Commentary: Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep.

We read with interest the paper by Lecci et al. (2017), who showed oscillations of the electroencephalographic (EEG) spectral power in the sigma band (10\u201315 Hz) during non-rapid-eye-movement (NREM) sleep at frequencies in the infra-slow range (ISO = 0.001\u20130.1 Hz). The occurrence of this rhythm (sigma-ISO) in human subjects and mice, and its correlation with autonomic and behavioral components suggest that it reflects a fundamental physiological mechanism

The stenoendemic cave-dwelling planarians (Platyhelminthes, Tricladida) of the Italian Alps and Apennines: Conservation issues

Despite being a fundamental component of biodiversity, several highly diverse taxa of aquatic invertebrates are still poorly known and poorly considered in protection programs. This is the case especially of several invertebrate species that inhabit groundwater. In this environment, invertebrates play significant roles in ecosystem services closely connected to the usefulness of these systems for human welfare and survival. The groundwater biodiversity of continental Italy is largely unknown and its importance is neglected in national and regional legislation. One of the most poorly studied groups of Italian groundwater fauna are planarians (Platyhelminthes, Tricladida). Most known species are endemic to small, single karst areas or a single cave, their geographic range never having been investigated in detail after the original description. The aims of this study are i) to provide the first conservation assessment of cave-dwelling planarians in the Italian Alps and Apennines, whose status is at present Not Evaluated in IUCN categories and ii) to evaluate which environmental constraints, including potential threats, possibly affect the occurrence of the species within different cave systems. Our results suggest that most of the cave-dwelling planarian species of continental Italy are threatened by water pollution and habitat destruction/alteration; moreover, datasets underline that there is a considerable conservation issue concerning stenoendemic planarians that may involve other cave-dwelling invertebrates with narrow geographic ranges. Generally, the underground habitat of most surveyed species appears to be deeply compromised and changed since the first species description

Free and forced wave motion in a two-dimensional plate with radial periodicity

In many practical engineering situations, a source of vibrations may excite a large and flexible structure such as a ship’s deck, an aeroplane fuselage, a satellite antenna, a wall panel. To avoid transmission of the vibration and structure-borne sound, radial or polar periodicity may be used. In these cases, numerical approaches to study free and forced wave propagation close to the excitation source in polar coordinates are desirable. This is the paper’s aim, where a numerical method based on Floquet-theory and the FE discretision of a finite slice of the radial periodic structure is presented and verified. Only a small slice of the structure is analysed, which is approximated using piecewise Cartesian segments. Wave characteristics in each segment are obtained by the theory of wave propagation in periodic Cartesian structures and Finite Element analysis, while wave amplitude change due to the changes in the geometry of the slice is accommodated in the model assuming that the energy flow through the segments is the same. Forced response of the structure is then evaluated in the wave domain. Results are verified for an infinite isotropic thin plate excited by a point harmonic force. A plate with a periodic radial change of thickness is then studied. Free waves propagation are shown, and the forced response in the nearfield is evaluated, showing the validity of the method and the computational advantage compared to FE harmonic analysis for infinite structures

The effects of flank collapses on volcano plumbing systems

The growth of large volcanoes is commonly interrupted by episodes of flank collapse that may be accompanied by catastrophic debris avalanches, explosive eruptions, and tsunamis. El Hierro, the youngest island of the Canary Archipelago, has been repeatedly affected by such mass-wasting events in the last 1 Ma. Our field observations and petrological data suggest that the largest and most recent of these flank collapses—the El Golfo landslide—likely influenced the magma plumbing system of the island, leading to the eruption of higher proportions of denser and less evolved magmas. The results of our numerical simulations indicate that the El Golfo landslide generated pressure changes exceeding 1 MPa down to upper-mantle depths, with local amplification in the surroundings and within the modeled magma plumbing system. Stress perturbations of that order might drastically alter feeding system processes, such as degassing, transport, differentiation, and mixing of magma batches

Commercial sponge fishing in Libya: Historical records, present status and perspectives

