MODLEACH: A Variant of LEACH for WSNs

Wireless sensor networks are appearing as an emerging need for mankind. Though, Such networks are still in research phase however, they have high potential to be applied in almost every field of life. Lots of research is done and a lot more is awaiting to be standardized. In this work, cluster based routing in wireless sensor networks is studied precisely. Further, we modify one of the most prominent wireless sensor network's routing protocol "LEACH" as modified LEACH (MODLEACH) by introducing \emph{efficient cluster head replacement scheme} and \emph{dual transmitting power levels}. Our modified LEACH, in comparison with LEACH out performs it using metrics of cluster head formation, through put and network life. Afterwards, hard and soft thresholds are implemented on modified LEACH (MODLEACH) that boast the performance even more. Finally a brief performance analysis of LEACH, Modified LEACH (MODLEACH), MODLEACH with hard threshold (MODLEACHHT) and MODLEACH with soft threshold (MODLEACHST) is undertaken considering metrics of throughput, network life and cluster head replacements.Comment: IEEE 8th International Conference on Broadband and Wireless Computing, Communication and Applications (BWCCA'13), Compiegne, Franc

Methanol fractionations of Catha edulis frosk (Celastraceae) contracted lewis rat aorta in vitro: a comparison between crimson and green leaves

The study investigated the effect of methanol extract and its fractionations obtained from Yemeni khat on the smooth muscle isometric tension in Lewis rat aortal ring preparations and compared the effects of the crimson and green leaves. Khat leaves were sorted into green (khat Light; KL) and crimson (khat Dark; KD) leaves, extracted with methanol, followed with solvent-solvent extraction (benzene, chloroform and ethylacetate). The contractile activity of the fractions was tested using aortal ring preparations. The control (phenylepherine contraction) methanol extracts contracted aortas at concentrations 250, 125 and 67.5 μg /1 ml buffer by 80.2% , 57.3%, 26.4% and 81.5%, 65.6% , 24.6% for KL and KD, respectively. Fractions of benzene (BF) and ethylacetate (EaF) contracted the aorta with 2μgm, whereas, chloroform (ChF) with 1 μgm / 1 ml buffer was less potent. The shape of contraction curve produced by EaF differed from that of ChF and BF of both (KL and KD). The EaF induced-contraction peaked after 3.3 ± 0.94 mins, whereas those of BF and CHF peaked after 18.0 ± 2.2, 19.7 ± 0.94 mins, respectively. Pre-incubation with nifedipine (10-6 M) insignificantly reduced the contraction induced by all fractionations, but prazosin (10-6 M) reduced the contraction by 81.9%, 63.1%, 71.8% with p= 0.23, 0.09, 0.15 for BF, ChF and EaF of KL, respectively. It significantly reduced contraction of ChF, 64.1%; p= 0.02, and of EaF, 73.5%; p= 0.04 of KD, while the reduction in contraction of BF was 63.1%; p= 0.06. In conclusion, fractions of green and crimson Yemeni khat leaves contracted aortas of Lewis rats. Both leaves behave almost similarly. Contraction induced by chloroform fraction produced alphasympathetic activity.Key words: Catha edulis, aorta contraction, rat, cathinone

In vitro measurement of nucleus pulposus swelling pressure: A new technique for studies of spinal adaptation to gravity

Swelling of the intervertebral disc nucleus pulposus is altered by posture and gravity. We have designed and tested a new osmometer for in vitro determination of nucleus pulposus swelling pressure. The functional principle of the osmometer involves compressing a sample of nucleus pulposus with nitrogen gas until saline pressure gradients across a 0.45 microns Millipore filter are eliminated. Swelling pressure of both pooled dog and pooled pig lumbar disc nucleus pulposus were measured on the new osmometer and compared to swelling pressures determined using the equilibrium dialysis technique. The osmometer measured swelling pressures comparable to those obtained by the dialysis technique. This osmometer provides a rapid, direct, and accurate measurement of swelling pressure of the nucleus pulposus

