loop quantum gravity. We present results for the leading-order corrections to the merger and ringdown waveforms, as well as the ringdown quasinormal mode spectrum. We estimate that such corrections may be discriminated in detections with signal to noise ratio ≳180–240, with the precise value depending on the dimension of the GR waveform family used in data analysis

Extremely low frequency magnetic field induces human neuronal differentiation through NMDA receptor activation

Magnetic fields with different frequency and intensity parameters exhibit a wide range of effects on different biological models. Extremely low frequency magnetic field (ELF MF) exposure is known to augment or even initiate neuronal differentiation in several in vitro and in vivo models. This effect holds potential for clinical translation into treatment of neurodegenerative conditions such as autism, Parkinson's disease and dementia by promoting neurogenesis, non-invasively. However, the lack of information on underlying mechanisms hinders further investigation into this phenomenon. Here, we examine involvement of glutamatergic Ca2+ channel, N-methyl-D-aspartate (NMDA) receptors in the process of human neuronal differentiation under ELF MF exposure. We show that human neural progenitor cells (hNPCs) differentiate more efficiently under ELF MF exposure in vitro, as demonstrated by the abundance of neuronal markers. Furthermore, they exhibit higher intracellular Ca2+ levels as evidenced by c-fos expression and more elongated mature neurites. We were able to neutralize these effects by blocking NMDA receptors with memantine. As a result, we hypothesize that the effects of ELF MF exposure on neuronal differentiation originate from the effects on NMDA receptors, which sequentially triggers Ca2+-dependent cascades that lead to differentiation. Our findings identify NMDA receptors as a new key player in this field that will aid further research in the pursuit of effect mechanisms of ELF MFs.European Molecular Biology Organization Short Term Fellowships, ASTF 7502. This work was partially supported by TUBITAK Projects under Grant No. 117Z864, Bogazici University Research Fund by Grant Number 6701. A.J. Salgado and A. Marote acknowledge the financial support from: Prémios Santa Casa Neurociências–Prize Melo e Castro for Spinal Cord Injury Research (MC-04/17); Portuguese Foundation for Science and Technology Pre–Doctoral fellowship to A. Marote PDE/BDE/113598/2015 and IF Development Grant to A. J. Salgado. This work is funded by national funds through FCT under the scope of grant reference TUBITAK/0007/2014. This article has been developed under the scope of the projects NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). This work has been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038 and POCI-01-0145-FEDER-02920

Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis

The present study is designed to assess if exosomes released from Chronic Myelogenous Leukemia (CML) cells may modulate angiogenesis. We have isolated and characterized the exosomes generated from LAMA84 CML cells and demonstrated that addition of exosomes to human vascular endothelial cells (HUVEC) induces an increase of both ICAM-1 and VCAM-1 cell adhesion molecules and interleukin-8 expression. The stimulation of cell-cell adhesion molecules was paralleled by a dose-dependent increase of adhesion of CML cells to a HUVEC monolayer. We further showed that the treatment with exosomes from CML cells caused an increase in endothelial cell motility accompanied by a loss of VE-cadherin and β-catenin from the endothelial cell surface. Functional characterization of exosomes isolated from CML patients confirmed the data obtained with exosomes derived from CML cell line. CML exosomes caused reorganization into tubes of HUVEC cells cultured on Matrigel. When added to Matrigel plugs in vivo, exosomes induced ingrowth of murine endothelial cells and vascularization of the Matrigel plugs. Our results suggest for the first time that exosomes released from CML cells directly affect endothelial cells modulating the process of neovascularization

Genetic regulation of glucoraphanin accumulation in Beneforté® broccoli

Diets rich in broccoli (Brassica oleracea var italica) have been associated with maintenance of cardiovascular health and reduction in risk of cancer. These health benefits have been attributed to glucoraphanin that specifically accumulates in broccoli. The development of broccoli with enhanced concentrations of glucoraphanin may deliver greater health benefits. Three high-glucoraphanin F1 broccoli hybrids were developed in independent programmes through genome introgression from the wild species Brassica villosa. Glucoraphanin and other metabolites were quantified in experimental field trials. Global SNP analyses quantified the differential extent of B. villosa introgression The high-glucoraphanin broccoli hybrids contained 2.5–3 times the glucoraphanin content of standard hybrids due to enhanced sulphate assimilation and modifications in sulphur partitioning between sulphur-containing metabolites. All of the high-glucoraphanin hybrids possessed an introgressed B. villosa segment which contained a B. villosa Myb28 allele. Myb28 expression was increased in all of the high-glucoraphanin hybrids. Two high-glucoraphanin hybrids have been commercialised as Beneforte broccoli. The study illustrates the translation of research on glucosinolate genetics from Arabidopsis to broccoli, the use of wild Brassica species to develop cultivars with potential consumer benefits, and the development of cultivars with contrasting concentrations of glucoraphanin for use in blinded human intervention studie

Numerical binary black hole collisions in dynamical Chern-Simons gravity

We produce the first numerical relativity binary black hole gravitational waveforms in a higher-curvature theory beyond general relativity. In particular, we study head-on collisions of binary black holes in order-reduced dynamical Chern-Simons gravity. This is a precursor to producing beyond-general-relativity waveforms for inspiraling binary black hole systems that are useful for gravitational wave detection. Head-on collisions are interesting in their own right, however, as they cleanly probe the quasinormal mode spectrum of the final black hole. We thus compute the leading-order dynamical Chern-Simons modifications to the complex frequencies of the postmerger gravitational radiation. We consider equal-mass systems, with equal spins oriented along the axis of collision, resulting in remnant black holes with spin. We find modifications to the complex frequencies of the quasinormal mode spectrum that behave as a power law with the spin of the remnant, and that are not degenerate with the frequencies associated with a Kerr black hole of any mass and spin. We discuss these results in the context of testing general relativity with gravitational wave observations