Publicly funded research, development and demonstration projects on electric and plug-in vehicles in Europe - update

The previous report on the publicly funded research and development and demonstration projects included ongoing and recently concluded projects with the information available in 2011-2012. The aim of the current work was to update the collection of the on-going or recently concluded research, development and demonstration projects on electric and plug-in hybrid vehicles, which received EU and national public funding with the total budget of more than 500000 Euro, in order to update the EV-Radar tool with new projects. Altogether 158 R&D and demonstration projects have been found and analysed in this report from EU member states and EFTA countries.JRC.F.6-Energy Technology Policy Outloo

fUel-SAVing trip plannEr (U-SAVE): a product of the JRC PoC Instrument: Final report

Available tools for trip planning mostly rely on travel time and travel distance. Fuel costs, when taken into account, are based on simplified fuel consumption models and are usually independent from vehicle type and technology. Building on the work carried out by the Sustainable Transport Unit of the Joint Research Centre, European Commission, in developing (a.) CO2MPAS, the official tool supporting the WLTP/NEDC Correlation Exercise and allowing the back-translation of a WLTP test to the equivalent NEDC CO2 emission value during the type approval, and (b.) Green Driving, an interactive web-based tool allowing the estimation of fuel costs and CO2 emissions of individual car journeys on the basis of variables such as car segment, engine power, fuel type and driving style, the present project aimed at developing and proving the concept of a routing machine to be used when fuel consumption minimization is considered. Throughout the project a stand-alone off-board trip planner has been developed, the U-SAVE Desktop Version, while a smartphone application, the U-SAVE Navigation Application, is currently under the last development phase, and shall be used once completed as a low cost in-board navigation system. The tool has been extensively validated internally demonstrating both its capability to accurately estimate fuel and energy consumption via alternative trip options, and its capacity to provide a more efficient route when different from the shortest and/or fastest options. An open-access version of the tool is expected to become a reference instrument for private citizens who are concerned about their fuel consumption and a more efficient use of their vehicles, while a premium API-based commercial version of the tool can operate as a viable and scalable business model targeting, among others, established navigation software providers who want to extend their offering by providing an alternative route option to their clients, mainly private companies managing fleets of light-duty vehicles, for whom saving fuel from the daily vehicle operations is of crucial financial importance.JRC.C.4-Sustainable Transpor

Erratum to nodal management and upstaging of disease. Initial results from the Italian VATS Lobectomy Registry

[This corrects the article DOI: 10.21037/jtd.2017.06.12.]

Tools for Customized Consumer Information on Vehicle Energy Consumption and Costs - A European Case Study

The European Commission’s Joint Research Centre, in line with the European Strategy for Low-Emission Mobility, has launched in 2016 the Green Driving Tool, an interactive web-based tool aiming at estimating fuel costs and CO2 emissions of individual car journeys. In parallel, it has developed U-SAVE, a routing system for fuel-efficient trip planning aiming at fuel consumption minimization and vehicle specific calibration. This paper provides a first assessment of the performance of the two tools in predicting fuel consumption and CO2 emissions over real-world trips. The analysis focused on the accuracy and uncertainty of the two tools when varying the detail of vehicle input data and of the velocity profile used in the calculation. These elements are particularly important in case of future integration of the tools with traffic simulation models where the level of detail regarding the vehicle input or the speed profile may vary. Results show that U-SAVE prediction is positively affected by the detail of vehicle specifications, while is not significantly sensitive to the detail of the velocity profile. Contrary, Green Driving didn’t show any remarkable change when varying both parameters. Overall, U-SAVE demonstrates a good performance in predicting CO2 emissions over on-road tests reaching an average prediction accuracy over an entire test trip of -4.6% and a standard deviation of 5.2%, while Green Driving exhibit higher uncertainty (on average 12%) but lower bias which ranged in the order of 0 to +3% depending on the vehicle and the test trip considered.JRC.C.4-Sustainable Transpor

Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: Our experience on 1,592 patients

Background: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion. Methods: A retrospective study on 1,592 SPN patients was carried out following approval by the Italian Registry of VATS Lobectomies. Results: All patients underwent VATS lobectomy. On histologic examination, 98.1% had primary or second metachronous primary lung cancers. In addition, 10.7% presented occult lymph node metastases (pN1 or pN2) on histological examination. Nodule attenuation on CT was associated with the histology of the lesion (p= 0.030); in particular, pure ground glass opacities (pGGOs) and partially solid nodules were related to adenocarcinomatous histotypes. Conversely, a significant relationship between SUVmax and age, nodule size, pathological node status (pN) was found (P=0.007, P=0.000 and P=0.002 respectively). Conclusions: Nodule attenuation can predict the histology of the lesion whereas SUVmax may relate to the propensity to lymph node metastases. Keywords: Solitary pulmonary nodule (SPN); maximum standardized uptake value; ground glass opacities; lymph node metastases; lung adenocarcinom

National adoption of video-assisted thoracoscopic surgery (VATS) lobectomy: The Italian VATS register evaluation

