Debugging experiment machinery through time-course event sequence analysis

This application note describes an open-source web application software package for viewing and analysing time-course event sequences in the form of log files containing timestamps. Web pages allow the visualisation of time-course event sequences as time curves and the comparison of sequences against each other to visualise deviations between the timings of the sequences. A feature allows the analysis of the sequences by parsing selected sections with a support vector machine model that heuristically calculates a value for the likelihood of an error occurring based on the textual output in the log files. This allows quick analysis for errors in files with large numbers of log events. The software is written in ASP.NET with Visual Basic code-behind to allow it to be hosted on servers and integrated into web application frameworks

[RuCl2(η6 ‑p‑cymene)(P*)] and [RuCl2(κ-P*‑η6 ‑arene)] Complexes Containing P‑Stereogenic Phosphines. Activity in Transfer Hydrogenation and Interactions with DNA

The preparation of a series of half-sandwich ruthenium complexes, [RuCl2(η6-p-cymene)(P*)] (P* = SPMeRR′) and [RuCl2(κ-P*-η6-arene)], containing P-stereogenic phosphines is reported. The borane-protected Pstereogenic phosphines have been obtained by addition of the (H3B)PMe2R (R = t-Bu (1), Cy (2), Fc (3))/sec-BuLi/ (−)-sparteine adduct to benzyl halides, carbonyl functions, and epoxides with yields between 40 and 90% and ee values in the 70−99% range. Those containing an aryl secondary function have been used in the preparation of [RuCl2(η6 -p-cymene)-(P*)] complexes. Borane deprotection has been performed using HBF4, except for (H3B)PRMe(CH2SiMe2Ph) phosphines, where DABCO was used to avoid partial cleavage of the CH2− Si bond. In the case of (H3B)P(t-Bu)Me(CH2C(OH)Ph2) (1l) the dehydrated phosphine was obtained. The tethered complexes were obtained by p-cymene substitution in chlorobenzene at 120 °C, except for ferrocenyl-containing complexes, which decomposed upon heating. The presence of substituents in the aryl arm of some of the phosphines introduces new chiral elements in the tethered [RuCl2(κ-P*-η6-arene)] compounds. Full characterization of all compounds both in solution and in the solid state has been carried out. Crystal structure determinations of four phosphine−borane molecules confirm the S configuration at the phosphorus atom (1a,e,l and 2d). Moreover, the crystal structure of one p-cymene complex (5i) and four tethered complexes reveal the strain of the compounds with two atoms in the tether (7c,g,l and 8i). Tethering has a marked effect on the catalytic performance transfer hydrogenation of acetophenone and on the nature of hydridic species originating during the activation period. The chiral induction attains 58% ee with complexes with the bulkiest substituents in the pendant arm of the phosphine. Three of the prepared complexes can interact with DNA and present a reasonable cytotoxicity toward cancer cells. Intercalation of the free aromatic pendant arm of the phosphines seems to be fundamental for such interactions

RSE y ODS como herramientas del crecimiento en PyMEs: un estudio comparativo

El crecimiento empresarial es detonante para el desarrollo de los países, las empresas en la actualidad se han alineado a los ODS y la RSE como herramientas que potencializan su capacidad hacia generar dicho crecimiento. En el presente estudio se tiene como objetivo general comparar el nivel en que las PyMEs comerciales y de servicios del sur del estado Veracruz que realizan acciones alineadas a los ODS y RSE, está contribuyendo al crecimiento empresarial. La investigación se posiciona desde el paradigma empírico-analítico, con un enfoque cuantitativo y transversal. Para la recolección de la información se diseñó una encuesta basada en la revisión de la literatura y la cual fue validada, además se recurrió a un muestreo no probabilístico a conveniencia, obteniendo dos muestras independientes: 75 comerciales y 34 de servicios, los informantes fueron gerentes o dueños. El método de análisis utilizado fue el análisis descriptivo y se recurrió a la prueba de hipótesis a través de la técnica de U de Mann-Whitney. Los resultados demuestran que existen diferencias entre ambas muestras, obteniendo un nivel tanto en comerciales y de servicios medio-alto, no obstante, se observaron diferencias, la prueba de hipótesis denota que se apoya la hipótesis de investigación, en donde se apoya que el nivel en el crecimiento entre ambas muestras es diferente. En definitiva, las acciones que adopta las PyMEs sobre ODS y RSE si están impactando en el crecimiento empresarial en el mercado donde se desarrollan

