Analysis Expression of ZIP1 and Caspase-3 Protein in Adenocarsinoma of the Prostate

Background: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells. Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit apoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyse the correlation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by Gleason Score. This was a cross-sectional, retrospective analytical study on 31 Formalin-fixed, paraffin-embedded tissue that meets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3. Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data from the cases' reports. The correlation of their expression with respect to Gleason score was analysed with Pearson's correlation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were 35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression (r=0.379; p=0.018). However, their correlation was stronger in intermediate-grade group (r=0.73; p=0.01) and the correlation was much weaker in high-grade group (r=0.04; p=0.48). Conclusions: There was a positive correlation between ZIP1 and Caspase-3 expression in prostate adenocarcinoma.&nbsp

Pengaruh Motivasi terhadap Kinerja Karyawan di Usaha Dagang Kalasta Desa Ekasari Kabupaten Jembrana Tahun 2011

Masalah dalam penelitian ini adalah bagaimana tingkat motivasi dan kinerja karyawan serta seberapa besar pengaruh motivasi terhadap kinerja di Usaha Dagang Kalasta Dusun Parwatasari Desa Eksari Kabupaten Jembrana Tahun 2011. Penelitian ini bertujuan untuk mengetahui tingkat motivasi dan kinerja karyawan serta besarnya pengaruh motivasi terhadap kinerja karyawan di Usaha Dagang Kalasta Dusun Parwatasari, Desa Ekasari, Kabupaten Jembrana Tahun 2011. Metode penelitian yang digunakan adalah penelitian deskriptif kausalitas. Pengumpulan data dalam penelitian ini menggunakan kuisioner yang kemudian dianalisis menggunakan analisis regresi sederhana. Berdasarkan analisis data diperoleh hasil penelitian yang dapat disimpulkan bahwa motivasi karyawan berada pada kategori cukup tinggi dengan skor 709, kinerja karyawan berada pada kategori cukup tinggi dengan skor 858, dan besar pengaruh motivasi terhadap kinerja karyawan di UD. Kalasta Dusun Parwatasari, Desa Ekasari, Kabupaten Jembrana sebesar 67,5% dan sisanya 32,5% dipengaruhi oleh faktor lain. Kata-kata kunci: kinerja karyawan, motivasi kerja, Usaha Dagang Kalast

Analisis Sistem Akuntansi Penggajian & Pengupahan Karyawan Dalam USAha Meningkatkan Pengendalian Intern Perusahaan (Studi Pada PT. Japfa Comfeed Indonesia, Tbk Kantor Cabang Sidoarjo)

This research aims to run the internal control system of accounting analysis based on company payroll waging. This research is descriptive research with qualitative approach. The Data used are secondary data, obtained from www.japfacomfeed.co.id. The technique of data collection was done through the documentation. Data analysis starts from the related functions in payroll and accounting systems, waging a document used in the payroll and accounting systems, procedures that form the waging system accounting payroll and accounting records, waging used in payroll and accounting systems, organizational structure, waging authorization system, a healthy practice in performing the duties and functions of each unit of the organization. The results of this research were obtained when cheating happens all the employees did a timesheet using clock card, perangkapan function in the administration of the Human Resource Development (HRD)

Evaluasi Kewajaran Harga dan Kesesuaian Metode Transfer Pricing dengan Perdirjen Pajak Nomor Per-32/pj/2011 (Studi Kasus pada PT. Mertex Indonesia)

PT. MERTEX using Transactional Net Margin Method as a pricing method in transfer pricing transactions with related parties. Related to this method, needs to be applicated Arm's Length Principles as defined in PER-32/PJ/2011. This study used a descriptive research with a qualitative approach based on case studies. The results showed that, transfer pricing methods used by PT. MERTEX in accordance with the Arm's Length Principles and PT. MERTEX has implemented procedures and measures, as stipulated in PER-32/PJ/2011. There are differences between PT. MERTEX and Directorate General of Taxes Auditor in the disclosure of arm's length price on transfer pricing transaction, so it needs to be continued to the Objection level. Documentation of PT. MERTEX's transaction with related parties needs to be continued to meet the requirements in applying the Arm's Length Principles as defined in PER-32/PJ/2011. If PT. MERTEX can show that documents in case of investigation by the Director General of Taxes Auditor, PT. MERTEX have strong evidence to support his argument in applying the arm's length price/ earnings, thus PT. MERTEX able to resolve their disputes with the Auditor until the Appeals level

Analisis Just In Timе Systеm dalam USAha Mеningkatkan еFisiеnsi Biaya Produksi (Studi Kasus pada Kbm-ik II Grеsik)

