A Reanalysis of the Hydrodynamic Theory of Fluid, Polar-Ordered Flocks

I reanalyze the hydrodynamic theory of fluid, polar ordered flocks. I find new linear terms in the hydrodynamic equations which slightly modify the anisotropy, but not the scaling, of the damping of sound modes. I also find that the nonlinearities allowed {\it in equilibrium} do not stabilize long ranged order in spatial dimensions $d=2$; in accord with the Mermin-Wagner theorem. Nonequilibrium nonlinearities {\it do} stabilize long ranged order in $d=2$, as argued by earlier work. Some of these were missed by earlier work; it is unclear whether or not they change the scaling exponents in $d=2$.Comment: 6 pages, no figures. arXiv admin note: text overlap with arXiv:0909.195

Spin Transfers for Baryon Production in Polarized pp Collisions at RHIC-BNL

We consider the inclusive production of longitudinally polarized baryons in ${\vec p}p$ collisions at RHIC-BNL, with one longitudinally polarized proton. We study the spin transfer between the initial proton and the produced baryon as a function of its rapidity and we elucidate its sensitivity to the quark helicity distributions of the proton and to the polarized fragmentation functions of the quark into the baryon. We make predictions using an SU(6) quark spectator model and a perturbative QCD (pQCD) based model. We discuss these different predictions, and what can be learned from them, in view of the forthcoming experiments at RHIC-BNL.Comment: 28 pages, 11 figure

Evidence for SU(3) symmetry breaking from hyperon production

We examine the SU(3) symmetry breaking in hyperon semileptonic decays (HSD) by considering two typical sets of quark contributions to the spin content of the octet baryons: Set-1 with SU(3) flavor symmetry and Set-2 with SU(3) flavor symmetry breaking in HSD. The quark distributions of the octet baryons are calculated with a successful statistical model. Using an approximate relation between the quark fragmentation functions and the quark distributions, we predict polarizations of the octet baryons produced in $e^+e^-$ annihilation and semi-inclusive deeply lepton-nucleon scattering in order to reveal the SU(3) symmetry breaking effect on the spin structure of the octet baryons. We find that the SU(3) symmetry breaking significantly affects the hyperon polarization. The available experimental data on the $\Lambda$ polarization seem to favor the theoretical predictions with SU(3) symmetry breaking. We conclude that there is a possibility to get a collateral evidence for SU(3) symmetry breaking from hyperon production. The theoretical errors for our predictions are discussed.Comment: 3 tables, 14 figure

Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young

BACKGROUND: There is a significant clinical overlap between patients with hepatocyte nuclear factor (HNF)-1A and HNF4A maturity-onset diabetes of the young (MODY), two forms of monogenic diabetes. HNF1A and HNF4A are transcription factors that control common and partly overlapping sets of target genes. We have previously shown that elevated serum pancreatic stone protein / regenerating protein A (PSP/reg1A) levels can be detected in subjects with HNF1A-MODY. In this study, we investigated whether PSP/reg is differentially regulated by HNF1A and HNF4A. METHODS: Quantitative real-time PCR (qPCR) and Western blotting were used to validate gene and protein expression in cellular models of HNF1A- and HNF4A-MODY. Serum PSP/reg1A levels and high-sensitivity C-reactive protein (hsCRP) were measured by ELISA in 31 HNF1A- and 9 HNF4A-MODY subjects. The two groups were matched for age, body mass index, diabetes duration, blood pressure, lipid profile and aspirin and statin use. RESULTS: Inducible repression of HNF1A and HNF4A function in INS-1 cells suggested that PSP/reg induction required HNF4A, but not HNF1A. In contrast, crp gene expression was significantly reduced by repression of HNF1A, but not HNF4A function. PSP/reg levels were significantly lower in HNF4A subjects when compared to HNF1A subjects [9.25 (7.85-12.85) ng/ml vs. 12.5 (10.61-17.87) ng/ml, U-test P = 0.025]. hsCRP levels were significantly lower in HNF1A-MODY [0.22 (0.17-0.35) mg/L] compared to HNF4A-MODY group [0.81 (0.38-1.41) mg/L, U-test P = 0.002], Parallel measurements of serum PSP/reg1A and hsCRP levels were able to discriminate HNF1A- and HNF4A-MODY subjects. CONCLUSION: Our study demonstrates that two distinct target genes, PSP/reg and crp, are differentially regulated by HNF1A and HNF4A, and provides clinical proof-of-concept that serum PSP/reg1A and hsCRP levels may distinguish HNF1A-MODY from HNF4A-MODY subjects

Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis

BACKGROUND: Exposure to vanadium pentoxide (V(2)O(5)) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V(2)O(5 )in vitro in order to identify candidate genes that could play a role in inflammation, fibrosis, and repair during the pathogenesis of V(2)O(5)-induced bronchitis. METHODS: Normal human lung fibroblasts were exposed to V(2)O(5 )in a time course experiment. Gene expression was measured at various time points over a 24 hr period using the Affymetrix Human Genome U133A 2.0 Array. Selected genes that were significantly changed in the microarray experiment were validated by RT-PCR. RESULTS: V(2)O(5 )altered more than 1,400 genes, of which ~300 were induced while >1,100 genes were suppressed. Gene ontology categories (GO) categories unique to induced genes included inflammatory response and immune response, while GO catogories unique to suppressed genes included ubiquitin cycle and cell cycle. A dozen genes were validated by RT-PCR, including growth factors (HBEGF, VEGF, CTGF), chemokines (IL8, CXCL9, CXCL10), oxidative stress response genes (SOD2, PIPOX, OXR1), and DNA-binding proteins (GAS1, STAT1). CONCLUSION: Our study identified a variety of genes that could play pivotal roles in inflammation, fibrosis and repair during V(2)O(5)-induced bronchitis. The induction of genes that mediate inflammation and immune responses, as well as suppression of genes involved in growth arrest appear to be important to the lung fibrotic reaction to V(2)O(5)

Neurite outgrowth inhibitory levels of organophosphates induce tissue transglutaminase activity in differentiating N2a cells: evidence for covalent adduct formation

Organophosphate compounds (OPs) induce both acute and delayed neurotoxic effects, the latter of which is believed to involve their interaction with proteins other than acetylcholinesterase. However, few OP-binding proteins have been identified that may have a direct role in OP-induced delayed neurotoxicity. Given their ability to disrupt Ca2+ homeostasis, a key aim of the current work was to investigate the effects of sub-lethal neurite outgrowth inhibitory levels of OPs on the Ca2+-dependent enzyme tissue transglutaminase (TG2). At 1–10 µM, the OPs phenyl saligenin phosphate (PSP) and chlorpyrifos oxon (CPO) had no effect cell viability but induced concentration-dependent decreases in neurite outgrowth in differentiating N2a neuroblastoma cells. The activity of TG2 increased in cell lysates of differentiating cells exposed for 24 h to PSP and chlorpyrifos oxon CPO (10 µM), as determined by biotin-cadaverine incorporation assays. Exposure to both OPs (3 and/or 10 µM) also enhanced in situ incorporation of the membrane permeable substrate biotin-X-cadaverine, as indicated by Western blot analysis of treated cell lysates probed with ExtrAvidin peroxidase and fluorescence microscopy of cell monolayers incubated with FITC-streptavidin. Both OPs (10 µM) stimulated the activity of human and mouse recombinant TG2 and covalent labelling of TG2 with dansylamine-labelled PSP was demonstrated by fluorescence imaging following SDS-PAGE. A number of TG2 substrates were tentatively identified by mass spectrometry, including cytoskeletal proteins, chaperones and proteins involved protein synthesis and gene regulation. We propose that the elevated TG2 activity observed is due to the formation of a novel covalent adduct between TG2 and OPs

