Geochemistry and provenance of the Lower Siwaliks from southwestern Kohat, western Himalayan Foreland Basin, NW Pakistan

Equivalent to the Lower Siwalik Group, the Late Miocene Chinji Formation in Pakistan consists of interbedded in-channel sandstone (SSt) and overbank mudstone (MSt) sequences. Twelve sandstone and sixteen mudstone samples from three different sections of the formation in southwestern Kohat, NW Pakistan were analyzed for major elements and selected trace elements. The Chinji sandstones are feldspathic and lithic arenites. They are mostly matrix-supported, moderately to well sorted, and contain angular to rounded framework grains. Authigenic carbonate makes up most of the matrix. The framework grains consist of abundant monocrystalline quartz, alkali feldspar, and lithic fragments with subordinate mica and trace to accessory amounts of heavy minerals including epidote, monazite, apatite, garnet, rutile, and brown hornblende. The lithic fragments consist of sedimentary, volcanic, and low-grade metamorphic rocks.The average concentration of Zr, Nb and Y, and the Ba/Sc and Ba/Co ratios in the studied samples are lower than the corresponding values for the upper continental crust (UCC) and Post-Archean Australian Shale (PAAS) indicating the presence of mafic phases in the source area(s). The high average Cr/Zr and Cr/V ratios of the investigated samples relative to UCC and PASS also support the presence of mafic lihtologies, possibly chromite and ultramafic rocks in the source region. The La/Sc and Th/Sc ratios of the Chingi samples are more like the UCC while the Th/Co and Cr/Th ratios suggest a major contribution from mafic rocks. The average percent differences of the Chinji samples from both the UCC and PAAS in terms of critical silicic to basic trace element ratios (Ba/Co, Ba/Sc, La/Co, La/Sc, Th/Co, Th/Sc, Zr/Cr, and Zr/Sc) suggest a mafic contribution of 23 to 47% (mudstone) and 56 to 69% (sandstone). The lower Th/U, Rb/Sr and Zr/Sc ratios in the studied samples than the corresponding values of the UCC and PAAS suggest negligible recycling for the sediments of the Chinji Formation. Petrographic point count data on the Chinji sandstone indicate sediment derivation from a dissected arc, suture belt, and recycled orogen corresponding to the Kohistan-Ladakh Arc, the Indus Suture Zone, and the Himalayan Tectonic units, respectively. The different source rocks identified on the basis of various petrographic and geochemical parameters occur as part of the mentioned tectonic domains

Geochemistry and provenance of the Lower Siwaliks from southwestern Kohat, western Himalayan Foreland Basin, NW Pakistan

Equivalent to the Lower Siwalik Group, the Late Miocene Chinji Formation in Pakistan consists of interbedded in-channel sandstone (SSt) and overbank mudstone (MSt) sequences. Twelve sandstone and sixteen mudstone samples from three different sections of the formation in southwestern Kohat, NW Pakistan were analyzed for major elements and selected trace elements. The Chinji sandstones are feldspathic and lithic arenites. They are mostly matrix-supported, moderately to well sorted, and contain angular to rounded framework grains. Authigenic carbonate makes up most of the matrix. The framework grains consist of abundant monocrystalline quartz, alkali feldspar, and lithic fragments with subordinate mica and trace to accessory amounts of heavy minerals including epidote, monazite, apatite, garnet, rutile, and brown hornblende. The lithic fragments consist of sedimentary, volcanic, and low-grade metamorphic rocks.The average concentration of Zr, Nb and Y, and the Ba/Sc and Ba/Co ratios in the studied samples are lower than the corresponding values for the upper continental crust (UCC) and Post-Archean Australian Shale (PAAS) indicating the presence of mafic phases in the source area(s). The high average Cr/Zr and Cr/V ratios of the investigated samples relative to UCC and PASS also support the presence of mafic lihtologies, possibly chromite and ultramafic rocks in the source region. The La/Sc and Th/Sc ratios of the Chingi samples are more like the UCC while the Th/Co and Cr/Th ratios suggest a major contribution from mafic rocks. The average percent differences of the Chinji samples from both the UCC and PAAS in terms of critical silicic to basic trace element ratios (Ba/Co, Ba/Sc, La/Co, La/Sc, Th/Co, Th/Sc, Zr/Cr, and Zr/Sc) suggest a mafic contribution of 23 to 47% (mudstone) and 56 to 69% (sandstone). The lower Th/U, Rb/Sr and Zr/Sc ratios in the studied samples than the corresponding values of the UCC and PAAS suggest negligible recycling for the sediments of the Chinji Formation. Petrographic point count data on the Chinji sandstone indicate sediment derivation from a dissected arc, suture belt, and recycled orogen corresponding to the Kohistan-Ladakh Arc, the Indus Suture Zone, and the Himalayan Tectonic units, respectively. The different source rocks identified on the basis of various petrographic and geochemical parameters occur as part of the mentioned tectonic domains

