Proyecto de rehabilitación y acondicionamiento de vivienda unifamiliar aislada en Tamarite de Litera (Huesca)

Vivienda unifamiliar aislada construida en suelo urbano, situada en el casco histórico del término municipal de Tamarite de Litera, provincia de Huesca (Aragón) en la calle San Antonio Alta Nº 1. Según información de catastro, su construcción data del año 1888, con posteriores reformas. Después de una valoración del lugar, del entorno y las posibilidades de la edificación, se ha optado por un desarrollo de un proyecto que tiene como propósito la rehabilitación y acondicionamiento de dicha vivienda unifamiliar para su transformación en una vivienda plurifamiliar formada por dos viviendas, una por planta útil, planta garaje y zona ajardinada. Dicha solución preservará la imagen residencial del entorno, formada por una arquitectura de casas señoriales, actualmente de uso residencial que ha ido pasando de generación en generación, alrededor de la Excolegiata Santa María La Mayor. Este proyecto propondrá rehabilitar la vivienda y acondicionarla, incorporando todo lo necesario para satisfacer necesidades actuales de confort y comodidad de acuerdo con la normativa actual e intentará darle una imagen de vivienda de burguesía de la época, combinando las soluciones constructivas actuales con la esencia de la arquitectura de la época

Concomitant Crystallization in Propylene/Ethylene Random Copolymer with Strong Flow at Elevated Temperatures

Flow-induced crystallization of α- and γ-phases was studied for a propylene/ethylene random copolymer with 3.4 mol % ethylene at two high temperatures of 132 and 142 °C by combining a pressure-driven slit flow device with real-time synchrotron wide-angle X-ray diffraction. At 132 °C, it was found that both α- and γ-phases were generated at shear stresses ranging from 0.091 to 0.110 MPa and that the γ-phase always appeared later than the α-phase. However, for 142 °C and the same stresses, only the α-phase formed. Only upon cooling the partially crystallized copolymer did the γ-phase emerge. The lack of γ-crystals obtained at 142 °C is opposite to the behavior reported for quiescent crystallization under pressure, for which increasing temperature results in more and even pure γ-crystals. In the current study, the absence of γ-phase at 142 °C is tentatively associated with lack of epitaxial nucleation on α-lamellae and to relatively low growth rate of γ-crystals

Revisión bibliográfica de implantología bucofacial del año 2008. Primera parte

La actividad asistencial de los profesionales de la Odontología tiene como consecuencia una baja disponibilidad de tiempo para dedicarse a la lectura de artículos científicos. Ante la dificultad de mantener un buen nivel de información en el campo de la Implantología Bucofacial, nuestro interés es exponer de forma sintética una revisión de la literatura científica publicada en las revistas más relevantes de la especialidad durante el año 2008. El lector interesado encontrará en este artículo algunos de los diferentes temas que integran esta disciplina, expuestos por apartados (plan de tratamiento, pacientes especiales, diseño y superficies, regeneración ósea, regeneración tisular guiada, carga inmediata, pacientes irradiados, implantes extraorales)

Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers

Ivermectin is a pivotal drug for the control of onchocerciasis and lymphatic filariasis, which is increasingly identified as a useful drug for the control of other Neglected Tropical Diseases. Its role in the treatment of soil transmitted helminthiasis through improved efficacy against Trichuris trichiura in combination with other anthelmintics might accelerate the progress towards breaking transmission. Ivermectin is a derivative of Avermectin B1, and consists of an 80:20 mixture of the equipotent homologous 22,23 dehydro B1a and B1b. Pharmacokinetic characteristics and safety profile of ivermectin allow to explore innovative uses to further expand its utilization through mass drug administration campaigns to improve coverage rates. We conducted a phase I clinical trial with 54 healthy adult volunteers who sequentially received 2 experimental treatments using a new 18 mg ivermectin tablet in a fixed-dose strategy of 18 and 36 mg single dose regimens, compared to the standard, weight based 150-200 μg/kg, regimen. Volunteers were recruited in 3 groups based on body weight. Plasma concentrations of ivermectin were measured through HPLC up to 168 hours post treatment. Safety data showed no significant differences between groups and no serious adverse events: headache was the most frequent adverse event in all treatment groups, none of them severe. Pharmacokinetic parameters showed a half-life between 81 and 91 h in the different treatment groups. When comparing the systemic bioavailability (AUC0t and Cmax) of the reference product (WA-ref) with the other two study groups using fixed doses, we observed an overall increase in AUC0t and Cmax for the two experimental treatments of 18 mg and 36 mg. Body mass index (BMI) and weight were associated with t1/2 and V/F, probably reflecting the high liposolubility of IVM with longer retention times proportional to the presence of more adipose tissue. Systemic exposure to ivermectin (AUC0t or Cmax) was not associated with BMI or weight in our study. These findings contribute to further understand the pharmacokinetic characteristics of ivermectin, highlighting its safety across different dosing regimens. They also correlate with known pharmacokinetic parameters showing stable levels of AUC and Cmax across a wide range of body weights, which justifies the strategy of fix dosing from a pharmacokinetic perspective

