Evaluation of the oxidative profile in leukocytes of jiu jtisu athletes

Oxidative stress is a process where there is an increase in reactive species, both oxygen and nitrogen. This can happen at both systemic and mitochondrial levels. One of the physiological conditions currently associated with oxidative stress is high-performance physical activity. In this way, it is possible to relate that this problem impacts on sports competitions, especially in Jiu-Jitsu, a growing sport in the world and which demands intense physical effort. Thus, the objective was to evaluate the level of mitochondrial and systemic oxidation in leukocytes of jiu-jitsu athletes. 20 adult men were selected for the control group and 13 athletes for the experimental group. A blood collection was performed to perform MTT and chemiluminescence assays for an analysis of mitochondrial and systemic oxidation, respectively. In addition, two reactive nitrogen species were measured: nitric oxide and peroxynitrite. The evaluation of the leukocyte reducing capacity by MTT showed that the athletes presented a greater reducing environment compared to the control. On the other hand, the chemiluminescence evaluation showed that the athletes' leukocytes showed greater systemic oxidation. There was an increase in both reactive nitrogen species in alteta leukocytes. Given this, it was possible to notice that the athletes presented greater systemic oxidative stress, but with mitochondria with better adaptive capacity to the cell's metabolic demands

Zero Temperature Limit of Holographic Superconductors

We consider holographic superconductors whose bulk description consists of gravity minimally coupled to a Maxwell field and charged scalar field with general potential. We give an analytic argument that there is no "hard gap": the real part of the conductivity at low frequency remains nonzero (although typically exponentially small) even at zero temperature. We also numerically construct the gravitational dual of the ground state of some holographic superconductors. Depending on the charge and dimension of the condensate, the infrared theory can have emergent conformal or just Poincare symmetry. In all cases studied, the area of the horizon of the dual black hole goes to zero in the extremal limit, consistent with a nondegenerate ground state.Comment: 27 pages, 8 figure

A high-flux source of polarization-entangled photons from a periodically-poled KTP parametric downconverter

We have demonstrated a high-flux source of polarization-entangled photons using a type-II phase-matched periodically-poled KTP parametric downconverter in a collinearly propagating configuration. We have observed quantum interference between the single-beam downconverted photons with a visibility of 99% and a measured coincidence flux of 300/s/mW of pump. The Clauser-Horne-Shimony-Holt version of Bell's inequality was violated with a value of 2.711 +/- 0.017.Comment: 7 pages submitted to Physical Review

Spin-pairing instabilities at the coincidence of two Landau levels

The effect of interactions near the coincidence of two Landau levels with opposite spins at filling factor 1/2 is investigated. By mapping to Composite Fermions it is shown that the fluctuations of the gauge field induces an effective attractive Fermion interaction. This can lead to a spin-singlet ground state that is separated from the excited states by a gap. The magnitude of the gap is evaluated. The results are consistent with the recently observed half-polarized states in the FQHE at a fixed filling factor. It is suggested that similar anomalies exist for other spin configurations in degenerate spin-up and spin-down Landau levels. An experiment for testing the spin-singlet state is proposed.Comment: to be published in Physical Review

Inclusion Complex Of S(-) Bupivacaine And 2-hydroxypropyl- β-cyclodextrin: Study Of Morphology And Cytotoxicity

Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-) bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Differential scanning calorimetry, scanning electron microscopy and X-Ray diffraction analysis showed structural changes in the complex. In preliminary toxicity studies, the cell viability tests revealed that the inclusion complex decreased the toxic effect (p<0.001) produced by S(-) bvc. These results suggest that the S(-) bvc:HP-β-CD inclusion complex represents a promising agent for the treatment of regional pain.273207212Araújo, D.R., Cereda, C.M., Brunetto, G.B., Pinto, L.M.A., Santana, M.H., de Paula, E., Encapsulation of mepivacaine prolongs the analgesia provided by sciatic nerve blockade in mice (2004) Can J Anaesth, 51, pp. 566-572Araújo, D.R., Fraceto, L.F., Braga, A.F.A., de Paula, E., Drug-delivery systems for racemic bupivacaine (S50-R50) and bupivacaine enantiomeric mixture (S75-R25):cyclodextrins complexation effects on sciatic nerve blockade in mice (2005) Rev Bras Anestesiol, 55, pp. 316-328Araújo, D.R., Moraes, C.M., Fraceto, L.F., Braga, A.F.A., de Paula, E., Cyclodextrin-bupivacaine enantiomeric mixture (S75-R25) inclusion complex and intrathecal anesthesia in rats (2006) Rev Bras Anestesiol, 56, pp. 495-506Bibby, D., Davies, N.M., Tueker, I.G., Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems (2000) Int J Pharm, 197, pp. 1-11Covino, B.G., Vassalo, H.G., (1976) Local anesthetics: Mechanisms of action and clinical use, , New York: Grune and Stratton;, 255pFoster, R.H., Markham, A., Levobupivacaine. A review of its pharmacology and use as a local anaesthetic (2000) Drugs, 59, pp. 551-579Grant, G.J., Bansinath, M., Liposomal delivery systems for local anesthetics (2001) Reg Anesth Pain Med, 26, pp. 61-63Gristwood, R.W., Cardiac and CNS toxicity of levobupivacaine: Strengths of evidence for advantage over bupivacaine (2002) Drug Saf, 25, pp. 153-163Hirayama, F., Uekama, K., Cyclodextrin-based controlled drug release system (1999) Adv Drug Deliv Rev, 36, pp. 125-141Huang, Y.F., Pryor, M.E., Mather, L.E., Veering, B.T., Cardiovascular and central nervous system effects of intravenous S-bupivacaine and bupivacaine in sheep (1998) Anesth Analg, 86, pp. 797-804Jong, R.H., (1994) Local anesthetics, , Springfield: CC. Thomas;, 325pKohata, S., Jyodi, K., Ohyoshi, A., Thermal decomposition of cyclodextrins (α -, β-, γ, and modified β-CyD) and of metal-(β-CyD) complex in the solid phase (1993) Thermochim Acta, 217, pp. 187-198Loftsson, T., Brewster, M.E., Pharmaceutical application of Cyclodextrin. 1. Drug solubilization and stabilization (1996) J Pharm Sci, 85, pp. 1017-1025Loukas, Y.L., Vraka, V., Gregoriadis, G., Novel non-acidic formulations of haloperidol complexed with beta-cyclodextrin derivatives (1997) J Pharm Biomed Anal, 16, pp. 263-268Mather, L.E., McCall, P., McNicol, P.L., Bupivacaine enantiomer pharmacokinetics after intercostal neural blockade in liver transplant patients (1995) Anesth Analg, 80, pp. 328-335Michaud, M., Icart, S., Determination of the substitution of hydroxypropylbetadex using fourier transform infrared spectrophotometry (2001) PharmEuropa, 13, pp. 714-716Naidu, N.B., Chowdary, K.P.R., Murthy, K.V.R., Satyanarayana, V., Hayman, A.R., Becket, G., Physicochemical characterization and dissolution properties of meloxicam-cyclodextrin binary systems (2004) J Pharm Biomed Anal, 35, pp. 75-86Pinto, L.M.A., Fraceto, L.F., Santana, M.H.A., Pertinhez, T.A., Oyama, S., de Paula, E., Physico-chemical characterization of benzocaine-β-cyclodextrin inclusion complexes (2005) J Pharm Biomed Anal, 39, pp. 956-963Ren, X., Xue, Y., Liu, J., Zhang, K., Zheng, J., Lou, G., Gou, C., Shen, J., A novel cyclodextrin-deri ved tellurium compound with glutathione peroxidase (2002) Chembiochem, 3, pp. 363-365Rose, J.S., Neal, J.M., Kopacz, D.J., Extended-duration analgesia: Update on microspheres and liposomes (2005) Reg Anesth Pain Med, 30, pp. 275-285Strichartz, G.R., Ritchie, J.M., (1987) Local anesthetics: Handbook of experimental pharmacology, , Berlin: Springer-Verlag;, 445pThompson, D.O., Cyclodextrin-enabling excipients: Their present and future use in pharmaceuticals (1997) Crit Rev Ther Drug Carrier Syst, 14, pp. 1-10

