63 research outputs found
Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses
Search for fourth generation quarks and leptons at the Fermilab Tevatron and CERN Large Hadron Collider
If next generations of heavy quarks and leptons exist within the standard
model (SM), they can manifest themselves in Higgs boson production at the
Tevatron and the LHC, before being actually observed. This generation leads to
an increase of the Higgs boson production cross section via gluon fusion at
hadron colliders by a factor 6-9. So, the study of this process at the Tevatron
and LHC can finally fix the number of generations in the SM. Using the
Higgs boson decay channel, the studies at the upgraded Tevatron will answer the
question about the next generation for mass values 135 GeV \lsim M_H\lsim 190
GeV. Studying the channel we show its large potential for the
study of the Higgs boson at the LHC even in the standard case of three
generations. At the Tevatron, studies in this channel could explore the mass
range 110-140 GeV.Comment: 13 pages, 4 figures, LaTeX/RevTeX, final version accepted for
publicatio
Gravitomagnetic Effects in the Propagation of Electromagnetic Waves in Variable Gravitational Fields of Arbitrary-Moving and Spinning Bodies
Propagation of light in the gravitational field of self-gravitating spinning
bodies moving with arbitrary velocities is discussed. The gravitational field
is assumed to be "weak" everywhere. Equations of motion of a light ray are
solved in the first post-Minkowskian approximation that is linear with respect
to the universal gravitational constant . We do not restrict ourselves with
the approximation of gravitational lens so that the solution of light geodesics
is applicable for arbitrary locations of source of light and observer. This
formalism is applied for studying corrections to the Shapiro time delay in
binary pulsars caused by the rotation of pulsar and its companion. We also
derive the correction to the light deflection angle caused by rotation of
gravitating bodies in the solar system (Sun, planets) or a gravitational lens.
The gravitational shift of frequency due to the combined translational and
rotational motions of light-ray-deflecting bodies is analyzed as well. We give
a general derivation of the formula describing the relativistic rotation of the
plane of polarization of electromagnetic waves (Skrotskii effect). This formula
is valid for arbitrary translational and rotational motion of gravitating
bodies and greatly extends the results of previous researchers. Finally, we
discuss the Skrotskii effect for gravitational waves emitted by localized
sources such as a binary system. The theoretical results of this paper can be
applied for studying various relativistic effects in microarcsecond space
astrometry and developing corresponding algorithms for data processing in space
astrometric missions such as FAME, SIM, and GAIA.Comment: 36 pages, 1 figure, submitted to Phys. Rev.
New hadrons as ultra-high energy cosmic rays
Ultra-high energy cosmic ray (UHECR) protons produced by uniformly
distributed astrophysical sources contradict the energy spectrum measured by
both the AGASA and HiRes experiments, assuming the small scale clustering of
UHECR observed by AGASA is caused by point-like sources. In that case, the
small number of sources leads to a sharp exponential cutoff at the energy
E<10^{20} eV in the UHECR spectrum. New hadrons with mass 1.5-3 GeV can solve
this cutoff problem. For the first time we discuss the production of such
hadrons in proton collisions with infrared/optical photons in astrophysical
sources. This production mechanism, in contrast to proton-proton collisions,
requires the acceleration of protons only to energies E<10^{21} eV. The diffuse
gamma-ray and neutrino fluxes in this model obey all existing experimental
limits. We predict large UHE neutrino fluxes well above the sensitivity of the
next generation of high-energy neutrino experiments. As an example we study
hadrons containing a light bottom squark. These models can be tested by
accelerator experiments, UHECR observatories and neutrino telescopes.Comment: 17 pages, revtex style; v2: shortened, as to appear in PR
Differential response to pallidal deep brain stimulation among monogenic dystonias: systematic review and meta-analysis
ObjectiveGenetic subtypes of dystonia may respond differentially to deep brain stimulation of the globus pallidus pars interna (GPi DBS). We sought to compare GPi DBS outcomes among the most common monogenic dystonias.MethodsThis systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses and Meta-analysis of Observational Studies in Epidemiology guidelines. We searched PubMed for studies on genetically confirmed monogenic dystonia treated with GPi DBS documenting pre-surgical and post-surgical assessments using the Burke-Fahn-Marsden Dystonia Rating Scale Motor Score (BFMMS) and Burke-Fahn-Marsden Disability Score (BFMDS). We performed (i) meta-analysis for each gene mutation; (ii) weighted ordinary linear regression analyses to compare BFMMS and BFMDS outcomes between DYT-TOR1A and other monogenic dystonias, adjusting for age and disease duration and (iii) weighted linear regression analysis to estimate the effect of age, sex and disease duration on GPi DBS outcomes. Results were summarised with mean change and 95% CI.ResultsDYT-TOR1A (68%, 38.4 points; p<0.001), DYT-THAP1 (37% 14.5 points; p<0.001) and NBIA/DYT-PANK2 (27%, 21.4 points; p<0.001) improved in BFMMS; only DYT-TOR1A improved in BFMDS (69%, 9.7 points; p<0.001). Improvement in DYT-TOR1A was significantly greater than in DYT-THAP1 (BFMMS -31%), NBIA/DYT-PANK2 (BFMMS -35%; BFMDS -53%) and CHOR/DYT-ADCY5 (BFMMS -36%; BFMDS -42%). Worse motor outcomes were associated with longer dystonia duration and older age at dystonia onset in DYT-TOR1A, longer dystonia duration in DYT/PARK-TAF1 and younger age at dystonia onset in DYT-SGCE.ConclusionsGPi DBS outcomes vary across monogenic dystonias. These data serve to inform patient selection and prognostic counselling
Two-Loop O(alpha_s G_F M_Q^2) Heavy-Quark Corrections to the Interactions between Higgs and Intermediate Bosons
By means of a low-energy theorem, we analyze at O(alpha_s G_F M_Q^2) the
shifts in the Standard-Model W^+W^-H and ZZH couplings induced by virtual
high-mass quarks, Q, with M_Q >> M_Z, M_H, which includes the top quark.
Invoking the improved Born approximation, we then find the corresponding
corrections to various four- and five-point Higgs-boson production and decay
processes which involve the W^+W^-H and ZZH vertices with one or both of the
gauge bosons being connected to light-fermion currents, respectively. This
includes e^+e^- -> f anti-f H via Higgs-strahlung, via W^+W^- fusion (with f =
nu_e), and via ZZ fusion (with f = e), as well as H -> 2V -> 4f (with V = W,
Z).Comment: 20 pages (Latex); Physical Review D (to appear
Synaptic processes and immune-related pathways implicated in Tourette syndrome.
Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS
A Kinematical Approach to Conformal Cosmology
We present an alternative cosmology based on conformal gravity, as originally
introduced by H. Weyl and recently revisited by P. Mannheim and D. Kazanas.
Unlike past similar attempts our approach is a purely kinematical application
of the conformal symmetry to the Universe, through a critical reanalysis of
fundamental astrophysical observations, such as the cosmological redshift and
others. As a result of this novel approach we obtain a closed-form expression
for the cosmic scale factor R(t) and a revised interpretation of the space-time
coordinates usually employed in cosmology. New fundamental cosmological
parameters are introduced and evaluated. This emerging new cosmology does not
seem to possess any of the controversial features of the current standard
model, such as the presence of dark matter, dark energy or of a cosmological
constant, the existence of the horizon problem or of an inflationary phase.
Comparing our results with current conformal cosmologies in the literature, we
note that our kinematic cosmology is equivalent to conformal gravity with a
cosmological constant at late (or early) cosmological times. The cosmic scale
factor and the evolution of the Universe are described in terms of several
dimensionless quantities, among which a new cosmological variable delta emerges
as a natural cosmic time. The mathematical connections between all these
quantities are described in details and a relationship is established with the
original kinematic cosmology by L. Infeld and A. Schild. The mathematical
foundations of our kinematical conformal cosmology will need to be checked
against current astrophysical experimental data, before this new model can
become a viable alternative to the standard theory.Comment: Improved version, with minor changes. 58 pages, including 7 figures
and one table. Accepted for publication in General Relativity and Gravitation
(GERG
A New Day: The Role of Telemedicine in Reshaping Care for Persons With Movement Disorders
Contains fulltext :
229724.pdf (Publisher’s version ) (Closed access)The COVID-19 pandemic has demonstrated the fragility of clinic-based care for Parkinson's disease and other movement disorders. In response to the virus, many clinics across the world abruptly closed their doors to persons with Parkinson's disease. Fortunately, a niche care model, telemedicine-first described in this journal a generation ago-emerged as the dominant means of providing care. As we adjust to a new normal, we should focus future care not on clinics but on patients. Their needs, guided by clinicians, should determine how care is delivered, whether in the clinic, at home, remotely, or by some combination. Within this patient-centered approach, telemedicine is an attractive care option but not a complete replacement for in-person consultations, which are valuable for specific problems and for those who have access. Now that many clinicians and patients have gained exposure to telemedicine, we can better appreciate its advantages (eg, convenience) and disadvantages (eg, restricted examination). We can also create a new future that utilizes the Internet, video conferencing, smartphones, and sensors. This future will bring many clinicians to one patient, connect individual experts to countless patients, use widely available devices to facilitate diagnosis, and apply novel technologies to measure the disease in new ways. These approaches, which extend to education and research, enable a future where we can care for anyone anywhere and will help us stem the tide of Parkinson's disease. © 2020 International Parkinson and Movement Disorder Society
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