190 research outputs found
Gravity as Archimedes' thrust and a bifurcation in that theory
Euler's interpretation of Newton's gravity (NG) as Archimedes' thrust in a
fluid ether is presented in some detail. Then a semi-heuristic mechanism for
gravity, close to Euler's, is recalled and compared with the latter. None of
these two "gravitational ethers" can obey classical mechanics. This is logical
since the ether defines the very reference frame, in which mechanics is
defined. This concept is used to build a scalar theory of gravity: NG
corresponds to an incompressible ether, a compressible ether leads to
gravitational waves. In the Lorentz-Poincar\'e version, special relativity is
compatible with the ether, but, with the heterogeneous ether of gravity, it
applies only locally. A correspondence between metrical effects of uniform
motion and gravitation is assumed, yet in two possible versions (one is new).
Dynamics is based on a (non-trivial) extension of Newton's second law. The
observational status for the theory with the older version of the
correspondence is summarized.Comment: 24 pages, invited contribution to the Franco Selleri Festschrift, to
appear in Found. Physics. v3: Endnote 45 on absolute simultaneity improved
(formerly footnote 6: class file changed to revtex4), a few references
updated (and now with titles). v2: minor correction in subsect. 3.2, some
wording improvements, and a few references adde
On a modified-Lorentz-transformation based gravity model confirming basic GRT experiments
Implementing Poincar\'e's `geometric conventionalism' a scalar
Lorentz-covariant gravity model is obtained based on gravitationally modified
Lorentz transformations (or GMLT). The modification essentially consists of an
appropriate space-time and momentum-energy scaling ("normalization") relative
to a nondynamical flat background geometry according to an isotropic,
nonsingular gravitational `affecting' function Phi(r). Elimination of the
gravitationally `unaffected' S_0 perspective by local composition of space-time
GMLT recovers the local Minkowskian metric and thus preserves the invariance of
the locally observed velocity of light. The associated energy-momentum GMLT
provides a covariant Hamiltonian description for test particles and photons
which, in a static gravitational field configuration, endorses the four `basic'
experiments for testing General Relativity Theory: gravitational i) deflection
of light, ii) precession of perihelia, iii) delay of radar echo, iv) shift of
spectral lines. The model recovers the Lagrangian of the Lorentz-Poincar\'e
gravity model by Torgny Sj\"odin and integrates elements of the precursor
gravitational theories, with spatially Variable Speed of Light (VSL) by
Einstein and Abraham, and gravitationally variable mass by Nordstr\"om.Comment: v1: 14 pages, extended version of conf. paper PIRT VIII, London,
2002. v2: section added on effective tensorial rank, references added,
appendix added, WEP issue deleted, abstract and other parts rewritten, same
results (to appear in Found. Phys.
Electrodeposition of Co-Ni-MoxOy Powders: Part I. The Influence of Deposition Conditions on Powder Composition and Morphology
The Co-Ni-MoxOy powders were obtained electrochemically at a constant current density from ammonia electrolyte. Ni and Co were anomalously deposited, inducing Mo deposition, which cannot be deposited separately from aqueous solutions. The obtained Co-Ni-MoxOy powders were investigated by energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and scanning electon microscope (SEM) methods. Based on the obtained experimental results, it was concluded that the particle size of deposited powders is influenced by the chemical composition of the electrolyte and current density imposed. XRD results suggested that obtained powders were of amorphous structure, although a Co3Mo compound can be formed if certain experimental conditions are applied
Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex: CatSpers and CatSperβ