Chiral Polymerization in Open Systems From Chiral-Selective Reaction Rates

We investigate the possibility that prebiotic homochirality can be achieved exclusively through chiral-selective reaction rate parameters without any other explicit mechanism for chiral bias. Specifically, we examine an open network of polymerization reactions, where the reaction rates can have chiral-selective values. The reactions are neither autocatalytic nor do they contain explicit enantiomeric cross-inhibition terms. We are thus investigating how rare a set of chiral-selective reaction rates needs to be in order to generate a reasonable amount of chiral bias. We quantify our results adopting a statistical approach: varying both the mean value and the rms dispersion of the relevant reaction rates, we show that moderate to high levels of chiral excess can be achieved with fairly small chiral bias, below 10%. Considering the various unknowns related to prebiotic chemical networks in early Earth and the dependence of reaction rates to environmental properties such as temperature and pressure variations, we argue that homochirality could have been achieved from moderate amounts of chiral selectivity in the reaction rates.Comment: 15 pages, 6 figures, accepted for publication in Origins of Life and Evolution of Biosphere

Low-Lying Excited States and Low-Temperature Properties of an Alternating Spin-1 / Spin-1/2 Chain : A DMRG study

We report spin wave and DMRG studies of the ground and low-lying excited states of uniform and dimerized alternating spin chains. The DMRG procedure is also employed to obtain low-temperature thermodynamic properties of the system. The ground state of a 2N spin system with spin-1 and spin-1/2 alternating from site to site and interacting via an antiferromagnetic exchange is found to be ferrimagnetic with total spin $s_G=N/2$ from both DMRG and spin wave analysis. Both the studies also show that there is a gapless excitation to a state with spin $s_G-1$ and a gapped excitation to a state with spin $s_G+1$. Surprisingly, the correlation length in the ground state is found to be very small from both the studies for this gapless system. For this very reason, we show that the ground state can be described by a variational ``ansatz'' of the product type. DMRG analysis shows that the chain is susceptible to a conditional spin-Peierls' instability. The DMRG studies of magnetization, magnetic susceptibility ($\chi$) and specific heat show strong magnetic-field dependence. The product $\chi T$ shows a minimum as a function of temperature($T$) at low-magnetic fields and the minimum vanishes at high-magnetic fields. This low-field behaviour is in agreement with earlier experimental observations. The specific heat shows a maximum as a function of temperature and the height of the maximum increases sharply at high magnetic fields. It is hoped that these studies will motivate experimental studies at high-magnetic fields.Comment: 22 pages in latex; 16 eps figures available upon reques

Cetuximab Augments Cytotoxicity with Poly (ADP-Ribose) Polymerase Inhibition in Head and Neck Cancer

Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of head and neck cancers and confers increased resistance and inferior survival rates. Despite targeted agents against EGFR, such as cetuximab (C225), almost half of treated patients fail this therapy, necessitating novel therapeutic strategies. Poly (ADP-Ribose) polymerase (PARP) inhibitors (PARPi) have gained recent attention due to their unique selectivity in killing tumors with defective DNA repair. In this study, we demonstrate that C225 enhances cytotoxicity with the PARPi ABT-888 in UM-SCC1, UM-SCC6, and FaDu head and neck cancer cells. The mechanism of increased susceptibility to C225 and PARPi involves C225-mediated reduction of non-homologous end-joining (NHEJ)- and homologous recombination (HR)-mediated DNA double strand break (DSB) repair, the subsequent persistence of DNA damage, and activation of the intrinsic apoptotic pathway. By generating a DSB repair deficiency, C225 can render head and neck tumor cells susceptible to PARP inhibition. The combination of C225 and the PARPi ABT-888 can thus be an innovative treatment strategy to potentially improve outcomes in head and neck cancer patients. Furthermore, this strategy may also be feasible for other EGFR overexpressing tumors, including lung and brain cancers