51 research outputs found
Development of an advanced water filtering system based on graphene irradiated by gas cluster and highly charged ions
Effects of a heavy low energy ion bombardment
of various materials are explored for the purposes of
creating new materials that have advanced
properties. In this study, features of the defectsβ
formation in the samples of graphene, graphene
oxide and silicon by Ar cluster ions irradiation are
given..
Self-Heating Model of Spherical Aluminum Nanoparticle Oxidation
Aluminum-oxygen reaction is important in highly energetic and high pressure generating systems. Nanoenergetic thermites include mixtures of nanostructured Al and oxidizer particles. The main distinguishing features of these reactive systems are their significant enthalpy release and tunable rate of energy discharge, which gives rise to a wide range of combustion rates, energy release, and ignition sensitivity. In this paper, we consider rapid oxidation of a spherically symmetric aluminum particle. We use the Cabrera Mott oxidation model to describe the kinetics of oxide growth of an aluminum nanoparticle and to predict reaction temperature and oxidation time. We assume that aluminum particle of diameter 10 to 50 nm is covered by a thin oxide layer (1-4 nm) and is surrounded by abundant amount of oxygen stored by oxidizers. The particle is rapidly heated up to ignition temperature to initiate self-sustaining oxidation reaction as a result of highly exothermic reaction. We numerically investigated the oxidation model by using COMSOL multiphysics software. The software creates a mesh fitted to geometric configuration of a nanoparticle, and performs finite element method computations
Development of an advanced water filtering system based on graphene irradiated by gas cluster and highly charged ions
Effects of a heavy low energy ion bombardment
of various materials are explored for the purposes of
creating new materials that have advanced
properties. In this study, features of the defectsβ
formation in the samples of graphene, graphene
oxide and silicon by Ar cluster ions irradiation are
given..
Luminescence of sapphire single crystals irradiated with high-power ion beams
Optical absorption, photo- and cathodoluminescence of a sapphire single crystal (Ξ±-Al 2 O 3 ) exposed to pulsed nanosecond radiation with high-power ion beams C + /H + with an energy of 300 keV and energy density 0.5-1.5 J/cm 2 were first investigated in this work. It was found that under ion irradiation accompanied by heating of sapphire up to melting, the formation of F-type centers and their aggregates associated with oxygen vacancies was observed in the crystals under study. These centers have luminescence bands at 330, 410 and 500 nm which depend on the type and wavelength of the optical excitation. The appearance of a new PL emission at 435 nm, presumably associated with a complex vacancy-impurity defect, was also observed in the photoluminescence spectra. Β© Published under licence by IOP Publishing Ltd.The work was supported by the initiative scientific project β 16.5186.2017/8.9 of the Ministry of Education and Science of the Russian Federation. Experiments on ion irradiation of sapphire was done at the KIPT as a part of the state task
Effect of the Porosity Ran ge and its Nature on Mechanical Properties of Magnesium Alloys Mg-Al-Zn
The possibilities of porosity adjustment in alloys of the Mg-Al-Zn system obtained by melting under a layer of flux were studied. The elements that significantly increase corrosion resistance and heat resistance, and improve mechanical strength and technological characteristics were chosen as doping components. Measurements showed that the range of porosity varied between 5.9 and 14.8%, and the relationshipΠΒ between porosity and strength of alloys was defined for the first time for this range. For an alloy with porosity of 14.8%, the percentage of open pores was 12.8% while the percentage of closed pores was 2%. Micro-hardness of alloys with the given porosity was 661 MPa after casting, 876 MPa after homogenizing annealing and 897 MPa after artificial aging. The tensile strength was 235 MPa. Analysis identified that the main cause of porosity was catching atoms of hydrogen from atmosphere by molten alloys during melting, casting and liquation. In order to reduce the percentage of porosity alloys were doped by metal manganese, liquid metal was processed by calcium and hexachloroethane, and casting form was treated by boron nitride. These manipulations resulted in reduction of samples porosity up to 5.9%, increase of tensile strength up to 240 MPa. Open porosity was 4.5%, while closed porosity was 1.4%. At the same time micro-hardness of cast samples was 867 MPa, 903 MPa after homogenization annealing and 961 MPa after artificial aging. Further reduction of porosity and increasing of magnesium alloys strength is possible with the use of inert gases or vacuum melting. Samples porosity can be increased by more than 14.8% with the help of melting in the hydrogen containing atmosphere
