AN ENVIRONMENT FOR ENGINEERING EXTENDED AFFIX GRAMMAR ENVIRONMENTS

Existing formalisms for the specification of programming environments are complex and strongly biased by the problems of environment generation. It has been investigated whether a simple two-level grammar, describing a programming language, can be used without further modification for the generation of an environment for that language. We believe that there is enough information in most language definitions - albeit implicitly - to generate most of the tools used in syntax-directed editors. This paper proposes some simple and elegant improvements in the use of place- holders and templates, and in the unparsing mechanism. Although the improvements are implemented in a completely newly designed prototype they can also be applied to existing syntax-directed editors to improve their workability

Recursion Aware Modeling and Discovery For Hierarchical Software Event Log Analysis (Extended)

This extended paper presents 1) a novel hierarchy and recursion extension to the process tree model; and 2) the first, recursion aware process model discovery technique that leverages hierarchical information in event logs, typically available for software systems. This technique allows us to analyze the operational processes of software systems under real-life conditions at multiple levels of granularity. The work can be positioned in-between reverse engineering and process mining. An implementation of the proposed approach is available as a ProM plugin. Experimental results based on real-life (software) event logs demonstrate the feasibility and usefulness of the approach and show the huge potential to speed up discovery by exploiting the available hierarchy.Comment: Extended version (14 pages total) of the paper Recursion Aware Modeling and Discovery For Hierarchical Software Event Log Analysis. This Technical Report version includes the guarantee proofs for the proposed discovery algorithm

Involvement of the hypothalamic-pituitary-thyroid axis and its interaction with the hypothalamic-pituitary-adrenal axis in the ontogeny of avian thermoregulation: a review

The emergence of thermoregulation in avian species is a complex matter in which neural as well as hormonal processes are involved. In a previous paper, the neural aspects of primary avian thermoregulation were discussed. In this paper the role of the hypothalamus-pituitary-thyroid axis (HPT-axis) and the hypothalamus-pituitary-adrenal axis (HPA-axis) in the ontogeny of avian thermoregulation is evaluated. The regulatory mechanisms and different important hormones of both axes, which have stimulatory or inhibitory effects, are discussed. Because the onset of functionality of the thermoregulatory system is of great interest, the ontogeny and functionality of the hormonal axes are clarified. There is a great difference between precocial and altricial birds in hormonal events as well as in neural processes which are involved in the emergence of thermoregulation. In precocial avian species the HPT-axis becomes functional during the mid- to late embryonic period while the same axis only becomes fully functional during the first week post-hatch in altricial avian species. As early as the sixties, the emergence of homeothermy in chickens was investigated. It was concluded that the thyroid gland plays an important role in the thermoregulatory mechanisms of newly hatched chicks. More recent studies however were not able to show any direct effect of the thyroid hormones on the thermoregulation of day-old chicks, although blocking the conversion of T4 to T3 caused a decrease in body temperature in young chicks. Thyrotropin releasing hormone (TRH) is known to act in thermoregulation in mammals and several authors have found an effect of TRH on the metabolism of young and older chicks. However, the exact mechanism still remains unclear. Because the HPT- and the HPA-axis show close relationships, the role of the HPA-axis in the ontogeny of thermoregulation is also taken into consideration in this review. In mammals as well as in birds, corticotropin releasing hormone (CRH) is involved in the primary thermoregulation. We conclude that the HPT-axis has an important role in the ontogeny of avian thermoregulation. The exact role of the HPA-axis remains largely unclear although at least CRH is definitely of some importance

Evolving a DSL implementation

Domain Specific Languages (DSLs) are small languages designed for use in a specific domain. DSLs typically evolve quite radically throughout their lifetime, but current DSL implementation approaches are often clumsy in the face of such evolution. In this paper I present a case study of an DSL evolving in its syntax, semantics, and robustness, implemented in the Converge language. This shows how real-world DSL implementations can evolve along with changing requirements

Pretty-printing within the ASF+SDF meta-environment : a generic approach

The automatic generation of formatters for (programming) languages within the Asf+Sdf Meta-Environment is a research topic that is concerned with the construction of language specific formatters (or pretty-printers) given a language definition in Sdf. In this paper, we give an overview of pretty-printers that have been developed within this project and observe that these pretty-printers are either language dependent or non-customizable. Language independence and customizability are inevitable properties of pretty-printers however, when faced with the problem of formatting many different, evolving languages. Therefore, we introduce in this paper a generic framework for pretty-printing and describe an instantiation of the framework that forms a language independent and customizable pretty-printer

Prototyping the Semantics of a DSL using ASF+SDF: Link to Formal Verification of DSL Models

A formal definition of the semantics of a domain-specific language (DSL) is a key prerequisite for the verification of the correctness of models specified using such a DSL and of transformations applied to these models. For this reason, we implemented a prototype of the semantics of a DSL for the specification of systems consisting of concurrent, communicating objects. Using this prototype, models specified in the DSL can be transformed to labeled transition systems (LTS). This approach of transforming models to LTSs allows us to apply existing tools for visualization and verification to models with little or no further effort. The prototype is implemented using the ASF+SDF Meta-Environment, an IDE for the algebraic specification language ASF+SDF, which offers efficient execution of the transformation as well as the ability to read models and produce LTSs without any additional pre or post processing.Comment: In Proceedings AMMSE 2011, arXiv:1106.596

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization.

Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality. It is feared that these viruses become pandemic, therefore the development of safe and effective vaccines is desirable. MVA-based H5N1 vaccines already proved to be effective when two immunizations with high doses were used. Dose-sparing strategies would increase the number of people that can be vaccinated when the amount of vaccine preparations that can be produced is limited. Furthermore, protective immunity is induced ideally after a single immunization. Therefore the minimal requirements for induction of protective immunity with a MVA-based H5N1 vaccine were assessed in mice. To this end, mice were vaccinated once or twice with descending doses of a recombinant MVA expressing the HA gene of influenza virus A/Vietnam/1194/04. The protective efficacy was determined after challenge infection with the homologous clade 1 virus and a heterologous virus derived from clade 2.1, A/Indonesia/5/05 by assessing weight loss, virus replication and histopathological changes. It was concluded that MVA-based vaccines allowed significant dose-sparing and afford cross-clade protection, also after a single immunization, which are favorable properties for an H5N1 vaccine candidate