Performance Evaluation of Mutual Funds in Pakistan

In Pakistan Mutual Funds were introduced in 1962, when the public offering of National Investment (Unit) Trust (NIT) was introduced which is an open-end mutual fund. In 1966 another fund that is Investment Corporation of Pakistan (ICP) was establishment. ICP subsequently offered a series of closed-end mutual funds. Up to early 1990s, twenty six (26) closed-end ICP mutual funds had been floated by Investment Corporation of Pakistan. After considering the option of restructuring the corporation, government decided to wind up ICP in June, 2000. In 2002, the Government started Privatisation of the Investment Corporation of Pakistan. 25 Out of 26 closed-end funds of ICP were split into two lots. There had been a competitive bidding for the privatisation of funds. Management Right of Lot-A comprising 12 funds was acquired by ABAMCO Limited. Out of these 12, the first 9 funds were merged into a single closed-end fund and that was named as ABAMCO Capital Fund, except 4th ICP mutual fund as the certificate holders of the 4th ICP fund had not approved the scheme of arrangement of Amalgamation into ABAMCO capital fund in their extra ordinary general meeting held on December 20, 2003. The fund has therefore been reorganised as a separate closedend trust and named as ABAMCO Growth Fund. Rest of the three funds were merged into another single and named as ABAMCO Stock Market Fund. So far as the Lot-B is concerned, it comprised of 13 ICP funds, for all of these thirteen funds, the Management Right was acquired by PICIC Asset Management Company Limited. All of these thirteen funds were merged into a single closed-end fund which was named as “PICIC Investment Fund”. Later on the 26th fund of ICP (ICP-SEMF) was also acquired by PICIC Asset Management Company Limited

(2Z)-4-[(2-Hy­droxy­phen­yl)carbamo­yl]prop-2-enoic acid

In the title compound, C10H9NO4, the 2-hy­droxy­anilinic and the 4-oxobut-2-enoic acid groups are almost planar, with r.m.s. deviations of 0.0086 and 0.0262 Å, respectively. The dihedral angle between the two groups is 6.65 (1)°. Intra­molecular N—H⋯O, C—H⋯O and O—H⋯O hydrogen bonds form S(5), S(6) and S(7) ring motifs. In the crystal, the mol­ecules are dimerized due to C—H⋯O and O—H⋯O inter­molecular hydrogen bonds, with R 2 2(8) ring motifs. The dimers are inter­linked into polymeric chains along [010] with R 4 3(13) ring motifs by C—H⋯O, N—H⋯O and O—H⋯O hydrogen bonds

2-[6-Thioxo-5-(2,4,6-trimethyl­phen­yl)-1,3,5-thia­diazinan-3-yl]acetic acid

In the mol­ecule of the title compound, C14H18N2O2S2, the 1,3,5-thia­diazinane-2-thione ring adopts an envelope conformation with one of the N atoms at the flap position. The plane throught the five co-planar atoms of the heterocycle is oriented at a dihedral angle of 80.59 (8)° with respect to the aromatic ring. In the crystal structure, weak inter­molecular O—H⋯S inter­actions link the mol­ecules into chains along the b axis

