10 research outputs found
Impacts of Climate Change on indirect human exposure to pathogens and chemicals from agriculture
- Author
- Adhikari A
- Alistair B.A. Boxall
- Anthony Hardy
- David B. Turley
- David Stone
- Edward Topp
- Elizabeth M.H. Wellington
- European Communities
- Food and Agriculture Organization
- Gale P
- Giovanni Leonardi
- Githecko AK
- Gordon Nichols
- Haines A
- Hawkes C
- Kerry Walsh
- Laura Burgin
- Laura Potts
- Leonard S. Levy
- Patterson DT
- Peter D. Falloon
- Philip M. Haygarth
- R. Sari Kovats
- Richard J. Williams
- Sabine Beulke
- Simon A. Parsons
- Tatiana Boucard
- Thomas Hutchinson
- van den Berg H
- Publication venue
- 'Environmental Health Perspectives'
- Publication date
- 10/12/2008
- Field of study
Objective: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today. In this review, we assess the implications of climate change for changes in human exposures to pathogens and chemicals in agricultural systems in the United Kingdom and discuss the subsequent effects on health impacts.
Data sources: In this review, we used expert input and considered literature on climate change ; health effects resulting from exposure to pathogens and chemicals arising from agriculture ; inputs of chemicals and pathogens to agricultural systems ; and human exposure pathways for pathogens and chemicals in agricultural systems.
Data synthesis: We established the current evidence base for health effects of chemicals and pathogens in the agricultural environment ; determined the potential implications of climate change on chemical and pathogen inputs in agricultural systems ; and explored the effects of climate change on environmental transport and fate of different contaminant types. We combined these data to assess the implications of climate change in terms of indirect human exposure to pathogens and chemicals in agricultural systems. We then developed recommendations on future research and policy changes to manage any adverse increases in risks.
Conclusions: Overall, climate change is likely to increase human exposures to agricultural contaminants. The magnitude of the increases will be highly dependent on the contaminant type. Risks from many pathogens and particulate and particle-associated contaminants could increase significantly. These increases in exposure can, however, be managed for the most part through targeted research and policy changes
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22:Transporters
- Author
- Alexander Stephen P. H.
- Amarosi Laura
- Anderson Catriona M.H.
- Armstrong Jane F.
- Beart Philip Mark
- Broer Stefan
- Davies Jamie A.
- Dawson Paul A.
- Faccenda Elena
- Hagenbuch Bruno
- Hammond James R.
- Harding Simon D.
- Inui Ken ichi
- Kanai Yoshikatsu
- Kelly Eamonn
- Kemp Stephan
- Mathie Alistair
- Pawson Adam J.
- Peters John A.
- Southan Christopher
- Stewart Gavin
- Thwaites David T.
- Veale Emma L.
- Verri Tiziano
- Publication venue
- 'Wiley'
- Publication date
- 01/10/2021
- Field of study
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15543. Transporters are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
- Author
- Aalfs C.M. (Cora)
- Adenis C. (Claude)
- Adlard J.W. (Julian)
- Agata S. (Simona)
- Agnarsson B.A. (Bjarni)
- Aittomäki K. (Kristiina)
- Andersen M.K. (Mette)
- Andrulis I.L. (Irene)
- Angelakos M. (Maggie)
- Antoniou A.C. (Antonis)
- Ardern-Jones A. (Audrey)
- Ardnor C.E. (Christina Edwinsdotter)
- Arnold N. (Norbert)
- Arun B.K. (Banu)
- Arver B. (Brita Wasteson)
- Asperen C.J. (Christi) van
- Attard V. (Virginia)
- Ausems M.G.E.M. (Margreet)
- Bacot F. (Francois)
- Bae-Jump V.L. (Victoria L.)
- Balmana J. (Judith)
- Bancroft E.K. (Elizabeth)
- Bardsley C. (Cathryn)
- Barjhoux L. (Laure)
- Barkardottir R.B. (Rosa)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barton D.E. (David)
- Barwell J. (Julian)
- Beattie M.S. (Mary)
- Belotti M. (Muriel)
- Benítez J. (Javier)
- Berlin C. (Cheryl)
- Berthet P. (Pascaline)
- Bignon Y.-J. (Yves-Jean)
- Bignon Y.-J. (Yves-Jean)
- Blanco I. (Ignacio)
- Blank S.V. (Stephanie)
- Blok M.J. (Marinus)
- Bock G.H. (Geertruida) de
- Bonadona V. (Valérie)
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- Bonnet F. (Françoise)
- Borg Å. (Åke)
- Bourdon V. (Violaine)
- Bradshaw N. (Nicola)
- Brady A.F. (Angela)
- Bressac-de Paillerets B. (Brigitte)
- Brewer C. (C.)
