THE FIRST EXPERIENCE WITH TISSUCOL AT MOSCOW CITY CANCER HOSPITAL SIXTY-TWO

The paper describes the first experience with the fibrin sealant Tissucol at Moscow City Cancer Hospital Sixty-Two. The authors used this agent in different clinical situations. However, Tissucol showed the highest efficacy in arresting long-term severe lymphorrhea. The described clinical case clearly demonstrates the abilities of this agent and allows it to be recommended for use in other areas of oncology

Effect of high-temperature annealing on the residual strain and bending of freestanding GaN films grown by hydride vapor phase epitaxy

The effect of high-temperature high-pressure annealing on the residual strain, bending, and point defect redistribution of freestanding hydride vapor phase epitaxial GaN films was studied. The bending was found to be determined by the difference in the in-plane lattice parameters in the two faces of the films. The results showed a tendency of equalizing the lattice parameters in the two faces with increasing annealing temperature, leading to uniform strain distribution across the film thickness. A nonmonotonic behavior of structural parameters with increasing annealing temperature was revealed and related to the change in the point defect content under the high-temperature treatment.Peer reviewe

Anisotropic strain and phonon deformation potentials in GaN

We report optical phonon frequency studies in anisotropically strained c-plane- and a-plane-oriented GaN films by generalized infrared spectroscopic ellipsometry and Raman scattering spectroscopy. The anisotropic strain in the films is obtained from high-resolution x-ray diffraction measurements. Experimental evidence for splitting of the GaN E1(TO), E1(LO), and E2 phonons under anisotropic strain in the basal plane is presented, and their phonon deformation potentials cE1(TO) , cE1(LO) , and cE2 are determined. A distinct correlation between anisotropic strain and the A1(TO) and E1(LO) frequencies of a-plane GaN films reveals theaA1TO, bA1TO, aE1LO, andbE1LO phonon deformation potentials. The aA1TO and bA1TOaA1TO and aE1LO phonon deformation potentials agree well with recently reported theoretical estimations [J.-M. Wagner and F. Bechstedt, Phys. Rev. B 66, 115202 (2002)], while bA1TO and bE1LO are found to be significantly larger than the theoretical values. A discussion of the observed differences is presented

Improvement of cupcake technologies adapted for gluten enteropathy

The effect of a composite mixture of rice, corn and pumpkin flour on organoleptic and physical and chemical parameters of gluten-free cupcakes has been studied. The optimal ratio of the ingredients has been selected and the technology for preparing the developed gluten-free cakes from the following composite mixtures has been worked out: corn / rice is 1:1; corn / pumpkin is 1:1; flaxseed / rice is 1:2, 3. Physical and chemical studies have shown that the moisture content in three experimental samples of gluten-free cakes is 13.5 % in sample No. 3, 14.1 % in sample No. 6; 16.5 % in sample No. 9.The sugar content in the studied objects is 24.7 % in sample No. 3, 25.0 % in sample No. 6, 24.1 % in sample No. 9. The ash content in the samples is 0.02 % in No. 3, 0.02 % in No. 6, 0.05 % in No. 9, respectively. The fat content of the test samples is 27.5 % in No. 3, 27.3 % in No.6, 21.8 % in No. 9, respectively, which exceeds the permissible norm (22.0 %) for samples No. 6 and No. 9, this is due to the fact that the nutritional value of fat in pumpkin and flaxseed flour is higher relative to wheat flour. The alkalinity content in the experimental samples is 1.3 degrees in No. 3, 1.3 degrees in No. 6, 1.7 degrees in No. 9, respectively. The developed products have high nutritional and energy values and considered to be high-caloric, and they are enriched with macro- and microelements

