Real-life effectiveness of sofosbuvir/velpatasvir/voxilaprevir in hepatitis C patients previously treated with sofosbuvir/velpatasvir or glecaprevir/pibrentasvir

Altres ajuts: acords transformatius de la UABSofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct-acting antivirals (DAAs). Data are limited on the effectiveness of this treatment after the current first-line therapies. Our aim was to analyse the effectiveness and safety of SOF/VEL/VOX among patients failing sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB). Retrospective multicentre study (26 Spanish hospitals), including chronic hepatitis C patients unsuccessfully treated with SOF/VEL or GLE/PIB, and retreated with SOF/VEL/VOX ± ribavirin for 12 weeks between December 2017 and December 2022. In total, 142 patients included: 100 (70.4%) had failed SOF/VEL and 42 (29.6%) GLE/PIB. Patients were mainly men (84.5%), White (93.9%), with hepatitis C virus genotype (GT) 3 (49.6%) and 47.2% had liver cirrhosis. Sustained virological response (SVR) was evaluated in 132 patients who completed SOF/VEL/VOX and were followed 12 weeks after end of treatment; 117 (88.6%) achieved SVR. There were no significant differences in SVR rates according to initial DAA treatment (SOF/VEL 87.9% vs. GLE/PIB 90.2%, p = 0.8), cirrhosis (no cirrhosis 90% vs. cirrhosis 87.1%, p = 0.6) or GT3 infection (non-GT3 91.9% vs. GT3 85.5%, p = 0.3). However, when considering the concurrent presence of SOF/VEL treatment, cirrhosis and GT3 infection, SVR rates dropped to 82.8%. Ribavirin was added in 8 (6%) patients, all achieved SVR. SOF/VEL/VOX is an effective rescue therapy for failures to SOF/VEL or GLE/PIB, with an SVR of 88.6%. Factors previously linked to lower SVR rates, such as GT3 infection, cirrhosis and first-line therapy with SOF/VEL were not associated with lower SVRs

Micro-photogrammetric and morphometric differentiation of cut marks on bones using metal knives, quartzite, and flint flakes

In a previous article, we presented an innovative method to analyze cut marks produced with metal tools on animal bones from a metrical and tridimensional perspective (Maté-González et al. 2015). Such analysis developed a low-cost alternative technique to traditional microscopic methods for the tridimensional reconstruction of marks, using their measurements and sections. This article presents the results of an experimental study to test this photogrammetric and morphometric method for differentiating cut marks generated with metal, flint, and quartzite flakes. The results indicate statistically significant differences among cut marks produced by these three types of raw material. These results encourage the application of this method to archeological assemblages in order to establish a link between carcass processing and lithic reduction sequences on different raw materials and also to define the kind of tools used during butchery

3D analysis of cut marks using a new geometric morphometric methodological approach

The arrival of new methodological approaches to study microscopic qualities in cut mark morphology has been a major improvement in our understanding of butchering activities. Micro-morphological differences can be detected in multiple different taphonomic alterations on bone cortical surfaces that can later be used to compare different trace mark types. Through this, we can generate studies that are able to diagnose the specific taphonomic agents and activities that produce said traces that can be found on osteological surfaces. This paper presents experimental data that have been studied using micro-photogrammetry and geometric morphometrics, successfully distinguishing morphological differences in cut marks produced by different lithic tool types as well as different raw materials. The statistical results and methodologies presented here can later be applied to archaeological sites; aiding in our understanding of raw material exploitation, tool production as well as the different butchering activities that are present in faunal assemblages