- Brewer C. (Carole)
- Brice G. (Glen)
- Bronner M. (Myriam)
- Brunet J. (Joan)
- Bubien V. (Virginie)
- Buecher B. (Bruno)
- Bustinza G.B.
- Buys S.S. (Saundra)
- Caldes T. (Trinidad)
- Calender A. (Alain)
- Caligo M.A. (Maria)
- Campbell I. (Ian)
- Caron O. (Olivier)
- Castera L. (Laurent)
- Castro E. (Elena)
- Chan S. (Salina)
- Chenevix-Trench G. (Georgia)
- Chiquette J. (Jocelyne)
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- Claber O. (Oonagh)
- Claes K. (Kathleen)
- Cohn D.E. (David)
- Colas C. (Chrystelle)
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- Collier R. (Rebecca)
- Collée J.M. (Margriet)
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- Coulet F. (Florence)
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- Crawford G. (Gabe)
- Cronenburg T.C.T.E.F. van
- Cunningham J. (Jane)
- Daly M.B. (Mary)
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- Deurzen C.H.M. (Carolien) van
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/04/2013
- Field of study
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat
Constraints on cosmic strings using data from the first Advanced LIGO observing run
- Author
- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Acernese F.
- Ackley K.
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- Addesso P.
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- Adya V.B.
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- Bouffanais Y.
- Bozzi A.
- Bradaschia C.
- Brady P.R.
- Braginsky V.B.
- Branchesi M.
- Brau J.E.
- Briant T.
- Brillet A.
- Brinkmann M.
- Brisson V.
- Brockill P.
- Broida J.E.
- Brooks A.F.
- Brown D.A.
- Brown D.D.
- Brown N.M.
- Brunett S.
- Buchanan C.C.
- Buikema A.
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- Bulten H.J.
- Buonanno A.
- Buskulic D.
- Buy C.
- Byer R.L.
- Bécsy B.
- Cabero M.
- Cadonati L.
- Cagnoli G.
- Cahillane C.
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- Publication venue
- Publication date
- 01/01/2018
- Field of study
Cosmic strings are topological defects which can be formed in grand unified theory scale phase transitions in the early universe. They are also predicted to form in the context of string theory. The main mechanism for a network of Nambu-Goto cosmic strings to lose energy is through the production of loops and the subsequent emission of gravitational waves, thus offering an experimental signature for the existence of cosmic strings. Here we report on the analysis conducted to specifically search for gravitational-wave bursts from cosmic string loops in the data of Advanced LIGO 2015-2016 observing run (O1). No evidence of such signals was found in the data, and as a result we set upper limits on the cosmic string parameters for three recent loop distribution models. In this paper, we initially derive constraints on the string tension Gμ and the intercommutation probability, using not only the burst analysis performed on the O1 data set but also results from the previously published LIGO stochastic O1 analysis, pulsar timing arrays, cosmic microwave background and big-bang nucleosynthesis experiments. We show that these data sets are complementary in that they probe gravitational waves produced by cosmic string loops during very different epochs. Finally, we show that the data sets exclude large parts of the parameter space of the three loop distribution models we consider
Building the e-science grid in the UK: middleware, applications and tools deployed at level 2
- Author
- Publication venue
- Publication date
- 01/01/2003
- Field of study
Over the period September 2002-April 2003 the UK Grid Engineering Task Force and staff at Regional e-Science Centres and CCLRC deployed the Globus Toolkit GT2 at 14 sites and on approximately 80
compute resources to set up the first production-quality e-Science Grid for the UK. This work is proving to be exemplary of what can be achieved using heterogeneous resources on a national scale and is feeding discussions on how to link Grids with multiple virtual organisations across Europe. This paper therefore reports on experiences of this deployment exercise, compares with other efforts worldwide and suggests further work to be done
From Microform to the Drawing Bot: The Photographic Image as Data
- Author
- Alexander Samuel N.
- Black Alistair
- Bush Vannevar
- Bush Vannevar
- Crayons Lantern Slide
- Estelle Blaschke
- Garabanati M.H.
- Garfield Eugene
- Germain Richard N.
- Goldberg Emanuel
- Gull C.D.
- John Stewart John Herschel
- Kodak The
- Lachapelle Guy
- Latour Bruno
- Luther Frederic
- Martin Gordon P.
- Poindron Paul
- Serena Tiziana
- Shaw Ralph R.
- This
- Publication venue
- 'MIT Press - Journals'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
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- Williams Toran
- Willis C.
- Willis Heather
- Wills M.
- Willson J.
- Wilson A.
- Wilson D.J.
- Wilson James F.
- Wilson Jean
- Winnard Sarah
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford Brooke N.
- Wong Joanna
- Wood D.
- Wood Hannah-Louise
- Wood Suzanne
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt Wiesia
- Woolley A.E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wright D.
- Wright J.
- Wright M.
