Computation of propagation characteristics in complex plane for multilayer optical waveguide

This paper provides a numerical simulation for determining the complex propagation constants of integrated optics waveguide. The waveguide under consideration may consist of any number of layers with complex indices due to gain and loss. A general- purpose mode solver MAPLE program has been developed to implement the transfer matrix method, and then it applied to solving the multilayer waveguide dispersion equation in complex plane. Additionally, our program can be used to determine the electromagnetic mode structure including modal power, spatial distribution, mode size parameters, and the position of the modal peak power. Therefore, all necessary parameters for a wide range of laser devices can be calculated

Computation of propagation characteristics in complex plane for multilayer optical waveguide

This paper provides a numerical simulation for determining the complex propagation constants of integrated optics waveguide. The waveguide under consideration may consist of any number of layers with complex indices due to gain and loss. A general- purpose mode solver MAPLE program has been developed to implement the transfer matrix method, and then it applied to solving the multilayer waveguide dispersion equation in complex plane. Additionally, our program can be used to determine the electromagnetic mode structure including modal power, spatial distribution, mode size parameters, and the position of the modal peak power. Therefore, all necessary parameters for a wide range of laser devices can be calculated

Immunohistochemical Expression of Estrogen Receptor Beta in Urothelial Carcinoma of the Urinary Bladder

Background: The tenth most prevalent cancer type in the world is bladder cancer. Males are four times more likely than females to have it. The most prevalent subtype is urothelial carcinoma. Development and progression of bladder cancer are influenced by estrogen receptors. Objectives: To examine the expression of estrogen receptor beta in bladder urothelial carcinoma and how it relates to other pathological factors of prognostic significance. Materials and method: Fifty formalin fixed and paraffin-embedded tissue sections of cases of urothelial carcinoma from transurethral resection and radical cystectomy specimens were examined histopathologically by routine H&E stain and immunohistochemically stained with Anti-ER-beta antibody. The immunohistochemical expression of estrogen receptor beta was assessed. Results: Of the 50 cases of urothelial carcinoma, mean age 60 ±8.7 range (41-85) years, 34 male and 16 female, estrogen receptor beta was expressed in 29 (58%) of the cases. The expression of ERβ was significantly elevated in high grade (p value 0.006). The ERβ expression was also significantly increased in advanced tumor stages (p value 0.03) and in muscle invasive tumor (p value 0.004). The presence of lymphovascular emboli was associated with higher ERβexpression. Conclusion: ERβ expression is significantly associated with high grade and with advanced stages of urothelial carcinoma

The emerging field of venom-microbiomics for exploring venom as a microenvironment, and the corresponding Initiative for Venom Associated Microbes and Parasites (iVAMP)

Venom is a known source of novel antimicrobial natural products. The substantial, increasing number of these discoveries have unintentionally culminated in the misconception that venom and venom-producing glands are largely sterile environments. Culture-dependent and -independent studies on the microbial communities in venom microenvironments reveal the presence of archaea, algae, bacteria, endoparasites, fungi, protozoa, and viruses. Venom-centric microbiome studies are relatively sparse to date and the adaptive advantages that venom-associated microbes might offer to their hosts, or that hosts might provide to venom-associated microbes, remain unknown. We highlight the potential for the discovery of venom-microbiomes within the adaptive landscape of venom systems. The considerable number of known, convergently evolved venomous animals juxtaposed with the comparatively few studies to identify microbial communities in venom provides new possibilities for both biodiversity and therapeutic discoveries. We present an evidence-based argument for integrating microbiology as part of venomics to which we refer to as venom-microbiomics. We also introduce iVAMP, the Initiative for Venom Associated Microbes and Parasites (https://ivamp-consortium.github.io/), as a growing consortium for interested parties to contribute and collaborate within this subdiscipline. Our consortium seeks to support diversity, inclusion and scientific collaboration among all researchers interested in this subdiscipline

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

Arab-West Report 2002 Weeks 04-52: In- depth coverage of Coptic affairs, Inter-Religious Dialogue and Media Criticism

