450 research outputs found
Estimating sorber capacity for multiple contaminants
Computer program estimates quantity of activated charcoal required to control multiple contaminants. Program scans all contaminants by potential parameter value and then orders them from lowest to highest values. It calculates quantity of sorbent required to remove most strongly adsorbed material; and then, using potential plot data, capacity of other materials is calculated on basis of corrected capacity
Sixty day manned evaluation of zero gravity humidity control system
Manned evaluation of zero gravity humidity control system in potable water recovery unit for simulated spacecraft cabin
Development of a sorber trace contaminant control system including pre- and post-sorbers for a catalytic oxidizer
A general methodology was developed for spacecraft contaminant control system design. Elements considered for contaminant control were catalytic oxidation with isotope or electrical heat and pre- and post-sorbers, charcoal with regeneration and non-regeneration, and reactive constituents. A technique is described for sizing a charcoal bed for a multiple contaminant load
Study and preliminary design of an isotope- heated catalytic oxidizer system
Isotope fuel and catalyst selection for optimum isotope heated catalytic oxidizer system /ICHOS/ for control of trace contaminant
Development and design of an isotope-heated catalytic oxidizer trace contaminant control system
Development and design of isotope heated catalytic oxidizer trace contaminant control syste
Design, development, and fabrication of a water electrolysis system for a 90-day manned test Final report
Design, fabrication, and testing of circulating electrolyte type water electrolysis system for automatic control of spacecraft total pressure and oxygen partial pressur
Evaluation testing of zero gravity humidity control system
Design criteria for zero gravity hydrophobic/ hydrophilic type humidity control syste
Why dictators veto: legislation, legitimation and control in Kazakhstan and Russia
Why do authoritarian presidents still use their legislative power? Although recent studies have argued that authoritarian legislatures are more than “rubberstamps” and can serve as arenas for elite bargaining over policy, there is no evidence that legislators would pass bills that go against presidential preferences. This article investigates this apparent paradox and proposes a theoretical framework to explain presidential activism in authoritarian regimes. It argues that any bills that contravene constraints on policy-making set by the president should generally be stopped or amended by other actors loyal to the regime. Thus, presidents will rather use their veto (1) to protect the regime’s output legitimacy and stability, and/or (2) to reinforce their power vis-à-vis other actors. The argument is tested using two case studies of veto use in Kazakhstan and Russia over the last 10 years. The analysis supports the propositions of the theoretical framework and furthermore highlights the potential use of vetoes as a means of distraction, particularly in relation to international audiences. The article extends research on presidential veto power to authoritarian regimes and its findings contribute to the growing literature on the activities of authoritarian legislatures
Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response.
Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 (NLR, nucleotide oligomerization domain-like receptor) inflammasome was recently highlighted as a dominant etiological factor for acne vulgaris. Therefore, therapeutics targeting both the stimulus and the cascade would be ideal. Nitric oxide (NO), a potent biological messenger, has documented broad-spectrum antimicrobial and immunomodulatory properties. To harness these characteristics to target acne, we used an established nanotechnology capable of generating/releasing NO over time (NO-np). P. acnes was found to be highly sensitive to all concentrations of NO-np tested, although human keratinocyte, monocyte, and embryonic zebra fish assays revealed no cytotoxicity. NO-np significantly suppressed IL-1β, tumor necrosis factor-α (TNF-α), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively. Importantly, silencing of NLRP3 expression by small interfering RNA did not limit NO-np inhibition of IL-1 β secretion from monocytes, and neither TNF-α nor IL-6 secretion, nor inhibition by NO-np was found to be dependent on this pathway. The observed mechanism by which NO-np impacts IL-1β secretion was through inhibition of caspase-1 and IL-1β gene expression. Together, these data suggest that NO-np can effectively prevent P. acnes-induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response
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