The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex, together with an auxiliary subunit, CatSperβ. Here, we report a comprehensive comparative genomics study and evolutionary analysis of CatSpers and CatSperβ, with important correlation to physiological significance of molecular evolution of the CatSper channel complex. The development of the CatSper channel complex with four CatSpers and CatSperβ originated as early as primitive metazoans such as the Cnidarian Nematostella vectensis. Comparative genomics revealed extensive lineage-specific gene loss of all four CatSpers and CatSperβ through metazoan evolution, especially in vertebrates. The CatSper channel complex underwent rapid evolution and functional divergence, while distinct evolutionary constraints appear to have acted on different domains and specific sites of the four CatSper genes. These results reveal unique evolutionary characteristics of sperm-specific Ca2+ channels and their adaptation to sperm biology through metazoan evolution
Recent evolution of the NF-κB and inflammasome regulating protein POP2 in primates
<p>Abstract</p> <p>Background</p> <p>Pyrin-only protein 2 (POP2) is a small human protein comprised solely of a pyrin domain that inhibits NF-κB p65/RelA and blocks the formation of functional IL-1β processing inflammasomes. Pyrin proteins are abundant in mammals and several, like POP2, have been linked to activation or regulation of inflammatory processes. Because <it>POP2 </it>knockout mice would help probe the biological role of inflammatory regulation, we thus considered whether <it>POP2 </it>is common in the mammalian lineage.</p> <p>Results</p> <p>BLAST searches revealed that <it>POP2 </it>is absent from the available genomes of not only mice and rats, but those of other domestic mammals and New World monkeys as well. <it>POP2 </it>is however present in the genome of the primate species most closely related to humans including <it>Pan troglodytes </it>(chimpanzees), <it>Macaca mulatta </it>(rhesus macaques) and others. Interestingly, chimpanzee POP2 is identical to human POP2 (huPOP2) at both the DNA and protein level. Macaque POP2 (mqPOP2), although highly conserved is not identical to the human sequence; however, both functions of the human protein are retained. Further, <it>POP2 </it>appears to have arisen in the mammalian genome relatively recently (~25 mya) and likely derived from retrogene insertion of <it>NLRP2</it>.</p> <p>Conclusion</p> <p>Our findings support the hypothesis that the NLR loci of mammals, encoding proteins involved in innate and adaptive immunity as well as mammalian development, have been subject to recent and strong selective pressures. Since POP2 is capable of regulating signaling events and processes linked to innate immunity and inflammation, its presence in the genomes of hominids and Old World primates further suggests that additional regulation of these signals is important in these species.</p
Electrodeposition of Co-Ni-MoxOy Powders: Part I. The Influence of Deposition Conditions on Powder Composition and Morphology
Endosymbiont DNA in Endobacteria-Free Filarial Nematodes Indicates Ancient Horizontal Genetic Transfer
Background: Wolbachia are among the most abundant symbiotic microbes on earth; they are present in about 66% of all insect species, some spiders, mites and crustaceans, and most filarial nematode species. Infected filarial nematodes, including many pathogens of medical and veterinary importance, depend on Wolbachia for proper development and survival. The mechanisms behind this interdependence are not understood. Interestingly, a minority of filarial species examined to date are naturally Wolbachia-free.
Methodology/PrincipalFindings:We used 454 pyrosequencing to survey the genomes of two distantly related Wolbachia- free filarial species, Acanthocheilonema viteae and Onchocerca flexuosa. This screen identified 49 Wolbachia-like DNA sequences in A. viteae and 114 in O. flexuosa. qRT-PCR reactions detected expression of 30 Wolbachia-like sequences in A. viteae and 56 in O. flexuosa. Approximately half of these appear to be transcribed from pseudogenes. In situ hybridization showed that two of these pseudogene transcripts were specifically expressed in developing embryos and testes of both species.
