PHARMACEUTICAL AND ANALYTICAL STUDY OF TRINETRA RAS – HERBO-MINERAL FORMULATION

Trinetraras is a Kharliya Rasayan mentioned in Yogratnakar for the treatment of Hridroga (Yogratnakar Uttarardha Hridroga Chikitsa 1,2). It consists of Shuddha Parad, Shuddhagandhak and Abhrakbhasma where Bhavanadravya is Arjuna bark decoction. Aim: Pharmaceutical and analytical study of Trinetraras. Materials and methods: Paradshodhan, Gandhakshodhan, Vajrabhrakshodhan, Dhanyabhraknirmana, preparation of Abhrakbhasma, preparation of Kajjali are the procedures required to be performed before the preparation of Trinetraras. Total 40 times Abhrak was subjected to Maransanskar in Gajaputa (40 puti Abhrakbhasma). Trinetraras can be prepared from Shuddha Parad, Shuddhagandhak and Abhrakbhasma, Arjuna bark decoction is needed for 21 Bhavana. Total three batches of Trinetra Ras were prepared as per the classical method mentioned in the reference. Observations and results: Prepared samples of Trinetraras and Abhrakbhasma were tested on the basis of organoleptic and physicochemical parameters. Along with Ayurvedic parameters modern parameters such as L.O.D., L.O.I., pH, conductivity, successive solubility, elemental assay of Hg, S and Fe, TLC, phenolic assay etc. were applied to the samples of Trinetraras. Conclusion: Analytical study of Trinetraras revealed the uniformity of the procedures in the three samples of Trinetraras, as evidenced by the observations of the analytical values of the three samples were not much variation found. Analytical profile showed the presence of the ingredients used. Data generated from pharmaceutical, analytical studies can be used to develop a preliminary standard profile for the formulation of Trinetra Ras

Role of fine needle aspiration cytology in diagnosis of breast lumps

Background: Breast cancer is the most common cancer in women worldwide. Fine needle aspiration cytology is a cost effective, easy procedure in the diagnosis of breast lump.Methods: This was a one year retrospective study between January 2016 and December 2016. Needle aspiration was done in 100 patients presenting with breast lump. Histopathology correlation was done in 33 cases.Results: Fibroadenoma were most common lesions. Malignancy was reported in 13 cases. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were found to be 85%, 100%, 100%, 96.3% and 97% respectively.Conclusions: Fine needle aspiration cytology is a simple, easy, OPD based, cost effective procedure with high sensitivity, specificity and accuracy in diagnosis of breast lumps

High Speed Modified Booth’s Signed 64x64 Bit Multiplier Using Wallace Structure by Radix-32

The Main objective of the implemented work is completely based on enhancing speed performance multiplication process using radix-32 modified Booth algorithm and Wallace Tree Structure. It is designed for fixed length 64x64 bit operands. In Wallace structure, 3:2and 4:2 Compressors are used which accumulate the partial products. The implemented modified Booth multiplier is verified and advantages over the existing multiplier are quantitatively analyzed. This implemented multiplier provides less delay 0.238 ns. Many researchers had been worked and presented the modified booth multiplier with optimized delay. In this paper, it has been shown that the implemented 64 bit multiplier provides better delay in comparison with those existing papers. A VHDL code has been written and successfully synthesized and simulated using Xilinx ISE 13.1 simulator software. Also partial products which are generated are less as compared to conventional multiplier. No. of logic blocks required for fast multiplication process has been reduced in terms of no. of slices in comparison with previous ones. DOI: 10.17762/ijritcc2321-8169.150712

Sacrificial Support Fixture Optimisation for the CNC Rapid Machining of Medical Parts with Thin Ends

The purpose of this paper is to develop a methodology for optimising the shape of automated sacrificial support fixture (SSF) design, so as to machine a part with thin ends (like the hip joint) using a rapid machining process. A sacrificial support fixture is created at the ends of the part to give support to the part during machining. Finite element analysis (FEA) is used to optimise the shape of sacrificial support fixture for the machining of a part via computer numerical control rapid prototyping (CNC-RP). The research work proves that the optimised design of a sacrificial support fixture has been extremely flexible in securing a variety of intricate parts having thin ends in the computer numerical control rapid prototyping machining. For rapid machining, a tapered support is best suited for the part with thin ends. The limitation of the optimised sacrificial support fixture, designed for an intricate part, is that it is applicable only to CNC machining with the four axis rotational setup

STUDY OF NIRUDDHA PRAKASH WITH SPECIAL REFERENCE TO PHIMOSIS: A REVIEW

In Ayurvedic Samhita Niruddha Prakash (phimosis) vyadhi (disease) is described to be formed because of vitiated Vata Dosha where constricted Shishnacharma (prepuce) covers Mani (glans penis). This creates obstructed, slow urine flow and the prepuce could not be retracted. Treatment described in Ayurvedic epics is dilatation of preputial meatus by Niruddhaprakash Nadiyantra and Vatadosh Shamak medicated tail (oil) Parishek (fomentation). Surgery is advised if this measure fails. Niruddha prakash has similar features to that of phimosis described in modern medical science. Recent researches shows that glans penis and prepuce has common epithelium and its complete separation essential for complete prepitual retraction exposing whole of glans may normally occur up to the age of 17 years. This may lead to wrong diagnosis of phimosis. Circumcision is considered as treatment of choice for phimosis. In this review article efforts have made to analyze description of Niruddha prakash in Ayurved Epics, and recent researches regarding development and separation of prepuce, non surgical treatment of phimosis for bypass of surgical and anaesthetic complications, and surgical procedure with less complications compared to circumcision that will preserve prepuce as it is important structure protecting glans and urethral meatus and also for coital pleasure.

