Antimicrobial susceptibility pattern and multidrug resistance ındex in Pseudomonas aeruginosa among clinical isolates in Denizli, Turkey

Background: Pseudomonas aeruginosa is an important hospital infection agent causing morbidity and mortality with the ability to gain resistance to many antimicrobials. The objective of this study was to determine the sensitivity profiles of nosocomial P. aeruginosa isolates in Denizli, Turkey. Methods: A total 120 P. aeruginosa strains which were isolated from specimens sent to the microbiology laboratory between January 2015 and December 2015 were investigated. Antimicrobial resistance was determined by agar disc diffusion method using Mueller-Hinton agar according to Clinical and Laboratory Standards Institute recommendations. Results: With respect to sensitivity pattern, the most sensitive antimicrobials were Amikacin, colistin, tobramisin, netilmicin and gentamicin and the resistance rates were detected as 97%, 96%, 92%, 90%, 83%, respectively over 120 P. aeruginosa strains. The sensitivity rates for the other antimicrobials were 56% for Piperacilin and 54% for Tazobactam. P. aeruginosa strains 62 (52%) isolates showed multiple antimicrobial resistance to 13 antimicrobials Conclusion: To prevent the spread of the resistant bacteria, it is critically important to have strict antimicrobial policies while surveillance programmes for multidrug resistant organisms and infection control procedures need to be implemented. In the meantime, it is desirable that the antimicrobial susceptibility pattern of bacterial pathogens like P. aeruginosa in specialized clinical units to be continuously monitored and the results readily made available to clinicians so as to minimize the development of resistance. © 2018, National Institute for Medical Research. All rights reserved

Finite volume analysis of reinforced concrete structure cracking using a thermo-plastic-damage model

This paper proposes modifications to the phenomenological model formulation called CDPM2, developed by Grassl et al. [1]. The proposed modifications are designed to enhance model performance with coupling to temperature effects. A very strong coupling between nonlinear elasticity, plasticity, nonlocal damage evolution and temperature gradient is used to simulate arbitrary crack propagation. The use of FVM to model solid damage is a numerical challenge. This approach presents some advantages such as: ensuring that discretization is conservative even when the geometry is changing; providing a simple formulation that can be obtained directly from a difference method; and employing unstructured meshes. Most authors have neglected the nonlinearity of concrete in the elastic domain from the start of loading to the plastic domain. In this paper we confirm that concrete rheology is not linear even under low loading. Also, since the so-called fracture energy is a key parameter needed to determine the size of cracks and how they propagate in space, we consider that the fracture energy is both material and geometrical parameter dependent. For this reason, we developed a new approach which includes adaptive mesh, nonlinear rheology and thermal effects to re-calculate fracture energy at each time step. Many authors use a constant value obtained from experiments to calculate fracture energy; others use a numerical correlation. In this study, the fracture energy parameter is not constant and can vary with temperature or/and with a change in geometry due to concrete failure. As is well known, the mesh quality of complex geometries is very important for making accurate predictions. A new meshing tool was developed using the C++ programming language. This tool is faster, more accurate and produces a high-quality structured mesh. The predictions obtained were compared to a wide variety of experimental data and showed good agreement

Feedback Enhances Simultaneous Wireless Information and Energy Transmission in Multiple Access Channels

In this report, the fundamental limits of simultaneous information and energy transmission in the two-user Gaussian multiple access channel (G-MAC) with and without feedback are fully characterized. More specifically, all the achievable information and energy transmission rates (in bits per channel use and energy-units per channel use, respectively) are identified. Furthermore, the fundamental limits on the individual and sum- rates given a minimum energy rate ensured at an energy harvester are also characterized. In the case without feedback, an achievability scheme based on power-splitting and successive interference cancellation is shown to be optimal. Alternatively, in the case with feedback (G-MAC-F), a simple yet optimal achievability scheme based on power-splitting and Ozarow's capacity achieving scheme is presented. Finally, the energy transmission enhancement induced by the use of feedback is quantified. Feedback can at most double the energy transmission rate at high SNRs when the information transmission sum-rate is kept fixed at the sum-capacity of the G-MAC, but it has no effect at very low SNRs.Comment: INRIA REPORT N{\deg}8804, accepted for publication in IEEE transactions on Information Theory, March, 201

How to Defend Those Who Defend: An Examination of the Underfunding of the Public Defender System

The public defender system in the United States is in an indigent defense crisis because it is often unable to provide adequate representation to the citizens that the United States Constitution requires them to give. The growing attention on the system today is shedding light on public defenders’ stifling caseloads and on the people who are failing to receive the legal representation to which they are entitled by the constitution. The lack of political prioritization, the systemic inequities throughout the criminal justice system, and the underfunding of the public defender system has often rendered public defenders unable to provide their clients with adequate representation in court. The purpose of this research is to examine the history of the public defender system, to address the problems within the system as it stands today, to explore what scholars suggest can be done to improve the system, and to give my own suggestions as to what should be done after conducting this research. The specific shortcomings that will be investigated include the lack of financial support given to public defenders; the disparate impact a lack of public defenders has on specific communities; and how implementing standardization to the current legislation would allow all public defenders to provide their defendants with adequate representation