Laparoscopic Roux-en-Y reconstruction in a patient with afferent loop syndrome and peptic ulcers of gastroenteroanastomosis - A first experience

This paper is devoted to the description of a currently rare clinical observation of the surgical treatment of a patient with postgastroresection syndrome (afferent loop syndrome and peptic ulcers of gastroenteroanastomosis) - resection of the stomach stump with laparoscopic Roux-en-Y reconstructio

Aneurysm of internal carotid artery, which simulated paratonsillary abscess (clinical case)

This article describes a rare case of paratonsillar abscess imitation among the patients with the aneurysm of ICA. The purpose of the study is to describe the methods of this disease diagnosing using the example of a clinical case, to give a general description of this nosology occurrence frequency, and to recommend a detailed approach to the differential diagnosis among this category of patient

ESTRTOGENE AT EARLY PREGNANCY WITH HERPES-VIRUS EXACERBATION

Decrease of estriol and estradiol concentration, was found, at herpes-viral infection exacerbation, in placenta of pregnant at early stages of gestations. Revealed, change was shown by result of defect of base steroid. — cholesterol content, as well as distribution, of the steroid, hormone syntheses process: low activity of placental 17β-hydroxysteroid dehydrogenase and. inadequacy steroidogenesis regulating mechanism.

Морфофункциональная характеристика фетоплацентарного барьера при герпес-вирусной инфекции

Herpes-virus infection decrease of activity of villus Bcl-2 was increased in process of increase of a credit of antibodies to virus herpes. The increase of activity kaspasa-3 created action on DNK nucleus sincythiotrophoblast.При обострении герпес-вирусной инфекции во время беременности на фетоплацентарный барьер повреждающее влияние оказывают интерлейкин, фактор некроза опухоли α, нитросоединения, приводящее к подавлению активности белка Bcl2 и увеличению активности каспазы-3

INTERRELATION OF CHANGES IN CONCENTRATION OF LEPTIN AND ω-3 FAMILY ACIDS IN THE PLACENTA AT THE REACTIVATION OF CYTOMEGALOVIRUS INFECTION IN THE III TRIMESTER OF HUMAN PREGNANCY

A gas-chromatographic study was conducted of the content of essential polyunsaturated fatty acids of the ω-3 family: eicosapentaenoic and docosahexaenoic, an enzyme-linked immunosorbent assay of leptinin the homogenate of placental tissue in women who during the third trimester of gestation (32 weeks) underwent reactivation of chronic cytomegalovirus infection with an antibody titer Immunoglobulin class G to cytomegalovirus 1:1600. The main group of studies was 42 placentas taken from women with cytomegalovirus infection during the period of labor. The obtained data were compared with similar parameters of the control group, which included 35 placental tissues of practically healthy women in childbirth. Based on the analysis of the data obtained, it was found that the reactivation of chronic cytomegalovirus infection in the third trimester of pregnancy (32 weeks) is associated with decrease in the concentration of ω-3 essential polyunsaturated fatty acids: eicosapentaenoic by 23 % (р < 0.01) and docosahexaenoic by 42 % (р < 0.001) with a simultaneous increase in the concentration of leptin in the placental tissue by 61 % (р < 0.001). In these conditions, the mechanisms of regulation of the transmission of fatty acids from the peripheral blood of the mother to the blood of the developing fetus through the placenta are disrupted. The contents of leptin during pregnancy is an important indicator that carries information not only about the energy reserves of the maternal organism, but also about the state of the fe^lacental complex

Реализация апоптоза в ядрах синцитиотрофобласта ворсинок плаценты у беременных, перенесших обострение герпес-вирусной инфекции в зависимости от содержания в гомогенате плаценты аннексина V

The reason of increase apoptosis in sincythiotrophoblast is suppression of activity ATP-ase, moving phosphatydilserin on an external membrane sincythiotrophoblast, and increase of quantity annexin V in homogenate placentae.Причиной увеличения апоптоза в синцитиотрофобласте является подавление активности аденозинтрифосфатазы, перемещение фосфатидилсерина на внешнюю мембрану синцитиотрофобласта, повышение количества аннексина V в гомогенате плаценты

Ideal MHD theory of low-frequency Alfven waves in the H-1 Heliac

A part analytical, part numerical ideal MHD analysis of low-frequency Alfven wave physics in the H-1 stellarator is given. The three-dimensional, compressible ideal spectrum for H-1 is presented and it is found that despite the low beta (approx. 10^-4) of H-1 plasmas, significant Alfven-acoustic interactions occur at low frequencies. Several quasi-discrete modes are found with the three-dimensional linearised ideal MHD eigenmode solver CAS3D, including beta-induced Alfven eigenmode (BAE)- type modes in beta-induced gaps. The strongly shaped, low-aspect ratio magnetic geometry of H-1 causes CAS3D convergence difficulties requiring the inclusion of many Fourier harmonics for the parallel component of the fluid displacement eigenvector even for shear wave motions. The highest beta-induced gap reproduces large parts of the observed configurational frequency dependencies in the presence of hollow temperature profiles

Патогенетичні фактори розвитку аутоімунних захворювань. Сучасні підходи до їх лікування

In experimental models of pathologies of autoimmune genesis there was grounded the possibility and confirmed the efficiency of using the products of fetoplacental complex. There was tested their ability to activate T-regulatory immunity link and normalize cell indices in experimental animals. More pronounced immune correcting potential of cryopreserved material has been shown at cell and molecular levels. На экспериментальных моделях патологий аутоиммунного генеза обоснована возможность и доказана эффективность применения продуктов фетоплацентарного комплекса. Продемонстрирована их способность к  активации Т-регуляторного звена иммунитета и нормализации клинических показателей экспериментальных животных. Показан более выраженный  иммунокорригирующий потенциал криоконсервированного материала на клеточном и молекулярном уровнях.На експериментальних моделях патологій аутоімунного генезу обгрунтована можливість і доведена ефективність застосування продуктів фетоплацентарного комплексу. Продемонстровано їхню здатність до активації Т-регуляторної ланки імунітету і нормалізації клінічних показників експериментальних тварин. Показано більш виражений імунокоригуючий потенціал кріоконсервованого матеріалу на клітинному і молекулярному рівнях

DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral  agent causing an imbalance in the production of placenta  progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone. The aim was to evaluate the concentration  of progesterone and its metabolites – 5α-dihydroprogesterone and  allopregnenolone – in placenta during exacerbation of CMV infection  in the first trimester of pregnancy, and the impact of these  disturbances on the development of neurological disorders in children. We examined 30 pregnant women with exacerbation of  CMV infection in the first trimester of pregnancy and 30 pregnant  women with latent disease; and later their newborns. The enzyme  immunoassay was used to determine  concentration of progesterone  in placenta; the histochemical method – to determine 5α-dihydroprogesterone and allopregnenolone. Newborns underwent  neurosonography studies. Exacerbation of CMV infection in the first  trimester of pregnancy decreased progesterone in placenta by 1.3  times, 5α-dihydroprogesterone – by 1.73 times and allopregnenolone – by 2 times. Ultrasound examination of the brain  showed ventriculomegaly, periventricular ischemia, and pseudocysts  in newborns up to one year from mothers with exacerbation of CMV  during pregnancy. Later, minimal brain dysfunctions were manifested by motor disorders, increased general, vegetative excitability, and a  tendency to digestive and sleep disorders. The data obtained  indicate that the exacerbation of CMV infection in the first trimester  of pregnancy is interrelated with a decrease in the concentration of progesterone and its metabolites (5α-dihydroprogesterone, allopregnenolone) in the placenta and development of neurological dysfunction in newborns