Natural bath sponges (genera Spongia and Hippospongia, Porifera, Demospongiae) have been harvested for millennia to be used as aids to beauty and body tools, in traditional and modem medicine as well as in painting. Recently, a series of severe epidemics have affected Mediterranean commercial sponges fostering the overexploitation of remaining fishing grounds. Furthermore, Mediterranean bath sponges attain the highest prices compared to Caribbean or Indo-Pacific ones but little or no correct information on origin is transferred to the final buyer. A complex network of re-selling activities and the lack of labelling make it almost impossible to track the pathway of sponge trade. Some of the finest Mediterranean natural bath sponges come from Libya. Nevertheless, little information on Libyan sponge banks and trade have been available mostly given the former international ban. Under an Italian-Libyan joint-project it was possible to assess the past and present situation of sponge fishing in Libya, roughly covering a period of 150 years. After rather low production in years 1860-1879, average crop exceeded 40 t/year between 1880 and 1929. The peak was recorded in years 1920-1929 (almost 70 t/year on average). Today Libyan sponge fishery and trade are mostly confined to the eastern area of the country. Less than 10 t/year are currently harvested. According to a preliminary SCUBA diving survey along the Libyan coasts, sponges belonging to the order Dictyoceratida appear to be the most conspicuous sessile invertebrates in the investigated areas. Here, sponges belonging to the genera Ircinia and Sarcotragus (commonly defined "wild sponges" with no commercial value) appear to be more abundant than those belonging to the genera Spongia and Hippospongia. Sustainable approaches to the exploitation of this valuable natural resource such as sponge farming are proposed and discussed. (c) 2007 Elsevier B.V. All rights reserved

Conservazione e valorizzazione delle grotte sarde: biodiversit\ue0 e ruolo socio-economico-culturale

Stima del valore economico del bene grotta e individuazione del target di fruitore; studio dei percorsi turistici per ottimizzare il numero dei visitatori per la salvaguardia del bene ambientale grotta, Stima della Capacit\ue0 di Carico turistica. Modello di una ottima fruizione di una grotta modello. Modello complesso di integrazione tra beni culturali, enogastronomici, ambientali e demo-etno-antropologici. Studio e creazione di network degli interessi

New approaches to the study of periodic leg movements during sleep in restless legs syndrome

Study Objectives: To describe a new approach for the analysis of quantity, type, and periodicity of the leg motor activity during sleep in patients with restless legs syndrome (RLS) and periodic leg movements (PLM). Methods: The following parameters were taken into account for LM: duration, amplitude, area under the curve, sleep stage, side, interval, and bilaterality. The analysis of inter-LM intervals was carried out by drawing their distribution graphs. A new index evaluated their periodicity and was validated by means of a Markovian analysis. The differences in inter-LM intervals, LM duration, and area under the curve between normal controls and patients and between the 3 patient subgroups identified on the basis of their periodicity were statistically analyzed. Setting: N/A Participants: Sixty-five patients with RLS and periodic LM and 22 young healthy controls. Measurements and Results: The RLS patients' inter-LM interval distribution graph showed a wide peak with a maximum located at around 15 to 30 seconds and extending from 10 to 90 seconds, not present in controls, and another peak for intervals less than 8 seconds, higher than that of controls. Three patient subgroups were identified with different proportions of these 2 peaks, periodicity, and Markovian parameters. Periodicity was not dependent on the periodic leg movement index. Patients showing the peak mainly at around 15 to 30 seconds tended to show slightly longer and higher area under the curve LM than did the other 2 subgroups. Conclusions: Our new approach seems to be useful in a new qualitative differentiation among patients with PLM, which is not possible by using the simple PLM index

Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

Neurological disorders (Alzheimer’s disease, vascular and mixed dementia) and visual loss (cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy) are among the most common conditions that afflict people of at least 65 years of age. An increasing body of evidence is emerging, which demonstrates that memory and vision impairment are closely, significantly, and positively linked and that statins and aspirin may lessen the risk of developing age-related visual and neurological problems. However, clinical studies have produced contradictory results. Thus, the intent of the present study was to reliably establish whether a relationship exist between various types of dementia and age-related vision disorders, and to establish whether statins and aspirin may or may not have beneficial effects on these two types of disorders. We found that participants with dementia and/or vision problems were more likely to be depressed and displayed worse functional ability in basic and instrumental activities of daily living than controls. Mini mental state examination scores were significantly lower in patients with vision disorders compared to subjects without vision disorders. A closer association with macular degeneration was found in subjects with Alzheimer’s disease than in subjects without dementia or with vascular dementia, mixed dementia, or other types of age-related vision disorders. When we considered the associations between different types of dementia and vision disorders and the use of statins and aspirin, we found a significant positive association between Alzheimer’s disease and statins on their own or in combination with aspirin, indicating that these two drugs do not appear to reduce the risk of Alzheimer’s disease or improve its clinical evolution and may, on the contrary, favor its development. No significant association in statin use alone, aspirin use alone, or the combination of these was found in subjects without vision disorders but with dementia, and, similarly, none in subjects with vision disorders but without dementia. Overall, these results confirm the general impression so far; namely, that macular degeneration may contribute to cognitive disorders (Alzheimer’s disease in particular). In addition, they also suggest that, while statin and aspirin use may undoubtedly have some protective effects, they do not appear to be magic pills against the development of cognitive impairment or vision disorders in the elderly