Micro turbinas de gas con generadores de alta velocidad para sistemas de energia locales inteligentes

At present, the share of energy collected from renewable resources and low-power units is growing, and the generation becomes distributed, having many facilities that operate in co-generation mode. That is why the construction of an energy system with distributed heterogeneous sources and the improvement of its efficiency have become widely discussed issues. This paper proposes a solution of a local smart energy systemfortheTechnoEcoPark, a sciencepark of Rostov State Transport University, Rostov, Russia. The solution aims to integrate the distributed generation facilities, including environmentally friendly renewable resources, grid infrastructure and consumers with controllable and uncontrollable load. Theapproachtothe problem is the application of a smart control systemthatmanagesgeneration, distribution and consumptionof energy in a mini-CHP-based autonomous energy system. Such smart control systems reveal the trends of optimal energydistribution in a autonomousenergysystem. The study substantiates that installation of an in-house mini-CHP can solve the task of supplying heat and powertotheTechnoEcoPark. The important advantage of the solution is a significant reduction of expenses on energy consumption as the generation costs less compared to the grid tariffs. The proposed energy supply system of the TechnoEcoPark exemplifies the integration of heterogeneous heat and power sources and consumers into a commonnetwork. The paper outlines the mechanisms of the energy system efficiency improvement. These mechanisms make it possible to provide heat and power supply services to consumers and to return the generated power into the centralized grid. The materials of the paper can be of use to the specialists and researchers who are interested in generation and distribution of energy in autonomous systems.En la actualidad, la proporción de energía recolectada de recursos renovables y unidades de baja potencia está creciendo, y la generación se distribuye, teniendo muchas instalaciones que operan en modo de cogeneración. Es por eso que la construcción de un sistema de energía con fuentes heterogéneas distribuidas y la mejora de su eficiencia se han convertido en temas ampliamente discutidos. Este documento propone una solución de un sistema de energía inteligente local para TechnoEcoPark, un parque científico de la Universidad Estatal de Transporte de Rostov, Rostov, Rusia. La solución tiene como objetivo integrar las instalaciones de generación distribuida, incluidos los recursos renovables ecológicos, la infraestructura de la red y los consumidores con carga controlable e incontrolable. El enfoque del problema es la aplicación de un sistema de control inteligente que gestiona la generación, distribución y consumo de energía en un sistema de energía autónomo basado en mini-CHP. Tales sistemas de control inteligente revelan las tendencias de distribución óptima de energía en un sistema energético autónomo. El estudio confirma que la instalación de un mini-CHP interno puede resolver la tarea de suministrar calor y energía al TechnoEcoPark. La ventaja importante de la solución es una reducción significativa de los gastos en consumo de energía, ya que la generación cuesta menos en comparación con las tarifas de la red. El sistema de suministro de energía propuesto por TechnoEcoPark ejemplifica la integración de fuentes heterogéneas de calor y energía y consumidores en una red común. El documento describe los mecanismos de mejora de la eficiencia del sistema energético. Estos mecanismos permiten proporcionar servicios de suministro de calor y energía a los consumidores y devolver la energía generada a la red centralizada. Los materiales del documento pueden ser de utilidad para los especialistas e investigadores interesados ​​en la generación y distribución de energía en sistemas autónomos

An Indacenopicene‐based Buckybowl Catcher for Recognition of Fullerenes

A novel buckybowl catcher with an extended π-surface has been synthesized via cross-coupling of two bowl shaped bromoindacenopicene moieties with a tolyl linker. The obtained catcher has been unambiguously characterized by 2D-NMR and mass spectrometry. DFT calculations indicate that the curved shape of the receptor moieties is favourable for binding fullerenes. Effective binding was confirmed for interactions with C$_{60}$ and C$_{70}$ utilizing NMR spectroscopy and isothermal titration calorimetry (ITC). The resulting binding values show a higher affinity of the catcher towards C$_{70}$ over C$_{60}$. The designed catcher demonstrated the fundamental possibility of creating sensors for spherical aromaticity

Исправление к статье «Бифункциональные хелаторы к катиону галлия»

Page 126, in Acknowledgments instead ofНа странице 126 в разделе Благодарности вмест