Evaluating the usefulness of continuous leaf turgor pressure measurements for the assessment of Persimmon tree water status

Continuous plant water status monitoring is crucial in order to improve irrigation management. The noninvasive Yara ZIM-probe was assessed for detecting plant water stress in Persimmon trees (Diospyros kaki L.f.). The probe measures the pressure transfer function (Pp) through a patch of an intact leaf, which is inversely correlated with the turgor pressure. This technology was evaluated in two parallel experiments involving either distinct watering regimes or rootstocks with different drought tolerance [Diospyros lotus (L) and Diospyros virginiana (V)]. Concomitant measurements of midday stem water potential (Ψstem) and trunk diameter variations were taken throughout the experiments. Pp was highly correlated with Ψstem. Persimmon leaves exhibited the inversed Pp curve phenomena under water stress, which enabled the association of a particular range of Ψstem to each of the three leaf turgor states defined. Persimmon trees with no sign of initial or total inversion ensured Ψstem above −0.8 MPa, values considered of a well-watered Persimmon tree. Yara ZIM-probe readings as well as Ψstem and trunk diameter variation measurements pointed L as a more sensitive rootstock to drought than V. In conclusion, results showed that the Yara ZIM-probe can be used to continuously monitor water status in Persimmon trees although further research would be needed to ensure their feasibility for scheduling irrigation

FASTLens (FAst STatistics for weak Lensing) : Fast method for Weak Lensing Statistics and map making

With increasingly large data sets, weak lensing measurements are able to measure cosmological parameters with ever greater precision. However this increased accuracy also places greater demands on the statistical tools used to extract the available information. To date, the majority of lensing analyses use the two point-statistics of the cosmic shear field. These can either be studied directly using the two-point correlation function, or in Fourier space, using the power spectrum. But analyzing weak lensing data inevitably involves the masking out of regions or example to remove bright stars from the field. Masking out the stars is common practice but the gaps in the data need proper handling. In this paper, we show how an inpainting technique allows us to properly fill in these gaps with only $N \log N$ operations, leading to a new image from which we can compute straight forwardly and with a very good accuracy both the pow er spectrum and the bispectrum. We propose then a new method to compute the bispectrum with a polar FFT algorithm, which has the main advantage of avoiding any interpolation in the Fourier domain. Finally we propose a new method for dark matter mass map reconstruction from shear observations which integrates this new inpainting concept. A range of examples based on 3D N-body simulations illustrates the results.Comment: Final version accepted by MNRAS. The FASTLens software is available from the following link : http://irfu.cea.fr/Ast/fastlens.software.ph

Spatial based Expectation Maximizing (EM)

<p>Abstract</p> <p>Background</p> <p>Expectation maximizing (EM) is one of the common approaches for image segmentation.</p> <p>Methods</p> <p>an improvement of the EM algorithm is proposed and its effectiveness for MRI brain image segmentation is investigated. In order to improve EM performance, the proposed algorithms incorporates neighbourhood information into the clustering process. At first, average image is obtained as neighbourhood information and then it is incorporated in clustering process. Also, as an option, user-interaction is used to improve segmentation results. Simulated and real MR volumes are used to compare the efficiency of the proposed improvement with the existing neighbourhood based extension for EM and FCM.</p> <p>Results</p> <p>the findings show that the proposed algorithm produces higher similarity index.</p> <p>Conclusions</p> <p>experiments demonstrate the effectiveness of the proposed algorithm in compare to other existing algorithms on various noise levels.</p

Cognitive functioning in dyskinetic cerebral palsy: Its relation to motor function, communication and epilepsy

Background: Cerebral palsy (CP) is a disorder of motor function often accompanied by cognitive impairment. There is a paucity of research focused on cognition in dyskinetic CP and on the potential effect of related factors. Aim: To describe the cognitive profile in dyskinetic CP and to assess its relationship with motor function and associated impairments. Method: Fifty-two subjects with dyskinetic CP (28 males, mean age 24 y 10 mo, SD 13 y) and 52 typically-developing controls (age- and gender-matched) completed a comprehensive neuropsychological assessment. Gross Motor Function Classification System (GMFCS), Communication Function Classification System (CFCS) and epilepsy were recorded. Cognitive performance was compared between control and CP groups, also according different levels of GMFCS. The relationship between cognition, CFCS and epilepsy was examined through partial correlation coefficients, controlling for GMFCS. Results: Dyskinetic CP participants performed worse than controls on all cognitive functions except for verbal memory. Milder cases (GMFCS I) only showed impairment in attention, visuoperception and visual memory. Participants with GMFCS II-III also showed impairment in language-related functions. Severe cases (GMFCS IV-V) showed impairment in intelligence and all specific cognitive functions but verbal memory. CFCS was associated with performance in receptive language functions. Epilepsy was related to performance in intelligence, visuospatial abilities, visual memory, grammar comprehension and learning. Conclusion: Cognitive performance in dyskinetic CP varies with the different levels of motor impairment, with more cognitive functions impaired as motor severity increases. This study also demonstrates the relationship between communication and epilepsy and cognitive functioning, even controlling for the effect of motor severity

Association of central obesity with unique cardiac remodelling in young adults born small for gestational age

Being born small for gestational age (SGA, 10% of all births) is associated with increased risk of cardiovascular mortality in adulthood together with lower exercise tolerance, but mechanistic pathways are unclear. Central obesity is known to worsen cardiovascular outcomes, but it is uncertain how it affects the heart in adults born SGA. We aimed to assess whether central obesity makes young adults born SGA more susceptible to cardiac remodelling and dysfunction.A perinatal cohort from a tertiary university hospital in Spain of young adults (30-40 years) randomly selected, 80 born SGA (birth weight below 10th centile) and 75 with normal birth weight (controls) was recruited. We studied the associations between SGA and central obesity (measured via the hip-to-waist ratio and used as a continuous variable) and cardiac regional structure and function, assessed by cardiac magnetic resonance using statistical shape analysis. Both SGA and waist-to-hip were highly associated to cardiac shape (F = 3.94, P < 0.001; F = 5.18, P < 0.001 respectively) with a statistically significant interaction (F = 2.29, P = 0.02). While controls tend to increase left ventricular end-diastolic volumes, mass and stroke volume with increasing waist-to-hip ratio, young adults born SGA showed a unique response with inability to increase cardiac dimensions or mass resulting in reduced stroke volume and exercise capacity.SGA young adults show a unique cardiac adaptation to central obesity. These results support considering SGA as a risk factor that may benefit from preventive strategies to reduce cardiometabolic risk.© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: [email protected]

Proxy-reported quality of life in adolescents and adults with dyskinetic cerebral palsy is associated with executive functions and cortical thickness

Purpose: Quality of life (QOL) is a key outcome for people with cerebral palsy (CP), and executive functioning is an important predictor of QOL in other health-related conditions. Little is known about this association in CP or about its neural substrate. We aim to analyze the influence of executive functioning (including cognitive flexibility) as well as that of other psychological, motor, communication and socioeconomic variables on QOL and to identify neuroanatomical areas related to QOL in adolescents and adults with CP. Methods: Fifty subjects diagnosed with dyskinetic CP (mean age 25.96 years) were recruited. Their caregivers completed the primary caregiver proxy report version of the CP QOL-Teen questionnaire. Motor status, communication, IQ, four executive function domains, anxiety/depression and socioeconomic status were evaluated. Correlations and multiple linear regression models were used to relate CP QOL domains and total score to these variables. Thirty-six participants underwent an MRI assessment. Correlations were examined between cortical thickness and CP QOL total score and between cortical thickness and variables that might predict the CP QOL total score. Results: Executive functions predict scores in four domains of CP QOL (General well-being and participation, Communication and physical health, Family health and Feelings about functioning) in the regression model. Among the cognitive domains that comprise executive function, only cognitive flexibility measured in terms of performance on the Wisconsin card sorting test (WCST) predicts the CP QOL total score. Monthly income, fine motor functioning and communication ability predict scores on the domains Access to services and Family Health, Feelings about functioning and School well being, respectively. The clusters resulting from the correlation between cortical thickness and both CP QOL total score and WCST performance overlapped in the posterior cingulate and precuneus cortices. Conclusions: Cognitive flexibility predicts proxy report CP QOL-Teen total score in dyskinetic CP. This relationship has its anatomical correlate in the posterior cingulate and precuneus cortices