Global well-posedness of the Kirchhoff equation and Kirchhoff systems

This article is devoted to review the known results on global well-posedness for the Cauchy problem to the Kirchhoff equation and Kirchhoff systems with small data. Similar results will be obtained for the initial-boundary value problems in exterior domains with compact boundary. Also, the known results on large data problems will be reviewed together with open problems.Comment: arXiv admin note: text overlap with arXiv:1211.300

Identification of five picorna-like viruses associated with the endangered cave-dwelling bivalve Congeria kusceri (Bole, 1962)

Congeria kusceri is a bivalve mollusk species endemic to the Dinaric Karst, which displays unique adaptations that have allowed its survival in the subterranean environment with small morphological changes compared with its fossil relatives. Anthropic activities have recently impacted the surface flow of the Neretva river, impairing the seasonal water cycle that has characterized the habitat of this species for hundreds of thousands of years. The lack of an adequate water supply, together with pollution from agricultural and farm water runoff, are posing a serious threat to C. kusceri, as evidenced by the sharp population decline observed in several locations during the past few decades. Due to the limited knowledge available about the basic biology of this filter-feeding species, the precise factors that may affect its health status and reproduction and therefore represent a hazard for its conservation are still unclear. Here, through a transcriptomic approach, we describe the nearly-complete genomes of five C. kusceri-associated RNA viruses belonging to the Picornaviridae family and phylogenetically related with picorna-like viruses previously described in other Mollusca. Although it is presently unknown whether these viruses may have a detrimental effect on bivalve health, we observed a significant increase of viral load during the summer seaso

Međudjelovanje atmosfere s morem u Jadranu: simulacije bure i juga

Two simulations of the response of Adriatic Sea to severe wind performed by an atmosphere-ocean coupled model and the comparisons with observed data and modelled fields published in literature are presented. The model RAMS-DieCAST was applied to simulate the variations of sea currents and temperature profiles, from surface to bottom, induced by two episodes of intense wind over the Adriatic sea: a Bora wind event that occurred in January 1995 and a Sirocco wind event in November 2002. The results of the simulations are compared with observed data at the sea surface. In the Bora episode, the computed surface temperatures are compared with satellite SSTs and in situ observed temperatures; in the Sirocco event the simulated surface currents and temperatures are compared with experimental data collected by surface drifters released in different regions of the Adriatic Sea during the same Sirocco event. In both episodes the simulated temperature trends agree with the observed values and during the Sirocco episode the current fields are in quite good agreement with the drifter data. The modelled sea temperature and velocity fields show also a good concordance with other simulation results in literature.Dvije simulacije jakog vjetra nad Jadranom simuliraju se združenim atmosfersko-oceanografskim modelom te se analiziraju i uspoređuju s mjerenjima i drugim objavljenim modeliranim poljima. U tu svrhu se koristi model RAMS-DieCAST za simulaciju promjena morskih struja i temperaturnih profila po vertikali, uzrokovanih dvjema epizodama intenzivnog vjetra nad Jadranom: burom u siječnju 1995. godine i jugom u studenom 2002. godine. Rezultati simulacija se uspoređuju s opažanjima na morskoj površini. Tijekom bure, modelirana površinska temperatura uspoređuje se s površinskom temperaturom mora dobivene satelitskim mjerenjima i mjerenjima temperature u određenim točkama prostora. Tijekom juga, simulirane površinske struje i temperature se uspoređuju s eksperimentalnim mjerenjima dobivenih na temelju površinskih driftera koji su pušteni u različitim dijelovima Jadrana za istu epizodu. U obje epizode trendovi simulirane temperature dobro se podudaraju s opažanjima. Također se tijekom juga, površinske struje dobro podudaraju s mjerenjima driftera. Modelirana temperatura mora kao i vektorsko polje brzina pokazuju dobro slaganje s rezultatima sličnih simulacija u literaturi

Međudjelovanje atmosfere s morem u Jadranu: simulacije bure i juga

Two simulations of the response of Adriatic Sea to severe wind performed by an atmosphere-ocean coupled model and the comparisons with observed data and modelled fields published in literature are presented. The model RAMS-DieCAST was applied to simulate the variations of sea currents and temperature profiles, from surface to bottom, induced by two episodes of intense wind over the Adriatic sea: a Bora wind event that occurred in January 1995 and a Sirocco wind event in November 2002. The results of the simulations are compared with observed data at the sea surface. In the Bora episode, the computed surface temperatures are compared with satellite SSTs and in situ observed temperatures; in the Sirocco event the simulated surface currents and temperatures are compared with experimental data collected by surface drifters released in different regions of the Adriatic Sea during the same Sirocco event. In both episodes the simulated temperature trends agree with the observed values and during the Sirocco episode the current fields are in quite good agreement with the drifter data. The modelled sea temperature and velocity fields show also a good concordance with other simulation results in literature.Dvije simulacije jakog vjetra nad Jadranom simuliraju se združenim atmosfersko-oceanografskim modelom te se analiziraju i uspoređuju s mjerenjima i drugim objavljenim modeliranim poljima. U tu svrhu se koristi model RAMS-DieCAST za simulaciju promjena morskih struja i temperaturnih profila po vertikali, uzrokovanih dvjema epizodama intenzivnog vjetra nad Jadranom: burom u siječnju 1995. godine i jugom u studenom 2002. godine. Rezultati simulacija se uspoređuju s opažanjima na morskoj površini. Tijekom bure, modelirana površinska temperatura uspoređuje se s površinskom temperaturom mora dobivene satelitskim mjerenjima i mjerenjima temperature u određenim točkama prostora. Tijekom juga, simulirane površinske struje i temperature se uspoređuju s eksperimentalnim mjerenjima dobivenih na temelju površinskih driftera koji su pušteni u različitim dijelovima Jadrana za istu epizodu. U obje epizode trendovi simulirane temperature dobro se podudaraju s opažanjima. Također se tijekom juga, površinske struje dobro podudaraju s mjerenjima driftera. Modelirana temperatura mora kao i vektorsko polje brzina pokazuju dobro slaganje s rezultatima sličnih simulacija u literaturi