Rasgos de emprendimiento social de estudiantes de una IES

The arrival of globalization has brought great changes in the world and its effects have been reflected in the political, economic, social and of course in the educational context. The purpose of this research is to analyze the characteristics of social entrepreneurship that undergraduate students have attached to the Faculty of Accounting and Administration of the Universidad Veracruzana from Coatzacoalcos, for it, a methodology is followed with an empirical-analytical, descriptive and cross-sectional approach. In relation to the design, the survey technique was used and applied to a representative sample of 248 students. The results show that students have strong attitudes about social entrepreneurship, the main recommendations indicate that the topic of social entrepreneurship should be included in the Educational Experiences of the Study Program in view of the new trends in cur design. La llegada de la globalización ha traído consigo grandes cambios en el mundo y sus efectos se han visto reflejado en lo político, económico, social y por supuesto en el contexto educativo. La presente investigación tiene como objetivo analizar los rasgos de emprendimiento social que poseen los estudiantes de nivel licenciatura adscritos a la Facultad de Contaduría y Administración (FCA) de la Universidad Veracruzana (UV) campus Coatzacoalcos, para ello, se sigue una metodología con un enfoque empírico-analítico, de alcance descriptivo y de corte transversal. En relación al diseño, se utilizó la técnica de encuesta y aplico a una muestra representativa de 248 estudiantes. Los resultados muestran que los estudiantes poseen actitudes solidas acerca de emprendimiento social, las principales recomendaciones indican que se debe de incluir el tema de emprendimiento social en las Experiencias Educativas (EE) de los Programa de Estudio (PE) ante las nuevas tendencias en diseño curricular en el Área Económico Administrativa(AEA)

Percepción de RSU en Estudiantes de Contaduría Pública de una IES

The University Social Responsibility (USR) is the alignment of the functions; ethics, social relevance and sustainable development that the universities to up add to attend the needed of the society. The present study was conducted with the finality determinate the level of perception of USR of enrolled students to degree in Public Accounting of the Faculty of Economic Sciences (FES) of the University of the Llanos (Unillanos) of Villavicencio, Meta, Colombia, in the period February to July 2017, It was managed one methodology of quantitative focus, descriptive scope and cross-section. It was obtained of a sample of 190 students to the total of 378, it was calculating with 95% confidence interval and 5% margin error. main results indicated that perception level in the students was of 67%, percentage that considering affable. In conclusion, it is recommended that the students Unillanos make a diffusion campaign of the activities when where the students can be participants.La Responsabilidad Social Universitaria (RSU) es la alineación de las funciones; ética, pertinencia social y desarrollo sostenible que las universidades suman para atender las necesidades de la sociedad. El presente estudio se realizó con la finalidad de determinar el nivel de percepción de RSU de estudiantes inscritos en el Pregrado en Contaduría Pública de la Facultad de Ciencias Económicas (FCE) de la Universidad de los Llanos (Unillanos) de Villavicencio, Meta, Colombia, en el periodo febrero-julio 2017, se manejó una metodología de enfoque cuantitativo, alcance descriptivo y corte transversal. Se obtuvo una muestra de 191 estudiantes de un total de 378, se calculó con un 95% de de confianza y 5% de error. Los principales resultados indican que el nivel de percepción de los estudiantes es de 67%, porcentaje considerando bueno. En conclusión, se recomienda que la Unillanos realice una campaña de difusión de las actividades donde los estudiantes puedan ser partícipes

Does sex impact the differences and relationships in the one repetition maximum performance across weightlifting overhead pressing exercises?

This study aimed to determine the impact of sex on the differences and relationships of the one repetition maximum (1RM) performance between 3 overhead pressing exercises (push press [PP], push jerk [PJ] and split jerk [SJ]). 15 men (body mass [BM]: 82.3 ± 9.9 kg; weightlifting training experience: 2.6 ± 1.6 years) and 15 women (BM: 64.4 ± 7.0 kg; weightlifting training experience: 2.2 ± 1.4 years) participated in this study. A ratio-scaled (1RM·BM) was used for the comparison between them. The 1RM of the 3 exercises were evaluated within the same testing session using a combined 1RM assessment method. The interaction effect of exercise and sex did not reach statistical significance (p = 0.671; η = 0.001). In contrast, there were significant main effects of exercise (p ≤ 0.01) and sex (p < 0.001) with medium (η = 0.096) and large effect sizes (η = 0.306), respectively. A similar main effect of exercise was reported for both men (PP [1.0 ± 0.1 kg·kg] < PJ [1.1 ± 0.2 kg·kg] ∼ SJ [1.2 ± 0.2 kg·kg]) and women (PP [0.8 ± 0.1 kg·kg] < PJ [0.9 ± 0.2 kg·kg] ∼ SJ [0.9 ± 0.2 kg·kg]). The 1RM performance of the 3 exercises was significantly correlated for men (r [range] = 0.856-0.963) and women (r [range] = 0.636-0.925). Sex does not affect the differences in the 1RM performance across weightlifting overhead pressing exercises. However, stronger correlations and lower variation in the 1RM performance during the PP, PJ, and SJ are expected for men compared with women

