Efficacy of bifocal diagnosis-independent group psychoeducation in severe psychiatric disorders: results from a randomized controlled trial

Despite evidence for its efficacy, diagnosis-specific psychoeducation is not routinely applied. This exploratory randomized controlled trial analyses the efficacy of an easily implementable bifocal diagnosis-mixed group psychoeducation in the treatment of severe psychiatric disorders regarding readmission, compliance and clinical variables, for example global functioning. Inpatients of the Psychiatric Hospital of the University of Basel (N=82) were randomly assigned to a diagnosis-mixed psychoeducational (PE) or a non-specific intervention control group. Relatives were invited to join corresponding family groups. Results at baseline, 3- and 12-month follow-ups are presented. Better compliance after 3months and a lower suicide rate were significant in favour of PE. For most other outcome variables, no significant differences, however advantages, in PE were found. In summary, it can be concluded that diagnosis-mixed group psychoeducation is effective in the treatment of severe psychiatric disorders. The effects can be classified as induced by distinctive psychoeducational elements. Findings similar to those on psychosis-specific programmes justify clinical application and further investigatio

A machine learning approach to evaluate the influence of higher-order generalized variables on shell free vibrations

This work focuses on deriving guidelines for choosing structural theories for composite shells using Convolutional Neural Networks (CNN). The Axiomatic/Asymptotic Method (AAM) is used to evaluate higher-order structural theories’ accuracy and computational efficiency based on polynomial expansions. AAM exploits the Carrera Unified Formulation to derive the finite element matrices and obtain natural frequencies. The outcomes of AAM concerning the accuracy and computational cost are used to train CNN for various composite shell configurations. The trained network can then be used as a substitute for finite element models to estimate the accuracy of a given structural theory. The results are provided via Best Theory Diagrams (BTD), in which the set of generalized displacement variables to retain the best accuracy can be read for a given amount of nodal degrees of freedom. Verification is carried out using results from FEM. The results proved the computational efficiency of CNN and highlighted the influence of the shell thickness for the proper choice of the structural theory. Third-order terms and transverse stretching are often necessary to obtain acceptable accuracy

Thermoelastic micromechanical analysis of CFRP with voids

The work investigates the effect of dispersed air gaps – voids – within the matrix on the local stress and strain fields and the influence on the thermoelastic properties of carbon fiber reinforced plastic polymers (CFRPs). The micromechanics framework is based on the use of 1D higher-order structural theories obtained via the Carrera Unified Formulation (CUF) and periodic boundary conditions (PBC), including plasticity over the matrix. Voids are randomly generated within the matrix, considering different volume fractions. Moreover, several distributions at the same void volume fraction permit to perform statistical analyses of the results. Based on numerical results, increasing void fractions leads to higher stress and strain values. Regarding the thermoelastic properties, the results show a good agreement with the benchmarks, thus confirming that voids have a remarkable effect on thermoelastic properties

The high-intensity hyperon beam at CERN

A high-intensity hyperon beam was constructed at CERN to deliver Sigma- to experiment WA89 at the Omega facility and operated from 1989 to 1994. The setup allowed rapid changeover between hyperon and conventional hadron beam configurations. The beam provided a Sigma-flux of 1.4 x 10^5 per burst at mean momenta between 330 and 345 Gev/c, produced by about 3 x 10^10 protons of 450 GeV/c . At the experiment target the beam had a Sigma-/pi- ratio close to 0.4 and a size of 1.6 x 3.7 cm^2. The beam particle trajectories and their momenta were measured with a scintillating fibre hodoscope in the beam channel and a silicon microstrip detector at the exit of the channel. A fast transition radiation detector was used to identify the pion component of the beam.Comment: 20 pages, 13 figures. Submitted to Nucl. Instr. Meth.

Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis

The treatment of human leishmaniasis is currently based on few compounds that are highly toxic, expensive and have a high rate of treatment failure. A number of recent studies on new drugs focuses on natural or semi-synthetic compounds. Among them, the endoperoxide artemisinin, extracted from Artemisia annua, and some of its derivatives have shown leishmanicidal activity. In the present work, a series of structurally simple, fully synthetic 1,2-dioxanes were evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani; the cytotoxicity for mammalian cells was also assessed. The six most promising compounds in terms of activity and selectivity were further investigated for their antileishmanial activity on the promastigote forms of L. tropica, L. major and L. infantum and against L. donovani amastigotes. The good performance in terms of potency and selectivity makes these six hits promising candidates for a preliminary lead optimization as antileishmanial agents

