14 research outputs found
Does nipple preservation in mastectomy improve satisfaction with cosmetic results, psychological adjustment, body image and sexuality?
Apoptosis and circulating levels of cytokines in patients with the systemic inflammatory response sindrome in intensive care unit
Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome
OBJECTIVES: Granulocyte-macrophage colony stimulating factor (GM-CSF) is a keyregulator cytokine that modulates the proliferation and maturation ofpolymorphonuclear and mononuclear progenitors. This study was designed toinvestigate and clarify the role of GM-CSF in 52 critically ill patients withsystemic inflammatory response syndrome (SIRS).METHODS: Serum levels of GM-CSF were detected by an immunoenzyme assay.RESULTS: Our results clearly show that the serum concentrations of GM-CSF weresignificantly elevated in patients with infectious and noninfectious SIRS(33.2+/-45.7pg/ml, controls: 17.2+/-9.8pg/ml; p=0.0303). In addition, GM-CSFlevels significantly decreased in patients with SIRS, particularly in patientswith infectious SIRS, 5 and 7 days later. There was a clear tendency towardhigher levels of GM-CSF in patients with poor, as compared with those having agood outcome of the disease.CONCLUSION: These results show that GM-CSF may play an important role in patientswith infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS