810 research outputs found
Preparación de mallas mediante electrohilado para la inhibición de la angiogénesis
La preparación de nanofibras por electrohilado está ganando mucho interés en la actualidad debido a su posible aplicación como sistemas de liberación controlada de fármaco. La incorporación del compuesto activo en la matriz polimérica de las fibras permite su protección frente a los procesos degradativos del organismo y su liberación controlada y localizada.
Numerosas enfermedades (psoriasis, retinopatías diabéticas, crecimiento de tumores) están relacionadas con alteraciones en la angiogénesis (formación de nuevos vasos sanguíneos a partir de otros ya formados), por tanto el desarrollo de nuevos compuestos que regulen adecuadamente los procesos angiogénicos se está estudiando como una posible vía en el tratamiento de estas enfermedades. En el presente trabajo se han preparado y caracterizado nanofibras de ácido poli(D,L-láctico) cargadas con ácido 5-amino-2-naftalensulfónico o el homopolímero del ácido 2-acrilamido-2-metilpropanosulfónico, compuestos inhibidores de la acción de algunos factores de crecimiento proangiogénicos dependientes de heparina.
La distinta naturaleza de los compuestos activos utilizados permitieron la obtención de diferentes perfiles de liberación, dependientes de la hidrofilia del compuesto activo, su peso molecular y la biodegradabilidad del ácido poli(D,L-láctico). Ambos sistemas mostraron una alta capacidad para inhibir la mitogénesis de fibroblastos inducida por aFGF.Preparation of nanofibers by electrospinning is gaining much attention due to their potential application as drug delivery systems. The incorporation of the active compound in the polymeric matrix of the fibers prevents degradation and allows a controlled and localized delivery of the drug.
Many diseases (psoriasis, diabetic retinopathy, tumor growth) have been related to alterations in the angiogenic processes, therefore the control of angiogenesis is being investigated as a possible treatment for these diseases. In this work poly(D, L-lactic acid) nanofibers loaded with sulfonated active compounds that inhibit heparin-dependent proangiogenic growth factors (5-amino acid-2-naphthalene sulfonic acid and poly(2-acrylamido-2-methylpropane sulfonic acid) have been prepared and characterized.
The different nature of the active compounds gave rise different release profiles that depended on the hydrophilic nature of the drug, molecular weight, and the biodegradation of poly (D, L-lactic acid). Both systems showed a high inhibition of fibroblasts aFGF- induced mitogenesis.Peer Reviewe
Pre-main-sequence population in NGC 1893 region
In this paper we continued our efforts to understand the star formation
scenario in and around the young cluster NGC 1893. We used a sample of the
young stellar sources (YSOs) identified on the basis of multiwavelength data
(optical, near-infrared (NIR), mid-infrared (MIR) and X-ray) to study the
nature of YSOs associated with the region. The identified YSOs show an age
spread of ~ 5 Myr. The YSOs located near the nebulae at the periphery of the
cluster are relatively younger in comparison to those located within the
cluster region. The present results are in accordance with those obtained by us
in previous studies. Other main results from the present study are: 1) the
fraction of disk bearing stars increases towards the periphery of the cluster;
2) there is an evidence supporting the notion that the mechanisms for disk
dispersal operate less efficiently for low-mass stars; 3) the sample of Class
II sources is found to be relatively older in comparison to that of Class III
sources. A comparison of various properties of YSOs in the NGC 1893 region with
those in the Tr 37/ IC 1396 region is also discussed.Comment: Accepted for publication in New Astronom
Single top-quark production by strong and electroweak supersymmetric flavor-changing interactions at the LHC
(Abridged) We report on a complete study of the single top-quark production
by direct supersymmetric flavor-changing neutral-current (FCNC) processes at
the LHC. The total cross section for pp(gg)->t\bar{c}+\bar{t}c is computed at
the 1-loop order within the unconstrained Minimal Supersymmetric Standard Model
(MSSM). The present study extends the results of the supersymmetric strong
effects (SUSY-QCD), which were advanced by some of us in a previous work, and
includes the computation of the full supersymmetric electroweak corrections
(SUSY-EW). Our analysis of pp(gg)->t\bar{c}+\bar{t}c in the MSSM has been
performed in correspondence with the stringent low-energy constraints from b->s
gamma. In the most favorable scenarios, the SUSY-QCD contribution can give rise
to production rates of around 10^5 events per 100 fb^{-1} of integrated
luminosity. Furthermore, we show that there exist regions of the MSSM parameter
space where the SUSY-EW correction becomes sizeable. In the SUSY-EW favored
regions, one obtains lower, but still appreciable, event production rates that
can reach the 10^3 level for the same range of integrated luminosity. We study
also the possible reduction in the maximum event rate obtained from the full
MSSM contribution if we additionally include the constraints from
B^0_s-\bar{B}^0_s. In view of the fact that the FCNC production of heavy quark
pairs of different flavors is extremely suppressed in the SM, the detection of
a significant number of these events could lead to evidence of new physics --
of likely supersymmetric origin.Comment: LaTex, 35 pages, typos corrected. Version accepted in JHE
Mass Suppression in Octet Baryon Production
There is a striking suppression of the cross section for production of octet
baryons in annihilation, as the mass of the produced hadron
increases. We present a simple parametrization for the fragmentation functions
into octet baryons guided by two input models: the SU(3) flavor symmetry part
is given by a quark-diquark model, and the baryon mass suppression part is
inspired by the string model. We need only eight free parameters to describe
the fragmentation functions for all octet baryons. These free parameters are
determined by a fit to the experimental data of octet baryon production in annihilation. Then we apply the obtained fragmentation functions to
predict the cross section of the octet baryon production in charged lepton DIS
and find consistency with the available experimental data. Furthermore, baryon
production in collisions is suggested to be an ideal domain to check the
predicted mass suppression.Comment: 20 pages, 5 figure
CP asymmetries in the supersymmetric trilepton signal at the LHC
In the CP-violating Minimal Supersymmetric Standard Model, we study the
production of a neutralino-chargino pair at the LHC. For their decays into
three leptons, we analyze CP asymmetries which are sensitive to the CP phases
of the neutralino and chargino sector. We present analytical formulas for the
entire production and decay process, and identify the CP-violating
contributions in the spin correlation terms. This allows us to define the
optimal CP asymmetries. We present a detailed numerical analysis of the cross
sections, branching ratios, and the CP observables. For light neutralinos,
charginos, and squarks, the asymmetries can reach several 10%. We estimate the
discovery potential for the LHC to observe CP violation in the trilepton
channel.Comment: 39 pages, 8 figures, version to appear in EPJC, discussion(s) added,
typo in (D.79), (D.118) corrected, new Fig. 7; The European Physical Journal
C, Volume 72, Issue 3, 201
The Infrared Behaviour of the Pure Yang-Mills Green Functions
We review the infrared properties of the pure Yang-Mills correlators and
discuss recent results concerning the two classes of low-momentum solutions for
them reported in literature; i.e. decoupling and scaling solutions. We will
mainly focuss on the Landau gauge and pay special attention to the results
inferred from the analysis of the Dyson-Schwinger equations of the theory and
from "{\it quenched}" lattice QCD. The results obtained from properly
interplaying both approaches are strongly emphasized.Comment: Final version to be published in FBS (54 pgs., 11 figs., 4 tabs
Approximate k-state solutions to the Dirac-Yukawa problem based on the spin and pseudospin symmetry
Using an approximation scheme to deal with the centrifugal
(pseudo-centrifugal) term, we solve the Dirac equation with the screened
Coulomb (Yukawa) potential for any arbitrary spin-orbit quantum number
{\kappa}. Based on the spin and pseudospin symmetry, analytic bound state
energy spectrum formulas and their corresponding upper- and lower-spinor
components of two Dirac particles are obtained using a shortcut of the
Nikiforov-Uvarov method. We find a wide range of permissible values for the
spin symmetry constant C_{s} from the valence energy spectrum of particle and
also for pseudospin symmetry constant C_{ps} from the hole energy spectrum of
antiparticle. Further, we show that the present potential interaction becomes
less (more) attractive for a long (short) range screening parameter {\alpha}.
To remove the degeneracies in energy levels we consider the spin and pseudospin
solution of Dirac equation for Yukawa potential plus a centrifugal-like term. A
few special cases such as the exact spin (pseudospin) symmetry Dirac-Yukawa,
the Yukawa plus centrifugal-like potentials, the limit when {\alpha} becomes
zero (Coulomb potential field) and the non-relativistic limit of our solution
are studied. The nonrelativistic solutions are compared with those obtained by
other methods.Comment: 21 pages, 6 figure
Complementarity of the CERN Large Hadron Collider and the International Linear Collider
The next-generation high-energy facilities, the CERN Large Hadron Collider
(LHC) and the prospective International Linear Collider (ILC), are
expected to unravel new structures of matter and forces from the electroweak
scale to the TeV scale. In this report we review the complementary role of LHC
and ILC in drawing a comprehensive and high-precision picture of the mechanism
breaking the electroweak symmetries and generating mass, and the unification of
forces in the frame of supersymmetry.Comment: 14 pages, 17 figures, to be published in "Supersymmetry on the Eve of
the LHC", a special volume of European Physical Journal C, Particles and
Fields (EPJC) in memory of Julius Wes
Nucleon axial and pseudoscalar form factors from the covariant Faddeev equation
We compute the axial and pseudoscalar form factors of the nucleon in the
Dyson-Schwinger approach. To this end, we solve a covariant three-body Faddeev
equation for the nucleon wave function and determine the matrix elements of the
axialvector and pseudoscalar isotriplet currents. Our only input is a
well-established and phenomenologically successful ansatz for the
nonperturbative quark-gluon interaction. As a consequence of the axial
Ward-Takahashi identity that is respected at the quark level, the
Goldberger-Treiman relation is reproduced for all current-quark masses. We
discuss the timelike pole structure of the quark-antiquark vertices that enters
the nucleon matrix elements and determines the momentum dependence of the form
factors. Our result for the axial charge underestimates the experimental value
by 20-25% which might be a signal of missing pion-cloud contributions. The
axial and pseudoscalar form factors agree with phenomenological and lattice
data in the momentum range above Q^2 ~ 1...2 GeV^2.Comment: 17 pages, 7 figures, 1 tabl
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