This dataset consists of the articles and reports of the RNSAW content that were published in the year 2002. As previously noted that at the time the articles were published, Arab-West Report did not exist. Religious News Service from the Arab World, the organization which would ultimately become Arab-West Report, published the following documents. The dataset contains primarily the writings of Cornelis Hulsman, Drs., reporting on Christians situation in Egypt and subjects related to the Copts in the US with a number of editorials serve as a media critique of the Coptic organizations press releases issued abroad and other articles published in the local Egyptian newspapers. The reports covered the following topics: - A report that addressed a conflict between the Coptic Orthodox and Brethren Churches in Al- Ashmonein and described the relations between the two denomination there as “tense”. - A critique of what the authored believed as” Distorted Reporting” About Coptic Christians in Egypt. The three authors criticized a report in the Layman, an American Presbyterian publication, claiming Christians in Egypt are persecuted. They believe the author of this article was ill-informed and provided readers with wrong information. - An overview of the contents of the three books about Coptic Orthodox ecclesiastical law, published by the Monastery of Makarios. - A List of Churches in Assiut Governorate for Which Governorate Decrees For Restoration And Presidential Decrees For Building And Renovated Were Issued. -An overview of the activities of the Coptic Catholic peace movement, Justice and Peace in Egypt Media critique: Press release of the US Copts Association about the decision of the governor of Assiut instructing to remove an illegally built section of the church which the association does not mention and thereby providing only part of the information needed to form an accurate picture of this issue. The press release is also very aggressive in the last paragraph where it calls the governor an Islamic extremist. - Criticizing the press release of the US Copts Association. Some Copts frequently resort to claims of Islamic extremism if they are dissatisfied with the decisions made. - An Interview with Bishop Marcos about the Succession of Pope Shenouda, Father Matta Al-Meskeen, Ecommunications and Other Subjects. In Addition to that the dataset included an Interview with Father Johanna and Father Basilius of the Monastery of Makarios. -Summary of the Ph.D. thesis of Revd. Dr. Wolfram Reiss about the Sunday School movement in the Coptic Orthodox Church with a focus on the role of Pope Shenouda III and Father Matta el-Meskeen and the place of the church in a Muslim society. Reiss´ study provides an excellent insight into the contemporary history of the church and explains differences between church leaders in the past decades. - A crisis in the Egyptian Church Resulting from an article in the Sunday School magazine requesting the pope to avoid public [political] activities. -A text of the statement of the Anglican/Al-Azhar Dialogue Commission - Egyptian TV Addresses Inter-Religious Dialogue -Egyptian Cultural TV broadcasted on October 27 a live discussion with Patrick Haenni, social researcher at the CEDEJ in Cairo and Cornelis Hulsman, Drs., on inter-religious dialogue. A report about A group of Germans belonging to the YMCA [Young Men´s Christian Association] and Evangelical Church of Saxony, Germany [Evangelische Kirche Deutschland] who discovered a very different Christian Egypt from what they had expected from press reports in their home country. The group had followed the trail of the Holy Family between Beni Suef and Assiut and met with many different people. - A report about a claimed apparition of the Holy Virgin In Giza - An analysis of the Arab and Western Press in terms of the biases of the Western media and the limits imposed on political and freedom press in Egypt. - A report about Dr. Naṣr Ḥāmid Abū Zayd, sympathizer and supporter of the RNSAW, receiving the Franklin Delano Roosevelt prize for his contribution to the Freedom of Worship - Media criticism of ‘Reckless, Anti-Islamic Statement’ of major US Christian leader. - An evaluation of the RNSAW workshop for Egyptian journalists. The report shed light on the objectives and program of a RNSAW workshop for Egyptian journalists in cooperation with the Al-Ahram Institute for Regional Journalism. The workshop was financed by the Dutch Embassy and Friedrich Ebert Stiftung and covered human rights issues, women, Western and Arab media, freedom of expression and reporting about the Israel-Palestinian conflict. - The Dialogue Agreement between the Azhar and the Church of England The authors of this material include Cornelis Hulsman, Drs., Jos Strengholt, Rudolph Yanni, Peter Zarqah, Dr. Kamal Burayqa‘ ‘Abd al-Salam, Israel Shamir, Holger Jensen, Phil Reeves, Philip Smucker, Paul Perry, Michael Fowler, Michael Sabah, Dr. Naṣr Ḥāmid Abū Zayd, Yusuf Sidhom, Nirmin Fawzi, Chris Patten, Wolfram Reiss, Otto Fridrich Augustus Meinardus, Basilius al-Maqārī, Corin Kazanjian, Jawdat Jabrah, Sayyid al-Qimni, Majid Musá Yanni, Rev. Dr. David D. Grafton, Rev. Dr. Mikhael Shelley