Variable Cycle Engine Technology Program Planning and Definition Study

The variable stream control engine, VSCE-502B, was selected as the base engine, with the inverted flow engine concept selected as a backup. Critical component technologies were identified, and technology programs were formulated. Several engine configurations were defined on a preliminary basis to serve as demonstration vehicles for the various technologies. The different configurations present compromises in cost, technical risk, and technology return. Plans for possible variably cycle engine technology programs were formulated by synthesizing the technology requirements with the different demonstrator configurations

Observations of fast anisotropic ion heating, ion cooling, and ion recycling in large-amplitude drift waves

Large-amplitude drift wave fluctuations are observed to cause severe ion temperature oscillations in plasmas of the Caltech Encore tokamak [J. M. McChesney, P. M. Bellan, and R. A. Stern, Phys. Fluids B 3, 3370 (1991)]. Experimental investigations of the complete ion dynamical behavior in these waves are presented. The wave electric field excites stochastic ion orbits in the plane normal (perpendicular to) to B, resulting in rapid perpendicular to heating. Ion-ion collisions impart energy along (parallel to) B, relaxing the perpendicular to-parallel to temperature anisotropy. Hot ions with large orbit radii escape confinement, reaching the chamber wall and cooling the distribution. Cold ions from the plasma edge convect back into the plasma (i.e., recycle), causing further cooling and significantly replenishing the density depleted by orbit losses. The ion-ion collision period tau(ii)similar to Tau(3/2)/n fluctuates strongly with the drift wave phase, due to intense (approximate to 50%) fluctuations in n and Tau. Evidence for particle recycling is given by observations of bimodal ion velocity distributions near the plasma edge, indicating the presence of cold ions (0.4 eV) superposed atop the hot (4-8 eV) plasma background. These appear periodically, synchronous with the drift wave phase at which ion fluid flow from the wall toward the plasma center peaks. Evidence is presented that such a periodic heat/loss/recycle/cool process is expected in plasmas with strong stochastic heating

Real-time phase-selective data acquisition system for measurement of wave phenomena in pulsed plasma discharges

A novel data acquisition system and methodology have been developed for the study of wave phenomena in pulsed plasma discharges. The method effectively reduces experimental uncertainty due to shot-to-shot fluctuations in high repetition rate experiments. Real-time analysis of each wave form allows classification of discharges by wave amplitude, phase, or other features. Measurements can then be constructed from subsets of discharges having similar wave properties. The method clarifies the trade-offs between experimental uncertainty reduction and increased demand for data storage capacity and acquisition time. Finally, this data acquisition system is simple to implement and requires relatively little equipment: only a wave form digitizer and a moderately fast computer

Implementation of a Standardized Handoff System for a General Surgery Residency Program

Introduction: The I-PASS Handoff Bundle is an evidence based standardized set of educational materials designed to decrease handoff failures in patient care. Two of every three sentinel events , the most serious events reported to the Joint Commission, are due to failures of communication, including miscommunication during patient care handoffs. Implementation of the I-PASS method results in decreased medical errors and preventable adverse events There are few studies that evaluate this validated method in the context of a General Surgery resident program We aim to implement the I-PASS system into the transition of care process for General Surgery residents at our institution, and to analyze of the quality of the handoff process before and after the implementation.https://jdc.jefferson.edu/patientsafetyposters/1047/thumbnail.jp

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM.

Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an excellent natural model that is genotypically and phenotypically similar to human HCM. The Maine Coon and Ragdoll cats are particularly valuable models of HCM because of myosin binding protein-C mutations and even higher disease incidence compared to the overall feline population. The cat overcomes many of the limitations of rodent HCM models, and can provide enhanced translation of information from in vitro and induced small animal models to human clinical trials. Physicians and veterinarians working together in a collaborative and interdisciplinary approach can accelerate the discovery of more effective treatments for this and other cardiovascular diseases affecting human and veterinary patients

Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions

Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of vascularized tumor growth, where the main novelty is the modeling of the interplay between functional tumor vasculature and effector cell recruitment dynamics. Parameters are calibrated on the basis of different in vivo immunocompromised Rag1-/- and wild-type (WT) BALB/c murine tumor growth experiments. The model analysis supports that tumor vasculature normalization can be a plausible and effective strategy to treat cancer when combined with appropriate immuno-stimulations. We find that improved levels of functional tumor vasculature, potentially mediated by normalization or stress alleviation strategies, can provide beneficial outcomes in terms of tumor burden reduction and growth control. Normalization of tumor blood vessels opens a therapeutic window of opportunity to augment the antitumor immune responses, as well as to reduce the intratumoral immunosuppression and induced-hypoxia due to vascular abnormalities. The potential success of normalizing tumor-associated vasculature closely depends on the effector cell recruitment dynamics and tumor sizes. Furthermore, an arbitrary increase of initial effector cell concentration does not necessarily imply a better tumor control. We evidence the existence of an optimal concentration range of effector cells for tumor shrinkage. Based on these findings, we suggest a theory-driven therapeutic proposal that optimally combines immuno- and vaso-modulatory interventions

Monopole and Dyon Bound States in N=2 Supersymmetric Yang-Mills Theories

We study the existence of monopole bound states saturating the BPS bound in N=2 supersymmetric Yang-Mills theories. We describe how the existence of such bound states relates to the topology of index bundles over the moduli space of BPS solutions. Using an $L^2$ index theorem, we prove the existence of certain BPS states predicted by Seiberg and Witten based on their study of the vacuum structure of N=2 Yang-Mills theories.Comment: 34 pages, harvma