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΎΠ΄Π½ΠΎΡΠΎΡΠΎΠ½Π½ΠΎΠΈ ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ, ΡΠΎΠ²ΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΌ Ρ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠ΅ΠΉ, Ρ ΡΠ΅Π»ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ
Objective. To evaluate the efficacy of single-photon emission computed tomography combined with computed tomography (SPECT-CT) in the diagnosis of breast cancer (BC).Materials and methods. We performed 44 SPECT-CT examinations in 40 women with malignant breast neoplasms.Study Results. The obtained data enabled us to calculate the characteristics of SPECT-CT in the evaluation of the primary tumor. The sensitivity, specificity, and diagnostic accuracy of the method were 88.1β%, 78.3β%, and 88.0β%, respectively. When the method was used to detect nodal and distant metastases, these characteristics were 87.3β%, 76.8β%, 86.9β% and 82.6β%, 73.1β%, 81.4β%, respectively.Conclusion. SPECT-CT is one of the most accurate methods to assess the primary tumor, lymph node involvement and distant metastases in BC.Β Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ·ΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΎΠ΄Π½ΠΎΡΠΎΡΠΎΠ½Π½ΠΎΠΉ ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ, ΡΠΎΠ²ΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ Ρ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠ΅ΠΉ (ΠΠ€ΠΠΠ’/ΠΠ’), Ρ ΡΠ΅Π»ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ (Π ΠΠ).ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ 44 ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΠ€ΠΠΠ’/ΠΠ’ 40 ΠΆΠ΅Π½ΡΠΈΠ½Π°ΠΌ ΡΠΎ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ ΠΌΠΎΠ»ΠΎΡΠ½ΡΡ
ΠΆΠ΅Π»Π΅Π·.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ Π½Π°ΠΌ ΡΠ°ΡΡΡΠΈΡΠ°ΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΠ€ΠΠΠ’/ΠΠ’ ΠΏΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. Π§ΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 88,1%, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ β 78,3%, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠ½ΠΎΡΡΡ β 88,0%. ΠΠ½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π»ΠΎΠ² ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, 87,3%, 76,8% ΠΈ 86,9%, ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² β 82,6%, 73,1% ΠΈ 81,4%.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ€ΠΠΠ’/ΠΠ’ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π»ΠΎΠ² ΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² ΠΏΡΠΈ Π ΠΠ.
Composite Medicine βAzisalβ Based on Azithromycin and Salicylic Acid
Salicylic acid essentially is obtained under the pressure by the method of Kolbe-Schmidt. One of the biggest
drawbacks of this method is the necessity of synthesizing sodium phenolate in advance which involves
considerable technological difficulties: water predistillation under vacuum and also the dry sodium phenolate
getting very hygroscopic. It is therefore of interest to look for more convenient alternative pathways
for the synthesis of salicylic acid, excluding the use of sodium phenolate and this drawback is eliminated
by using sodium and potassium salts of ethyl carbonic acid as carboxylation body. Consequently, according
to the more convenient method we obtained the salicylic acid. In medicine, 1% solution of salicylic acid
in 70 % alcohol called salicylic alcohol is used as an antiseptic. We investigated the antimicrobial activity
of a 1% solution of salicylic acid in various concentrations of ethanol (40%, 50%, 60%, 70%, 80% and
90%) in order to determine the effect of different concentrations of ethanol on the antimicrobial activity of
salicylic acid. The experiment proved that 1% solution of salicylic acid in various concentrations of ethanol
(40-90%) to the appropriate strains of bacteria acts with the same activity regardless of the concentration of
ethanol (40%, 50%, 60%, 70%, 80% and 90%). These actions of the acid are due to its solubility in alcohols
of different concentrations and complete disintegration of salicylic acid molecules into ions. Thus, on the
basis of antimicrobial research the necessity of preparation of 1% solution of salicylic acid in 40% alcohol
is proved as the drug is cheaper and cost-effective to produce. The technology of the new composition of
the drug βAzisalβ consisting of 0.25 g azithromycin and 1.0 g salicylic acid in 60% ethanol was developed,
in a similar way solution of azithromycin in different concentrations 0.25, 0.5, 0.75, 1.0% in 60% ethanol
were prepared and their antimicrobial activities were defined. The comparison of their antimicrobial activity
shows the effectiveness of the composite product called βAzisalβ
New materials for the electromechanical and acoustoelectric transducers