Drug resistance in B and non-B subtypes amongst subjects recently diagnosed as primary/recent or chronic HIV-infected over the period 2013–2016: Impact on susceptibility to first-line strategies including integrase strand-transfer inhibitors

Objectives To characterize the prevalence of transmitted drug resistance mutations (TDRMs) by plasma analysis of 750 patients at the time of HIV diagnosis from January 1, 2013 to November 16, 2016 in the Veneto region (Italy), where all drugs included in the recommended first line therapies were prescribed, included integrase strand transfer inhibitors (InNSTI). Methods TDRMs were defined according to the Stanford HIV database algorithm. Results Subtype B was the most prevalent HIV clade (67.3%). A total of 92 patients (12.3%) were expected to be resistant to one drug at least, most with a single class mutation (60/68–88.2% in subtype B infected subjectsand 23/24–95.8% in non-B subjects) and affecting mainly NNRTIs. No significant differences were observed between the prevalence rates of TDRMs involving one or more drugs, except for the presence of E138A quite only in patients with B subtype and other NNRTI in subjects with non-B infection. The diagnosis of primary/recent infection was made in 73 patients (9.7%): they had almost only TDRMs involving a single class. Resistance to InSTI was studied in 484 subjects (53 with primary-recent infection), one patient had 143C in 2016, a total of thirteen 157Q mutations were detected (only one in primary/recent infection). Conclusions Only one major InSTI-TDRM was identified but monitoring of TDRMs should continue in the light of continuing presence of NNRTI-related mutation amongst newly diagnosed subjects, sometime impacting also to modern NNRTI drugs recommended in first-line therapy

Benthic macroinvertebrate community shifts based on Bti-induced chironomid reduction also decrease Odonata emergence

Chironomid larvae (Diptera: Chironomidae) often dominate aquatic macroinvertebrate communities and are a key food source for many aquatic predators, such as dragonfly and damselfly larvae (Odonata). Changes in aquatic macroinvertebrate communities may propagate through terrestrial food webs via altered insect emergence. Bacillus thuringiensis israelensis (Bti)-based larvicides are widely used in mosquito control but can also reduce the abundance of non-biting chironomid larvae. We applied the maximum field rate of Bti used in mosquito control three times to six mesocosms in a replicated floodplain pond mesocosm (FPM) system in spring for two consecutive years, while the remaining six FPMs were untreated. Three weeks after the third Bti application in the first year, we recorded on average a 41% reduction of chironomid larvae in Bti-treated FPMs compared to untreated FPMs and a shift in benthic macroinvertebrate community composition driven by the reduced number of chironomid, Libellulidae and Coenagrionidae larvae (Odonata). Additionally, the number of emerging Libellulidae (estimated by sampling of exuviae in the second year) was reduced by 54% in Bti-treated FPMs. Since Odonata larvae are not directly susceptible to Bti, our results suggest indirect effects due to reduced prey availability (i.e., chironomid larvae) or increased intraguild predation. As Libellulidae include species of conservation concern, the necessity of Bti applications to their habitats, e.g. floodplains, should be carefully evaluated

Randomised evaluation of the Italian medicines use review provided by community pharmacists using asthma as a model (RE I-MUR)

Background The Italian Ministry of Health decided to introduce community professional services in 2010. This trial provides an opportunity to evaluate the outcomes of a new professional pharmacy service: Italian Medicines Use Review (I-MUR) aimed at reducing the severity of asthma and its associated costs. Methods/Design This is a cluster randomised controlled trial of the I-MUR service. Data will be collected over time before, during and after pharmacists’ intervention. Fifteen Italian regions will be involved and it is aimed to recruit 360 community pharmacists and 1800 patients. Each pharmacist will receive training in medicines use review, recruit five patients, administer the Asthma Control Test and provide the I-MUR service. Pharmacists will be allocated to different groups, one group will be trained in and provide the I-MUR service immediately after completion of the baseline ACT score, the other group will receive training in the I-MUR and provide this service three months later. Group allocation will be random, after stratification by region of Italy. The I-MUR service will involve gathering data following each patient consultation including demographic details, patients regular medications, including those used for asthma, their attitude towards their medications and self-reported adherence to treatments. In addition, pharmacists will identify and record pharmaceutical care issues and any advice given to patients during the I-MUR, or recommendations given to doctors. Pharmacists will upload trial data onto a web platform for analysis. The primary outcome measure is the severity of asthma before, during and after the I-MUR assessed using the Asthma Control Test score. Secondary measures: number of all active ingredients used by patients during and after the I-MUR, number of pharmaceutical care issues identified during the I-MUR, patients’ self-reported adherence to asthma medication during and after the I-MUR, healthcare costs based on the severity of asthma, before, during and after the I-MUR service provision. Discussion This study has been developed because of the need for a new way of working for pharmacists and pharmacies; it is the first trial of any community pharmacy-based pharmaceutical care intervention in Italy. The results will inform future policy and practice in Italian community pharmacy. Trial registration number ISRCTN72438848. Keywords Asthma – Medicines use review – Cluster randomised controlled trial (RCT) – Community pharmac

Polyclonal serum-free light chains elevation in HIV-infected patients.

We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample