The Zoril, Ictonyx striatus erythreae De Winton, 1898 in Egypt.

The Zoril Ictonyx striatus is one of the rarest mammals of Egypt, known from only two specimens collected more than 50 years ago. The collection of two new specimens and the observation of others in the Gabal Elba area provide new data on this little-known animal in Egypt. In this paper we provide information on the morphology of this species, and its cranial and dental characters, in comparison with published data on the speciesfrom Egypt and rest of Africa. We also present some data on its habitat requirements and feeding habits

Ranking Significant Discrepancies in Clinical Reports

Medical errors are a major public health concern and a leading cause of death worldwide. Many healthcare centers and hospitals use reporting systems where medical practitioners write a preliminary medical report and the report is later reviewed, revised, and finalized by a more experienced physician. The revisions range from stylistic to corrections of critical errors or misinterpretations of the case. Due to the large quantity of reports written daily, it is often difficult to manually and thoroughly review all the finalized reports to find such errors and learn from them. To address this challenge, we propose a novel ranking approach, consisting of textual and ontological overlaps between the preliminary and final versions of reports. The approach learns to rank the reports based on the degree of discrepancy between the versions. This allows medical practitioners to easily identify and learn from the reports in which their interpretation most substantially differed from that of the attending physician (who finalized the report). This is a crucial step towards uncovering potential errors and helping medical practitioners to learn from such errors, thus improving patient-care in the long run. We evaluate our model on a dataset of radiology reports and show that our approach outperforms both previously-proposed approaches and more recent language models by 4.5% to 15.4%.Comment: ECIR 2020 (short

GREEN, RAPID, SIMPLE, AND AN EFFECTIVE ONE-POT MULTICOMPONENT STRATEGY FOR SYNTHESIS OF NOVEL DIHYDROPYRANO[2,3-C]PYRAZOL-6-AMINES IN AQUEOUS MEDIUM

Objectives:  A series of new dihydropyrano [2,3-c]pyrazol-6-amines in this investigation  study, are synthesized  by the strategy of one-pot four component reaction in an aqueous medium. Methods:  After getting optimum conditions the reaction of different substituted aromatic aldehydes, ethyl acetoacetate, hydrazine hydrate,  and phenylacetonitrile catalysed by Sodium hydrogen sulphate NaHSO4 (0.5 m mol) by refluxing in ethanol-water (1:1) (5 ml) and heated at 80 oC. The synthesized molecules product was filtered, washed with water to get nearly pure product in excellent yield. Results:  The pure products which were got in a short duration, with excellent yield (80 – 87%). Those new compounds were identified by using spectroscopic techniques FT-IR, 1H-NMR and 13C-NMR. Conclusion: In conclusion, the usefulness of this one-pot multicomponents protocol include easily available starting materials, facile, simple and environment-friendly procedure, and easier separation of products by filtration.                                   Peer Review History: Received 5 March 2020; Revised 11 April; Accepted 9 May, Available online 15 May 2020 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Prof Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected] Dr. Md. Shahidul Islam, USTC, Chittagong, Bangladesh, [email protected] Similar Articles: TOXICITY AND ANTITRYPANOSOMAN ACTIVITY OF HEMI SYNTHESIS PRODUCTS OBTAINED FROM BIOACTIVE COMPOUNDS OF MITRACARPUS SCABER HARVESTED SOUTH OF BENI

Evaluation Of The Essential Oil Of Foeniculum Vulgare Mill (Fennel) Fruits Extracted By Three Different Extraction Methods By Gc/Ms

Background: Hydrodistillation (HD) and steam-distillation, or solvent extraction methods of essential oils have some disadvantages like thermal decomposition of extracts, its contamination with solvent or solvent residues and the pollution of residual vegetal material with solvent which can be also an environmental problem. Thus, new green techniques, such as supercritical fluid extraction and microwave assisted techniques, are potential solutions to overcome these disadvantages.Materials and Methods: The aim of this study was to evaluate the essential oil of Foeniculum vulgare subsp. Piperitum fruits extracted by three different extraction methods viz. Supercritical fluid extraction (SFE) using CO2, microwave-assisted extraction (MAE) and hydro-distillation (HD) using gas chromatography-mass spectrometry (GC/MS).Results: The results revealed that both MAE and SFE enhanced the extraction efficiency of the interested components. MAE gave the highest yield of oil as well as higher percentage of Fenchone (28%), whereas SFE gave the highest percentage of anethol (72%).Conclusion: Microwave-assisted extraction (MAE) and supercritical fluid extraction (SFE) not only enhanced the essential oil extraction but also saved time, reduced the solvents use and produced, ecologically, green technologies.Keywords: Foeniculum vulgare subsp. Piperitum, microwave-assisted extraction (MAE), Supercritical fluid extraction (SFE), Essential Oils,Anethol, Fenchone, Limonene, Pinene, GC/MS

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer

Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis. However, limited data are available on phenotypic/transcriptomic characteristics of the different MDSCs subsets in cancer. These cells include immature (I-MDSCs), monocytic (M-MDSCs), and polymorphonuclear/granulocytic (PMN-MDSCs). Phenotypic characterization of myeloid subsets from 27 colorectal cancer (CRC) patients was assessed by flow cytometric analyses. RNA-sequencing of sorted I-MDSCs, PMN-MDSCs, and antigen-presenting cells (APCs) was also performed. We found that the levels of I-MDSCs and PMN-MDSCs were increased in tumor tissues (TT), compared with normal tissues (NT) in colorectal cancer. Our functional annotation analyses showed that genes associated with histone deacetylase (HDAC) activation- and DNA methylation-mediated transcriptional silencing were upregulated, and histone acetyl transferase (HAT)-related genes were downregulated in tumor-infiltrating I-MDSCs. Moreover, pathways implicated in cell trafficking and immune suppression, including Wnt, interleukin-6 (IL-6), and mitogen-activated protein kinase (MAPK) signaling, were upregulated in I-MDSCs. Notably, PMN-MDSCs showed downregulation in genes related to DNA methylation and HDAC binding. Using an ex vivo model, we found that inhibition of HDAC activation or neutralization of IL-6 in CRC tumor tissues downregulates the expression of genes associated with immunosuppression and myeloid cell chemotaxis, confirming the importance of HDAC activation and IL-6 signaling pathway in MDSC function and chemotaxis. This study provides novel insights into the epigenetic regulations and other molecular pathways in different myeloid cell subsets within the CRC tumor microenvironment (TME), giving opportunities to potential targets for therapeutic benefits

The Quanta Image Sensor: Every Photon Counts

The Quanta Image Sensor (QIS) was conceived when contemplating shrinking pixel sizes and storage capacities, and the steady increase in digital processing power. In the single-bit QIS, the output of each field is a binary bit plane, where each bit represents the presence or absence of at least one photoelectron in a photodetector. A series of bit planes is generated through high-speed readout, and a kernel or “cubicle” of bits (x, y, t) is used to create a single output image pixel. The size of the cubicle can be adjusted post-acquisition to optimize image quality. The specialized sub-diffraction-limit photodetectors in the QIS are referred to as “jots” and a QIS may have a gigajot or more, read out at 1000 fps, for a data rate exceeding 1 Tb/s. Basically, we are trying to count photons as they arrive at the sensor. This paper reviews the QIS concept and its imaging characteristics. Recent progress towards realizing the QIS for commercial and scientific purposes is discussed. This includes implementation of a pump-gate jot device in a 65 nm CIS BSI process yielding read noise as low as 0.22 e− r.m.s. and conversion gain as high as 420 µV/e−, power efficient readout electronics, currently as low as 0.4 pJ/b in the same process, creating high dynamic range images from jot data, and understanding the imaging characteristics of single-bit and multi-bit QIS devices. The QIS represents a possible major paradigm shift in image capture

Epithelial lining of the endometrium during the luteal phase in patients under controlled ovarian hyperstimulation

The endometrium is receptive for the embryo and presents an implantation window for a limited time. This study is aimed at highlighting an alternation in pinopod expression and to provide more analysisof the structural characteristics of epithelial lining of the endometrium during luteal phase in patients undergoing controlled ovarian hyperstimmulation (COH). Twelve oocyte donors were used. Theyunderwent two endometrial biopsies 2-7 days after human chronic gonadotrophin (HCG) administration. Endometrial epithelial surface appearance was evaluated by scanning electron microscopy. Microvillibecame more uniformly distributed as the luteal phase progressed. Also the central aspects of the cells appeared to protrude more into the endometrial lumen as the cycle progressed. Apical protrusions(pinopods) were noted to develop and regress during the midluteal phase after HCG administration. Pinopods began development in the region of the glandular orifices to become much denser at the glandular orifices than in regions further away from the glands. In conclusion, epithelial lining ofendometrium in stimulated cycle during the luteal phase progresses in an orderly manner. This advanced development may result in an alteration of the window of implantation between the developing endometrium and the developing blastocyst and affect pregnancy rates in women undergoing controlled ovarian hyperstimmulation

Prenatal genotyping of Gaucher disease in Egypt

Objective: To use chorionic villi sampling (CVS) and amniocentesis to determine the genotyping of Gaucher Disease (GD) of fetuses of pregnant mothers who had a previous child affected by GD.Methods: The study was conducted between January 2009 and December 2012. It included 42 pregnant women that gave informed written consent. Thirty mothers presented early so they underwent CVS at 10–12 weeks of pregnancy while 12 mothers presented later and underwent amniocentesis at 14–16 weeks. Strip assay for the identification of Glucocerebrosidase (GBA) gene mutations in the samples of chrorionic villi and amniotic fluid was based on polymerase chain reaction (PCR) and reverse hybridization.Results: The age of the studied pregnant women ranged from 19 to 26 years. Consanguinity was present in 38 cases. Eighteen women were pregnant in affected fetuses. The results of genotyping revealed 15 cases were homozygous L444P/L444P and one case homozygous (N370s/N370s) while two cases were heterogeneous (L444P/D409H). Twenty-four pregnant women had carrier fetuses which were all heterozygous L444P.Conclusion: This study highlights the findings of an extended gene mutation examination for prenatal diagnosis of Guacher Disease. The study found out that the most common mutation was L444P/L444P.Keywords: Gaucher diseases; Prenatal diagnosis; Egypt; Gene; Mutatio

MyMukim2Cloud collaborative system: A mosque collaborative network for enhancing and serving the society needs in Malaysia

This conceptual paper seeks to put forth a novel vision, namely the combined deployment of the Quadruple Helix Model (QHM) collaboration mooted by Agensi Inovasi Malaysia, a Whole-of-Government (WoG) concept of ICT implementation across the Malaysian government agencies mooted by Malaysia Administrative and Modernization Planning Unit (MAMPU) and the Network of Mosques (NoM). This will be accomplished through leveraging the advances in cloud computing and mobile applications that could be used to set up what is proposed to be called the Collaborative MyMukim2Cloud System. The QHM actors, namely the Government, Academia, Industry and Citizen need to collaborate and share resources in nurturing and addressing the needs of less privileged and less fortunate people holistically, rather than the current practice which is executed in silos, isolation or independently. This proposed collaborative inter-organizational system is to enable a WoG and consolidated approach for government agencies, NGOs, the private sector and individuals in building up a single and trusted national database based on three (3) focus groups of people proposed in this paper, namely the Orphanage, the Poor and the Disabled. This database, proposed to be co-owned and managed by government agencies such as Department of Social Welfare (DSW) and Department of Islamic Development Malaysia (JAKIM), can be used and updated by all other authorized and relevant organizations and individuals in making a consolidated contribution in nurturing and developing these groups. Thus, this System shall eliminate unnecessary and duplication in data, efforts and investments made by the various organizations. The expected outcome of MyMukim2Cloud System will be an enhanced quality of life for the proposed focus groups through the execution of social entrepreneurship concept in healthcare, education and financial activities provided by the QHM collaborators

Anti-diabetic properties of Securinega virosa (Euphorbiaceae) leaf extract

This study was undertaken to evaluate the hypoglycemic effect of methanol extract of securinega virosa leaves on blood levels of streptozocin-induced diabetes rats. Three doses of the extract (100, 300 and 600 mg/kg) were administered intraperitoneally. After 2 h of extract administration there was no significant change in the blood glucose levels in all the three doses of the extract. Also after 4, 8 and 24 h of extract administration there was a significant (p < 0.05 - 0.001) decrease in the blood glucose levelsin all the three doses of the extract. The preliminary phytochemical screening revealed the presence of reducing sugars, cardiac glycosides, resin, tannins, saponins, glycosides, flavonoids, glycerin carbohydrate, anthraquine and steroids. The median lethal dose (LD50) in rats was calculated to be 1264.9 mg/kg body weight