Phase Diagram of the 1D Kondo Lattice Model

We determine the boundary of the fully polarized ferromagnetic ground state in the one dimensional Kondo lattice model at partial conduction electron band filling by using a newly developed infinite size DMRG method which conserves the total spin quantum number. The obtained paramagnetic to ferromagnetic phase boundary is below $J \approx 3.5$ for the whole range of band filling. By this we solve the controversy in the phase diagram over the extent of the ferromagnetic region close to half filling.Comment: 6 pages, 4 EPS figures. Presented at MOS9

Intérêt thérapeutique de la spiruline chez l’homme: revue général

Le Spirulina platensis est une algue utilisée pour ses effets nutritionnel et thérapeutique. De nombreuses études ont montré son intérêt pour l’homme. Le présent travail résume les études cliniques effectuées avec la spiruline chez homme jusqu’en juin 2012. La méthode a consisté à l’interrogation des bases de données Pubmed, OMS, Medline base donné des Universités de Ouagadougou et de Grenoble, centre de pharmacovigilance de Grenoble et de Bordeaux. Seules les études effectuées chez l’homme avec la spiruline uniquement et publiées ont été retenues. Les critères de jugements ont porté sur les paramètres anthropométriques, biologiques, et des données du protocole. Ces études ont montré l’effet de la spiruline sur les maladies cardiovasculaires par la diminution des valeurs des paramètres lipidiques. La spiruline a eu des effets antidiabétiques par la diminution de l’hémoglobine glyquée et de la glycémie chez les patients diabétiques de type 2. Des effets immuno - modulateurs, anti-inflammatoires, anticancéreux, antianémiques, de la spiruline ont été prouvés. La récupération nutritionnelle de la spiruline a été prouvée dans six études dont trois chez les personnes vivant avec le VIH. Ces résultats montrent les multiples effets thérapeutiques de la spiruline mais doivent être confirmés par des échantillons de grandes tailles.Mots clés: Intérêt, thérapeutique, Spiruline, Homme

Azimuthal anisotropy of jet quenching at LHC

We analyze the azimuthal anisotropy of jet spectra due to energy loss of hard partons in quark-gluon plasma, created initially in nuclear overlap zone in collisions with non-zero impact parameter. The calculations are performed for semi-central Pb-Pb collisions at LHC energy.Comment: Talk given at Fourth International Conference "Physics and Astrophysics of Quark-Gluon Plasma", November 26-30, 2001; 4 pages including 4 eps-figure

Dinamika Peran Indonesia Di Arf : Upaya Menyelaraskan Kepentingan Nasional Dengan Tekanan Stuktur Internasional

This study examines the driven factors of Indonesian involvement and developments in the ARF (ASEAN Regional Forum) by applying neo-classical realism perspective. The driven factors are both the external factors such as International structure, and internal ones such as political economic situation, regime interests, and leadership role that are giving impact to Indonesia's foreign policy implementations. The involvement of Indonesia in ARF is primarily influenced by a changing structure of International politics and security in Asia Pacific. In order to ensure the stability of the country that has been integrated into ASEAN, Indonesia is actively involved in the ARF. While, Indonesia's active participation in the multilateral forum is generally to show its role as a leading country in Southeast Asia, and try to balancing powers structure in the region through ASEAN. Thus, to understanding the driven factors of Indonesia's involvement in ARF are correspondence with neoclassical realism theory, which states that country's behavior in the International system needs to be interpreted by variables such as International structure and domestic factors

Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease

Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular and ultimately tissue and organ dysfunction. Mitochondria, as well as being a source of ROS, are vulnerable to oxidative stress-induced damage with a number of key biomolecules being the target of oxidative damage by free radicals, including membrane phospholipids, respiratory chain complexes, proteins, and mitochondrial DNA (mt DNA). As a result, a deficit in cellular energy status may occur along with increased electron leakage and partial reduction of oxygen. This in turn may lead to a further increase in ROS production. Oxidative damage to certain mitochondrial biomolecules has been associated with, and implicated in the pathophysiology of a number of diseases. It is the purpose of this review to discuss the impact of such oxidative stress and subsequent damage by reviewing our current knowledge of the pathophysiology of several inherited mitochondrial disorders together with our understanding of perturbations observed in the more commonly acquired neurodegenerative disorders such as Parkinson’s disease (PD). Furthermore, the potential use and feasibility of antioxidant therapies as an adjunct to lower the accumulation of damaging oxidative species and hence slow disease progression will also be discussed

Particle acceleration and the origin of gamma-ray emission from Fermi Bubbles

Fermi LAT has discovered two extended gamma-ray bubbles above and below the galactic plane. We propose that their origin is due to the energy release in the Galactic center (GC) as a result of quasi-periodic star accretion onto the central black hole. Shocks generated by these processes propagate into the Galactic halo and accelerate particles there. We show that electrons accelerated up to ~10 TeV may be responsible for the observed gamma-ray emission of the bubbles as a result of inverse Compton (IC) scattering on the relic photons. We also suggest that the Bubble could generate the flux of CR protons at energies > 10^15 eV because the shocks in the Bubble have much larger length scales and longer lifetimes in comparison with those in SNRs. This may explain the the CR spectrum above the knee.Comment: 5 pages, 4 figures. Expanded version of the contribution to the 32nd ICRC, Beijing, #0589. To appear in the proceeding

