A business model for the establishment of the European Grid Infrastructure

Abstract. An international grid has been built in Europe during the past years in the framework of various EC-funded projects to support the growth of e-Science. After several years of work spent to increase the scale of the infrastructure, to expand the user community and improve the availability of the services delivered, effort is now concentrating on the creation of a new organizational model, capable of fulfilling the vision of a sustainable European grid infrastructure. The European Grid Initiative (EGI) is the proposed framework to seamlessly link at a global level the European national grid e-Infrastructures operated by the National Grid Initiatives and European International Research Organizations, and based on a European Unified Middleware Distribution, which will be the result of a joint effort of various European grid Middleware Consortia. This paper describes the requirements that EGI addresses, the actors contributing to its foundation, the offering and the organizational structure that constitute the EGI business model

INDIGO-DataCloud: a Platform to Facilitate Seamless Access to E-Infrastructures

[EN] This paper describes the achievements of the H2020 project INDIGO-DataCloud. The project has provided e-infrastructures with tools, applications and cloud framework enhancements to manage the demanding requirements of scientific communities, either locally or through enhanced interfaces. The middleware developed allows to federate hybrid resources, to easily write, port and run scientific applications to the cloud. In particular, we have extended existing PaaS (Platform as a Service) solutions, allowing public and private e-infrastructures, including those provided by EGI, EUDAT, and Helix Nebula, to integrate their existing services and make them available through AAI services compliant with GEANT interfederation policies, thus guaranteeing transparency and trust in the provisioning of such services. Our middleware facilitates the execution of applications using containers on Cloud and Grid based infrastructures, as well as on HPC clusters. 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Aqueous normal phase retention of nucleotides on silica hydride-based columns: Method development strategies for analytes revelant in clinical analysis

An aqueous normal phase HPLC method coupled with UV or ESI/MS detection was used for the determination of a wide variety of nucleotides, essential in metabolomics studies. Fifteen nucleotides were tested in clinically relevant mixtures at levels of 100 g/mL for UV detection and 1 g/mL for ESI-MS detection. Analysis times for all protocols developed were less than 20 min. The chromatographic conditions were changed to achieve optimized retention and separation of the nucleotides studied. The aqueous normal phase-HPLC methods were developed utilizing two columns, one having a minimally modified hydride surface another having an undecanoic acid moiety on a hydride surface. Volatile, low ionic strength mobile phases were used. Negative ion mode ESI-MS at near neutral pH mobile phase, combined with a TOF detector provided a highly sensitive and specific method, which is equally suitable for quadrupole and ion trap instruments. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim