Evolution of Military Hospitals Architecture in Russia from 1707 Year Till Nowadays

In article authors show the history of evolution of military hospitals in Russia from 1707. More than 300 years are presented in a short to draw a picture of development of this type of buildings. Special attention is devoted to the modern projects and their characteristics. Also authors consider field and mobile hospitals, their constructivepeculiar properties and predictable future of this sphere

Архитектурно-планировочный анализ Демидовского заводского госпиталя: история почти 200-летней эксплуатации

Article is devoted to history one of the first Ural medical institutions — Demidovsky factory hospital. Authors consider architectural and planning decisions, reconstruction questions, condition of hospital today. During reconstruction the 120 beds hospital turned into clinic on 250 visits, its operation doesn’t stop and today.Статья посвящена истории одного из первых уральских лечебных учреждений — Демидовскому заводскому госпиталю. Авторы рассматривают архитектурно-планировочные решения, вопросы реконструкции, состояние госпиталя на сегодняшний день. В ходе реконструкции госпиталь на 120 коек превратился в поликлинику на 250 посещений, его эксплуатация не прекращается и сегодня

Gastroesophageal reflux disease associated with diseases of the respiratory tract

The European community of gastroenterologists in 1997 recognized GERB as "illness of the 21st century". Diseases of a respiratory tract take the leading place among all extra esophageal implications of a gastroesophageal reflux disease. Among them bronchial asthma and a chronic obstructive pulmonary disease are the most widespread. The study of the features of the current and modern methods of diagnosing bronchial asthma, obstructive sleep apnea syndrome and chronic obstructive pulmonary disease associated with gastroesophageal reflux disease is of great importance for identifying potential obstacles to effective treatment and preventing an increase in the risk of hospitalizations of patients with this co-morbid pathology. The morbidity of the pathology of the respiratory tract, combined with gastroesophageal reflux disease, is steadily growing. There is a large number of publications concerning the relationship between gastroesophageal reflux disease and diseases of the bronchopulmonary system, but the etiopathogenesis and the cause-and-effect relationship of these diseases remain in question. 1t is interesting to note that the syndrome of obstructive sleep apnea is not included in the list of extra-oesophageal manifestations, both probably and reliably associated with gastroesophageal reflux disease (according to the Montreal Consensus, 2006), but is of great interest to researchers in recent years

Social Materials as an Expression of Creative Freedom and Responsibility of a Journalist

Предметом исследования стала действенность СМИ, объектом — социальные медиапроекты. Методами исследования послужили анализ, описание и сравнение. В ходе работы был раскрыт общественный вектор деятельности современных СМИ, становление этого сегмента как полноценного социального института. Приведена связь внутренней интенции журналиста, личностных качеств и последующего продукта. В исследовании была обозначена актуальная тенденция, практика развития отечественных медиакомпаний.The subject of the study was the effectiveness of the media, the object — social media projects. The research methods were analysis, description and comparison. In the course of the work, the public vector of the activity of modern media was revealed, the formation of this segment as a full-fledged social institution. The connection of the internal intention of the journalist, personal qualities and the subsequent product is given. The study identified the current trend and practice of the development of Russian media companies

Architecture and evolution of the Simferopol military hospital from the moment of foundation till present

The article presents history of development of one of the oldest medical institutions, the military hospital named after St. Luke of Crimea, located in the city of Simferopol. For more than 200 years, it has been undergoing many changes and hardships, it has been subjected to many tests, the author considers how the architecture of this institution has changed over the past years. © 2023 Author(s)

Non-conservative Evolution of Cataclysmic Variables

We suggest a new mechanism to account for the loss of angular momentum in binaries with non-conservative mass exchange. It is shown that in some cases the loss of matter can result in increase of the orbital angular momentum of a binary. If included into consideration in evolutionary calculations, this mechanism appreciably extends the range of mass ratios of components for which mass exchange in binaries is stable. It becomes possible to explain the existence of some observed cataclysmic binaries with high donor/accretor mass ratio, which was prohibited in conservative evolution models.Comment: LaTeX, 32 pages, to be published in Astron. Z

T35 Epigenetic changes in human cervical carcinomas associated with viral induced pathogenesis

Epigenetics investigates mechanisms that control inheritance of gene expression program during somatic cell divisions. These mechanisms include regulation by DNA methylation, histone post-translational modifications and nucleosome positioning, functioning of regulatory non-coding RNAs, control of alternative splicing of mRNA precursors and high-order chromatin organization. Genome-wide loss of epigenetic stability and increased epigenetic plasticity are common features of all tumor types. In normal tissues epigenetic plasticity allow cells to response on environment signals. Thus, in tumor cells its constitutive activation leads to epigenetic heterogeneity that are the additional hallmark of the most of the classical cancers. Cervical cancers are one of the most interesting models for the analysis of the role of epigenetic changes in tumor progression. These types of tumors are associated with infection of human papilloma viruses of so-called high-risk group (HR-HPV) and characterized by well-defined stages of malignant conversion from intraepithelial neoplasias to carcinomas. The viral DNA can persist in episomal form or integrates into the host-cell genome.Cellular genomes encode genetic information in their linear sequence, but appropriate gene expression requires chromosomes to fold into dynamic complex three-dimensional structures. Scaffold/matrix attachment regions (S/MARs) are specialized genomic DNA sequences that take part in organization of these structures. We demonstrated that methylation of S/MARs was required for their attachment to nuclear matrix and that methylation status of S/MARs was changed in cervical cancer cell compared to normal cells.DNA methylation plays an important role in the regulation of gene expression. We found that methylation of the regulatory sequences in the HPV16 genome specifically changes in transformed compared to the normal cervical epithelial cells. Next, we showed that methylation of the transcription factor binding sites modulates the viral oncogene expression. These data suggest that the HPV16 genome methylation may represent an important mechanism that initiates the development of HPV-associated tumors.Using next generation sequencing, we identified pattern of differentially expressed microRNAs in clinical samples of the cervical lesions. We confirmed expression of microRNAs that have been described previously as well as identified new microRNAs that can be potentially involved in the development and progression of cervical cancer. Spectrum of differentially expressed microRNAs includes microRNAs targeting tumor-suppressor genes as well as oncogenes.Telomerase is a key regulator of cell proliferation. This enzyme is silent in normal cells and activated in most of the tumors. Few forms of RNA (hTERT), encoded by telomerase gene were detected in different tumor cells and among them three forms (alfa, beta and gamma) are most well pronounced. We found that in cervical tumors expression of all three forms are significantly increased. In some cases, we also observe higher level of hTERT expression in neighboring “normal tissue”. The correlation between expression levels of these three forms varied on different stages of the disease (three stages on intraepithelial neoplasias and carcinomas). The function of these three hTERT forms is still not well understood