The Size Distribution of Kuiper Belt Objects

We describe analytical and numerical collisional evolution calculations for the size distribution of icy bodies in the Kuiper Belt. For a wide range of bulk properties, initial masses, and orbital parameters, our results yield power-law cumulative size distributions, N_C propto r^{-q}, with q_L = 3.5 for large bodies with radii of 10-100 km, and q_s = 2.5-3 for small bodies with radii lesss than 0.1-1 km. The transition between the two power laws occurs at a break radius of 1-30 km. The break radius is more sensitive to the initial mass in the Kuiper Belt and the amount of stirring by Neptune than the bulk properties of individual Kuiper Belt objects (KBOs). Comparisons with observations indicate that most models can explain the observed sky surface density of KBOs for red magnitudes, R = 22-27. For R 28, the model surface density is sensitive to the amount of stirring by Neptune, suggesting that the size distribution of icy planets in the outer solar system provides independent constraints on the formation of Neptune.Comment: 24 pages of text, 12 figures; to appear in the Astronomical Journal, October 200

Densities and abundances of hot cometary ions in the coma of P/Halley

On its flight by P/Halley, the Giotto spacecraft carried a High Energy Range Spectrometer (HERS) for measuring the properties of cometary ions picked up by the solar wind in the nearly collisionless regions of the coma. Preliminary estimates of the ion densities observed by HERS were reevaluated and extended; density profiles along the Giotto trajectory are presented for 13 values of ion mass/charge. Comparison with the physical-chemical model of the interaction of sunlight and the solar wind with the comet by other researchers reveals that, with the exception of protons and H2(+), all ion densities were at least an order of magnitude higher than predicted. The high ion densities cannot be explained on the basis of compression of the plasma, but require additional or stronger ionization mechanisms. Ratios of the densities of different ion species reveal an overabundance of carbonaceous material and an underabundance of H2(+) compared to the predictions of the Schmidt. While the densities of solar wind ions (H(+) and He(++)) changed sharply across a magnetic discontinuity located 1.35(10)(exp 5) km from the comet, this feature, which has been called both the 'cometopause' and the 'magnetic pileup boundary' was barely distinguishable in the density profiles of hot cometary ions. This result is consistent with the interpretation that the magnetic pileup boundary detected by Giotto was caused by a discontinuity in the solar wind and is not an intrinsic feature of the interaction of the solar wind with an active comet

Assessment of Mitochondrial Dysfunction in Experimental Autoimmune Encephalomyelitis (EAE) Models of Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that involves the autoreactive T-cell attack on axonal myelin sheath. Lesions or plaques formed as a result of repeated damage and repair mechanisms lead to impaired relay of electrical impulses along the nerve, manifesting as clinical symptoms of MS. Evidence from studies in experimental autoimmune encephalomyelitis (EAE) models of MS strongly suggests that mitochondrial dysfunction presents at the onset of disease and throughout the disease course. The aim of this study was to determine if mitochondrial dysfunction occurs before clinical symptoms arise, and whether this is confined to the CNS. EAE was induced in C57B/L6 mice, and citrate synthase and mitochondrial respiratory chain (MRC) complex I–IV activities were assayed at presymptomatic (3 or 10 days post first immunisation (3 or 10 DPI)) and asymptomatic (17 days post first immunisation (17 DPI) time-points in central nervous system (CNS; spinal cord) and peripheral (liver and jaw muscle) tissues. Samples from animals immunised with myelin oligodendrocyte glycoprotein (MOG) as EAE models were compared with control animals immunised with adjuvant (ADJ) only. Significant changes in MOG compared to control ADJ animals in MRC complex I activity occurred only at presymptomatic stages, with an increase in the spinal cord at 10 DPI (87.9%), an increase at 3 DPI (25.6%) and decrease at 10 DPI (22.3%) in the jaw muscle, and an increase in the liver at 10 DPI (71.5%). MRC complex II/III activity changes occurred at presymptomatic and the asymptomatic stages of the disease, with a decrease occurring in the spinal cord at 3 DPI (87.6%) and an increase at 17 DPI (36.7%), increase in the jaw muscle at 10 DPI (25.4%), and an increase at 3 DPI (75.2%) and decrease at 17 DPI (95.7%) in the liver. Citrate synthase activity was also significantly decreased at 10 DPI (27.3%) in the liver. No significant changes were observed in complex IV across all three tissues assayed. Our findings reveal evidence that mitochondrial dysfunction is present at the asymptomatic stages in the EAE model of MS, and that the changes in MRC enzyme activities are tissue-specific and are not confined to the CNS

Cell Therapies for Spinal Cord Injury: Trends and Challenges of Current Clinical Trials

Cell therapies have the potential to revolutionize the treatment of spinal cord injury. Basic research has progressed significantly in recent years, with a plethora of cell types now reaching early-phase human clinical trials, offering new strategies to repair the spinal cord. However, despite initial enthusiasm for preclinical and early-phase clinical trials, there has been a notable hiatus in the translation of cell therapies to routine clinical practice. Here, we review cell therapies that have reached clinical trials for spinal cord injury, providing a snapshot of all registered human trials and a summary of all published studies. Of registered trials, the majority have used autologous cells and approximately a third have been government funded, a third industry sponsored, and a third funded by university or healthcare systems. A total of 37 cell therapy trials have been published, primarily using stem cells, although a smaller number have used Schwann cells or olfactory ensheathing cells. Significant challenges remain for cell therapy trials in this area, including achieving stringent regulatory standards, ensuring appropriately powered efficacy trials, and establishing sustainable long-term funding. However, cell therapies hold great promise for human spinal cord repair and future trials must continue to capitalize on the exciting developments emerging from preclinical studies