High speed train communications systems using free space optics

In this work, we propose a broad-band free space optical (FSO) wireless communications system for high-speed trains. The system consists of optical transceivers positioned outside the train and along the railway track. The train receivers are in the coverage area of base stations positioned along the railway track to ensure continuous link availability. In this paper, we present modelling of two cases for over-ground and underground train systems before embarking to practically implement the system in our research laboratory. Also discussed is the protocol for the data distribution along the track as well as the initial experimental demonstration of the proposed link

Antiviral Activity of Some Plants Used in Nepalese Traditional Medicine

Methanolic extracts of 41 plant species belonging to 27 families used in the traditional medicine in Nepal have been investigated for in vitro antiviral activity against Herpes simplex virus type 1 (HSV-1) and influenza virus A by dye uptake assay in the systems HSV-1/Vero cells and influenza virus A/MDCK cells. The extracts of Astilbe rivularis, Bergenia ciliata, Cassiope fastigiata and Thymus linearis showed potent anti-herpes viral activity. The extracts of Allium oreoprasum, Androsace strigilosa, Asparagus filicinus, Astilbe rivularis, Bergenia ciliata and Verbascum thapsus exhibited strong anti-influenza viral activity. Only the extracts of A. rivularis and B. ciliata demonstrated remarkable activity against both viruses

Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma.

Despite the large comorbidity between PTSD and opioid use disorders, as well as the common treatment of physical injuries resulting from trauma with opioids, the ability of opioid treatments to subsequently modify PTSD-related behavior has not been well studied. Using the stress-enhanced fear learning (SEFL) model for PTSD, we characterized the impact of chronic opioid regimens on the sensitization of fear learning seen following traumatic stress in mice. We demonstrate for the first time that chronic opioid pretreatment is able to robustly augment associative fear learning. Highlighting aversive learning as the cognitive process mediating this behavioral outcome, these changes were observed after a considerable period of drug cessation, generalized to learning about multiple aversive stimuli, were not due to changes in stimulus sensitivity or basal anxiety, and correlated with a marker of synaptic plasticity within the basolateral amygdala. Additionally, these changes were not observed when opioids were given after the traumatic event. Moreover, we found that neither reducing the frequency of opioid administration nor bidirectional manipulation of acute withdrawal impacted the subsequent enhancement in fear learning seen. Given the fundamental role of associative fear learning in the generation and progression of PTSD, these findings are of direct translational relevance to the comorbidity between opioid dependence and PTSD, and they are also pertinent to the use of opioids for treating pain resulting from traumas involving physical injuries

Single carrier optical FDM in visible light communication

In this paper a comparison between a spiral and a strip shaped LED is presented in terms of the maximum link distance achievable in visible light based car to car communications (VLC-C2C). The transmitted data is recovered from the frame brightness of the video signal. The intensity modulated LED is captured from two scenarios, using a focused and unfocused camera. A data rate of 180 bps with the bit error rate performance below the FEC limit of 10-3 at a distance of 100 cm is successfully achieved, sufficient for transmitting road safety messages for VLC-C2C. It is shown that under the same conditions, the strip LED can effectively recover the data from a greater distance than its spiral counterpart

Noggin depletion in adipocytes promotes obesity in mice.

ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin is largely unknown. The aim of the study was to define the role of Noggin, an extracellular BMP inhibitor, in adipogenesis.MethodsWe generated adipose-derived progenitor cells and a mouse model with adipocyte-specific Noggin deletion using the AdiponectinCre transgenic mouse, and determined the adipose phenotype of Noggin-deficiency.ResultsOur studies showed that Noggin is expressed in progenitor cells but declines in adipocytes, possibly allowing for lipid accumulation. Correspondingly, adipocyte-specific Noggin deletion in vivo promoted age-related obesity in both genders with no change in food intake. Although the loss of Noggin caused white adipose tissue hypertrophy, and whitening and impaired function in brown adipose tissue in both genders, there were clear gender differences with the females being most affected. The females had suppressed expression of brown adipose markers and thermogenic genes including peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1alpha) and uncoupling protein 1 (UCP1) as well as genes associated with adipogenesis and lipid metabolism. The males, on the other hand, had early changes in a few BAT markers and thermogenic genes, but the main changes were in the genes associated with adipogenesis and lipid metabolism. Further characterization revealed that both genders had reductions in VO2, VCO2, and RER, whereas females also had reduced heat production. Noggin was also reduced in diet-induced obesity in inbred mice consistent with the obesity phenotype of the Noggin-deficient mice.ConclusionsBMP signaling regulates female and male adipogenesis through different metabolic pathways. Modulation of adipose tissue metabolism by select BMP antagonists may be a strategy for long-term regulation of age-related weight gain and obesity