DNA triplexes in chemistry, biology and medicine

The formation of DNA triple helices offers the possibility of selectively targeting specific genes to control their expression in vivo. This anti-gene strategy provides powerful tools for the development of therapeutics (anti-cancer drugs, drugs for viral infections) at the transcriptional level. DNA triplexes are formed when an oligonucleotide binds to the major groove of double helical DNA; the third strand can bind in either a parallel motif, or an anti-parallel motif. The requirement of low pH for the protonation of cytosine in the parallel binding motif makes the formation of triple helices difficult under physiological conditions. Described in this thesis is a novel method for the synthesis of the deoxycytidine analogue, 2-amino-3-methyl-5-(2’-deoxy-β-D-ribofuranosyl)pyridine (MeP). The phosphoramidite monomer of MeP was synthesised and incorporated as a “protonated” cytidine analogue into triplex forming oligonucleotides (TFOs). It was compared with other cytosine analogues, 5-methyl-(2’-deoxy-β-D-ribofuranosyl)cytosine (MeC), 2’-Omethyl MeP (MePOMe), and 2’-O-aminoethyl MeC (MeCAE). Triplex stability studies indicate that over the pH range 6.2-8.0, the general trend observed in terms of melting temperature (Tm) was as follows: MeP > MeC > MePOMe > MeCAE. DNase I footprinting studies indicate that at pH 7.5, MeP, when incorporated into the TFO, enhances the stability of the triplex by three-fold relative to MeC. In addition, UV melting, DNase I footprinting, and gel electrophoresis studies were carried out on a triplex formed by the binding of a TFO containing MeP and a 5’-Psoralen to a target duplex. This revealed the benefits of the combined modifications on the stability of the resultant triplex. “Soaking” experiments (in vivo) were also performed with this TFO on the organism C. elegans (the worms were soaked in solutions of the TFO for TFO delivery), to observe whether the TFO would induce loss-of-function phenotypes. Tm measurements indicated that in the pH range 6.6-8.0, photo-crosslinking of the TFO to the duplex created a shift in the triplex Tm of ~ + 26 °C when compared to the un-crosslinked triplexEThOS - Electronic Theses Online ServiceGBUnited Kingdo

Influence of the composition of composite mixtures with a reduced gluten content on the rheological properties of the dough based on their basis

The article presents experimental data on the assessment of the rheological properties of dough from new types of flour, formed on the basis of cumulative curves using the Mixolab device. The data of mixolabograms and radial diagrams (Mixolab profiler) made it possible to reveal the existing differences in the parameters of the rheological profile and Mixolab indices. The object of the study is composite mixtures of gluten-free flours: No. 1 is 50% of pumpkin and 50% of corn flour, No. 2 is 50% of linseed and 50% of corn flour, No. 3 – 50% of rice and 50% of corn flour, No. 4 – 75% of linseed and 25% of corn flour, No. 5 is 30% of linseed and 70% of rice flour. The use of composite mixtures is promising due to high oven rise and low starch thickening because of its high water absorption capacity (WAC). In addition, there is certain economic efficiency, since it is possible to produce more dough at a lower cost

Application of paraffin emulsion as apolar co-reagent during sylvinite flotation process

The research is devoted to finding more affordable apolar reagent paraffinic base for their use in the process of potash ore flotation, as well as improve the form in which the reagent is introduced into the flotation process. Found that the introduction of paraffinic oil flotation system in the form of emulsions provides extraction of potassium chloride at a level comparable to the same period of the industrial process

Impact of MOCVD-GaN 'templates' on the spatial non-uniformities of strain and doping distribution in hydride vapour phase epitaxial GaN

Thick HVPE-GaN layers are grown on Si-doped and undoped MOCVD-GaN 'template' layers as well as directly on sapphire, with the aim to investigate the effect of the MOCVD template on the strain relaxation and spatial distribution of free carriers in the overgrown HVPE films. Spatially resolved cross-sectional micro-Raman measurements, cathodoluminescence and transmission electron microscopy show improved crystalline quality resulting in elimination of the non-uniformities of electron distribution, a low free carrier concentration (< 1017 cm-3) as well as a significant strain relaxation effect.4 page(s