Thermal reaction of Al/Ti bilayers with contaminated interface

We have studied some new aspects of thermal reactions in Al/Ti bilayers in which the interface is purposely contaminated with oxygen. After annealing at a temperature of 460 °C, an Al_3Ti compound forms at the interface, moreover some Al diffuses through the Ti to form a compound at the free surface. The amount of aluminum at the free surface can be as large as at the interface. Nucleation and lateral growth of Al_3Ti at the interface are locally unfavorable. This results in a competition between the lateral growth of Al_3Ti at the Al/Ti interface and the diffusion of Al to the free surface. Once full coverage by Al_3Ti is obtained at the Al/Ti interface, the diffusion of Al to the surface becomes negligible

A six-parameter space to describe galaxy diversification

Galaxy diversification proceeds by transforming events like accretion, interaction or mergers. These explain the formation and evolution of galaxies that can now be described with many observables. Multivariate analyses are the obvious tools to tackle the datasets and understand the differences between different kinds of objects. However, depending on the method used, redundancies, incompatibilities or subjective choices of the parameters can void the usefulness of such analyses. The behaviour of the available parameters should be analysed before an objective reduction of dimensionality and subsequent clustering analyses can be undertaken, especially in an evolutionary context. We study a sample of 424 early-type galaxies described by 25 parameters, ten of which are Lick indices, to identify the most structuring parameters and determine an evolutionary classification of these objects. Four independent statistical methods are used to investigate the discriminant properties of the observables and the partitioning of the 424 galaxies: Principal Component Analysis, K-means cluster analysis, Minimum Contradiction Analysis and Cladistics. (abridged)Comment: Accepted for publicationin A\&

Reduction of Dilute Ising Spin Glasses

The recently proposed reduction method for diluted spin glasses is investigated in depth. In particular, the Edwards-Anderson model with \pm J and Gaussian bond disorder on hyper-cubic lattices in d=2, 3, and 4 is studied for a range of bond dilutions. The results demonstrate the effectiveness of using bond dilution to elucidate low-temperature properties of Ising spin glasses, and provide a starting point to enhance the methods used in reduction. Based on that, a greedy heuristic call ``Dominant Bond Reduction'' is introduced and explored.Comment: 10 pages, revtex, final version, find related material at http://www.physics.emory.edu/faculty/boettcher

When humans and computers induce social stress through negative feedback: Effects on performance and subjective state

People increasingly work with autonomous systems, which progressively take over functions previously performed exclusively by humans. This may lead to situations in which automated agents give negative performance feedback, which represents an important work-related social stressor. Little is known about how negative feedback provided by computers (as opposed to humans) affects human performance and subjective state. A first experiment (N = 60) focused on the influence of human feedback on performance. After participants had performed a cognitive task, they received a manipulated performance feedback (either positive or negative) from a human (comparing to a control with no feedback) and subsequent performance on several cognitive tasks and the participants' subjective state was measured. The results showed that while negative feedback had a negative influence on several subjective state measures, performance remained unimpaired. In a second experiment (N = 89), participants received manipulated negative feedback by a human or by a computer (or no feedback at all) after having completed an ability test. Subsequent performance was measured on attention tasks and creativity tasks and participants' subjective state was assessed. Although participants felt stressed by both negative computer and human feedback, subsequent performance was again not impaired. However, computer feedback was rated as being less fair than human feedback. Overall, our findings show that there are costs of protecting one's performance against negative feedback and they call for caution regarding the use of negative feedback by both human and automated agents in work settings

Identifying and reconstructing lateral transfers from distance matrices by combing the minimum contradiction method and neighbor-net

Identifying lateral gene transfers is an important problem in evolutionary biology. Under a simple model of evolution, the expected values of an evolutionary distance matrix describing a phylogenetic tree fulfill the so-called Kalmanson inequalities. The Minimum Contradiction method for identifying lateral gene transfers exploits the fact that lateral transfers may generate large deviations from the Kalmanson inequalities. Here a new approach is presented to deal with such cases that combines the Neighbor-Net algorithm for computing phylogenetic networks with the Minimum Contradiction method. A subset of taxa, prescribed using Neighbor-Net, is obtained by measuring how closely the Kalmanson inequalities are fulfilled by each taxon. A criterion is then used to identify the taxa, possibly involved in a lateral transfer between nonconsecutive taxa. We illustrate the utility of the new approach by applying it to a distance matrix for Archaea, Bacteria, and Eukaryota

Promoter polymorphisms and allelic imbalance in ABCB1 expression.

OBJECTIVE: The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to act on a broad range of prescription medicines. For this reason a large number of studies have assessed the functional consequences of variation in this gene. Particular attention has focused on the ABCB1_3435C>T polymorphism, an exonic variant resulting in a synonymous change. This variant has been associated with mRNA, protein and serum levels, and with responses to a number of medicines. The results of association studies have, however, been variable and it is not currently clear whether this polymorphism is functional or is in linkage disequilibrium with functionally distinct alleles. RESULTS: To identify functional variation in the ABCB1 gene we assessed allelic imbalance by pyrosequencing cDNA from 80 lymphoblastoid B cell lines from the Centre d'Etude du Polymorphisme Humain (CEPH) collection, including 74 individuals heterozygous for 3435C>T. We found that the degree of ABCB1 allelic imbalance differed among B-cell lines. In an effort to fine-map variants that influence the proportion of the two allelic mRNA species we genotyped representative common variations near the 3435C>T polymorphism by using a tagging single nucleotide polymorphism (SNP) approach. In one approach, we assessed in segregating families the impact of cis-acting variants on mRNA levels by using allelic imbalance as the phenotype in a regression analysis that distinguishes the coupling arrangements (phase) among alleles. In a second approach, we assessed allelic imbalance levels in lymphoblastoid B-cell lines from unrelated HapMap individuals, and performed an association using tagSNPs in a 5-Mb region surrounding the gene. Two potential cis-acting variants, a promoter rs28656907/rs28373093 dinucleotide polymorphism (P=0.007) and the rs10245483 SNP (P=0.0003) located 2 Mb upstream from the gene, were predictors of ABCB1 expression. CONCLUSIONS: The study outlines a general experimental approach for fine mapping gene variants that influence mRNA expression by using cultured cell lines