4,929 research outputs found
Combined coherent x-ray micro-diffraction and local mechanical loading on copper nanocrystals
Coherent x-ray micro-diffraction and local mechanical loading can be combined
to investigate the mechanical deformation in crystalline nanostructures. Here
we present measurements of plastic deformation in a copper crystal of
sub-micron size obtained by loading the sample with an Atomic Force Microscopy
tip. The appearance of sharp features in the diffraction pattern, while
conserving its global shape, is attributed to crystal defects induced by the
tip
The SciCryo Project and Cryogenic Scintillation of for Dark Matter
International audienceWe discuss cryogenic scintillation of Al2O3. Room-temperature measurements with α particles are first carried out to study effect of Ti concentration on response. Measurements under X-rays between room temperature and 10 K confirm a doubling of light output. The integration of a scintillation-phonon detector into an ionization-phonon dark matter search is underway, and the quenching factor for neutrons has been verified
Extenders for alpaca epididymal spermatozoa: Comparison of INRA96 and andromed
Artificial insemination would be a useful technique for alpaca breeders to use as an aid to breeding to increase fleece quality. The technique, however, is not well developed in alpacas, partly because of the viscous nature of their seminal plasma. Castration conducted for husbandry purposes can provide a source of epididymal spermatozoa to test semen extenders or handling regimens, thus circumventing the problem of the viscous ejaculate. In this experiment, two semen extenders (Andromed and INRA96) developed for other species (bovine and equine, respectively) were tested with alpaca spermatozoa derived from the cauda epididymis. Sperm total motility (mean ± SEM A: 29.1 ± 4.8 % compared with I: 35.4 ± 4.8 %; NS), membrane integrity (A: 58 ± 9% compared with I: 56 ± 9%; NS) and acrosome integrity (A: 65 ± 7% compared with I: 54 ± 7%; NS) were not different between the two extenders. Progressive motility with use of INRA96 was greater after incubating for 30 min than after incubating for 10 min (35 ± 4% vs. 12 ± 4%, respectively; P = 0.03). In conclusion, viable epididymal spermatozoa could be extracted from the castrated organs after overnight transport. There were no differences in sperm quality between the two extenders; therefore, it appears that either extender could be used for alpaca spermatozoa. These results could help in the development of a technique for artificial insemination in alpacas
Testicular length as an indicator of the onset of sperm production in alpacas under Swedish conditions
Background: The popularity of alpacas (Vicugna pacos) is increasing in Sweden as well as in other countries; however, knowledge about optimal management practices under Swedish conditions is still limited. The wide age range reported when the onset of puberty can occur, between 1 and 3years of age, makes management decisions difficult and may be influenced by the conditions under which the alpacas are kept. The aim of this study was to find out when Swedish alpacas can be expected to start producing sperm, by using testicular length and body condition score as a more precise indirect indicator than age.
Results: This study suggests that animals with a testicular length â„3.8cm would be producing sperm; however, if it is crucial to know that there is no sperm production for management purposes, the threshold level for testicular length used to differentiate between sperm-producing and non-sperm producing animals should be â€1.6cm instead. If only one variable is considered, testicular length appears to better than age alone to predict sperm production. Body condition score together with testicular length explains the individual onset of puberty and better guide management recommendations.
Conclusions: Using a combination of these parameters (testicular length, body condition score and age) as a tool for decision making for alpaca husbandry under Swedish conditions is suggested
Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate
Parkinsonâs disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism, efficacy, biodistribution, and transcriptional impact of canine adenovirus type 2 (CAV-2) vectors in the brain of Microcebus murinus, a nonhuman primate that naturally develops neurodegenerative lesions. We show that introducing helper-dependent (HD) CAV-2 vectors results in long-term, neuron-specific expression at the injection site and in afferent nuclei. Although HD CAV-2 vector injection induced a modest transcriptional response, no significant adaptive immune response was generated. We then generated and tested HD CAV-2 vectors expressing LRRK2 (leucine-rich repeat kinase 2) and LRRK2 carrying a G2019S mutation (LRRK2G2019S), which is linked to sporadic and familial autosomal dominant forms of PD. We show that HD-LRRK2G2019S expression induced parkinsonian-like motor symptoms and histological features in less than 4 months
Adsorption-like Collapse of Diblock Copolymers
A linear copolymer made of two reciprocally attracting N-monomer blocks
collapses to a compact phase through a novel transition, whose exponents are
determined with extensive MC simulations in two and three dimensions. In the
former case, an identification with the statistical geometry of suitable
percolation paths allows to predict that the number of contacts between the
blocks grows like . In the compact phase the blocks are mixed and, in
two dimensions, also zipped, in such a way to form a spiral, double chain
structure.Comment: 4 pages, 5 Postscript figure
Dynamic Critical Behavior of an Extended Reptation Dynamics for Self-Avoiding Walks
We consider lattice self-avoiding walks and discuss the dynamic critical
behavior of two dynamics that use local and bilocal moves and generalize the
usual reptation dynamics. We determine the integrated and exponential
autocorrelation times for several observables, perform a dynamic finite-size
scaling study of the autocorrelation functions, and compute the associated
dynamic critical exponents . For the variables that describe the size of the
walks, in the absence of interactions we find in two dimensions
and in three dimensions. At the -point in two dimensions
we have .Comment: laTeX2e, 32 pages, 11 eps figure
Final results of the EDELWEISS-II WIMP search using a 4-kg array of cryogenic germanium detectors with interleaved electrodes
The EDELWEISS-II collaboration has completed a direct search for WIMP dark
matter with an array of ten 400-g cryogenic germanium detectors in operation at
the Laboratoire Souterrain de Modane. The combined use of thermal phonon
sensors and charge collection electrodes with an interleaved geometry enables
the efficient rejection of gamma-induced radioactivity as well as near-surface
interactions. A total effective exposure of 384 kg.d has been achieved, mostly
coming from fourteen months of continuous operation. Five nuclear recoil
candidates are observed above 20 keV, while the estimated background is 3.0
events. The result is interpreted in terms of limits on the cross-section of
spin-independent interactions of WIMPs and nucleons. A cross-section of
4.4x10^-8 pb is excluded at 90%CL for a WIMP mass of 85 GeV. New constraints
are also set on models where the WIMP-nucleon scattering is inelastic.Comment: 23 pages, 5 figures; matches published versio
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