18 research outputs found
Gantrez AN Nanoparticles for Ocular Delivery of Memantine: In vitro Release Evaluation in Albino Rabbits
Full text linkInterspecies allometric scaling: prediction of clearance in large animal species: Part II: mathematical considerations
No full textGantrez AN nanoparticles for ocular delivery of memantine: in vitro release evaluation in albino rabbits
No full textAIM:
To prepare and evaluate the in vitro release of memantine-loaded poly(anhydride) (Gantrez®) nanoparticles (NPs). The clinical safety and retinal toxicity caused by unloaded NPs after sub-Tenon and intravitreal ocular injections were also evaluated.
METHODS:
Preparation and characterization of this type of NP as well as the in vitro release study are described. Twenty-three healthy New Zealand rabbits were used for clinical and histological assessment after sub-Tenon and intravitreal ocular injections of unloaded NPs.
RESULTS:
The amount of drug associated with NPs was 55 µg of memantine/mg of NP. The release profile of memantine from this type of NPs was characterized by an initial burst effect, followed by continuous release of the drug for at least 15 days. No relevant complications were found during the clinical follow-up. The histological evaluation suggested that Gantrez NPs are well tolerated after sub-Tenon ocular injection and that signs of inflammation during the first days after intravitreal ocular injections can be considered a normal reaction of the eye's defence mechanism
Gantrez AN nanoparticles for ocular delivery of memantine: in vitro release evaluation in albino rabbits
No full textAIM:
To prepare and evaluate the in vitro release of memantine-loaded poly(anhydride) (Gantrez®) nanoparticles (NPs). The clinical safety and retinal toxicity caused by unloaded NPs after sub-Tenon and intravitreal ocular injections were also evaluated.
METHODS:
Preparation and characterization of this type of NP as well as the in vitro release study are described. Twenty-three healthy New Zealand rabbits were used for clinical and histological assessment after sub-Tenon and intravitreal ocular injections of unloaded NPs.
RESULTS:
The amount of drug associated with NPs was 55 µg of memantine/mg of NP. The release profile of memantine from this type of NPs was characterized by an initial burst effect, followed by continuous release of the drug for at least 15 days. No relevant complications were found during the clinical follow-up. The histological evaluation suggested that Gantrez NPs are well tolerated after sub-Tenon ocular injection and that signs of inflammation during the first days after intravitreal ocular injections can be considered a normal reaction of the eye's defence mechanism
Determination of lomefloxacin in plasma samples by HPLC with fluorescence detection. Application to pharmacokinetic studies
No full textPopulation pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin in ill cows
No full textPrediction of xenobiotic clearance in avian species using mammalian or avian data: how accurate is the prediction?
No full textRésultats de la biopsie prostatique chez les patients algériens avec un PSA élevé et/ou un toucher rectal suspect
No full textAge-related changes in the pharmacokinetics of marbofloxacin after intravenous administration in goats
No full textAllometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis
No full text
