2,240 research outputs found

    Dermatological Manifestations of Down Syndrome

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    WhatsApp? Opportunities and Challenges in the Use of a Messaging App as a Qualitative Research Tool

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    This article evaluates the use of the popular Mobile Messaging App (MMA) WhatsApp as a way to conduct qualitative research with geographically dispersed samples. Through the use of a case study of Latino expat-wives around the globe, we show how traditional methods of qualitative interviewing were adapted and evolved through the use of this application. Findings suggest that WhatsApp is a valuable tool for conducting qualitative research with specific advantages over other MMAs and VoIPs due to its familiarity amongst the target group and its flexible blending of video, audio, and written forms of communication. Particularly its use on smartphones led to interactions that went beyond regular face-to-face interviews, thus allowing us access normally only gained in ethnography studies. While this can be a gain in terms of building rapport and increase the depth of data collection, it also brings new challenges in terms of ensuring data quality, interpreting non-verbal cues and ensuring high ethical standards

    High-resolution mass spectrometry applied to the study of metabolome modifications in various chicken tissues after amoxicillin administration

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    The performance of high resolution accurate mass spectrometry (HRMS) operating in full scan MS mode was investigated for the quantitative determination of amoxicillin (AMX) as well as qualitative analysis of metabolomic profiles in tissues of medicated chickens. The metabolomic approach was exploited to compile analytical information on changes in the metabolome of muscle, kidney and liver from chickens subjected to a pharmacological program with AMX. Data consisting of m/z features taken throughout the entire chromatogram were extracted and filtered to be treated by Principal Component Analysis. As a result, it was found that medicated and non-treated animals were clearly clustered in distinct groups. Besides, the multivariate analysis revealed some relevant mass features contributing to this separation. In this context, recognizing those potential markers of each chicken class was a priority research for both metabolite identification and, obviously, evaluation of food quality and health effects associated to food consumption

    Multiresidue determination of quinolones regulated by the European Union in bovine and porcine plasma. Application of chromatographic and capillary electrophoretic methodologies

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    This paper presents the multiresidue determination of the series of quinolones regulated by the European Union (marbofloxacin, ciprofloxacin, danofloxacin, enrofloxacin, sarafloxacin, difloxacin, oxolinic acid and flumequine) in bovine and porcine plasma using capillary electrophoresis and liquid chromatography with ultraviolet detection (CE-UV, LC-UV), liquid chromatography-mass spectrometry and -tandem mass spectrometry (LC-MS, LC-MS/MS) methods. These procedures involve a sample preparation by solid-phase extraction for clean-up and preconcentration of the analytes before their injection into the separation system. All methods give satisfactory results in terms of linearity, precision, accuracy and limits of quantification. The suitability of the methods to determine quinolones was evaluated by determining the concentration of enrofloxacin and ciprofloxacin in real samples from pig plasma and cow plasm

    Role of lepton flavor violating (LFV) muon decay in Seesaw model and LSND

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    The aim of the work is to study LFV in a newly proposed Seesaw model of neutrino mass and to see whether it could explain LSND excess. The motivation of this Seesaw model was that there was no new physics beyond the TeV scale. By studying \mu \to 3e in this model, it is shown that the upper bound on the branching ratio requires Higgs mass m_{h} of a new scalar doublet with lepton number L=-1 needed in the model has to be about 9 TeV. The predicted branching ratio for \mu \to e\nu_{l}\bar{\nu}_{l} is too small to explain the LSND. PACS: 11.30.Hv, 14.60.PqComment: 05 pages, three figures, the version to appear in PR

    Metabolomic assays of amoxicillin, cephapirin and ceftiofur in chicken muscle. Application to treated chicken samples by liquid chromatography quadrupole time-of-flight mass spectrometry