- Wrobel Nicola
- Wu Yang
- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier Kugan
- Xue X.
- Yadav A.
- Yang Jian
- Yassen Amr M.
- Yates Brian
- Ye C.
- Yun Nikki
- Zainy Tala
- Zak Anne
- Zaki Ahmed
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg Hugo
- Zechner Marie
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng Chenqing
- Zhou W.
- Zitter L.
- Zlatopolsky Menachem
- Zongo Olivier
- Zucchi P.
- Zyndorf Marissa
- Zöllner S.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries
- Author
- A.A. Essam
- A.B. Jayathilake
- Abbas Chabok
- Abd Elkhalek Sallam
- Abdalla Gamal Saad
- Abdelaziz Abdelaal
- Abdelaziz Elhendawy
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Soliman
- Abdelrhman K.Z. Darwish
- Abdul Rehman Alvi
- Abdulaziz Altwijri
- Abdullah Altamimi
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulrahman Abdel-Aty
- Abdulrasheed Nasir
- Abdulrazzaq Lawal
- Abdulshafi Khaled Abdrabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abeer Esam
- Abhishek Sharma
- Abiboye Yifieyeh
- Abobaker Younis
- Abrar Nawawi
- Adam Boggon
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B. Hassanein
- Adel Denewar
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adesoji O. Ademuyiwa
- Adewale Adeniyi
- Adewale O. Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian Palma
- Adrienne Ho
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahed Ghaben
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Ashour
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Gudal
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Abd Elsameea
- Ahmed Adamu
- Ahmed Al-Bahrani
- Ahmed Al-Khatib
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Dahy
- Ahmed El Kashash
- Ahmed El-Sehily
- Ahmed Essam
- Ahmed Farag
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed M. Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed mohamed Ibrahim
- Ahmed Moustafa
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Raza
- Ahmed Saidbadr
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W. Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M. Kandil
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- Alberto Miyar de León
- Alberto Realis Luc
- Alejandro Matheu
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alex Makupe
- Alex Reece-Smith
- Alexander Canta Calua
- Alexander Smedley
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- Alexia Farrugia
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- Tina Gaarder
- Tobias Schuetz
- Todisoa Emmanuella Christina Tolotra
- Tolg Cecilia
- Tom Abbott
- Tom Arthur
- Tomas Abaliksta
- Tomas Jankus
- Tomas Poskus
- Tomas Poskus
- Tomas Poškus
- Tomas Urbonas
- Tommaso Bocchetti
- Tommaso Campagnaro
- Tommaso Fontana
- Toqa Khafagy
- Torhild Veen
- Tracy E. Roberts
- Tsz-Yan Katie Chan
- Tuan Nur'Azmah Tuan Mat
- Tunde Sholadoye
- Turgut Bora Cengiz
- Tyler Rouse
- Tzu-Ling Chen
- Uday Muddebihal
- Umar Muktar
- Umberto Tedeschi
- Umme Salma
- Usama Hantour
- Uttaran Datta
- Vahit Mutlu
- Valdemaras Jotautas
- Valeria Andriola
- Vanessa Msosa
- Vanessa Msosa
- Vania Guglielmo
- Vania Silvestri
- Vasileios Kalles
- Vasileios Kalles
- Vasiliki Soulou
- Vassilis Kalles
- Vedatcan Işler
- Veeranna Shatkar
- Venerand Barendegere
- Veronica Lazzari
- Vicky Jennings
- Victor Dassah
- Victor Etwire
- Victor Kong
- Victor Nwinee
- Vijaid Upadhyaya
- Viktorija Nevieraite
- Ville Sallinen
- Vincas Jonas Banaitis
- Virginia Jiménez Carneros
- Virginia Ramos Pérez
- Viviana Sollazzo
- Vladimir Khokha
- Volkan Ozben
- Vu Thanh Hien Le
- Vytautas Gaižauskas
- Vytautas Lipnickas
- Wadah Ali
- Wai Cheong Soon
- Wai Him Lam
- Wairimu Ndegwa
- Waleed Thabet
- Walter Ruiz Panez
- Wan Nurul 'Ain Wan Mohd Nasir
- Ward Hamsho
- Wasim Dar
- Wedyan Alhazmi
- Weihei Dao
- Wennweoi Goh
- Wifanto Saditya Jeo
- Wiktor Rutkowski
- William Appeadu-Mensah
- William Bonney
- William English
- Willy Alcca Ticona
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yakubu Momohsani Adinoyi
- Yasmin Elfouly
- Yasmin Soliman
- Ye Ru Chin
- Yee Wen Tan
- Yehia Zakaria
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yong Yong Tew
- Yoshan Moodley
- Yousef Abuowda
- Ysabel Esthefany Alejos Bermúdez
- Yucel Cengiz
- Yucel Cengiz
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yuksel Altinel
- Yun Lin Ang
- Yung Kok Ng
- Yuri Macchitella
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zakaria Rob
- Zhan Herr Ng
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Ömer Faruk Toto
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2023
- Field of study
Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ().Results:HighFiO2maybecost−effective(cheaperandeffective).InNigeria,theaveragecostforhighFiO2was216 compared with 222forlowFiO2leadingtoa −6 (95% confidence interval [CI]: −13to −1) difference in costs. In India, the average cost for high FiO2 was 184comparedwith195 for low FiO2 leading to a −11(9515 to −6)differenceincosts.InSouthAfrica,theaveragecostforhighFiO2was1164 compared with 1257forlowFiO2leadingtoa −93 (95% CI: −132to −65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this
Plant drought stress: effects, mechanisms and management
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- A. Ahmadi
- A. Ajouri
- A. Bahieldina
- A. Bouchereau
- A. Gigon
- A. Grossman
- A. Jiménez
- A. Korkmaz
- A. Lux
- A. Lux
- A. Lux
- A. Manikavelu
- A. Nerd
- A. Nerd
- A. Sakamoto
- A. Wahid
- A. Wahid
- A. Wahid
- A. Wahid
- A. Wahid
- A. Wingler
- A. Yokota
- A.B. Wagner
- A.C. Harmon
- A.D. Peuke
- A.D. Peuke
- A.G. Condon
- A.H. Folkert
- A.J. Golding
- A.L. Moore
- A.L.S. Lima
- A.M. Atteya
- A.M. Kinnersley
- A.R. Reddy
- A.Y. Kamara
- B. Bektaşoĝlu
- B. Halliwell
- B. Huang
- B. Jongdee
- B. Kumar
- B. Wan
- B.K. Garg
- B.L. Orvar
- B.L. Shelp
- B.R. Huang
- B.S. Berlett
- B.Y. Fu
- C. Abdul Jaleel
- C. Lamb
- C. Maurel
- C. Maurel
- C. Somerville
- C. Tournaire-Roux
- C. Zinselmeier
- C.D. Buchanan
- C.H. Foyer
- C.I. Ogbonnaya
- D. Fujita
- D. Harris
- D. Harris
- D. McWilliams
- D. Prochazkova
- D.L. Miralles
- D.R. Sandquist
- D.W. Choi
- D.W. Lawlor
- E. Epstein
- E. Horváth
- E. Komor
- E.A. Bray
- E.A. Davidson
- E.A.H. Pilon-Smits
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- E.H. DeLucia
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- G. Cornic
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- G. Estrada-Campuzano
- G. Okcu
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- G.O. Edmeades
- G.S. Premachandra
- G.V. Subbarao
- G.V. Subbarao
- H. Earl
- H. Gong
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- R.C. Babu
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- T.E. Young
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- Y.G. Shen
- Z. Shang
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- 'EDP Sciences'
- Publication date
- Field of study
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- A. Mitcham
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- A.B. Cameron
- Acorn Milton.
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- Amprimoz Alexandre.
- Anderson Patrick.
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- Atwood Margaret.
- Aubert de Gaspé Philippe.
- B. Amtmann.
- B. Barrie
- B. Davies
- B. Godard
- B. Godard
- B. Howell
- B. Lee.
- B. Lever.
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- B. Stock
- B. Stock
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- Baltensperger Peter.
- Barbour Douglas.
- Barr Robert.
- Bartlett Brian.
- Bates Ronald.
- Bell John.
- Bennett Lawrence.
- Benson Eugene.
- Beresford-Howe Constance.
- Bessette Gerard.
- Biel Kent C.
- Birney Earle.
- Birney Earle.
- Bissett Bill.
- Blais Marie-Claire.
- Blaise Clark.
- Bodsworth Fred.
- Bolt Carol.
- Boston Stewart.
- Bowering George.
- Boxer Avi.
- Boyer Agnes.
- Boyle Harry J.
- Braithwaite Max.
- Brewster Elizabeth.
- Brewster Elizabeth.
- Brooke Frances.
- Brown Amy Hatchard.
- Buckaway Catherine M.
- Buckler Ernest.
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- Denham Alice.
- Denison Merrill.
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- J. Ayre
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- J.W. Lennox
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- Jacques Ferron
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- Jean Barbeau
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- Johnston George.
- Julian Marilyn.
- K. Dewar
- K. Mulhallen
- K. Thompson
- Kartzmark Ross.
- Keeling Nora.
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- Klein A.M.
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- Seton Ernest
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- Smith Goldwin.
- Smith Ray.
- Smith Robert.
- Smyth Donna E.
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- Solway David.
- Stead Robert J.
- Stegmayer Nancy.
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- Sutherland Barry.
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- W.H. New
- W.J. Keith
- Waddington Miriam.
- Waddington Miriam.
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- Publication venue
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- Publication date
- Field of study