Shrinking Lung Syndrome in a Young Female: A Rare Pulmonary Manifestation of Systemic Lupus Erythematosus

Shrinking lung syndrome (SLS) is a rare pulmonary complication of autoimmune conditions. It has been sparsely described in the literature and its pathophysiology remains unclear. SLS is typically reported in patients with a history of systemic lupus erythematosus (SLE) who present with shortness of breath and chest pain associated with breathing. Chest imaging demonstrates no alveolar, interstitial, or pleural abnormalities. Pulmonary function tests (PFTs) are characterized by a restrictive pattern with reduced lung volumes. SLS is a diagnosis of exclusion and there are no validated criteria for the diagnosis. Evaluation requires extensive testing to rule out alternative causes of dyspnea and pleuritic chest pain. In this report, we present a case of SLS in a young African American woman

Deep-Diving and Diel Changes in Vertical Habitat Use by Caribbean Reef Sharks Carcharhinus perezi

Longline sampling (83 sets) supplemented with 6 pop-off archival transmitting (PAT) tag deployments were used to characterize vertical habitat use by Caribbean reef sharks Carcharhinus perezi at Glover\u27s Reef atoll, Belize. Longline catch-per-unit-effort (CPUE) in 2 shallow reef habitats (lagoon \u3c18 m depth, fore-reef \u3c40 m depth) underwent significant nocturnal increases for sharks larger than 110 cm total length (TL), but not for smaller sharks. Nocturnal CPUE of small sharks appeared to increase in the lagoon and decrease on the fore-reef, suggestive of movements to avoid larger conspecifics. PAT tag deployments (7 to 20 d) indicate that large C. perezi generally increased the amount of time they spent in the upper 40 m of the water column during the night, and inhabited much greater depths and tolerated lower temperatures than previously described. The wide vertical (0 to 356 m) and temperature range (31 to 12.4°C) documented for this top-predator reveals ecological coupling of deep and shallow reef habitats and has implications for Marine Protected Area (MPA) design

Cytomegalovirus reactivation after bortezomib treatment for multiple myeloma and light chain amyloidosis

Objective: Cytomegalovirus (CMV) is an opportunistic herpesvirus, and reactivation of infection is possible in immunocompromised patients. Historically, the risk for haematology patients is restricted to those treated with an allogeneic transplant or T‐cell depleting agents. Bortezomib is a highly efficacious proteasome inhibitor widely used to treat multiple myeloma and light chain (AL) amyloidosis patients. The objective of this small prospective study was to quantify the risk of CMV reactivation associated with bortezomib treatment. Methods: Fifty‐seven consecutive multiple myeloma or AL amyloidosis patients commencing bortezomib‐based therapy were included. Viral copy numbers were established at baseline and then at fortnightly intervals during treatment. Pre‐emptive anti‐viral treatment was initiated in patients with a viral load >7500 copies/mL. Results: Reactivation of CMV was detected in 39% (n = 12/31) of seropositive bortezomib treated patients compared with 0% of CMV seronegative patients. Detectable DNAemia developed during the first two cycles of treatment in 83% (n = 10/12) patients. Anti‐viral treatment was initiated in 42% (n = 5/12), but no cases of active CMV disease were seen. Conclusion: This study suggests that there is a substantial risk of CMV reactivation in CMV‐seropositive plasma cell dyscrasia patients treated with bortezomib

Synergistic Use of Hypocotyl Explants and High Bap Preconditioning for Enhanced Transformation Frequency in Brinjal (Solanum melongena L.)

Poor regeneration is one of the limiting factors in the development of transgenic crops since Agrobacterium as a plant pathogen can disturb the fragile in vitro conditions with wounding and infection regimes. We have tried to optimize the transformation system in two important varieties of brinjal after Agrobacterium infection to the explants. The effect of explant was studied and hypocotyls were found to be better than cotyledonary leaves. High BAP during the preconditioning period was found to further enhance the regeneration rate. Therefore, use of hypocotyls and high BAP during preconditioning can improve the regeneration of transformed cells and recovery of transformants in vegetables especially brinjal