Handover - Enabling Learning in Communication for Safety (HELiCS): a report on achievements at two hospital sites

The provision of health care is becoming increasingly complex and fragmented.1,2 As a result, to ensure continuity of care, the handover of clinical tasks is becoming more frequent and important. However, the general lack of clinical handover planning and training in handover communication creates unacceptable risks for patients.1 Not surprisingly, clinical handover has been identified as a major international policy and research priority

Vehicular Visible Light Positioning using Receiver Diversity with Machine Learning

This paper proposes a 2-D vehicular visible light positioning (VLP) system using existing streetlights and diversity receivers. Due to the linear arrangement of streetlights, traditional positioning techniques based on triangulation or similar algorithms fail. Thus, in this work, we propose a spatial and angular diversity receiver with machine learning (ML) techniques for VLP. It is shown that a multi-layer neural network (NN) with the proposed receiver scheme outperforms other ML algorithms and can offer high accuracy with root mean square (RMS) error of 0.22 m and 0.14 m during the day and night time, respectively. Furthermore, the NN shows robustness in VLP across different weather conditions and road scenarios. The results show that only dense fog deteriorates the performance of the system due to reduced visibility across the road

Experimental evaluation of adaptive maximum power point tracking for a standalone photovoltaic system

The adaptability of maximum power point tracking (MPPT) of a solar PV system is important for integration to a microgrid. Depending on what fixed step-size the MPPT controller implements, there is an impact on settling time to reach the maximum power point (MPP) and the steady state operation for conventional tracking techniques. This paper presents experimental results of an adaptive tracking technique based on Perturb and Observe (P&O) and Incremental Conductance (IC) for standalone Photovoltaic (PV) systems under uniform irradiance and partial shading conditions. Analysis and verification of measured and MATLAB/Simulink simulation results have been carried out. The adaptive tracking technique splits the operational region of the solar PV’s power–voltage characteristic curve into four and six operational sectors to understand the MPP response and stability of the technique. By implementing more step-sizes at sector locations based on the distance of the sector from the MPP, the challenges associated with fixed step-size is improved on.The measured and simulation results clearly indicate that the proposed system tracks MPP faster and displays better steady state operation than conventional system. The proposed system’s tracking efficiency is over 10% greater than the conventional system for all techniques. The proposed system has been under partial shading condition has been and it outperforms other techniques with the GMPP achieved in 0.9 s which is better than conventional techniques

Consulting (in Writing) to the Corporation: Principles and Pragmatics

Provenance information provides a useful basis to verify whether a particular application behavior has been adhered to. This is particularly useful to evaluate the basis for a particular outcome, as a result of a process, and to verify if the process involved in making the decision conforms to some pre-defined set of rules. This is significant in a healthcare scenario, where it is necessary to demonstrate that patient data has been processed in a particular way. Understanding how provenance information may be recorded, stored, and subsequently analyzed by a decision maker is therefore significant in a service oriented architecture, which involves the use of third party services over which the decision maker does not have control. The aggregation of data from multiple sources of patient information plays an important part in subsequent treatments that are proposed for a patient. A tool to navigate through and analyze such provenance information is proposed, based on the use of a portal framework that allows different views on provenance information to co-exist. The portal enables users to add custom portlets enabling application specific views that would facilitate particular decision making