The technology for creation of the polymer-microsized piezoelectriccomposite substrate is developed by employing the electric gas dis-charge plasma method. It is determined experimentally that as aresult of the nano-structurization of the volume of the polymer-pie-zoceramic composite close to the surface it is Young and piezo-modulus as well as the mechanical quality and electromechanicalcoupling coefficients and the dielectric constant has been increased,whereas, tangent losses are decreased depending on the type of thenanoparticle and its volume rate
ΠΠΠ«Π’ ΠΠ ΠΠΠΠΠΠΠΠ― ΠΠΠΠΠ¦ΠΠΠ£ΠΠΠΠ Π£ ΠΠΠΠ¬ΠΠ«Π₯ ΠΠΠΠΠΠ ΠΠΠΠΠ¬ΠΠ«Π ΠΠΠΠΠ ΠΠΠ’ΠΠΠ¬ΠΠ«Π Π ΠΠΠΠ Π ΠΠΠ ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ‘Π’Π
Purpose. To conduct retrospective analysis of treatment results of combined first line therapy of metastatic colorectal cancer with bevacizumab with further bevacizumab maintenance and second line treatment with or without bevacizumab use in Kirov regional clinical oncology dispensary.Materials and methods. The study was conducted in Kirov regional clinical oncology dispensary from 2008 until 2014. 35 patients treated with combined first line therapy including bevacizumab with further bevacizumab maintenance and second line treatment with or without bevacizumab were retrospectively evaluated. Overall response was evaluated using RECIST ver. 1.1 criteria. Long term outcomes β progression free and overall survival were evaluated. Treatment safety was evaluated using NCI CTCAE.Results. There were no complete remissions in second line bevacizumab treatment, partial remissions were detected for 4 (22.2 %) patients, stable disease for 14 (77.8 %). Median progression free survival in both groups was comparable 9.1 and 10.4 months respectively. Patients treated with bevacizumab in first and second lines of treatment had 8.2 months survival benefit (p > 0.05).Conclusions. Combined first line therapy of metastatic colorectal cancer with bevacizumab with further bevacizumab maintenance and second line treatment with bevacizumab improves overall survival on 8.2 months in comparison with patients who stopped bevacizumab treatment after first disease progression.ΠΠ°Π΄Π°ΡΠΈ. ΠΡΠΎΠ²Π΅ΡΡΠΈ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ 1-ΠΉ Π»ΠΈΠ½ΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° (ΠΌΠΠ Π ) Ρ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ Ρ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ 2-ΠΉ Π»ΠΈΠ½ΠΈΠΈ Ρ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° ΠΈΠ»ΠΈ Π±Π΅Π· Π½Π΅Π³ΠΎ Π½Π° Π±Π°Π·Π΅ ΠΠΠΠΠ£Π Β«ΠΠΈΡΠΎΠ²ΡΠΊΠΈΠΉ ΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π΄ΠΈΡΠΏΠ°Π½ΡΠ΅ΡΒ».ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Π² ΠΠΈΡΠΎΠ²ΡΠΊΠΎΠΌ ΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π΄ΠΈΡΠΏΠ°Π½ΡΠ΅ΡΠ΅ Ρ 2008 ΠΏΠΎ 2014 Π³. Π Π΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΎΡΠ΅Π½Π΅Π½ΠΎ 35 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ 1-ΠΉ Π»ΠΈΠ½ΠΈΠΈ ΠΌΠΠ Π Ρ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ Ρ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΡ 2-ΠΉ Π»ΠΈΠ½ΠΈΠΈ Ρ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° ΠΈΠ»ΠΈ Π±Π΅Π· Π½Π΅Π³ΠΎ. ΠΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΎΡΠ΅Π½ΠΊΠ° Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° (ΠΎΠ±ΡΠΈΠΉ ΠΎΡΠ²Π΅Ρ) ΠΏΠΎ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ RECIST Π²Π΅ΡΡΠΈΡ 1.1. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»Π°ΡΡ ΠΌΠ΅Π΄ΠΈΠ°Π½Π° ΠΎΠ±ΡΠ΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ (ΠΠ) ΠΈ ΠΌΠ΅Π΄ΠΈΠ°Π½Π° Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ Π±Π΅Π· ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ (ΠΠΠ). ΠΡΠ΅Π½ΠΈΠ²Π°Π»Π°ΡΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ NCI CTCAE.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΠ²ΡΠΈΡ
ΡΠ΅ΡΠ°ΠΏΠΈΡ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±ΠΎΠΌ Π²ΠΎ 2-ΠΉ Π»ΠΈΠ½ΠΈΠΈ, ΠΏΠΎΠ»Π½ΡΡ
ΡΠ΅ΠΌΠΈΡΡΠΈΠΉ Π½Π΅ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ, ΡΠ°ΡΡΠΈΡΠ½ΡΠ΅ ΡΠ΅ΠΌΠΈΡΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π±ΡΠ»ΠΈ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Ρ Ρ 4 (22,2 %) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ Ρ 14 (77,8 %). ΠΠ΅Π΄ΠΈΠ°Π½Π° ΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
Π±ΡΠ»Π° ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΠΎΠΉ β 9,1 ΠΈ 10,4 ΠΌΠ΅Ρ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ (Π₯Π’) Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±ΠΎΠΌ Π² 1-ΠΉ ΠΈ 2-ΠΉ Π»ΠΈΠ½ΠΈΠΈ, Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΠ Π½Π° 8,2 ΠΌΠ΅Ρ (p > 0,05).ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±Π° Π² 1-ΠΉ Π»ΠΈΠ½ΠΈΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΌΠΠ Π Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±ΠΎΠΌ Π΄ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π²ΠΎ 2-ΠΉ Π»ΠΈΠ½ΠΈΠΈ ΡΠΎ ΡΠΌΠ΅Π½ΠΎΠΉ ΡΠ΅ΠΆΠΈΠΌΠ° Π₯Π’ Π΄ΠΎ 2-Π³ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΏΡΠΈΠ²Π΅Π»ΠΎ ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΠ Π½Π° 8,2 ΠΌΠ΅Ρ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π·Π°Π²Π΅ΡΡΠΈΠ²ΡΠΈΡ
ΡΠ΅ΡΠ°ΠΏΠΈΡ Π±Π΅Π²Π°ΡΠΈΠ·ΡΠΌΠ°Π±ΠΎΠΌ ΠΏΡΠΈ 1-ΠΌ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
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