Fem and Von Mises analysis of OSSTEM ® dental implant structural components: evaluation of different direction dynamic loads

Abstract PURPOSE: The objective of this investigation is to study prosthodontics and internal components resistance to the masticatory stress and considering different force directions by using Finite Element Method analysis (FEM). The structural materials of the components are usually Titanium alloy grade 4 or 5 and thus, guarantee the integration of the fixture in the bone due to the osteointegration phenomena. Even if the long-term dental implant survival rate is easy to be obtained and confirmed by numerous researches, the related clinical success, due to the alteration of the mechanical and prosthodontics components is still controversial. METHODS: By applying engineering systems of investigations like FEM and Von Mises analyses, it has been investigated how dental implant material was held against the masticatory strength during the dynamic masticatory cycles. A three-dimensional system involved fixture, abutment and the connection screws, which were created and analyzed. The elastic features of the materials used in the study were taken from recent literature data. RESULTS: Data revealed a different response for both types of devices, although implant neck and dental abutment showed better results for all conditions of loading while the abutment screw represented aweak point of the system. CONCLUSION: The data of this virtual model showed all the features of different prosthetic retention systems under the masticatory load. Clinicians should find better prosthetic balance in order to better distribute the stress over the component and to guarantee patients' clinical long-term results

Expression and distribution of leptin and its receptors in the digestive tract of DIO (diet-induced obese) zebrafish.

The expression and localization of leptin (A and B) and its receptor family in control and diet-induced obese (DIO) adult male zebrafish gut, after 5-weeks overfeeding, administering Artemia nauplii, as fat-rich food, were investigated. Recently, the obese adult zebrafish was considered an experimental model with pathophysiological pathways similar to mammalian obesity. Currently, there are no reports about leptin in fish obesity, or in a state of altered energy balance. By qRT-PCR, leptin A and leptin B expression levels were significantly higher in DIO zebrafish gut than in the control group (CTRL), and the lowest levels of leptin receptor mRNA appeared in DIO zebrafish gut. The presence of leptin and its receptor proteins in the intestinal tract was detected by western blot analysis in both control and DIO zebrafish. By single immunohistochemical staining, leptin and leptin receptor immunoreactive endocrine cells were identified in the intestinal tract either in DIO or control zebrafish. Moreover, leptin immunopositive enteric nervous system elements were observed in both groups. By double immunohistochemical staining, leptin and its receptor were colocalized especially in DIO zebrafish. Thus, our study represents a starting point in the investigation of a possible involvement of leptin in control of energy homeostasis in control and DIO zebrafish

The impact of interactive, computerized educational modules on preclinical medical education

Interactive computerized modules have been linked to improved retention of material in clinical medicine. This study examined the effects of a new series of interactive learning modules for preclinical medical education, specifically in the areas of quiz performance, perceived difficulty of concepts, study time, and perceived stress level. We randomly allocated 102 medical student volunteers into control and experimental groups. All participants studied selected anatomical and physiologic concepts using existing material (lecture notes, textbooks, etc.), while those in the experimental groups used the new interactive modules as well. All participants completed a quiz to test their knowledge of the assigned concepts and a survey to assess their subjective experiences in studying with the modules. We found a trend toward higher quiz scores in the experimental group relative to the control group, though it did not reach statistical significance ( P = 0.31). Perceived concept difficulty was significantly reduced among those who studied with the modules ( P < 0.001), and the number of hours spent studying the concepts was significantly increased ( P = 0.028). Of those who used the modules, 83% rated them as “very helpful” or “extremely helpful.” No significant differences existed between participants' reported stress levels during the course of the study ( P = 0.44). Our data suggest that medical students may learn more effectively and feel less intimidated by difficult concepts when interactive modules supplement traditional instruction. Anat Sci Ed 1:247–251, 2008. © 2008 American Association of Anatomists.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/61447/1/55_ftp.pd

Antimicrobial, Antioxidant Activity and Phytochemical Screening of Tecoma stans (L.) Juss. ex Kunth.

The ethanol, methanol and water extracts of Tecoma stans effective against tested bacteria (Pseudomonas fluorescens, Clavibacter michiganensis sub sp. michiganensis, Xanthomonas axanopodis pv. malvacearum, Staphylococcus aureus, E. coli, Pseudomonas aeruginosa and Klebsiella pneumonia) and fungi (all species of Aspergillus and Alternaria). Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, phenols, steroids, anthraquinones and tannins. The three extract fractions have showed highest total Phenolic content (177-216 mg gallic acid equivalent/g). These three solvent fractions possessed strong radical scavenging activity from FRAP and DPPH. It was ranged from 1433.75 to 3841.17 g/ml. The results indicate that this plant is a potential candidate to be used as an antimicrobial and antioxidant.Key words: Tecoma stans, Antimicrobial, antioxidant, phytochemicals Govindappa M et al. Antimicrobial, Antioxidant Activity and Phytochemical Screening of Tecoma stans (L.) Juss. ex Kunth. J Phytol 3/3 (2011) 68-76

PENGARUH PENAMBAHAN BIOFLOK DENGAN DOSIS BERBEDA TERHADAP PERTUMBUHAN BENIH UDANG WINDU (Penaeus monodon FABRICIUS 1798)

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh penambahan bioflok terhadap pertumbuhan dan kelangsungan benih udang windu. Penelitian dilakukan selama 30 hari dari Juni hingga Juli 2016 di Laboratorium Program Studi Budidaya Perairan Universitas Almuslim Bireuen. Penelitian dilaksanakan secara eksperimental dengan menggunakan rancangan acak lengkap dengan empat perlakuan dan tiga ulangan. Perlakuan yang diberikan terdiri dari perlakuan A (kontrol) tanpa penambahan bioflok, perlakuan B (penambahan bioflok sebanyak 10 ml dan 5% pakan komersil), C (penambahan bioflok sebanyak 15 ml dan 5% pakan komersil) dan D (penambahan bioflok sebanyak 15 ml tanpa penambahan pakan komersil. Uji startistik menggunakan ANOVA RAL satu faktor dengan selang kepercayaan 0,05. Parameter yang diamati meliputi laju pertumbuhan rata rata spesifik harian (SGR), Pertambahan Panjang Mutlak dan kelangsungan hidup (SR). Hasil penelitian menunjukan bahwa Penambahan bioflok berpengaruh nyata terhadap laju pertumbuhan rata rata spesifik harian dan pertambahan panjang mutlak. Laju pertumbuhan rata rata spesifik harian tertinggi diperoleh pada perlakuan B sebesar 0,55±0,02 %/hari, laju pertumbuhan panjang mutlak tertinggi terdapat pada perlakuan B sebesar 3,7±0,1 cm. Penambahan bioflok tidak memberikan pengaruh yang nyata terhadap kelangsungan hidup benih udang windu.Kata kunci: Bioflok, kelangsungan hidup, laju pertumbuhan rata rata spesifik haria

A clinico – radiological study of ischemic stroke in a tertiary care hospital in North Telangana

Introduction : Stroke is the second leading cause of mortality worldwide. Patients present with varied clinical presentations. Objective : To evaluate the clinical profile and radiological profile of ischemic stroke patients. To assess the outcome in relation to various clinical and radiological presentations using National Institutes of Health Stroke Scale (NIHSS). Materials & Methods : This is a hospital based prospective cross sectional study done in Prathima Institute of Medical Sciences during the period from February 2016 to July 2016 which comprised of 150 patients. Results : Stroke is most common as the age advances. Risk factor association is the main cause for development of stroke. Conclusion: NIHSS is helpful in identifying persons with stroke from those suspected to have stroke. Knowledge about identifying and reading radiological investigations will help in assessing the severity of strok

Maternal Risk Factors Associated with Hypospadias

AbstractIntroduction: Epidemiological studies have elucidated maternal and fetal factors that are associated with an increased risk of hypospadias .This study examined the association of hypospadias risk with several maternal reproductive and demographic characteristics: age, parity, body mass index (BMI), nausea and vomiting of pregnancy, fertility treatments , education and diet .Materials and Methods: Mothers of children with hypospadias were invited to participate in this case control study. Participating mothers completed a self administered questionnaire or a social worker administered/assisted questionnaire. Mothers of age matched children without hypospadias acted as controls and they too similarly completed the same questionnaire.Results: The risk factors associated with hypospadias were maternal age, primiparity , previous fertility treatment and nausea and vomiting of pregnancy .Conclusions: Increased maternal age, primiparity and previous fertility treatments in mothers are associated with an increased risk of hypospadias in male offsprings.Keywords: Hypospadias, Maternal age, Parity, Fertility, Maternal education, Nausea and vomitin

Spectrum of acute central nervous system demyelinating diseases

Central nervous system(CNS) demyelinative diseases are mainly Multiple Sclerosis, Acute Disseminated Encephalomyelitis (ADEM), Acute hemorrhagic Leucoencephalitis (AHL). Multiple Sclerosis is the most common. A clinically isolated syndrome is the result of a single episode of demyelination in one area of the central nervous system (a monofocal episode) or several areas of the central nervous system (a multifocal episode) which lasts for at least 24 hours. Among the people who are diagnosed with Multiple Sclerosis(MS), 85% experience an initial onset of symptoms or a first attack that is referred to as a clinically isolated syndrome (CIS). Here we are reporting different cases of central nervous system demyelinating diseases presented to Prathima Institute of Medical Sciences(PIMS) with various manifestations. Magnetic Resonance Imaging(MRI) findings have been discussed

Genetic Screening of Anderson-Fabry Disease in Probands Referred From Multispecialty Clinics.

BACKGROUND: Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants is 0.62%, with diagnosis confirmation in 0.12%. OBJECTIVES: This study sought to expand screening from these settings to include ophthalmology, dermatology, gastroenterology, internal medicine, pediatrics, and medical genetics to increase diagnostic yield and comprehensively evaluate organ involvement in AFD patients. METHODS: In a 10-year prospective multidisciplinary, multicenter study, we expanded clinical, genetic, and biochemical screening to consecutive patients enrolled from all aforementioned clinical settings. We tested the GLA gene and α-galactosidase A activity in plasma and leukocytes. Inclusion criteria comprised phenotypical traits and absence of male-to-male transmission. Screening was extended to relatives of probands harboring GLA mutations. RESULTS: Of 2,034 probands fulfilling inclusion criteria, 37 (1.8%) were carriers of GLA mutations. Cascade family screening identified 60 affected relatives; clinical data were available for 4 affected obligate carriers. Activity of α-galactosidase A in plasma and leukocytes was diagnostic in male subjects, but not in female subjects. Of the 101 family members harboring mutations, 86 were affected, 10 were young healthy carriers, and 5 refused clinical evaluation. In the 86 patients, involved organs or organ systems included the heart (69%), peripheral nerves (46%), kidney (45%), eye (37%), brain (34%), skin (32%), gastrointestinal tract (31%), and auditory system (19%). Globotriaosylceramide accumulated in organ-specific and non-organ-specific cells in atypical and classic variants, respectively. CONCLUSIONS: Screening probands with clinically suspected AFD significantly increased diagnostic yield. The heart was the organ most commonly involved, independent of the clinical setting in which the patient was first evaluated