Evaluation of the IS6110 PCR assay for the rapid diagnosis of tuberculous meningitis

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Visualize and Correlate changes to network device to anomalies in network

NOM products enable users to manage their network by enforcing controlled changes to configuration of network devices apart from monitoring performance, fault and compliance of all devices in their network. While monitoring a network, it is always been a challenge to deduce and represent correlation, among anomalies across thousands of devices, in a format that users can consume, validate and act on. This paper proposes a method to deduce and visualize, possibly related anomalies on connected devices in the network based on user’s selection of an anomaly on a device of interest. While this paper takes network domain as an example to demonstrate the idea, it could be applied to any of the infrastructure and application management solutions in a datacenter. This paper proposes a unique approach to solve this problem by leveraging ML and network operator’s deployment/domain knowledge

Differentiation in morphometric traits of Chanos chanos stocks along the Indian coast

233-238Stocks of Chanos chanos (Milkfish) are identified based on the morphometric traits from four different locations from the Indian coast. A total of 246 fish samples were collected for the present study from the East coast (Mandapam Lagoon and Chilika Lake) and West coast (Mandovi–Zuari estuarine system and Cochin backwaters). Digital imaging techniques were employed to extract 18 morphometric characters from the specimens. Principal component analysis showed that horizontal depth measurements, dorsal fin length and pelvic fin length were helpful in differentiating the milkfish populations. First and second principal components explained the variance of 37.62% and 31.26 % respectively. Cross-validated results of the discriminant analysis showed the overall classification rate of 90.4%. The present study decoded the differentiation and occurrence of separate stocks of milkfish in Indian waters. The findings of the present study could be utilized for conservation and management of the species

Prox-imal Femoral Nail in Reverse Trochanteric Femoral Fractures: An Analysis of 53 Cases at One Year Follow-Up

Abstract Treatment of reverse oblique trochanteric femoral fractures poses a lot of challenges. There have been proponents of intramedullary devices as well as extramedullary devices. We present the results of proximal femoral nailing surgery performed for reverse obliquity intertrochanteric fractures using two proximal lag screws and a nail of 250 mm. There is prospective study of fifty three patients with AO/OTA 31 A-A3 fractures being treated by proximal femoral nailing in our institute after seeking approval from the Hospital ethics board. The quality of the reduction, the operative time, complications and the functional status of the patients were the parameters on which the results were evaluated. The mean Harris hip score was 76.66 (range 70 -93) and the mean Barthel activity score was 16.21 (range 12 -20). The average surgical time was 50 minutes and the mean consolidation time was 11.5 weeks. Intramedullary nailing with proximal femoral nails seems to be a good option in the treatment of reverse obliquity intertrochanteric fractures as against the various existing options available for the management

Recent Innovations & Daily Problems. A new prosthesis in inguinal hernia repair:preliminary results of a pilot study.

Introduction: Elective surgery for inguinal hernia is affected by very low mortality « 1 per 10000 operation); in contrast, when surgery is carried out for complicated inguinal hernia, risks of postoperative complication are higher. TAPP is a world-wide accepted surgical practice in the treatment of elective bilateral or recurrent inguinal hernia, above all in young patients. Few exploratory studies were published on laparoscopic approach in the treatment of urgent complicated inguinal hernia. Aim of this study was to analyze feasibility (operative time, conversion rate), safety (postoperative morbidity, length of hospital stay) and quality of life (acute and chronic pain, return to work) of trans-abdominal pre-peritoneal laparoscopic hernia repair in acute incarcerated inguinal hernia. Rationale of laparoscopic trans-abdominal approach is the easier hernia reduction under vision and a better exploration of the abdominal cavity. Methods: from September 2012 to September 2013, 15 consecutive patients admitted in emergency at the Division of General Surgery of University "Sapienza", Polo Pontino, for acute incarcerated inguinal hernia were submitted to TAPP using 3 trocars (1 of 10 mm and 2 of 5mm) and polyester prosthesis fixed by fibrin glue. Exclusion criteria for laparoscopic approach were age III, previous abdominal surgery, signs of strangulated hernia. All of them were evaluated for operative time, conversion rate, postoperative morbidity, organ resection or other surgery required. All patients were scored for pain by Visual Analogic Scale (VAS) during postoperative in hospital stay at 7 days, 1,6 and 12 months after surgery. Results: median follow-up was 16 months and 12 as minimum. In all cases reduction of hernia was always possible and none conversion to open surgery was recorded, median operative time was 89 minutes (55-137 as range), omental resection was carried out in one patient (6,6%), no other organ resections needed, whereas contralateral hernia was diagnosed and repaired at the same time in 4 patients (26,6%). No major complications were observed, median blood loss was 100 ml, minor morbidity was contained to 18% represented by fever and wound infection of surgical umbilical scar. Median in hospital stay was 1,5 days with 1-5 days as range. Postoperative median acute pain, measured by visual analogic scale (VAS), was 2 (range:0-4), none patient referred any pain during follow-up. Median time of return to work was 6,5 days, ranged between 3 to 15 days. Patients' compliance to treatment and to follow-up was complete as well their satisfaction. Conclusions: In centres skilled for laparoscopy in emergency, TAPP could be considered a feasible and safe technique. In well-selected patients (especially if emolled in controlled clinical trial) TAPP could represent an alternative surgical approach for complicated incarcerated inguinal hernia to conventional open surgery even in urgency. The main advantages of laparoscopic approach are the ability to perform surgical hernia reduction under vision, a better exploration and evaluation of abdominal cavity and diagnosis and treatment of eventual contralateral defect of wall, otherwise often missed. Finally, the good control of acute and chronic pain, faster return to normal activity and work, better aesthetic results contributed to total satisfaction and compliance of the patients