A scientific survey on 1550 cases of oral lesions diagnosed in a Brazilian referral center

ABSTRACT The present study aimed to perform an epidemiological survey on the prevalence rate of oral lesions diagnosed in a referral center in Brazil and to establish association between the lesions and the age and gender of the affected patients. This analytical observational study analyzed 3521 medical records of anatomopathological exams of the Pathological Anatomy and Cytopathology Laboratory of the Cancer Hospital of the state of Mato Grosso (Brazil), from December 2011 to September 2015. A total of 1550 relevant medical records was detected. Patients aging between 41 and 60 consisted of 42.84% of the sample. Males were more affected than females (60.13%). Inflammatory processess consisted of the most prevalent diagnosis (43.29%), followed by squamous cell carcinoma (6.06%), and periapical granuloma (5.23%). Oral health public policies must give major attention to Brazilian males aged between the fourth and sixth decades of life in order to improve their quality of life

DEPM 2014. Preliminary Egg Results for the Atlanto-Iberian Sardine ICES VIII and IXa

The triennial DEPM for estimation of sardine spawning biomass for the Atlanto-Iberian stock areas IXa – VIIIc and VIIIb up to 45 º N took place in the S and W (IPMA) from 15th March to 26th April and in the N (Galicia, Cantabrian Sea and French coast, IEO) between 29th March and 21st April. The whole area was surveyed however the Portuguese survey occurred much later than usual and suffered several interruptions; part of IPMA´s DEPM survey was conducted simultaneously to the acoustics survey onboard the same vessel. The number of fishing samples was maintained at levels similar to other years but it was evident that sardine schools were less available than during previous surveys in particular in the western and northern shores. Preliminary estimates highlighted a sharp decrease in egg production from 2011 to 2014; this pattern was particularly clear in the northern stratum

Model-based estimation of transmissibility and reinfection of SARS-CoV-2 P.1 variant

Acknowledgements We are grateful for the collaborative work of the reviewers and the entire group of the Observatório COVID-19 BR. In particular, we thank Verônica Coelho for critical inputs. We also thank the research funding agencies: the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil (Finance Code 001 to F.M.D.M., L.S.F. and T.P.P.), Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brazil (grant number: 315854/2020-0 to M.E.B., 141698/2018-7 to R.L.P.S., 313055/2020-3 to P.I.P., 312559/2020-8 to M.A.S.M.V., 311832/2017-2 to R.A.K., 305703/2019-6 to A.A.M.S.) and Fundação de Amparo à Pesquisa do Estado de São Paulo—Brazil (grant number: 2019/26310-2 and 2017/26770-8 to C.F., 2018/26512-1 to O.C., 2018/24037-4 to S.P. and contract number: 2016/01343-7 to R.A.K.). The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers of Disease Control and Prevention.Peer reviewe

Centrality Dependence of Charged Particle Multiplicity at Mid-Rapidity in Au+Au Collisions at sqrt(s_NN) = 130 GeV

We present a measurement of the pseudorapidity density of primary charged particles near mid-rapidity in Au+Au collisions at sqrt(s_NN) = 130 GeV as a function of the number of participating nucleons. These results are compared to models in an attempt to discriminate between competing scenarios of particle production in heavy ion collisions.Comment: 5 pages, 4 figures, revtex (submitted to Phys. Rev. Letters