This study is basеd on thе high lеvеl of compеtition in thе industrial sеctor. Еach company triеs to maximizе profits, thеrеforе companiеs nееd thе right stratеgy in ordеr to compеtе in thе global markеt and to gеt thе maximum profit as wеll. Thе stratеgy is just in timе systеm. Just in timе systеm aims to improvееfficiеncy of production costs. This study aims to dеtеrminе whеtеr thе application just in timе systеm in thе company KBM-IK II Grеsik can improvе thееfficiеncy of thе production costs. This study is a dеscriptivе rеsеarch with quantitivе approach. Thе focusеs of this study arе production and salеs throughout 2016, labor costs and production timе. For thе data analysis, thе writеr usеd pеrformancе achiеvеmеnt analysis. Thе rеsult of this study indicatе that thе application of just in timе systеm in KBM-IK II Grеsik can improvе thе production cost еfficiеncy of RST flooring. Thееfficiеncy was thе incrеasing of productivity of 71,4 %, dеcrеasing of production timе of 21,28 % and also thе dеcrеasing of dirеct labor costs of 21,28 %. Kеywords : just in timе systеm, production, production cost еfficiеnc

Mifepristone versus intracervical prostaglandin E2 gel for cervical ripening in primigravid patients at term

Background: The cervix has to play dual role in human reproduction. During pregnancy, it should remain firm and closed allowing the fetus to grow in utero until functional maturity is attained while during labour it should soften and dilate, allowing the fetus to pass through the birth canal. Objective of present study was to know and compare the effect of oral Mifepristone with intracervical dinoprostone gel for cervical priming prior to induction of labour at term in an unfavorable cervix of primigravida.Methods: This was prospective randomized comparative study. 100 primigravid patients were included, 50 were placed in each group A and B. Tablet Mifepristone 200mg orally was given in group A patients and intracervical dinoprostone gel induction was done in group B patients. Pre induction Bishop’s score was noted at beginning to compare improvement in Bishop’s score after induction. Mode of delivery and induction to delivery interval in both the groups were studied.Results: After induction with Mifepristone 76% women had successful cervical ripening as compared to 56% with dinoprostone. Rate of vaginal delivery was 70% with Mifepristone and 58% with dinoprostone. There was no significant difference in induction to delivery interval between the groups. Ten percent and 2% belonging to mifepristone and dinoprostone group respectively, required NICU admissions.Conclusions: Mifepristone is more effective than dinoprostone for preinduction cervical ripening as it has high success rate of achieving cervical ripening, however there is no significant difference in the vaginal delivery rate and other maternal and fetal outcome

Demokrasi dan Legalitas Mantan Narapidana dalam Pemilihan Kepala Daerah dan Pemilihan Umum

The focus of this study was on the decision of the Constitutional Court number 4/PUU-VII/2009 and decision number 14-17/PUU-V/2007 which legitimize former prisoners as regional head and legislative candidates. This study aimed to analyze the legality of former prisoners to participate in an election and the efforts to be made after the Constitutional Court\u27s decisions in terms of building democracy in Indonesia. This study used normative research method with statute and conceptual approaches. The results of this study concluded that first, a former prisoner has constitutional right as a candidate in an election that is a part of non-derogable rights except by a court decision that has permanent legal force. Some efforts to build democracy are made by issuing regulations that technically explain the decisions of the Constitutional Court for former prisoners who will participate in an election as well as severe sanctions for the violations, and involving the supervision of election organizing committee in the nomination process

Analisis Praanggapan Pada Slogan Iklan “Kendaraan” Harian Surat Kabar Solopos Edisi November 2013 – Februari 2014

Tujuan penelitian ini untuk mendeskripsikan praanggapan yang muncul pada slogan iklan “Kendaraan” harian surat kabar Solopos edisi November 2013 – Februariv2014 dan menganalisis makna pada praanggapan slogan iklan “Kendaraan” harian surat kabar Solopos edisi November 2013 – Februari 2014. Penelitian ini berjenis penelitian kualitatif. Objek yang akan dikaji dalamvpenelitian ini adalah praanggapan pada slogan iklan “Kendaraan” harian surat kabarvSolopos edisi November 2013 – Februari 2014. Sumber data dalam penelitian inivadalah sumber data tertulis berupa kata-kata atau slogan iklan kendaraan pada wacana yang berupa praanggapan pada slogan iklan “Kendaraan” harian surat kabar Solopos edisi November 2013 – Februari 2014. Teknik pengumpulan data yang digunakan adalah metode simak dengan teknik catat. Validitas data yang digunakan adalah teknik trianggulasi data. Metode analisis data yang digunakan adalah metode agih. Hasil penelitian dalam penelitian ini menegaskan bahwa dari 60 data slogan iklan diperoleh 100 praanggapan yang terdiri dari lima jenis praanggapan. Sesuai data yang di analisis praanggapan pada slogan iklan “Kendaraan” harian surat kabar Solopos edisi November 2013 – Februari 2014 ditemukan 9 data praanggapan eksistensial, 61 data praanggapan faktif, 20 data praanggapan leksikal, 9 data praanggapan struktural, dan 1 data praanggapan konterfaktual. Dari kelima jenis praanggapan yang paling sering muncul dalam slogan iklan “Kendaraan” harian surat kabar Solopos edisi November 2013 – Februari 2014 yaitu praanggapan faktif. Hal ini disebabkan karena informasi yang ditampilkan dalam slogan iklan “Kendaraan” merupakan informasi yang marak diberitakan oleh media, sehingga masyarakat akan cenderung tahu bahwa apa yang disampaikan adalah kebenaran