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    The aim of this study was to identity metabolites and transformation products (TPs) in chicken muscle from amoxicillin (AMX), cephapirin (PIR) and ceftiofur (TIO), which are antibiotics of the β-lactam family. Liquid chromatography coupled to quadrupole time-of-flight (QqTOF) mass spectrometry was utilized due to its high resolution, high mass accuracy and MS/MS capacity for elemental composition determination and structural elucidation. Amoxicilloic acid (AMA) and amoxicillin diketopiperazine (DKP) were found as transformation products from AMX. Desacetylcephapirin (DAC) was detected as a metabolite of PIR. Desfuroylceftiofur (DFC) and its conjugated compound with cysteine (DFC-S-Cys) were detected as a result of TIO in contact with chicken muscle tissue. The metabolites and transformation products were also monitored during the in vivo AMX treatment and slaughtering period. It was found that two days were enough to eliminate AMX and associated metabolites/transformation products after the end of administration

    Determination and characterization of quinolones in foodstuffs of animal origin by CE-UV,  LC-UV, LC-Fl, LC-MS and LC-MS/MS

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    In this work methods for the multiresidue determination of the series of quinolones include in the European regulation in food of animal origin are de veloped and validated in line with Commission Decision 2002/657/EC in terms of linearity, decision limit, capability detection, precision and stability. Mult iresidue methods were established to allow the determination of quinolones covered by EU legislation in 2377/90/EC in muscle of chicken, turkey, pig and cow, plasma of cow and pig, liver of pig and milk of cow. First an extraction step was optimized and a SPE step was applied to clean!up and preconcentrate quinolones prior to their separation by CE or LC and determination by CE!UV, LC!UV, LC!Fl, LC!MS with different ion sources (ESI ,ApCI) and different mass analyser (Q, ToF) and LC!E SI!QqQ tandem mass spectrometry. The limits of quantification obtained are always lower than Maxim um Residue Limit (MRL) established by EU for quinolones in animal products and they can be applied to the control of quinolones in foodstuffs of animal origin . Finally the proposed methods were applied to determine quinolones in samples of turkey and pig muscle, pig plasma and milk of cow. Excellent quality parameters and reduced time of analysis were obtained when LC!ESI!MS/MS is used, although the others techniques presented too satisfactory results

    A class of quasi-sparse companion pencils

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    In this paper, we introduce a general class of quasi-sparse potential companion pencils for arbitrary square matrix polynomials over an arbitrary field, which extends the class introduced in [B. Eastman, I.-J. Kim, B. L. Shader, K.N. Vander Meulen, Companion matrix patterns. Linear Algebra Appl. 436 (2014) 255-272] for monic scalar polynomials. We provide a canonical form, up to permutation, for companion pencils in this class. We also relate these companion pencils with other relevant families of companion linearizations known so far. Finally, we determine the number of different sparse companion pencils in the class, up to permutation.This work has been partially supported by theMinisterio de Economía y Competitividad of Spain through grants MTM2015-68805-REDT and MTM2015-65798-P

    Wavelength-Diverse Polarization Modulators for Stokes Polarimetry

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    Information about the three-dimensional structure of solar magnetic fields is encoded in the polarized spectra of solar radiation by a host of physical processes. To extract this information, solar spectra must be obtained in a variety of magnetically sensitive spectral lines at high spatial, spectral, and temporal resolution with high precision. The need to observe many different spectral lines drives the development of Stokes polarimeters with a high degree of wavelength diversity. We present a new paradigm for the design of polarization modulators that operate over a wide wavelength range with near optimal polarimetric efficiency and are directly applicable to the next generation of multi-line Stokes polarimeters. These modulators are not achromatic in the usual sense because their polarimetric properties vary with wavelength, but they do so in an optimal way. Thus we refer to these modulators as polychromatic. We present here the theory behind polychromatic modulators, illustrate the concept with design examples, and present the performance properties of a prototype polychromatic modulator.Comment: 13 pages, 1 table, 5 figures, accepted for publication in Applied Optic
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