RSE y ODS como herramientas del crecimiento empresarial en pymes lideradas por mujeres en Coatzacoalcos, México

La RSE y los ODS se han consolidado como un pilar para el desarrollo de las empresas, y con el protagonismo de las mujeres empresarias del siglo XXI se han constituido organizaciones dirigidas por ellas, quienes juegan un rol importante para el crecimiento empresarial. En este sentido, el objetivo del presente estudio es demostrar la incidencia de la RSE y los ODS, como herramientas que potencializan el crecimiento empresarial en las pymes lideradas por mujeres en Coatzacoalcos, Veracruz, México. Para ello, se emplea la metodología para estudios de enfoque cuantitativo, de alcance descriptivo-correlacional y de corte transversal, para la recolección de información se recurrió a la técnica de encuesta, respecto a la muestra se integró por un total de 57 pymes. Los resultados indican que las pequeñas empresas reflejan en menor proporción prácticas de RSE y ODS que las medianas, y las correlaciones indican una fuerte asociación de las variables con el crecimiento empresarial. Se concluye que las pymes lideradas por mujeres aplican en gran medida prácticas asociadas a la RSE y ODS que coadyuvan en el crecimiento empresarial

Mechanical power production assessment during weightlifting exercises. A systematic review

The assessment of the mechanical power production is of great importance for researchers and practitioners. The purpose of this review was to compare the differences in ground reaction force (GRF), kinematic, and combined (bar velocity x GRF) methods to assess mechanical power production during weightlifting exercises. A search of electronic databases was conducted to identify all publications up to 31 May 2019. The peak power output (PPO) was selected as the key variable. The exercises included in this review were clean variations, which includes the hang power clean (HPC), power clean (PC) and clean. A total of 26 articles met the inclusion criteria with 53.9% using the GRF, 38.5% combined, and 30.8% the kinematic method. Articles were evaluated and descriptively analysed to enable comparison between methods. The three methods have inherent methodological differences in the data analysis and measurement systems, which suggests that these methods should not be used interchangeably to assess PPO in Watts during weightlifting exercises. In addition, this review provides evidence and rationale for the use of the GRF to assess power production applied to the system mass while the kinematic method may be more appropriate when looking to assess only the power applied to the barbell

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Whether initiation of antiretroviral therapy (ART) regimens aimed at achieving greater concentrations within gut associated lymphoid tissue (GALT) impacts the level of mucosal immune reconstitution, inflammatory markers and the viral reservoir remains unknown. We included 12 HIV- controls and 32 ART-naïve HIV patients who were randomized to efavirenz, maraviroc or maraviroc+raltegravir, each with fixed-dose tenofovir disoproxil fumarate/emtricitabine. Rectal and duodenal biopsies were obtained at baseline and at 9 months of ART. We performed a comprehensive assay of T-cell subsets by flow cytometry, T-cell density in intestinal biopsies, plasma and tissue concentrations of antiretroviral drugs by high-performance liquid chromatography/mass spectroscopy, and plasma interleukin-6 (IL-6), lipoteichoic acid (LTA), soluble CD14 (sCD14) and zonulin-1 each measured by ELISA. Total cell-associated HIV DNA was measured in PBMC and rectal and duodenal mononuclear cells. Twenty-six HIV-infected patients completed the follow-up. In the duodenum, the quadruple regimen resulted in greater CD8+ T-cell density decline, greater normalization of mucosal CCR5+CD4+ T-cells and increase of the naïve/memory CD8+ T-cell ratio, and a greater decline of sCD14 levels and duodenal HIV DNA levels (P = 0.004 and P = 0.067, respectively), with no changes in HIV RNA in plasma or tissue. Maraviroc showed the highest drug distribution to the gut tissue, and duodenal concentrations correlated well with other T-cell markers in duodenum, i.e., the CD4/CD8 ratio, %CD4+ and %CD8+ HLA-DR+CD38+ T-cells. Maraviroc use elicited greater activation of the mucosal naïve CD8+ T-cell subset, ameliorated the distribution of the CD8+ T-cell maturational subsets and induced higher improvement of zonulin-1 levels. These data suggest that combined CCR5 and integrase inhibitor based combination therapy in ART treatment naïve patients might more effectively reconstitute duodenal immunity, decrease inflammatory markers and impact on HIV persistence by cell-dependent mechanisms, and show unique effects of MVC in duodenal immunity driven by higher drug tissue penetration and possibly by class-dependent effects

Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection

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