Early renal damage assessed by the SLICC/ACR damage index is predictor of severe outcome in lupus patients in Pakistan

We investigated Patients with systemic lupus erythematosus with the objective of assessing whether early damage accrued in systemic lupus erythematosus as measured by the SLICC/ACR Damage Index predicts mortality in lupus Patients that have been followed prospectively in a single center. Patients with systemic lupus erythematosus from Aga Khan University hospital presenting between 1992 and 2007 were included. This enabled all Patients to be potentially followed for at least 10 years. Yearly SLICC/ACR Damage Index scores were determined for each Patient. Early damage was defined as a score \u3e= 1, and no damage as a score of 0 at the initial assessment. Kaplan-Meier and Log rank tests were used to compare the survival experience between those with and without damage, with all Patients being assessed at 10 years. In this inception cohort 198 Patients were identified and were followed for 10 years. Of these, 47 (23.7%) Patients had a SLICC/ACR Damage Index score of 0 (no damage) while 151 Patients (76.3%) had at least one SLICC/ACR Damage Index item scored (early damage). Mean renal damage score at 1, 5 and 10 years was 0.16, 0.34 and 0.67, respectively. Of lupus Patients who exhibited renal damage at their first SLICC/ACR Damage Index assessment, 31% died within 10 years of their illness as compared with only 13% who had no early renal damage (p \u3c 0.003). Mean renal damage score at 1 year after diagnosis was a significant predictor of death within 10 years of diagnosis (p \u3c 0.002)

Bis[3-(2H-benzotriazol-2-yl)-2-(prop-2-yn­yloxy)-5-(2,4,4-trimethyl­pentan-2-yl)phen­yl]methane

In the title compound, C47H54N6O2, the C—C—C bond angle between the rings is 108.40 (13)°. One aryl ring aligned at 38.5 (1)° with respect to the N-heterocyclic substituent and the other at 56.0 (1)° with respect to its substituent. In the crystal, adjacent mol­ecules are linked by C—H⋯N hydrogen bonds, forming a chain extending along the a axis

Effect of Permeation Enhancers on the Release Behavior and Permeation Kinetics of Novel Tramadol Lotions

Purpose: The aim of this research work was to formulate, characterize and evaluate the in vitro permeation behavior of tramadol lotion containing propylene glycol (PG) and polyethylene glycol (PEG) as permeation enhancers.Methods: The permeation experiments were conducted in vitro using full thickness rabbit skin in Franz diffusion cells. The donor compartment was filled with PBS (phosphate buffered saline) at pH 7.4 ± 0.1. The receptor phase was continuously stirred PBS (pH 7.4) at 37 °C ± 0.5. The amount of tramadol permeated into the receptor phase was determined spectrophotometrically at 271 nm. Various permeation parameters such as permeation coefficient (Kp), diffusion coefficient (D), flux (J), input rate,and enhancement ratio were obtained using Fick’s diffusion laws.Results: Permeation increased with increase in the concentrations of both enhancers tested. Maximum cumulative amount permeated for control lotion (Lc) was 357 ìg/cm2/min with input rate 0.574 ìg/min and lag time (tlag) of 34.93 min, while for the optimum test lotion (L4, containing 8 % PG/PEG in ratio of 1:1 v/v), it was 926 ìg/cm2/min, 1.482 ìg/min and 58.36 min, respectively. The significantly (p < 0.05) higher permeability shown by the test lotion L4 can be attributed, in part, to the interaction of PG withintercellular lipids leading to the disruption of their organization and increasing their fluidity, and also partly as a result of solubilization of lipid bilayers by PEG.Conclusion: A binary system of PG and PEG in lotion can be successfully utilized for the permeation enhancement of tramadol.Keyword: Tramadol, Transdermal delivery, Permeation, Propylene glycol, Polyethylene glycol, Rabbit skin