25 research outputs found
Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4
On the origin and evolution of the material in 67P/Churyumov-Gerasimenko
International audiencePrimitive objects like comets hold important information on the material that formed our solar system. Several comets have been visited by spacecraft and many more have been observed through Earth- and space-based telescopes. Still our understanding remains limited. Molecular abundances in comets have been shown to be similar to interstellar ices and thus indicate that common processes and conditions were involved in their formation. The samples returned by the Stardust mission to comet Wild 2 showed that the bulk refractory material was processed by high temperatures in the vicinity of the early sun. The recent Rosetta mission acquired a wealth of new data on the composition of comet 67P/Churyumov-Gerasimenko (hereafter 67P/C-G) and complemented earlier observations of other comets. The isotopic, elemental, and molecular abundances of the volatile, semi-volatile, and refractory phases brought many new insights into the origin and processing of the incorporated material. The emerging picture after Rosetta is that at least part of the volatile material was formed before the solar system and that cometary nuclei agglomerated over a wide range of heliocentric distances, different from where they are found today. Deviations from bulk solar system abundances indicate that the material was not fully homogenized at the location of comet formation, despite the radial mixing implied by the Stardust results. Post-formation evolution of the material might play an important role, which further complicates the picture. This paper discusses these major findings of the Rosetta mission with respect to the origin of the material and puts them in the context of what we know from other comets and solar system objects
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Concepts of Model Verification and Validation
Model verification and validation (V&V) is an enabling methodology for the development of computational models that can be used to make engineering predictions with quantified confidence. Model V&V procedures are needed by government and industry to reduce the time, cost, and risk associated with full-scale testing of products, materials, and weapon systems. Quantifying the confidence and predictive accuracy of model calculations provides the decision-maker with the information necessary for making high-consequence decisions. The development of guidelines and procedures for conducting a model V&V program are currently being defined by a broad spectrum of researchers. This report reviews the concepts involved in such a program. Model V&V is a current topic of great interest to both government and industry. In response to a ban on the production of new strategic weapons and nuclear testing, the Department of Energy (DOE) initiated the Science-Based Stockpile Stewardship Program (SSP). An objective of the SSP is to maintain a high level of confidence in the safety, reliability, and performance of the existing nuclear weapons stockpile in the absence of nuclear testing. This objective has challenged the national laboratories to develop high-confidence tools and methods that can be used to provide credible models needed for stockpile certification via numerical simulation. There has been a significant increase in activity recently to define V&V methods and procedures. The U.S. Department of Defense (DoD) Modeling and Simulation Office (DMSO) is working to develop fundamental concepts and terminology for V&V applied to high-level systems such as ballistic missile defense and battle management simulations. The American Society of Mechanical Engineers (ASME) has recently formed a Standards Committee for the development of V&V procedures for computational solid mechanics models. The Defense Nuclear Facilities Safety Board (DNFSB) has been a proponent of model V&V for all safety-related nuclear facility design, analyses, and operations. In fact, DNFSB 2002-1 recommends to the DOE and National Nuclear Security Administration (NNSA) that a V&V process be performed for all safety related software and analysis. Model verification and validation are the primary processes for quantifying and building credibility in numerical models. Verification is the process of determining that a model implementation accurately represents the developer's conceptual description of the model and its solution. Validation is the process of determining the degree to which a model is an accurate representation of the real world from the perspective of the intended uses of the model. Both verification and validation are processes that accumulate evidence of a model's correctness or accuracy for a specific scenario; thus, V&V cannot prove that a model is correct and accurate for all possible scenarios, but, rather, it can provide evidence that the model is sufficiently accurate for its intended use. Model V&V is fundamentally different from software V&V. Code developers developing computer programs perform software V&V to ensure code correctness, reliability, and robustness. In model V&V, the end product is a predictive model based on fundamental physics of the problem being solved. In all applications of practical interest, the calculations involved in obtaining solutions with the model require a computer code, e.g., finite element or finite difference analysis. Therefore, engineers seeking to develop credible predictive models critically need model V&V guidelines and procedures. The expected outcome of the model V&V process is the quantified level of agreement between experimental data and model prediction, as well as the predictive accuracy of the model. This report attempts to describe the general philosophy, definitions, concepts, and processes for conducting a successful V&V program. This objective is motivated by the need for highly accurate numerical models for making predictions to support the SSP, and also by the lack of guidelines, standards and procedures for performing V&V for complex numerical models
nmMLCK a key player in intermittent hypoxia-induced inflammatory vascular remodeling ?
International audienc
nmMLCK : a key player in intermittent hypoxia-induced inflammatory vascular remodeling ?
International audienc
nmMLCK : a key player in intermittent hypoxia-induced inflammatory vascular remodeling ?
International audienc
nmMLCK a key player in intermittent hypoxia-induced inflammatory vascular remodeling ?
International audienc
nmMLCK a key player in intermittent hypoxia-induced inflammatory vascular remodeling ?
International audienc
nmMLCK a key player in intermittent hypoxia-induced inflammatory vascular remodeling ?
International audienc