A Distributed Communication System for Integration with Logistics Software

Truckage companies need continuous and up-to-date information about their business processes in order to respond quickly to customers’ needs and problems emerging during transport processes. Therefore a reliable and user-friendly communication system is required, which improves the relationship between drivers and dispatchers. The project ”Mobile Spedition im Web (SpiW)**” presented here, develops a mobile communication system, which focuses on the driver/dispatcher interaction. The main goals are integration with legacy logistics software and the possible use of new telematics and communication techniques. To achieve these goals, a component based architecture allows the later change and extension of components, making it possible to add new features to the system as they become available. A distributed workflow server supports the adjustment of business processes to individual needs

Crystallization in suspensions of hard spheres: A Monte Carlo and Molecular Dynamics simulation study

The crystallization of a metastable melt is one of the most important non equilibrium phenomena in condensed matter physics, and hard sphere colloidal model systems have been used for several decades to investigate this process by experimental observation and computer simulation. Nevertheless, there is still an unexplained discrepancy between simulation data and experimental nucleation rate densities. In this paper we examine the nucleation process in hard spheres using molecular dynamics and Monte Carlo simulation. We show that the crystallization process is mediated by precursors of low orientational bond-order and that our simulation data fairly match the experimental data sets

Partial clustering prevents global crystallization in a binary 2D colloidal glass former

A mixture of two types of super-paramagnetic colloidal particles with long range dipolar interaction is confined by gravity to a flat interface of a hanging water droplet. The particles are observed by video microscopy and the dipolar interaction strength is controlled via an external magnetic field. The system is a model system to study the glass transition in 2D, and it exhibits partial clustering of the small particles. This clustering is strongly dependent on the relative concentration $\xi$ of big and small particles. However, changing the interaction strength $\Gamma$ reveals that the clustering does not depend on the interaction strength. The partial clustering scenario is quantified using Minkowski functionals and partial structure factors. Evidence that partial clustering prevents global crystallization is discussed

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

Metastasis is directly linked to poor prognosis of cancer patients and warrants search for effective anti-metastatic drugs. MACC1 is a causal key molecule for metastasis. High MACC1 expression is prognostic for metastasis and poor survival. Here, we developed novel small molecule inhibitors targeting MACC1 expression to impede metastasis formation. We performed a human MACC1 promoter-driven luciferase reporter-based high-throughput screen (HTS; 118.500 compound library) to identify MACC1 transcriptional inhibitors. HTS revealed 1,2,3,4-tetrazolo[1,5-b]pyridazine-based compounds as efficient transcriptional inhibitors of MACC1 expression, able to decrease MACC1-induced cancer cell motility in vitro. Structure-activity relationships identified the essential inhibitory core structure. Best candidates were evaluated for metastasis inhibition in xenografted mouse models demonstrating metastasis restriction. ADMET showed high drug-likeness of these new candidates for cancer therapy. The NFκB pathway was identified as one mode of action targeted by these compounds. Taken together, 1,2,3,4-tetrazolo[1,5-b]pyridazine-based compounds are effective MACC1 inhibitors and pose promising candidates for anti-metastatic therapies particularly for patients with MACC1-overexpressing cancers, that are at high risk to develop metastases. Although further preclinical and clinical development is necessary, these compounds represent important building blocks for an individualized anti-metastatic therapy for solid cancers

Heterogeneous nucleation and microstructure formation in colloidal model systems with various interactions

Recent studies of crystal nucleation and further microstructure formation in colloidal model systems are reviewed. Homogeneous as well as different heterogeneous nucleation scenarios will be discussed. We focus on the crystallization process of one component colloidal model systems with hard sphere like interaction, long range electrostatic interaction and depletion force induced attractive interaction. Heterogeneous crystallization on flat and smooth substrates, on structured substrates, induced by different kind of seed particles as well as inoculation adding a larger amount of seeds will be presented

Physical properties of highly oriented spray-deposited fluorine-doped tin dioxide films as transparent conductor

Heavily fluorine-doped tin dioxide films were deposited by spray pyrolysis using a high precursor concentration. The effect of film thickness was studied in the range 80-1230 nm. The films were polycrystalline and preferentially oriented along [200]. The grain size, carrier mobility mu, carrier concentration N and resistivity reached similar to 230 nm, 35 cm(2)/V s. 6 x 10(20) cm(-3) and 3 x 10(-4) Omega cm, respectively, for 1000 nm films. An unusual 'direct and linear' mu-N dependence revealed the importance of the structural properties. The 1000 nm thick films possessed an average visible transmittance similar to 81 % and a reflectance similar to 66% at 2500 nm. The electro-optical properties revealed their excellent quality as a TCO material. (C) 2009 Elsevier B.V. All rights reserved