Background: The expertise curve of video-assisted thoracoscopic surgery (VATS) lobectomies still stirs debate and controversy both because of the number of procedures to carry out and of the evaluation of the learning threshold. The purpose of our study was the examination of the variables related to the learning curve of the video-assisted approach, to establish what may be an expression of the technical maturity of the surgeon. Methods: The National Register for VATS lobectomy built in 2013 was used to collect data from 65 Thoracic Surgery Units. Out of more than 3,700 patients enrolled, only information from Units with \ue2\u89\ua5100 VATS lobectomies were retrospectively analysed. Unpaired Student's t-tests, Fisher's exact tests, Pearson's \ucf\u872were applied as needed. Cumulative summative analysis and one-way ANOVA were used to identify the expertise curve of VATS lobectomy. Results: Ten institutions contributed a total of 1,679 patients, who were divided into three uniform groups according to the chronological sequence of surgery. The length of utility incision, the number of dissected lymph nodes and the operative time were not statistically significant (P=0.999, P=0.972 and P=0.307, respectively) among groups. Conversion to thoracotomy and postoperative air leaks occurred in 125 (7.44%) and 109 (6.49%) patients, gradually declined in Group 3 with statistical significance (P=0.048 and P=0.00086). Conclusions: The conversion rate and the percentage of air leaks seem to define the expertise of VATS lobectomy, being linked to the ability to manage more complicated surgical cases or intraoperative adverse events

Safety of lymphadenectomy during video-assisted thoracic surgery lobectomy: Analysis from a national database

OBJECTIVES The Italian VATS Group database was accessed to evaluate whether preoperative and intraoperative factors may affect the safety of lymphadenectomy (LA) during video-assisted thoracic surgery lobectomy. METHODS All video-assisted thoracic surgery lobectomy procedures performed between 1 January 2014 and 30 March 2017 for non-small-cell lung cancer with cN0 or cN1 disease were identified in the database. LA safety was evaluated based on intraoperative (operative time, bleeding and conversion rate) and postoperative (30-day morbidity and mortality, chest drain duration and length of stay) outcomes and was correlated with the number of resected lymph nodes and the rates of nodal upstaging. Continuous variables were presented as mean \ub1 standard deviation and compared using the unpaired t-test; the X 2 test was used for categorical variables. Univariable analysis was performed on selected variables. Significant variables (P < 0.30) were entered into a Cox multivariable logistic regression model, using the overall and specific occurrence of complications as dependent variables. The Spearman's rank correlation coefficient was applied as needed. RESULTS A total of 3181 cases (2077 men, 65.3%; mean age of 69 years) met the enrolment criteria. Final pathology was consistent with adenocarcinoma (n = 2262, 67.5%), squamous cell (n = 520, 15.5%), typical (n = 184, 5.5%) and atypical carcinoid (n = 48, 1.4%) and other (n = 335, 10%). The mean number of resected lymph nodes was 13.42 \ub1 8.24; nodal upstaging occurred in 308 of 3181 (9.68%) cases. Six hundred and fifty-five complications were recorded in 404 (12.7%) patients; in this series, no mortality was observed. Univariable and multivariable analyses did not show any association between the extension of LA and intraoperative or postoperative outcomes. The number of resected lymph nodes and nodal upstagings showed a minimal correlation with intraoperative outcomes and a moderate correlation with postoperative air leak (p = 0.35 and p = 0.48, respectively), arrhythmia (p = 0.29 and p = 0.35, respectively), chest drain duration (p = 0.35 and p = 0.51, respectively) and length of stay (p = 0.35). CONCLUSIONS Based on the VATS Group data, video-assisted thoracic surgery LA proved to be safe and displayed good outcomes even when performed with an extended approach

Risk factors and impact of conversion from VATS to open lobectomy: analysis from a national database

Objective: The objective of the study is to analyse the causes and impact of conversion from VATS to thoracotomy identifying any possible pre-operative risk factors and related consequences. Methods: Data from patient who underwent VATS lobectomy (VATS-L) for NSCLC at VATS Group participating centres were retrospectively analysed and divided in two groups: patients treated with VATS-L and patients who suffered from conversion. Predictors of conversion were assessed with univariate and multivariable exact logistic regression. Complications were evaluated as dependent variables of conversion in a Cox multivariable logistic regression model. Results: A total of 4629 patients underwent planned VATS-L for NSCLC and of these, 432 (9.3%) required conversion; the most frequent causes were bleeding (30.4%) and fibro-calcified hilar lymph nodes (23.9%). The independent risk factors at multivariable analysis model were sex male (OR 1.458, p &lt; 0.01), age older than 70&nbsp;years (OR 1.248, p = 0.036) and the clinically node-positive disease (OR 2.258, p &lt; 0.01). The mortality rate was similar, but the percentage of patients who suffered from any complication (41.7% vs 24.4%, p &lt; 0.01), the complication rate (65% vs 32.2%, p &lt; 0.01), chest tube duration (p &lt; 0.01) and the hospitalisation rate (p &lt; 0.01) were higher for patients converted. Atrial fibrillation (OR 1.471, p = 0.019), prolonged air leak (OR 1.403, p = 0.043), blood transfusions (OR 4.820, p &lt; 0.01), sputum retention (OR 1.80, p = 0.027) and acute kidney failure (OR 2.758, p = 0.03) were significantly associated with conversion at multivariable analysis. Conclusions: Conversion is associated with increased surgical morbidity, blood loss and hospital stay. Sex male, old age and the clinical involvement of lymph nodes were the strongest predictors of conversion