Maternal and Paternal Representations in Assisted Reproductive Technology and Spontaneous Conceiving Parents: A Longitudinal Study

Aim of this study was to investigate whether parental mental representations during pregnancy and after delivery differed between parents who conceived after Assisted Reproductive Treatments (ART) and spontaneous conceiving (SC) parents. Effects of specific ART variables (previous ART attempts, treatment type and cause of infertility) were also taken into account. Seventeen ART couples and 25 SC couples were recruited at Santa Maria Nuova Hospital (Reggio Emilia, Italy). At both 32 weeks of gestation (T1) and 3 months postpartum (T2) participants completed the Semantic Differential of the IRMAG, a self-report tool which measures specific domains of mental representations pertaining either individual (Child, Self-as-woman/man, and Partner) or parental (Self-as-parent, Own parent) characteristics. Results showed that ART parents had significantly more positive representations of the child compared to SC parents, while the scores at Partner dimension improved from T1 to T2 for SC parents only. With regards to ART history, scores at the Self-as-woman/man dimension were significantly less positive for ICSI than IVF parents and improved substantially from T1 to T2 only in case of mothers with previous ART attempts and of fathers at the first ART cycle. The representation of own parents increased from T1 to T2 in case of infertility diagnosis due to male factors, while a decrease emerged when infertility was due to female factors. Findings suggest the need to investigate parental mental representations after ART, in order to improve the understanding on the transition to parenthood of infertile couples and to target more specific intervention for parenting support

The Relationship between Knowing Sign Language and Quality of Life among Italian People Who Are Deaf: A Cross-Sectional Study

Deafness is a medical condition with important relational implications. This conditioncould affect well-being and self-esteem and cause social anxiety. Sign language is not only a simplemimic but can be considered as a different kind of communication that could be protective for thosewho have learned it. However, some people do not use sign language because they think it canbe marginalizing. The present study aimed to compare the quality of life (QoL) between peoplewho learned Italian sign language as their first language with those who had never learned it orlearned it later. This cross-sectional study involved 182 deaf Italian adults (70.3% females) who wererecruited from Ente Nazionale Sordi (ENS) and by the main online deafness groups. The presentresults suggest that the deaf condition does not seem to significantly affect the dimensions of QoLpertaining to satisfaction and self-esteem, while it could have an effect on preventing high levels of social anxiety and in particular, the group who learned Italian sign language showed significantlyless social anxiety than those who had never learned it

The Impact of COVID-19 Pandemic and Lockdown Measures on Quality of Life among Italian General Population

The COVID-19 pandemic that has hit the world in the year 2020 has put a strain on our ability to cope with events and revolutionized our daily habits. On 9 March, Italy was forced to lock down to prevent the spread of the infection, with measures including the mandatory closure of schools and nonessential activities, travel restrictions, and the obligation to spend entire weeks in the same physical space. The aim of this study was to assess the impact of the COVID-19 pandemic and lockdown measures on quality of life (QoL) in a large Italian sample, in order to investigate possible differences in QoL levels related to both demographic and pandemic-specific variables. A total of 2251 Italian adults (1665 women, mainly young and middle adults) were recruited via a snowball sampling strategy. Participants were requested to answer to an online survey, which included demographic and COVID-related information items, and theWorld Health Organization Quality of Life BREF questionnaire (WHOQOL-BREF). The results showed statistically significant differences in QoL depending on a number of variables, including sex, area of residence in Italy, and being diagnosed with a medical/psychiatric condition. To our knowledge, this is the first study to assess QoL during COVID-19 pandemic in Italy, therefore the present findings can offer guidelines regarding which social groups are more vulnerable of a decline in QoL and would benefit of psychological interventions

Stopping and straggling of 60-250-keV backscattered protons on nanometric Pt films

The stopping power and straggling of backscattered protons on nanometric Pt films were measured at low to medium energies (60-250 keV) by using the medium-energy ion scattering technique. The stopping power results are in good agreement with the most recent measurements by Primetzhofer Phy s. Rev. B 86, 094102 (2012) and are well described by the free electron gas model at low projectile energies. Nevertheless, the straggling results are strongly underestimated by well-established formulas up to a factor of two. Alternatively, we propose a model for the energy-loss straggling that takes into account the inhomogeneous electron-gas response, based on the electron-loss function of the material, along with bunching effects. This approach yields remarkable agreement with the experimental data, indicating that the observed enhancement in energy-loss straggling is due to bunching effects in an inhomogeneous electron system. Nonlinear effects are of minor importance for the energy-loss straggling