Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation

Dendritic cells (DCs) have shown promise for use in cancer vaccine and cancer immunotherapy studies. However, we demonstrate that cancer cell lines can negatively interfere with DC generation in granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived cultures, although cancer cells are able to enhance CD80 cell surface activation marker and cytokine secretion. Furthermore, in the presence of cancer cells, GM-CSF-derived DCs are unable to stimulate T-cells. Additional stimulation with toll-like receptor 4 cannot fully reverse the suppressive effect of cancer cells or supernatant. Hence, it is imperative to understand the immunosuppressive effects of cancer on DCs in order for DC-based cancer immunotherapy to be successful

Weyl-Underhill-Emmrich quantization and the Stratonovich-Weyl quantizer

Weyl-Underhill-Emmrich (WUE) quantization and its generalization are considered. It is shown that an axiomatic definition of the Stratonovich-Weyl (SW) quantizer leads to severe difficulties. Quantization on the cylinder within the WUE formalism is discussed.Comment: 15+1 pages, no figure

Charged Rotating Black Holes in Four-Dimensional Gauged and Ungauged Supergravities

We study four-dimensional non-extremal charged rotating black holes in ungauged and gauged supergravity. In the ungauged case, we obtain rotating black holes with four independent charges, as solutions of N=2 supergravity coupled to three abelian vector multiplets. This is done by reducing the theory along the time direction to three dimensions, where it has an O(4,4) global symmetry. Applied to the reduction of the uncharged Kerr metric, O(1,1)^4\subset O(4,4) transformations generate new solutions that correspond, after lifting back to four dimensions, to the introduction of four independent electromagnetic charges. In the case where these charges are set pairwise equal, we then generalise the four-dimensional rotating black holes to solutions of gauged N=4 supergravity, with mass, angular momentum and two independent electromagnetic charges. The dilaton and axion fields are non-constant. We also find generalisations of the gauged and ungauged solutions to include the NUT parameter, and for the ungauged solutions, the acceleration parameter too. The solutions in gauged supergravity provide new gravitational backgrounds for a further study of the AdS_4/CFT_3 correspondence at non-zero temperature.Comment: Latex, 30 page

Pair Production of Topological anti de Sitter Black Holes

The pair creation of black holes with event horizons of non-trivial topology is described. The spacetimes are all limiting cases of the cosmological $C$ metric. They are generalizations of the $(2+1)$ dimensional black hole and have asymptotically anti de Sitter behaviour. Domain walls instantons can mediate their pair creation for a wide range of mass and charge.Comment: 4 pages, uses late

Testing Born-Infeld electrodynamics in waveguides

Waveguides can be employed to test non-linear effects in electrodynamics. We solve Born-Infeld equations for TE waves in a rectangular waveguide. We show that the energy velocity acquires a dependence on the amplitude, and harmonic components appear as a consequence of the non-linear behavior.Comment: 3 pages. To appear in PR

Charged Particles and the Electro-Magnetic Field in Non-Inertial Frames of Minkowski Spacetime: II. Applications: Rotating Frames, Sagnac Effect, Faraday Rotation, Wrap-up Effect

We apply the theory of non-inertial frames in Minkowski space-time, developed in the previous paper, to various relevant physical systems. We give the 3+1 description without coordinate-singularities of the rotating disk and the Sagnac effect, with added comments on pulsar magnetosphere and on a relativistic extension of the Earth-fixed coordinate system. Then we study properties of Maxwell equations in non-inertial frames like the wrap-up effect and the Faraday rotation in astrophysics.Comment: This paper and the second one are an adaptation of arXiv 0812.3057 for publication on Int.J.Geom. Methods in Modern Phys. 36