THE LEVEL AND QUALITY OF LIFE IN MODERN CONDITIONS (ULYANOVSK REGION AS AN EXAMPLE)

The article analyses the level and quality of life of the population of the Ulyanovsk region. The author shows demographic problems, the level of real monetary incomes and real wages. The article gives comparative analysis of the Ulyanovsk region with the Volga Federal District

THE LEVEL AND QUALITY OF LIFE IN MODERN CONDITIONS (ULYANOVSK REGION AS AN EXAMPLE)

The article analyses the level and quality of life of the population of the Ulyanovsk region. The author shows demographic problems, the level of real monetary incomes and real wages. The article gives comparative analysis of the Ulyanovsk region with the Volga Federal District

REGULATION OF WORKING MOBILITY AS A FACTOR OF REGION INVESTMENT ATTRACTIVENESS (ULYANOVSK REGION FOR EXAMPLE)

In the article analyzed existing migration flows in Ulyanovsk region. Using cluster analysis recieved groups of region districts with same migration activities. Found out reasons that have influence on migration process. Analyzed influence of migration to labor market development and given recommends to reducing migration

REGULATION OF WORKING MOBILITY AS A FACTOR OF REGION INVESTMENT ATTRACTIVENESS (ULYANOVSK REGION FOR EXAMPLE)

In the article analyzed existing migration flows in Ulyanovsk region. Using cluster analysis recieved groups of region districts with same migration activities. Found out reasons that have influence on migration process. Analyzed influence of migration to labor market development and given recommends to reducing migration

EVALUATION OF MOTIVATION CONDITIONS FOR REPRODUCTION OF LABOR RESOURCES AND SOCIAL-LABOR RELATIONS IN AGRICULTURE (ON THE EXAMPLE OF THE ULYANOVSK REGION)

The article assesses the motivational conditions for the reproduction of labor resources and social and labor relations in agriculture in the Ulyanovsk region. Reproduction of labor resources is considered. The demographic situation in the region is analyzed. Factors affecting the population size are given. The ways of solving the problem of labor shortage are shown. Internal migration and attracting the working-age population from outside are considered. The number of unemployed registered in the state institutions of the employment service of the Ulyanovsk region is shown and analyzed. The quality of life of the rural population and the development of social infrastructure in the region have been analyzed. The basic directions of an exit from the developed situation are given

DEVELOPMENT OF THE LABOR MARKET IN THE CONDITIONS OF FORMATION OF THE DIGITAL ECONOMY

The key problems of the development of the labor market in the conditions of formation of the digital economy have been considered. The digital economy dictates to all countries of the world the paradigm of development of new directions in the economic sphere. The influence of the digital economy on the state of the labor market has been investigated, a number of its new features has been shown. The number of people employed in the economy by gender and status has been analyzed, and it has been shown, how changes, related to the digital economy, affect the issues of retraining and personnel training. The importance of implementing information and communication technologies in modern Russia, taking into account the needs of the labor market, has been emphasized. Measures have been proposed to solve problems, identified by the results of the study

PERSONAL DEVELOPMENT WITHIN NEW CONCEPTS EDUCATION

In article the question of a modern Russian labor market of its globalization, of the competition is considered. Into the forefront quality of preparation acts by Highschools of the young specialist. New instruments of training and preparation: distant, electronic, media components are shown. Use of computer technologies allows students to take part in professional engineering competitions BEST, to solve difficult production problems to perform at the Olympiads and conferences.В статье рассматривается вопрос о современном российском рынке труда, его глобализации, конкуренции. На первый план выступает качество подготовки вузами молодого специалиста. Показаны новые инструменты обучения и подготовки: дистанционные, электронные, медийные компоненты. Использование компьютерных технологий позволяет студентам принимать участие в профессиональных, инженерных соревнованиях BEST, решать непростые производственные задачи, выступать на олимпиадах, конференциях

Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy

The receptor binding protein of parainfluenza virus, hemagglutinin-neuraminidase (HN), is responsible for actively triggering the viral fusion protein (F) to undergo a conformational change leading to insertion into the target cell and fusion of the virus with the target cell membrane. For proper viral entry to occur, this process must occur when HN is engaged with host cell receptors at the cell surface. It is possible to interfere with this process through premature activation of the F protein, distant from the target cell receptor. Conformational changes in the F protein and adoption of the postfusion form of the protein prior to receptor engagement of HN at the host cell membrane inactivate the virus. We previously identified small molecules that interact with HN and induce it to activate F in an untimely fashion, validating a new antiviral strategy. To obtain highly active pretriggering candidate molecules we carried out a virtual modeling screen for molecules that interact with sialic acid binding site II on HN, which we propose to be the site responsible for activating F. To directly assess the mechanism of action of one such highly effective new premature activating compound, PAC-3066, we use cryo-electron tomography on authentic intact viral particles for the first time to examine the effects of PAC-3066 treatment on the conformation of the viral F protein. We present the first direct observation of the conformational rearrangement induced in the viral F protein.IMPORTANCE Paramyxoviruses, including human parainfluenza virus type 3, are internalized into host cells by fusion between viral and target cell membranes. The receptor binding protein, hemagglutinin-neuraminidase (HN), upon binding to its cell receptor, triggers conformational changes in the fusion protein (F). This action of HN activates F to reach its fusion-competent state. Using small molecules that interact with HN, we can induce the premature activation of F and inactivate the virus. To obtain highly active pretriggering compounds, we carried out a virtual modeling screen for molecules that interact with a sialic acid binding site on HN that we propose to be the site involved in activating F. We use cryo-electron tomography of authentic intact viral particles for the first time to directly assess the mechanism of action of this treatment on the conformation of the viral F protein and present the first direct observation of the induced conformational rearrangement in the viral F protein.This work was supported by National Institute of Allergy and Infectious Diseases (NIAID), NIH, grants R01AI031971 and R01AI114736 to A.M. and by USA-Israel Binational Science Foundation (BSF) grant 2017293 to N.B.-T. E.Y. was partially funded by a fellowship from the Edmond J. Safra Center for Bioinformatics at Tel Aviv University. N.B.-T.’s research is supported in part by the Abraham E. Kazan Chair in Structural Biology, Tel Aviv University.S