Бифункциональные хелаторы к катиону галлия

Objectives. The chemistry of 67Ga and 68Ga radionuclides plays a key role in nuclear medicine for applications in radiopharmaceuticals, in particular, in noninvasive in vivo molecular imaging techniques. The use of radiometals for labeling biomolecules typically requires the use of bifunctional chelators, which contain a functional group for covalent bonding with the targeting vector in addition to the polydentate fragment coordinating the metal. The aim of the present review article is to analyze the currently accumulated experimental material on the development and application of bifunctional chelators of gallium cations in medical research, as well as to identify the main requirements for the structure of the chelator and its complexes with 68Ga, which are used to create effective Gabased pharmaceutical preparations.Results. The review analyzed macrocyclic bifunctional chelators forming stable in vivo complexes with 68Ga and acyclic chelators, whose main advantage is faster complexation kinetics due to the short half-life of 68Ga. The advantages and disadvantages of both types of ligands were evaluated. In addition, a critical analysis of the binding constants and the conditions for the formation of complexes was presented. Examples of the influence of the geometry, lipophilicity, and total charge of the metal complex on the biodistribution of target radiopharmaceuticals were also given.Conclusions. Despite the progress made in the considered areas of bifunctional chelators, the problem of correlating the chemical structure of a metal-based radiopharmaceutical with its behavior in vivo remains important. Comparative studies of drugs having an identical targeting vector but containing different bifunctional chelating agents could help further elucidate the effectof metal chelate moiety on pharmacokinetics. In order to create effective bifunctional chelating agents, it is necessary to take into account such factors as the stability and inertness of the chelator and its complexes under physiological conditions, lipophilicity, complexation kinetics, chelation selectivity, combinatoriality of the basic structure, along with economic aspects, e.g., the availability of raw materials and the complexity of the synthesis scheme.Цели. Химия радионуклидов 67Ga и 68Ga играет одну из ключевых ролей в ядерной медици­не для применения в радиофармпрепаратах, в частности, в неинвазивных методах мо­лекулярной визуализации in vivo. Использование радиометаллов для мечения биомолекул обычно требует использования бифункциональных хелаторов, которые, кроме полиден­татного фрагмента, координирующего металл, содержат функциональную группу для ковалентного связывания с вектором-мишенью. Цели данного обзора – проанализировать накопленный к настоящему времени экспериментальный материал, касающийся разра­ботки и применения в медицинских исследованиях бифункциональных хелаторов к кати­ону галлия, а также выявить и проанализировать основные требования, предъявляемые к структуре хелатора и его комплексов с 68Ga, необходимые для создания эффективных фармакологических препаратов на его основе.Результаты. Рассмотрены макроциклические бифункциональные хелаторы, образую­щие стабильные in vivo комплексы с 68Ga, а также ациклические хелаторы, преимуще­ство которых заключается в более быстрой кинетике комплексообразования, что явля­ется ключевым фактором, учитывающим короткий период полураспада 68Ga. Проведена оценка достоинств и недостатков обоих типов лигандов. Кроме того, осуществлен кри­тический анализ констант связывания и условий образования комплексов. Рассмотрены примеры влияния природы металлического комплекса (геометрия, липофильность, об­щий заряд) на биораспределение целевых радиофармацевтических препаратов.Выводы. Несмотря на достигнутые успехи в рассмотренных направлениях создания би­фунциональных хелаторов, по-прежнему важной остается проблема корреляции хими­ческой структуры радиофармпрепаратов на основе металлов с их поведением in vivo. В этом отношении сравнительные исследования препаратов, имеющих идентичный вектор нацеливания, но включающих разные бифункциональные хелатируюшие агенты, могут помочь в дальнейшем выявлении влияния металл-хелатного фрагмента на фар­макокинетику. В целом можно отметить, что для создания эффективного бифункци­онального хелатирующего агента нужно принимать во внимание целую совокупность факторов, включающую стабильность и инертность хелатора и его комплексов в физиологических условиях, липофильность, кинетику комплексообразования, селективность хеланирования, комбинаторность базовой структуры, а также экономические аспекты: доступность сырья, сложность схемы синтеза

The impact of terahertz radiation on an extremophilic archaean Halorubrum saccharovorum proteome

Nonthermal effects of terahertz radiation on living objects are currently intensely studied, as more sources of this radiation type and devices employing it are being constructed. Terahertz radiation is increasingly used in security and inspection systems, medical and scientific appliances due to its low quant energy, which does not cause severe effects on organisms as other radiation types with higher quant energies do. The aim of this study was the identification of protein complexes participating in the response of the archaea Halorubrum saccharovorum H3 isolated from an extreme natural environment to terahertz radiation. We developed a microfluidic system for irradiation of bacterial and archaeal cultures with terahertz radiation and performed a 5-hour-long exposure of H. saccharovorum to terahertz radiation at a wavelength of 130 μm and a power density of 0.8 Wt per cm2 for 5 h. We identified under- or overexpressed proteins in response to terahertz radiation using 2D electrophoresis with subsequent MALDI-TOF mass spectrometry. A total of 16 differentially expressed protein fractions with at least 1.5-fold changes in expression level were detected. The obtained data suggest that Halorubrum cells respond to exposure to terahertz radiation by expression changes in gene products involved in translation regulation

Improvement of the retrieval algorithm for GOSAT SWIR XCO₂ and XCH₄ and their validation using TCCON data

The column-averaged dry-air mole fractions of carbon dioxide and methane (XCO2 and XCH4) have been retrieved from Greenhouse gases Observing SATellite (GOSAT) Short-Wavelength InfraRed (SWIR) observations and released as a SWIR L2 product from the National Institute for Environmental Studies (NIES). XCO2 and XCH4 retrieved using the version 01.xx retrieval algorithm showed large negative biases and standard deviations (−8.85 and 4.75 ppm for XCO2 and −20.4 and 18.9 ppb for XCH4, respectively) compared with data of the Total Carbon Column Observing Network (TCCON). Multiple reasons for these error characteristics (e.g., solar irradiance database, handling of aerosol scattering) are identified and corrected in a revised version of the retrieval algorithm (version 02.xx). The improved retrieval algorithm shows much smaller biases and standard deviations (−1.48 and 2.09 ppm for XCO2 and −5.9 and 12.6 ppb for XCH4, respectively) than the version 01.xx. Also, the number of post-screened measurements is increased, especially at northern mid- and high-latitudinal areas