Conclusions/Significance: These results strongly suggest that the last common ancestor of extant filarial nematodes was infected with Wolbachia and that this former endosymbiont contributed to their genome evolution. Horizontally transferred Wolbachia DNA may explain the ability of some filarial species to live and reproduce without the endosymbiont while other
species cannot
The map-1 Gene Family in Root-Knot Nematodes, Meloidogyne spp.: A Set of Taxonomically Restricted Genes Specific to Clonal Species
Taxonomically restricted genes (TRGs), i.e., genes that are restricted to a limited subset of phylogenetically related organisms, may be important in adaptation. In parasitic organisms, TRG-encoded proteins are possible determinants of the specificity of host-parasite interactions. In the root-knot nematode (RKN) Meloidogyne incognita, the map-1 gene family encodes expansin-like proteins that are secreted into plant tissues during parasitism, thought to act as effectors to promote successful root infection. MAP-1 proteins exhibit a modular architecture, with variable number and arrangement of 58 and 13-aa domains in their central part. Here, we address the evolutionary origins of this gene family using a combination of bioinformatics and molecular biology approaches. Map-1 genes were solely identified in one single member of the phylum Nematoda, i.e., the genus Meloidogyne, and not detected in any other nematode, thus indicating that the map-1 gene family is indeed a TRG family. A phylogenetic analysis of the distribution of map-1 genes in RKNs further showed that these genes are specifically present in species that reproduce by mitotic parthenogenesis, with the exception of M. floridensis, and could not be detected in RKNs reproducing by either meiotic parthenogenesis or amphimixis. These results highlight the divergence between mitotic and meiotic RKN species as a critical transition in the evolutionary history of these parasites. Analysis of the sequence conservation and organization of repeated domains in map-1 genes suggests that gene duplication(s) together with domain loss/duplication have contributed to the evolution of the map-1 family, and that some strong selection mechanism may be acting upon these genes to maintain their functional role(s) in the specificity of the plant-RKN interactions
Kimmeridgian-Tithonian sea-level fluctuations in the Uljanovsk-Saratov Basin (Russian Platform)
Abstract
The Uljanovsk-Saratov Basin, located in the southeast of the Russian Platform, presents an intriguing record of the Kimmeridgian-Tithonian sea-level fluctuations. In the Late Jurassic, this basin was a trough within the Interior Russian Sea. The data available from both outcrops and boreholes have permitted outlining a number of lithostratigraphic units and regional hiatuses in the northeastern segment of the Uljanovsk-Saratov Basin, thus permitting a precise reconstruction of transgressions/regressions and deepenings/shallowings. In total, three transgressive-regressive cycles and two deepening pulses have been established. These regionally documented changes were both related in part to global eustatic changes, and they also corresponded in part to the regional sea-level changes in some basins of Western Europe and Northern Africa, but not to those of the Arabian Platform. Differences observed between the global and regional curves as well as rapid Tithonian sea-level oscillations are explained by the influences of tectonic activity. It is hypothesized that the regional Tithonian oxygen depletion might have been a consequence from the rapid flooding of a densely vegetated land
On the quest for selective constraints shaping the expressivity of the genes casting retropseudogenes in human
<p>Abstract</p> <p>Background</p> <p>Pseudogenes, the nonfunctional homologues of functional genes are now coming to light as important resources regarding the study of human protein evolution. Processed pseudogenes arising by reverse transcription and reinsertion can provide molecular record on the dynamics and evolution of genomes. Researches on the progenitors of human processed pseudogenes delved out their highly expressed and evolutionarily conserved characters. They are reported to be short and GC-poor indicating their high efficiency for retrotransposition. In this article we focused on their high expressivity and explored the factors contributing for that and their relevance in the milieu of protein sequence evolution.</p> <p>Results</p> <p>We here, analyzed the high expressivity of these genes configuring processed or retropseudogenes by their immense connectivity in protein-protein interaction network, an inclination towards alternative splicing mechanism, a lower rate of mRNA disintegration and a slower evolutionary rate. While the unusual trend of the upraised disorder in contrast with the high expressivity of the proteins encoded by processed pseudogene ancestors is accredited by a predominance of hub-protein encoding genes, a high propensity of repeat sequence containing genes, elevated protein stability and the functional constraint to perform the transcription regulatory jobs. Linear regression analysis demonstrates mRNA decay rate and protein intrinsic disorder as the influential factors controlling the expressivity of these retropseudogene ancestors while the latter one is found to have the most significant regulatory power.</p> <p>Conclusions</p> <p>Our findings imply that, the affluence of disordered regions elevating the network attachment to be involved in important cellular assignments and the stability in transcriptional level are acting as the prevailing forces behind the high expressivity of the human genes configuring processed pseudogenes.</p
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