Different coordination modes for disulfoxides towards diorganotin(IV) dichlorides. X-ray crystal structures of 1,2-cis-bis-(phenylsulfinyl)ethene (rac-,cis-cbpse) and adducts [{Ph2SnCl2(meso-bpse)}n] and [{n-Bu2SnCl2(pdtd)}2]

The reactions of meso-1,2-bis(phenylsulfinyl)ethane (meso-bpse) with Ph2SnCl2, 2-phenyl-1,3-dithiane trans-1-trans-3-dioxide (pdtd) with n-Bu2SnCl2 and 1,2-cis-bis-(phenylsulfinyl)ethene (rac-,cis-cbpse) with Ph2SnCl2, in 1:1 molar ratio, yielded [{Ph2SnCl2(meso-bpse)}n], [{n-Bu2SnCl2(pdtd)}2] and [{Ph2SnCl2(rac,cis-cbpse)}x] (x = 2 or n), respectively. All adducts were studied by IR, Mössbauer and 119Sn NMR spectroscopic methods, elemental analysis and single crystal X-ray diffractometry. The X-ray crystal structure of [{Ph2SnCl2(meso-bpse)}n] revealed the occurrence of infinite chains in which the tin(IV) atoms appear in a distorted octahedral geometry with Cl atoms in cis and Ph groups in trans positions. The X-ray crystal structure of [{n-Bu2SnCl2(pdtd)}2] revealed discrete centrosymmetric dimeric species in which the tin(IV) atoms possess a distorted octahedral geometry with bridging disulfoxides in cis and n-butyl moieties in trans positions. The spectroscopic data indicated that the adduct containing the rac,cis-cbpse ligand can be dimeric or polymeric. The X-ray structural analysis of the free rac-,cis-cbpse sulfoxide revealed that the crystals belong to the C2/c space group.As reações de meso-1,2-bis(fenilsulfinil)etano (meso-bpse) com Ph2SnCl2, de 2-fenil-1,3-ditiona trans-1-trans-dióxido (pdtd) com n-Bu2SnCl2 e de 1,2-cis-bis-(phenylsulfinyl)ethene (rac-,cis-cbpse) com Ph2SnCl2, na proporção molar 1:1, levaram à formação de [{Ph2SnCl2(meso-bpse)}n], [{n-Bu2SnCl2(pdtd)}2] e [{Ph2SnCl2(rac,cis-cbpse)}x] (x = 2 ou n), respectivamente. Na investigação das propriedades estruturais dos produtos foram empregadas as espectroscopias de absorção no infravermelho, Mössbauer e RMN de 119Sn, além de análise elementar e difratometria de raios X em monocristal. O estudo de [{Ph2SnCl2(meso-bpse)}n] por difratometria de raios X revelou a ocorrência de um encadeamento infinito no qual os átomos de tin(IV) apresentam uma geometria octaédrica distorcida com os átomos de Cl em posições cis e os grupos Ph em trans. A estrutura cristalina de [{n-Bu2SnCl2(pdtd)}2] revelou a presença de espécies diméricas centrossimétricas nas quais os átomos de tin(IV) possuem geometria octaédrica distorcida com dissulfóxidos em ponte ocupando posições cis e grupos n-butila ocupando posições trans. Os dados espectroscópicos indicaram que o produto contendo o ligante rac,cis-cbpse pode ser dimérico ou polimérico. O estudo por difratometria de raios X do sulfóxido rac-,cis-cbpse livre revelou que os cristais pertencem ao grupo espacial C2/c.CNPqFAPESPFINE

trans-5,6-Diphenyl­perhydro­pyran-2,4-dione

In the title compound, C17H14O3, the pyran ring adopts a boat conformation and the dihedral angle between the aromatic ring planes is 59.1 (1)°. In the crystal structure inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions link the mol­ecules

1,2-Dihydr­oxy-2-(3-methyl­but-2-en­yl)-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid monohydrate

The title compound, C15H16O5·H2O, is an inter­mediate of the Hooker oxidation reaction, used for the synthesis of 2-hydr­oxy-3-(2-methyl­prop-1-en­yl)naphthalene-1,4-dione (nor-lapachol). The packing in the crystal structure is arranged by an O—H⋯O hydrogen-bonded network along the [100] and [010] directions. Each organic mol­ecule is linked to four other mol­ecules via the hydr­oxy groups. The water solvent mol­ecule is connected to carboxylic acid groups by three hydrogen bonds

New ruthenium(II)/phosphines/diimines complexes: promising antitumor (human breast cancer) and Mycobacterium tuberculosis fighting agents

The synthesis and characterization of ruthenium compounds of the type [RuCl2(P)2(N–N)] [(P)2 = (PPh3)2, dppb = 1,4-bis(diphenylphosphino)butano; dppp = 1,3-bis(diphenylphosphino)propane; N–N = 5,5'- dimethyl-2,2'dipyridyl (5,5'-mebipy) or 4,4'-dimethyl-2,2'dipyridyl (4,4'-mebipy)] are described. The complexes were characterized using elemental analysis, UV–Vis and infrared spectroscopies, cyclic voltammetry, and X-ray crystallography. In vitro evaluation of the complexes, using the MTT methodology, revealed their cytotoxic activities in a range of 5.4–15.7 lM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The in vitro antimycobacterial activities of the complexes had their Minimum Inhibitory Concentration (MIC) for MTB cell growth measured, by the REMA method. The MICs for these complexes were found to be between 12.5 and 25.0 lg/mL. The results are comparable with the ‘‘second line’’ drug cycloserine (MIC = 12.5– 50.0 lg/mL), commonly used in the treatment of TB.CNPqCAPESFAPESPFAPERJCYTE